Staff Profile

As consultant Paediatric Infectious Diseases & Immunology and Honorary Professor of Paediatric Infectious Diseases I have a sound background in clinic and research from the start. I studied Medicine and Biomedical Sciences in Leiden, the Netherlands, after which I combined my Paediatric training with a PhD post in the Paediatric Infectious Diseases Laboratory at Erasmus MC, Rotterdam, The Netherlands.

I completed my PhD on immunogenetics of infectious and inflammatory diseases in 2008. Initially focussing on meningococcal disease I broadened my horizon to include other bacterial infections. My PhD formed the start of wonderful collaborations resulting in participation in two large European funded consortia.

The overarching theme in activities is the promotion of diagnostic and therapeutic possibilities for childhood infections, particularly in an era of increasing antimicrobial resistance. This requires focus of the research on:

1.     Early recognition of the type of infection: bacterial vs viral, and type of bacterial infection. This can minimise the unnecessary use of antimicrobials in patients presenting with fever at an A&E, and thus prevent antimicrobial resistance.

2.     Identification of alternative therapeutic targets, particularly in recurrent infective conditions to circumvent antimicrobial resistance. Innate immune factors could be these targets and elucidating their role in infection will aid in identifying which ones could also be targeted for prevention and/or treatment.

3.     Participation in randomised controlled trials facilitating registration of safe and effective antimicrobial/antiviral drugs for paediatric use. 

In addition, with my team I have started to explore heallth inequality in infectious diseases. Infections like brain abscesses are more prevalent in the deprived Northeast, and also ED attendance for febrile illness is high for children from low IMD score (more deprived) areas in the region.

Please click on the research tab above for further details.

This theme is also reflected in my work as consultant Paediatric Infectious Diseases & Immunology at the Great North Children's Hospital (GNCH) where I look after children with (severe) bacterial, fungal and viral infections. These include meningitis, osteomyelitis (in collaboration with the paediatric orthopaedic team) and congenital CMV infections. With our team, we provide a consultation service as part of the antimicrobial stewardship program. In addition, I am the Paediatric lead for the High Consequence Infectious Diseases Unit in the RVI

I am Curriculum director for the Post Graduate Clinical Research Programmes (Attendance and eLearning) for the Graduate School.

I am Deputy Clinical Director and Patient Safety & Governance Lead for the Children's Directorate, GNCH

Area of expertise

• Paediatric Infectious Diseases
• Immunology

ORCID: Click here.
ResearchGate: Click here.

My work spans basic science, observational research and randomised controlled trials (RCTs). The work focuses on infectious diseases in children with an interest in early diagnosis and innate immunity.

Additionally I conduct projects aimed at evaluation of infection management with direct impact on clinical practice.

Most of the work I am involved in is (inter)national and collaborative.

EUCLIDS (European childhood life threatening infectious diseases study) is a large FP7 funded project looking at genetics of severity and susceptibility of infection using bacterial meningitis and sepsis as a model. Using RNA expression analysis disease specific profiles are being assessed to identify relevant pathways. Our collaborators explore findings in our patient population in in vitro and animal models.

PERFORM (Personalised medicine for febrile illness) is an €18 million collaborative project funded under the European Commission’s Horizon 2020 programme for research and innovation.

This five-year project will look at ways to reduce antibiotic misuse, through the development of improved tests used to distinguish bacterial from viral infections. Currently, doctors have very limited capacity to reliably differentiate life-threatening bacterial infections from trivial viral illnesses in children. As a result, thousands of children worldwide undergo investigations such as lumbar punctures, x-rays and blood cultures, and are treated with broad spectrum antibiotics while waiting to rule out bacterial infection. Better tests to identify those children with life threatening infection amongst the infinitely more numerous children with viral infections are urgently needed if antibiotic use is to be reduced. PERFORM will apply sophisticated genomic and proteomic methods to study thousands of febrile children with the aim of identifying and developing a better test for bacterial infection than what is currently available.

Part of this study MOFICHE looks at resource use in 38,000 children visiting EDs in European hospitals. For children who visited the three participating hospitals in the UK we also looked at the association with deprivation.

DIAMONDS (Diagnosis and Management of Febrile Illness using RNA Personalised Molecular Signature Diagnosis) is an €22 million collaborative project funded under the European Commission’s Horizon 2020 IA programme.

