Staff Profile
Louise Reynard graduated from the University of Cambridge with a MA Cantab in Natural Sciences, specialising in Genetics. She completed her PhD studies in Developmental Genetics at the MRC National Institute for Medical Research. Louise joined Newcastle University in 2009 when she began her postdoctoral training with Professor John Loughlin. She has now been promoted to Lecturer.
Dr Reynard’s research is focused on the functional characterisation of OA susceptibility loci that have been identified by the arcOGEN consortium. Elucidating the molecular mechanisms that underlie the susceptibility mediated by these genes will increase our understanding of OA etiology, potentially aid diagnosis and treatment, and will suggest relevant targets for therapeutic investigation. Louise is also interested in the molecular interplay between genetics and epigenetics in OA susceptibility, in particular, how DNA methylation can modulate the effect of genetic variation on disease penetrance and severity.
As a STEMNET Ambassador, Louise has spoken about her research at several public events including two events at the Centre for Life museum in Newcastle organised by the Xplore Health consortium funded by the European commission. She supervises several PhD students and postdoctoral scientists within Professor Loughlin’s group. Louise’s research is funded by Arthritis Research UK, the Dr William Harker Foundation, and the JGW Patterson Foundation. She is a member of the MRC-ARUK Centre for Integrated Research into Musculoskeletal Ageing and of the European Commission FP7 D-Board consortium that aims to identify and validate novel biomarkers of OA.
Publications
- Thalayasingam N, Nair N, Skelton AJ, Massey J, Anderson AE, Clark AD, Diboll J, Lendrem DW, Reynard LN, Cordell HJ, Eyre S, Isaacs JD, Barton A, Pratt AG. CD4+ and B lymphocyte expression quantitative traits at rheumatoid arthritis risk loci in untreated early arthritis: implications for causal gene identification. Arthritis Rheumatol 2017 [Epub ahead of print].
- Ratnayake M, Tselepi M, Bloxham R, Plöger F, Reynard LN, Loughlin J. A consistent and potentially exploitable response during chondrogenesis of mesenchymal stem cells from osteoarthritis patients to the protein encoded by the susceptibility gene GDF5. PLoS One. 2017 May 8;12(5):e0176523
- Styrkarsdottir U, Helgason H, Sigurdsson A, Norddahl GL, Agustsdottir AB, Reynard LN, Villalvilla A, Halldorsson GH, Jonasdottir A, Magnusdottir A, Oddson A, Sulem G, Zink F, Sveinbjornsson G, Helgason A, Johannsdottir HS, Helgadottir A, Stefansson H, Gretarsdottir S, Rafnar T, Almdahl IS, Brækhus A, Fladby T, Selbæk G, Hosseinpanah F, Azizi F, Koh JM, Tang NLS, Danesphour M, Mayordomo J, Welt C, Braund PS, Samani NJ, Kiemeney L, Lohmander LS, Christiansen C, Andreassen OA, arcOGEN consortium, Magnusson O, Masson G, Kong A, Jonsdottir I, Gudbjartsson D, Sulem P, Jonsson H, Loughlin J, Ingvarsson T, Thorsteinsdottir U, Stefansson K. Whole genome sequencing finds rare genotypes in COMP and CHADL associated with high risk of hip osteoarthritis. Nat Genet. 2017 May;49(5):801-805.
- Reynard LN, Ratnayake M, Santibanez-Koref M and Loughlin J. Functional characterisation of the osteoarthritis susceptibility mapping to CHST11. PLoS ONE 11(7):e0159024.