This project aims to rapid test to develop and pilot a test to diagnose severe illnesses such as sepsis and meningitis, using personalised gene signatures. The international consortium will build a gene signature library where signatures of all common infectious and inflammatory diseases will be stored and made publicly available. Comparison of gene expression patterns in each patient's blood sample, allows that the diagnosis in each individual can be made rapidly.  

Newcastle leads on the cohort including immunocompromised patients in whom infection risk is increased and diagnosing cause of infection can be very challenging in these two projects. So far over 50000 patients have been recruited, about 4000 of which in Newcastle. In addition we work with the Young Persons Advisory Group North England and obtain their views regarding consent, biobanking, and use of data.

I welcome contact from any students or potential collaborators who may be interested in working with us.

Collaborators

The EUCLIDS project involves collaboration with investigator from multiple sites in the UK, the Netherlands, Spain, Austria, Germany, Switzerland, Singapore, and Gambia.

PERFORM is conducted in UK sites (Liverpool, London, Oxford, Newcastle), the Netherlands (Rotterdam, Amsterdam, Nijmegen), Spain (Santiago de Compostella), Austria (Graz), Germany (Munich), Latvia (Riga), Greece (Athens), Gambia, Australia (Melbourne), Switzerland (Bern), and Singapore.

DIAMONDS: all PERFORM sites, and in addition Italy (Rome, Milan), The Netherlands (Utrecht), France (Colombe), Spain (Madrid), Taiwan (Tainan)

Collaborators involved in Newcastle are:

Clinical: Dr Emma Lim and dr Rachel Agbeko

Business School Centre for Knowledge Innovation Technology and Enterprise (KITE): Dr Lucille Valentine

Translational Medicine and Clinical Research: Professor John Isaacs, Dr Neil Keegan

We collaborate with YPAG, the Young Person's Advisory Group North East whose input is vital to learn about their view on consent procedures and data sharing.

COVID-19 research

Next to DIAMONDS we recruit paediatric patients into RECOVERY an RCT, and in BATS, ISARIC, and Immunocovid, which are observational studies. In addition we recruit to Gypsophila, a phase Ib trial evaluating PK PD for tocilizumab.

HARMONIE

RSV vaccination trial ongoing follow up, recruitment completed

We participated in recruitment of patients for other studies such as CHIMES (Oxford and Liverpool lead), Dinosaur (Southampton lead), and the commercial (DAP-PEDOST) funded trial, and NIH funded RCT (DMID-11-0069) comparing valganciclovir vs placebo in toddlers with hearing loss due to congenital CMV infection. We were international top recruiters for this trial.

The European study Calypso evaluates antifungal use in paediatric patients.

INIMUTI was a pilot project looking at innate immunity in UTI in collaboration with DrsJudith Hall and Philip Aldridge (Institute for Cell & Molecular Biosciences).

Current grants:

H2020: PERFORM

H2020: DIAMONDS

I am involved in the clinical teaching of medical students in paediatrics at GNCH.

I supervise undergraduate medical student SSC projects, Erasmus Master students in Paediatric Infectious Diseases, MRes students and AFPs. Most our students present their work at (inter)national conferences. All projects inform improvement of day to day care for patients.

I am Curriculum director for the Post Graduate Clinical Research Programmes (Attendance and eLearning) for the Graduate School.

We were awarded funding by NIHR to develop a new PG Cert in Clinical Research Delivery, and enrolled the first learners in 2022

In addition I am a tutor and examiner for the postgraduate Diploma in Paediatric Infectious Diseases at Oxford University

 I welcome anyone contacting me who may be interested in working in the field of Paediatric Infectious Diseases.

• Articles

  • Reilly L, Emonts M. Recurrent or unusual infections in children – when to worry about inborn errors of immunity. Therapeutic Advances in Infectious Disease 2023, 10.
  • Cohen J, Ladhani SN, Royal College of Paediatrics and Child Health Monkeypox Working Group. Monkeypox and children. Archives of Disease in Childhood 2023, 107(12), 1065-1066.
  • Channon-Wells S, Vito O, McArdle AJ, Seaby EG, Patel H, Shah P, Pazukhina E, Wilson C, Broderick C, D'Souza G, Keren I, Nijman RG, Tremoulet A, Munblit D, Ulloa-Gutierrez R, Carter MJ, Ramnarayan P, De T, Hoggart C, Whittaker E, Herberg JA, Kaforou M, Cunnington AJ, Blyuss O, Levin M, Best Available Treatment Study (BATS) Consortium. Immunoglobulin, glucocorticoid, or combination therapy for multisystem inflammatory syndrome in children: a propensity-weighted cohort study. The Lancet Rheumatology 2023, 5(4), e184-e199.
  • Kohlmaier B, Leitner M, Hagedoorn NN, Borensztajn DM, von Both U, Carrol ED, Emonts M, van der Flier M, de Groot R, Herberg J, Levin M, Lim E, Maconochie IK, Martinon-Torres F, Nijman RG, Pokorn M, Rivero-Calle I, Tan CD, Tsolia M, Vermont CL, Zachariasse JM, Zavadska D, Moll HA, Zenz W, on behalf of the PERFORM consortium. European study confirms the combination of fever and petechial rash as an important warning sign for childhood sepsis and meningitis. Acta Paediatrica 2023, 112(5), 1058-1066.
  • Kumar V, Pouw RB, Autio MI, Sagmeister MG, Phua ZY, Borghini L, Wright VJ, Hoggart C, Pan B, Tan AKY, Binder A, Brouwer MC, Pinnock E, De Groot R, Hazelzet J, Emonts M, Van Der Flier M, Reiter K, Nothen MM, Hoffmann P, Schlapbach LJ, Bellos E, Anderson S, Secka F, Martinon-Torres F, Salas A, Fink C, Carrol ED, Pollard AJ, Coin LJ, Zenz W, Wouters D, Ang LT, Hibberd ML, Levin M, Kuijpers TW, Davila S. Variation in CFHR3 determines susceptibility to meningococcal disease by controlling factor H concentrations. American Journal of Human Genetics 2022, 109(9), 1680-1691.
  • Tan CD, el Ouasghiri S, von Both U, Carrol ED, Emonts M, van der Flier M, de Groot R, Herberg J, Kohlmaier B, Levin M, Lim E, Maconochie IK, Martinon-Torres F, Nijman RG, Pokorn M, Rivero-Calle I, Tsolia M, Vermont CL, Zenz W, Zavadska D, Moll HA, Zachariasse JM, On behalf of PERFORM consortium. Sex differences in febrile children with respiratory symptoms attending European Emergency Departments. PLOS One 2022, 17(8), e0271934.
  • Tan CD, Hagedoorn NN, Dewez JE, Borensztajn DM, Von Both U, Carrol ED, Emonts M, Van Der Flier M, De Groot R, Herberg J, Kohlmaier B, Levin M, Lim E, MacOnochie IK, Martinon-Torres F, Nijman RG, Pokorn M, Rivero-Calle I, Strle F, Tsolia M, Vermont CL, Yeung S, Zachariasse JM, Zenz W, Zavadska D, Moll HA. Rapid Viral Testing and Antibiotic Prescription in Febrile Children with Respiratory Symptoms Visiting Emergency Departments in Europe. Pediatric Infectious Disease Journal 2022, 41(1), 39-44.
  • Trobisch A, Schweintzger NA, Kohlfürst D, Sagmeister M, Sperl M, Grisold AJ, Feierl G, Herberg J, Carrol E, Paulus SC, Emonts M, Van Der Flier M, De Groot R, Cebey-López M, Rivero-Calle I, Boeddha NP, Agapow P-M, Secka F, Anderson S, Behrends U, Wintergerst U, Reiter K, Martinon-Torres F, Zenz W. Osteoarticular Infections in pediatric hospitals in Europe: a prospective cohort study from the EUCLIDS Consortium. Frontiers in Pediatrics 2022, 10, 744182.
  • Ramanathan S, Veramendi-Espinoza L, Shillitoe B, Flinn A, Owens S, Williams E, Emonts M, Hambleton S, Burton-Fanning S, Waugh S, Flood T, Gennery AR, Slatter M, Nademi Z. Haploidentical CD3+ TCR αβ/CD19+–depleted HSCT for MHC class II deficiency and persistent SARS-CoV-2 pneumonitis. Journal of Allergy and Clinical Immunology 2023, 2(1), 101-104.