- Reynard LN. Analysis of genetics and DNA methylation in osteoarthritis: what have we learnt from the disease? Semin Cell Dev Biol. 2017 Feb;62:57-66
- Meulenbelt IM, Bhutani N, den Hollander W, Gay S, Opperman U, Reynard LN, Skelton AJ, Young DA, Beir F, Loughlin J. The first international workshop on the epigenetics of osteoarthritis. Connect Tissue Res 2016 30:1-12
- Dang TS, Willet JD, Griffin HR, Morgan NV, O'Boyle G, Arkwright PD, Hughes SM, Abinun M, Tee LJ, Barge D, Engelhardt KR, Jackson M, Cant AJ, Maher ER, Koref MS, Reynard LN, Ali S, Hambleton S. Defective Leukocyte Adhesion and Chemotaxis Contributes to Combined Immunodeficiency in Humans with Autosomal Recessive MST1 Deficiency. J Clin Immunol. 2016 Feb;36(2):117-22.
- Shepherd C, Skelton AJ, Rushton MD, Reynard LN, Loughlin J. Expression analysis of the osteoarthritis genetic susceptibility locus mapping to an intron of the MCF2L gene and marked by the polymorphism rs11842874. BMC Med genet. 2015 16(1):108.
- Rushton MD1, Reynard LN1, Young DA, Shepherd C, Darlay R, Cordell H, Loughlin J. Methylation quantitive trait locus (meQLT) analysis of osteoarthritis links epigenetics with genetic risk. Hum Mol Genet. 2015 24(25):7432
- Johnson K, Reynard LN, Loughlin J. Functional characterisation of the osteoarthritis susceptibility locus at chromosome 6q14.1 marked by the polymorphism rs9350591. BMC Medical Genetics 2015 16(1):81-44.
- Rogers E, Reynard LN, Loughlin J. The role of inflammation-related genes in osteoarthritis. Osteoarthritis Cartilage. 2015 23(11):1933-8
- Gee F, Rushton MD, Loughlin J, Reynard LN. The osteoarthritis susceptibility that maps to chromosome 20q13 correlates with an expression quantitative trait locus operating on NCOA3 and with functional variation at the polymorphism rs116855380. Arthritis Rheumatol. 2015 67(11):2923-32
- Rushton MD, Young DA, Loughlin J, Reynard LN. Differential DNA methylation and expression of inflammatory and zinc transporter genes defines sub-groups of osteoarthritis hip patients. Ann Rheum Dis. 2015 74(9):1778.
- Loughlin J, Reynard LN. Osteoarthritis: Epigenetics of articular cartilage in knee and hip OA. Nat Rev Rheumatol 2015 Jan;11(1):6-7.
- Lu W, Zhang Y, McDonald DO, Jing H, Carroll B, Robertson N, Zhang Q, Griffin H, Sanderson S, Lakey J, Morgan N, Reynard LN, Zheng L, Murdock HM, Turvey SE, Hackett SJ, Prestidge T, Hall JM, Cant AJ, Matthews HF, Santibanez-Koref MF, Simon AK, Korolchuk VI, Lenardo MJ, Hambleton S and Su HC. Dual proteolytic pathways govern glycolysis and immune competence. Cell 2014;159(7):1578-90.
- Reynard LN, Bui C, Syddall CM and Loughlin J. CpG methylation regulates allelic expression of GDF5 by modulating binding of SP1 and SP3 repressor proteins to the osteoarthritis SNP rs143383. Hum Genet 2014;133(8):1059-73.
- Rushton MD, Reynard LN, Barter MJ, Refaie R, Rankin KS, Young DA and Loughlin J. Characterization of the cartilage DNA methylome in knee and hip osteoarthritis. Arthritis Rheumatol 2014;66(9):2450-60.
- Raine EV, Reynard LN, van der Laar IM, Bertoli-Avelia AM, and Loughlin J. Identification and analysis of a SMAD3 cis-acting eQTL operating in primary osteoarthritis and in the aneurysms and osteoarthritis syndrome. Osteoarthritis Cartilage 2014;22(5):698-705.
- Gee F, Clubbs CF, Raine EV, Reynard LN and Loughlin J. Allelic expression analysis of the osteoarthritis susceptibility locus that maps to chromosome 3p21 reveals cis-acting eQTLs at GNL3 and SPCS1. BMC Med Genet 2014;15(1):53.