  • Hagedoorn NN, Boeddha NP, Kohlfuerst DS, Anderson S, Carrol ED, Agapow P, van der Flier M, Hazelzet J, Herberg J, Kuijpers T, Levin M, Martinon-Torres M, van Rijswijk A, Schlapbach LJ, Vermont C, Zenz W, Dik WA, Driessen G, Emonts M, on behalf of the EUCLIDS consortium. Haemostasis proteins in invasive meningococcal and non-meningococcal infections: a prospective multicentre study. Pediatric Critical Care Medicine 2022, 23(12), e543-e554.
  • Tan CD, van der Walle E, Vermont CL, von Both U, Carrol ED, Eleftheriou I, Emonts M, van der Flier M, de Groot R, Herberg J, Kohlmaier B, Levin M, Lim E, Maconochie IK, Martinon-Torres F, Nijman RG, Pokorn M, Rivero-Calle I, Tsolia M, Yeung S, Zenz W, Zavadska D, on behalf of the PERFORM consortium. Guideline adherence in febrile children below 3 months visiting European Emergency Departments: an observational multicenter study. European Journal of Pediatrics 2022, 181, 4199–4209.
  • Boeddha NP, Atkins L, de Groot R, Driessen G, Hazelzet J, Zenz W, Carrol ED, Anderson ST, Martinon-Torres F, Agyeman PKA, Galassini R, Herberg J, Levin M, Schlapbach LJ, Emonts M, EUCLIDS Consortium. Group A streptococcal disease in paediatric inpatients: a European perspective. European Journal of Pediatrics 2023, 182, 697-706.
  • Van der Velden FJS, de Vries G, Martin A, Lim E, von Both U, Kolberg L, Carrol ED, Khanijau A, Herberg JA, De T, Galassini R, Kuijpers TW, Martinón-Torres F, Rivero-Calle I, Vermont CL, Hagedoorn NN, Pokorn M, Pollard AJ, Schlapbach LJ, Tsolia M, Elefhteriou I, Yeung S, Zavadska D, Fink C, Voice M, Zenz W, Kohlmaier B, Agyeman PKA, Usuf E, Secka F, de Groot R, Levin M, van der Flier M, Emonts M, PERFORM Consortium. Febrile illness in high‑risk children: a prospective, international observational study. European Journal of Pediatrics 2023, 182, 543-554.
  • Borensztajn DM, Hagedoorn NN, Carrol ED, von Both U, Emonts M, van der Flier M, de Groot R, Herberg J, Kohlmaier B, Levin M, Lim E, Maconochie IK, Martinon-Torres F, Nijman RG, Pokorn M, Rivero-Calle I, Tsolia M, Vermont C, Zavadska D, Zenz W, Zachariasse JM, Moll HA, on behalf of PERFORM consortium. Febrile children with comorbidities at the emergency department — a multicentre observational study. European Journal of Pediatrics 2022, 181(9), 3491-3500.
  • Emonts M. COVID-19 interventions in children: a balancing act. Archives of Disease in Childhood 2022, 107(3), e12.
  • Adler H, Gould S, Hine P, Snell LB, Wong W, Houlihan CF, Osborne JC, Rampling T, Beadsworth MBJ, Duncan CJA, Dunning J, Fletcher TE, Hunter ER, Jacobs M, Khoo SH, Newsholme W, Porter D, Porter RJ, Ratcliffe L, Schmid ML, Semple MG, Tunbridge AJ, Wingfield T, Price NM, on behalf of the NHS England High Consequence Infectious Diseases (Airborne) Network. Clinical features and management of human monkeypox: a retrospective observational study in the UK. The Lancet Infectious Diseases 2022, 22(8), 1153-1162.
  • Borensztajn D, Hagedoorn NH, Carrol E, von Both U, Dewez JE, Emonts M, van der Flier M, de Groot R, Herberg J, Kohlmaier B, Levin M, Lim E, Maconochie I, Torres FM, Nijman R, Pokorn M, Rivero-Calle I, Tsolia M, Vermont C, Zavadska D, Zenz W, Zachariasse J, Moll HA, On behalf of PERFORM Consortium. Characteristics and management of adolescents attending the ED with fever: a prospective multicentre study. BMJ Open 2022, 12, e053451.