- Syddall CM, Reynard LN, Young DA and Loughlin J. The identification of trans-acting factors that regulate the expression of GDF5 via the osteoarthritis susceptibility SNP rs143383. PLoS Genet 2013; 9(6).
- Raine EV, Dodd AW, Reynard LN and Loughlin J. Allelic expression analysis of the osteoarthritis susceptibility gene COL11A1 in human joint tissues. BMC Musculoskelet Disord 2013 Mar 8;14:85
- Reynard LN and Loughlin J. Insights from human genetic studies into the cellular and molecular switches involved in osteoarthritis etiology. Nature Reviews Rheumatology. 2013 9(10):573-83
- Reynard LN and Loughlin J. The genetics and functional analysis of primary osteoarthritis susceptibility. Expert Rev Mol Med. 2013 Feb 18;15.
- Raine E, Wreglesworth N, Dodd A, Reynard LN and Loughlin J. Gene expression analysis reveals HBP1 as a key target for the osteoarthritis susceptibility locus that maps to chromosome 7q22. Ann Rheum Dis.2012 Dec; 71(12):2020-7.
- Bui C, Barter MJ, Scott JL, Xu Y, Galler M, Reynard LN, Rowan AD and Young DA. cAMP response element-binding (CREB) recruitment following a specific CpG demethylation leads to the elevated expression of the matrix metalloproteinase 13 in human articular chondrocytes and osteoarthritis. FASEB J. 2012 Jul;26(7):300-11.
- Ratnayake M, Reynard LN, Raine EV, Santibanez-Koref M and Loughlin J. Allelic expression analysis of the osteoarthritis susceptibility locus that maps to MICAL3. BMC Med Genet. 2012 Mar 2;13(1):12
- Reynard LN and Loughlin J. Genetics and epigenetics of osteoarthritis. Maturitas. 2012 March;71(3):200-4.
- Dickinson RE, Griffin H, Bigley V, Reynard LN, Hussain R, Haniffa M, Lakey JH, Rahman T, Wang XN, McGovern N, Pagan S, Cookson S, McDonald D, Chua I, Wallis J, Cant A, Wright M, Keavney B, Chinnery PF, Loughlin J, Hambleton S, Santibanez-Koref M and Collin M. Exome sequencing identifies GATA-2 mutation as the cause of dendritic cell, monocyte, B and NK lymphoid deficiency. Blood. 2011 Sep 8;118(10):2656-8.
- Reynard LN, Bui C, Canty-Laid EG, Young DA and Loughlin J. Expression of the osteoarthritis-associated gene GDF5 is modulated epigenetically by DNA methylation. Hum Mol Genet 2011;20(September(17)):3450-60.
- Dodd AW, Rodriguez-Fontenla C, Calaza M, Carr A, Gomez-Reino JJ, Tsezou A, Reynard LN, Gonzalez A and Loughlin J. Deep sequencing of GDF5 reveals the absence of rare variants at this important osteoarthritis susceptibility locus. Osteoarthritis Cartilage. 2011 Apr;19(4):430-4.
- Reynard LN, Bui C, Syddall CM, Loughlin J. CpG methylation regulates allelic expression of GDF5 by modulating binding of SP1 and SP3 repressor proteins to the osteoarthritis susceptibility SNP rs143383. Human Genetics 2014, 133(8), 1059-1073.
- Rushton MD, Reynard LN, Barter MJ, Refaie R, Rankin KS, Young DA, Loughlin J. Characterization of the cartilage DNA methylome in knee and hip osteoarthritis. Arthritis & Rheumatology 2014, 66(9), 2450-2460.
- Raine EVA, Reynard LN, van de Laar IMBH, Bertoli-Avella AM, Loughlin J. Identification and analysis of a SMAD3 cis-acting eQTL operating in primary osteoarthritis and in the aneurysms and osteoarthritis syndrome. Osteoarthritis and Cartilage 2014, 22(5), 698-705.
- Gee F, Clubbs CF, Raine EVA, Reynard LN, Loughlin J. Allelic expression analysis of the osteoarthritis susceptibility locus that maps to chromosome 3p21 reveals cis-acting eQTLs at GNL3 and SPCS1 . BMC Medical Genetics 2014, 15, 53.
- Syddall CM, Reynard LN, Young DA, Loughlin J. The Identification of Trans-acting Factors That Regulate the Expression of GDF5 via the Osteoarthritis Susceptibility SNP rs143383. PLoS Genetics 2013, 9(6), e1003557.
- Reynard LN, Loughlin J. Insights from human genetic studies into the pathways involved in osteoarthritis. Nature Reviews Rheumatology 2013, 9, 573-583.
- Raine EV, Dodd AW, Reynard LN, Loughlin J. Allelic expression analysis of the osteoarthritis susceptibility gene COL11A1 in human joint tissues. BMC Musculoskeletal Disorders 2013, 14, 85.
- Reynard LN, Loughlin J. The genetics and functional analysis of primary osteoarthritis susceptibility. Expert Reviews in Molecular Medicine 2013, 15, e2-e16.
- Reynard LN, Loughlin J. Genetics and epigenetics of osteoarthritis. Maturitas 2012, 71(3), 200–204.
- Ratnayake M, Reynard LN, Raine EVA, Santibanez-Koref M, Loughlin J. Allelic expression analysis of the osteoarthritis susceptibility locus that maps to MICAL3. BMC Medical Genetics 2012, 13(1), 12.
- Bui C, Barter MJ, Scott JL, Xu Y, Galler M, Reynard LN, Rowan AD, Young DA. cAMP response element-binding (CREB) recruitment following a specific CpG demethylation leads to the elevated expression of the matrix metalloproteinase 13 in human articular chondrocytes and osteoarthritis. FASEB Journal 2012, 26(7), 3000-3011.
- Raine EVA, Wreglesworth N, Dodd AW, Reynard LN, Loughlin J. Gene expression analysis reveals HBP1 as a key target for the osteoarthritis susceptibility locus that maps to chromosome 7q22. Annals of the Rheumatic Diseases 2012, 71(12), 2020-2027.
- Reynard LN, Bui C, Canty-Laird EG, Young DA, Loughlin J. Expression of the osteoarthritis-associated gene GDF5 is modulated epigenetically by DNA methylation. Human Molecular Genetics 2011, 20(17), 3450-3460.
- Dodd AW, Rodriguez-Fontenla C, Calaza M, Carr A, Gomez-Reino JJ, Tsezou A, Reynard LN, Gonzalez A, Loughlin J. Deep sequencing of GDF5 reveals the absence of rare variants at this important osteoarthritis susceptibility locus. Osteoarthritis and Cartilage 2011, 19(4), 430-434.
- Dickinson RE, Griffin H, Bigley V, Reynard LN, Hussain R, Haniffa M, Lakey JH, Rahman T, Wang XN, McGovern N, Pagan S, Cookson S, McDonald D, Chua I, Wallis J, Cant A, Wright M, Keavney B, Chinnery PF, Loughlin J, Hambleton S, Santibanez-Koref M, Collin M. Exome sequencing identifies GATA-2 mutation as the cause of dendritic cell, monocyte, B and NK lymphoid deficiency. Blood 2011, 118(10), 2656-2658.
- Reynard LN, Turner JM. Increased sex chromosome expression and epigenetic abnormalities in spermatids from male mice with Y chromosome deletions. Journal of Cell Science 2009, 122(22), 4239-4248.
- Reynard L, Cocquet J, Burgoyne PS. The multi-copy mouse gene Sycp3-like Y-linked (Sly) encodes an abundant spermatid protein that interacts with a histone acetyltransferase and an acrosomal protein. Biology of Reproduction 2009, 81(2), 250-257.