  • RECOVERY Collaborative Group, Inc. The Newcastle Upon Tyne Hospitals NHS Foundation Trust, Hunter E, De Soyza A, Agbeko R, Baker K, Barr A, Cameron E, Campbell Hewson Q, Duncan C, Emonts M, Fenn A, Francis S, Glover Bengtsson J, Greenhalgh A, Hanrath A, Houghton K, Jerry D, Jones G, Kelly S, Lane N, Macfarlane J, McAlinden P, McCullagh I, McDonald S, Mohammed O, Obukofe R, Parker J, Patience A, Payne B, Price D, Razvi S, Robson S, Sanchez Gonzalez A, Stephenson E, Welton R, West S, Wong E, Yelnoorkar J. Casirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. The Lancet 2022, 399(10325), 665-676.
  • van der Velden FJS, Van Delft F, Owens S, Llevadias J, McKean M, Pulford L, Taha Y, Williamson G, Campbell-Hewson Q, Hambleton S, Payne RP, Duncan C, Johnston C, Spegarova J, Emonts M. Case report: severe acute pulmonary COVID-19 in a teenager post autologous hematopoietic stem cell transplant. Frontiers in Pediatrics 2022, 10, 809061.
  • Maggioni A, Gonzales-Zamora JA, Maggioni A, Peek L, McLaughlin SA, von Both U, Emonts M, Espinel Z, Shultz JM. Cascading Risks for Preventable Infectious Diseases in Children and Adolescents during the 2022 Invasion of Ukraine. International Journal of Environmental Research and Public Health 2022, 19(12), 7005.
  • Cohen JM, Bamford A, Eisen S, Emonts M, Ho D, Kadambari S, Kenny J, Lyall H, Owens S, Porter D, Riordan A, Whittaker E, Williams B, Ladhani S, on behalf of the Royal College of Paediatrics and Child Health Monkeypox Working Group. Care of children exposed to monkeypox. The Lancet Regional Health - Europe 2022, 21, 100514.
  • Van der Velden FJS, Gennery A, Emonts M. Biomarkers for diagnosing febrile illness in immunocompromised children: a systematic review of the literature. Frontiers in Pediatrics 2022, 10, 828569.
  • RECOVERY Collaborative Group. Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis. The Lancet 2022, 400, 359-368.
  • RECOVERY Collaborative Group. Aspirin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. The Lancet 2022, 399(10320), 143-151.
  • Gould S, Atkinson B, Onianwa O, Spencer A, Furneaux J, Grieves J, Taylor C, Milligan I, Bennett A, Fletcher T, Dunning J, NHS England Airborne High Consequence Infectious Diseases Network. Air and surface sampling for monkeypox virus in a UK hospital: an observational study. Lancet Microbe 2022, 3(12), e904-e911.
  • Borensztajn DM, Hagedoorn NN, Maconochie IK, von Both U, Carrol ED, Dewez M, Emonts M, van der Flier M, de Groot R, Herberg J, Kohlmaier B, Lim E, Martinon-Torres F, Nieboer D, Nijman R, Pokorn M, Strle F, Tsolia M, Vermont C, Yeung S, Zavadska D, Zenz W, Levin M, Moll HA. Variation in hospital admission in febrile children evaluated at the Emergency Department (ED) in Europe: PERFORM, a multicentre prospective observational study. PLoS ONE 2021, 16(1), e0244810.
  • McArdle AJ, Vito O, Harista Parel H, Seaby EG, Shah P, Wilson C, Broderick C, Nijman R, Tremoulet A, Munbilt D, Ulloa-Gutierrez R, Carter JM, De T, Hoggart C, Whittaker E, Herberg JA, Kaforou M, Cunnington AJ, Levin M, On behalf of The Best Available Treatment Study for MIS-C (BATS) consortium. Treatment of Multisystem Inflammatory Syndrome in Children. The New England Journal of Medicine 2021, 385, 11-22.
  • RECOVERY Collaborative Group. Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. The Lancet 2021, 397(10285), 1637-1645.
  • Dewez JE, Li EC, Luu QF, Emonts M, Maconochie I, Nijman R, Yeung S. The role of Point-of-Care-Tests in the management of febrile children: A qualitative study of hospital-based doctors and nurses in England. BMJ Open 2021, 11(5), e044510.