- Reynard LN, Turner JM, Burgoyne PS. Expression analysis of the mouse multi-copy X-linked gene Xlr-related, meiosis-regulated (Xmr), reveals that Xmr encodes a spermatid-expressed cytoplasmic protein, SLX/XMR. Biology of Reproduction 2007, 77(2), 329-335.
- Toure A, Clemente EJ, Ellis P, Mahadevaiah SK, Ojarikre OA, Ball PA, Reynard L, Loveland KL, Burgoyne PS, Affara NA. Identification of novel Y chromosome encoded transcripts by testis transcriptome analysis of mice with deletions of the Y chromosome long arm. Genome Biology 2005, 6(12), R102.
- Rushton MD, Young DA, Loughlin J, Reynard LN. Differential DNA methylation and expression of inflammatory and zinc transporter genes defines subgroups of osteoarthritic hip patients. Annals of the Rheumatic Diseases 2015, 74(9), 1778-1782.
- Johnson K, Reynard LN, Loughlin J. Functional characterisation of the osteoarthritis susceptibility locus at chromosome 6q14.1 marked by the polymorphism rs9350591. BMC Medical Genetics 2015, 16(1), 81.
- Rushton MD, Reynard LN, Young DA, Shepherd C, Darlay R, Cordell HJ, Loughlin J. Methylation of cartilage DNA is a mediator of genetic risk at several OA susceptibility loci. In: 2015 Osteoarthritis Research Society International (OARSI) World Congress. 2015, Seattle, WA, USA: Elsevier.
- Loughlin J, Reynard LN. Osteoarthritis: Epigenetics of articular cartilage in knee and hip OA. Nature Reviews Rheumatology 2015, 11(1), 6-7.
- Loughlin J, Reynard LN. Osteoarthritis: Epigenetics of articular cartilage in knee and hip OA. Nature Reviews Rheumatology 2015, 11(1), 7-8.
- Gee F, Rushton MD, Loughlin J, Reynard LN. Correlation of the Osteoarthritis Susceptibility Variants That Map to Chromosome 20q13 With an Expression Quantitative Trait Locus Operating on NCOA3 and With Functional Variation at the Polymorphism rs116855380. Arthritis & Rheumatology 2015, 67(11), 2923-2932.
- Rogers EL, Reynard LN, Loughlin J. The role of inflammation-related genes in osteoarthritis. Osteoarthritis and Cartilage 2015, 23(11), 1933-1938.
- Gee FH, Clubbs CF, Raine EV, Reynard LN, Loughlin J. Allelic expression analysis of genes from within the osteoarthritis susceptibility locus at chromosome 3p21 reveals functional gene expression effects at GNL3 and SPCS1 that correlate with the association signal. In: 2014 World Congress on Osteoarthritis: Promoting Clinical and Basic Research in Osteoarthritis. 2014, Paris: Elsevier.
- Gee F, Clubbs CF, Raine EV, Reynard LN, Loughlin J. Allelic expression analysis of the osteoarthritis susceptibility locus that maps to chromosome 3p21 reveals cis-acting eQTLs at GNL3 and SPCS1. BMC Medical Genetics 2014, 15, 53.
- Rushton MD, Reynard LN, Barter MJ, Rankin KS, Young DA, Loughlin J. Characterisation of the cartilage DNA methylome in knee and hip osteoarthritis using high-density genome-wide analysis. In: 2014 World Congress on Osteoarthritis: Promoting Clinical and Basic Research in Osteoarthritis. 2014, Paris: Elsevier.
- Lu W, Zhang Y, McDonald DO, Jing HE, Carroll B, Robertson N, Zhang Q, Griffin H, Sanderson S, Lakey JH, Morgan NV, Reynard LN, Zheng L, Murdock HM, Turvey SE, Hackett SJ, Prestidge T, Hall JM, Cant AJ, Matthews HF, Koref MFS, Simon AK, Korolchuk VI, Lenardo MJ, Hambleton S, Su HC. Dual Proteolytic Pathways Govern Glycolysis and Immune Competence. Cell 2014, 159(7), 1578-1590.
- Rogers EL, Reynard LN, Rennie K, Rankin K, Loughlin J. Expression analysis of osteoarthritis associated genes in mesenchymal stem cells differentiating into joint-associated cells. In: 2014 World Congress on Osteoarthritis: Promoting Clinical and Basic Research in Osteoarthritis. 2014, Paris: Elsevier.
- Johnson K, Reynard LN, Loughlin J. Functional analysis of the osteoarthritis susceptibility locus marked by the polymorphism rs10492367. In: 2014 World Congress on Osteoarthritis: Promoting Clinical and Basic Research in Osteoarthritis. 2014, Paris: Elsevier.
- Reynard LN, Ratnayake M, Santibanez-Koref M, Loughlin J. Functional analysis of the osteoarthritis susceptibility locus residing at the carbohydrate sulfotransferase 11 gene CHST11. In: 2014 World Congress on Osteoarthritis: Promoting Clinical and Basic Research in Osteoarthritis. 2014, Paris: Elsevier.
- Raine EV, Reynard LN, vandeLaar IM, Bertoli-Avella AM, Loughlin J. Identification and analysis of a SMAD3 cis-acting eQTL operating in primary osteoarthritis and in the aneurysms and osteoarthritis syndrome. Osteoarthritis Cartilage 2014, 22(5), 698-705.
- Rushton MD, Gee FH, Reynard LN, Loughlin J. The osteoarthritis association marked by SNP rs6094710 mediates its effect by reducing the expression of NCOA3 in joint tissues. In: 2014 World Congress on Osteoarthritis: Promoting Clinical and Basic Research in Osteoarthritis. 2014, Paris: Elsevier.
- Ratnayake M, Reynard LN, Raine EV, Santibanez-Koref M, Loughlin J. Allelic expression analysis of the osteoarthritis susceptibility locus that maps to MICAL3. BMC Medical Genetics 2012, 13, 12.
- Raine EV, Wreglesworth N, Dodd AW, Reynard LN, Loughlin J. Gene expression analysis reveals HBP1 as a key target for the osteoarthritis susceptibility locus that maps to chromosome 7q22. Annals of the Rheumatic Diseases 2012, 71(12), 2020-2027.
- Shepherd C, Skelton AJ, Rushton MD, Reynard LN, Loughlin J. Expression analysis of the osteoarthritis genetic susceptibility locus mapping to an intron of the MCF2L gene and marked by the polymorphism rs11842874. BMC Medical Genetics 2015, 16(1), 108.
- Rushton MD, Reynard LN, Young DA, Shepherd C, Aubourg G, Gee F, Darlay R, Deehan D, Cordell HJ, Loughlin J. Methylation quantitative trait locus (meQTL) analysis of osteoarthritis links epigenetics with genetic risk. Human Molecular Genetics 2015, 24(25), 7432-7444.
- Ratnayake M, Tselepi M, Bloxham R, Plöger F, Reynard LN, Loughlin J. A consistent and potentially exploitable response during chondrogenesis of mesenchymal stem cells from osteoarthritis patients to the protein encoded by the susceptibility gene GDF5. PLoS ONE 2017, 12(5), e0176523.
- Reynard LN. Analysis of genetics and DNA methylation in osteoarthritis: What have we learnt about the disease?. Seminars in Cell and Developmental Biology 2017, 62, 57-66.
- Thalayasingam N, Nair N, Skelton AJ, Massey J, Anderson AE, Clark AD, Diboll J, Lendrem DW, Reynard LN, Cordell HJ, Eyre S, Isaacs JD, Barton A, Pratt AG. CD4+ and B lymphocyte expression quantitative traits at rheumatoid arthritis risk loci in untreated early arthritis: implications for causal gene identification. Arthritis and Rheumatology 2018, 70(3), 361-370.
- Rice SJ, Aubourg G, Sorial AK, Deehan D, Loughlin J, Reynard LN. Epigenetic and transcriptional effects operate on the SUPT3H and RUNX2 genes residing at the chromosome 6p21.1 osteoarthritis susceptibility locus and correlate with the association signal. In: 2017 OARSI World Congress. 2017, Las Vegas, NV, USA.
- Meulenbelt IM, Bhutani N, den Hollander W, Gay S, Oppermann U, Reynard LN, Skelton AJ, Young DA, Beier F, Loughlin J. The first international workshop on the epigenetics of osteoarthritis. Connective Tissue Research 2017, 58(1), 37-48.
- Styrkarsdottir U, Helgason H, Sigurdsson A, Norddahl GL, Agustsdottir AB, Reynard LN, Villalvilla A, Halldorsson GH, Jonasdottir A, Magnusdottir A, Oddson A, Sulem G, Zink F, Sveinbjornsson G, Helgason A, Johannsdottir HS, Helgadottir A, Stefansson H, Gretarsdottir S, Rafnar T, Almdahl IS, Brækhus A, Fladby T, Selbæk G, Hosseinpana F, Azizi F, Koh JM, Tang NL, Danesphour M, Mayordomo JI, Welt C, Braund PS, Samani NJ, Kiemeney LA, Lohmander LS, Christiansen C, Andreassen OA, arcOGEN consortium, Magnusson O, Masson G, Kong A, Jonsdottir I, Gudbjartsson D, Sulem P, Jonsson H, Loughlin J, Ingvarsson T, Thorsteinsdottir U, Stefansson K. Whole-genome sequencing identifies rare genotypes in COMP and CHADL associated with high risk of hip osteoarthritis. Nature Genetics 2017, 49(5), 801-805.
- Skelton AJ, den Hollander W, Jeffries M, Gomez R, Donica M, Baker L, Lakenberg N, de Dijcker W, Slagboom EP, Loughlin J, Meulenbelt I, Reynard LN. Age-related DNA methylation changes in normal and osteoarthritis cartilage. In: 2016 OARSI World Congress on Osteoarthritis - Promoting Clinical and Basic Research in Osteoarthritis. 2016, Amsterdam, Netherlands: Elsevier.
- Singh Dang T, Willet JDP, Griffin HR, Morgan NV, O'Boyle G, Arkwright PD, Hughes SM, Abinun M, Tee LJ, Barge D, Engelhardt KR, Jackson M, Cant AJ, Maher ER, Santibanez Koref M, Reynard LN, Ali S, Hambleton S. Defective Leukocyte Adhesion and Chemotaxis Contributes to Combined Immunodeficiency in Humans with Autosomal Recessive MST1 Deficiency. Journal of Clinical Immunology 2016, 36(2), 117-122.
- Tselepi M, Ratnayake M, Bloxham R, Reynard LN, Loughlin J. Differences in the response of mesenchymal stem cells from healthy donors and OA patients to exogenous GDF5 during chondrogenic differentiation. In: 2016 OARSI World Congress on Osteoarthritis - Promoting Clinical and Basic Research in Osteoarthritis. 2016, Amsterdam, Netherlands: Elsevier.
- Villalvilla A, Gee F, Loughlin J, Reynard LN. DNA methylation in the 20q13 OA susceptibility region marked by rs6094710 is associated with modulation of NCOA3 gene expression. In: 2016 OARSI World Congress on Osteoarthritis: Promoting Clinical and Basic Research in Osteoarthritis. 2016, Amsterdam, The Netherlands: Elsevier.
- Dang TS, Willet JDP, Griffin HR, Morgan NV, O'Boyle G, Arkwright PD, Hughes SM, Abinun M, Tee LJ, Barge D, Engelhardt KR, Jackson M, Cant AJ, Maher ER, Koref MS, Reynard LN, Ali S, Hambleton S. Erratum to: Defective Leukocyte Adhesion and Chemotaxis Contributes to Combined Immunodeficiency in Humans with Autosomal Recessive MST1 Deficiency (vol 36, pg 117, 2016). Journal of Clinical Immunology 2016, 36(3), 336-337.
- Shepherd C, Skelton AJ, Rushton MD, Reynard LN, Loughlin J. Expression analysis of the osteoarthritis genetic susceptibility locus mapping to an intron of the MCF2L gene and marked by the polymorphism rs11842874. In: 2016 OARSI World Congress on Osteoarthritis: Promoting Clinical and Basic Research in Osteoarthritis. 2016, Amsterdam, The Netherlands: Elsevier.
- Reynard LN, Ratnayake M, Santibanez-Koref M, Loughlin J. Functional characterization of the osteoarthritis susceptibility mapping to CHST11 - a bioinformatics and molecular study. PLoS ONE 2016, 11(7), e0159024.
- Rogers EL, Reynard LN, Rankin K, Loughlin J. Functional Investigation of an OA susceptibility locus at chromsome 9q33.1 associated with female hip osteoarthritis. In: OARSI World Congress on Osteoarthritis: Promoting Clinical and Basic Research in Osteoarthritis. 2016, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND: Elsevier Science Ltd.
- Pratt AG, Massey J, Anderson AE, Nair N, Diboll J, Skelton A, Lendrem DW, Reynard LN, Cordell HJ, Eyre S, Barton A, Isaacs JD. Identification of novel expression quantitative trait loci in CD4+ T cells of untreated early arthritis patients. In: 36th European Workshop for Rheumatology Research. 2016, York: BMJ Group.
- Tregilgas L, Reynard LN, Tew SR, Loughlin J, Clegg PD, Canty-Laird EG. Investigating the effects of high-glucose exposure on DNA methylation and gene transcription in musculoskeletal cells. In: 2016 OARSI World Congress on Osteoarthritis: Promoting Clinical and Basic Research in Osteoarthritis. 2016, Amsterdam, The Netherlands: Elsevier.
- Rushton MD, Young DA, Loughlin J, Reynard LN. Differential DNA methylation and expression of inflammatory and zinc transporter genes defines sub-groups of osteoarthritic hip patients. In: 2015 OARSI World Congress on Osteoarthritis: Celebrating 25 Years of Osteoarthritis Research. 2015, Seattle, WA, USA: Elsevier.
- Reynard LN, Loughlin J. The carbohydrate sulfotransferase gene CHST11 is regulated by DNA methylation which impacts on the functional effect of the OA generic susceptibility residing at this locus. In: 2015 OARSI World Congress on Osteoarthritis: Celebrating 25 Years of Osteoarthritis Research. 2015, Seattle, Washington, USA: Elsevier.
- Shepherd C, Zhu D, Skelton AJ, Combe J, Threadgold H, Zhu L, Vincent TL, Stuart P, Reynard LN, Loughlin J. Functional characterization of the osteoarthritis genetic risk residing at ALDH1A2 identifies rs12915901 as a key target variant. Arthritis & Rheumatology 2018, 70(10), 1577-1587.
- Shepherd C, Reynard LN, Loughlin J. Genotype at the MGP OA risk locus correlates with an expression quantitative trait locus operating on MGP in cartilage and with DNA methylation at a cluster of regulatory CpGs within ARHGDIB. In: Osteoarthritis Research Society International 2018. 2018, Liverpool: Osteoarthritis & Cartilage.
- Shepherd C, Zhu D, Skelton AJ, Combe J, Reynard LN, Loughlin J. Functional characterisation of the osteoarthritis genetic risk locus that resides at the gene ALDH1A2, coding for the retinoic acid synthesis enzyme RALDH2, identifies rs4646636 and rs12915901 as key target SNPs. In: Osteoarthritis Research Society International 2017. 2017, Las Vegas, NV, USA: Elsevier.