  • Hagedoorn NN, Zachariasse JM, Borensztajn D, Adriaansens E, von Both U, Carrol ED, Eleftheriou I, Marieke Emonts M, van der Flier M, de Groot R, Herberg J, Kohlmaier B, Lim E, Maconochie I, Martinon-Torres F, Nijman R, Pokorn M, Rivero Calle I, Tsolia M, Zavadska D, Zenz W, Levin M, Vermont C, Moll HA, on behalf of PERFORM consortium. Shock Index in the early assessment of febrile children at the Emergency Department: a prospective multicentre study. Archives of Disease in Childhood 2022, 107(2), 116-122.
  • Ferreras-Antolín L, Irwin A, Atra A, Chapelle F, Drysdale SB, Emonts M, McMaster P, Paulus S, Patel S, Rompola M, Vergnano S, Whittaker E, Warris A. Pediatric Antifungal Prescribing Patterns Identify Significant Opportunities to Rationalize Antifungal Use in Children. Pediatric Infectious Disease Journal 2022, 41(3), e69-e74.
  • Hagedoorn NN, Wagenaar J, Nieboer D, Bath D, von Both U, Carrol ED, Eleftheriou I, Emonts M, van der Flier M, de Groot R, Herberg J, Kohlmaier B, Levin M, Lim E, Maconochie IK, Martinon-Torres F, Nijman R, Pokorn M, Rivero Calle I, Tsolia M, Yeung S, Zavadska D, Zenz W, Vermont C, Oostenbrink R, Moll HA. Impact of a Clinical Decision Rule on Antibiotic Prescription for Children with suspected Lower Respiratory Tract Infections presenting to European Emergency Departments - A simulation study based on routine data. Journal of Antimicrobial Chemotherapy 2021, 76(5), 1349-1357.
  • Hagedoorn NH, Borensztajn DM, Nijman R, Nieboer D, Herberg J, Balode A, von Both U, Carrol ED, Eleftheriou I, Emonts M, van der Flier M, de Groot R, Kohlmaier B, Lim E, Maconochie I, Martinon-Torres F, Pokorn M, Strle F, Tsolia M, Zavadska D, Zenz W, Levin M, Vermont C, Moll HA, and PERFORM consortium. Development and validation of a prediction model for invasive bacterial infections in febrile children at European Emergency Departments: MOFICHE a prospective observational study. Archives of Disease in Childhood 2021, 106(7), 641-647.
  • Boeddha N, Driessen GJ, Hagedoorn NN, Kohlfuerst DS, Hoggart CJ, van Rijswijk A, Ekinci E, Priem D, Schlapbach L, Herberg JA, de Groot R, Anderson ST, Fink CG, Carrol ED, van der Flier M, Martinon-Torres F, Levein M, Leebeek FW, Zenz W, de Maat MPM, Hazelzet JA, Dik WA, Emonts M, EUCLIDS Consortium. Detectable A Disintegrin and Metalloproteinase With Thrombospondin Motifs-1 in Serum Is Associated With Adverse Outcome in Pediatric Sepsis. Critical Care Explorations 2021, 3(11), e0569.
  • Shaunak M, Patel R, Driessens C, Mills L, Leahy A, Gbesemete D, Owens DR, Lucas JS, Faust SN, de Graaf H, on behalf of the ImmunoCOVID study group. COVID-19 symptom surveillance in immunocompromised children and young people in the UK: a prospective observational cohort study. BMJ Open 2021, 11, e044899.
  • RECOVERY Collaborative Group. Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial. The Lancet 2021, 397(10289), 2049-2059.
  • RECOVERY Collaborative Group. Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. The Lancet 2021, 397(10274), 605-612.
  • Martin A, Sen ES, Emonts M. Atypical juvenile dermatomyositis complicated by systemic capillary leak syndrome: case report and review of the literature. Rheumatology 2021, 60(1), e1-e2.
  • Nijman RG, Oostenbrink R, Moll H, Casals-Pascual C, von Both U, Cunnington A, De T, Eleftheriou I, Emonts M, Fink CG, Van Der Flier M, de Groot R, Kaforou M, Kohlmaier B, Kuijpers T, Lim E, Maconochie I, Paulus SC, Martinon-Torres F, Pokorn M, Romaine S, Rivero Calle I, Schlapbach L, Smit F, Tsolia M, Usuf E, Wright VJ, Yeung S, Zavadska D, Zenz W, Levin M, Herberg J, Carrol E. A novel framework for phenotyping children with suspected or confirmed infection for future biomarker studies. Frontiers in Pediatrics 2021, 9, 688272.
  • Borensztajn DM, Hagedoorn NN, Carrol ED, von Both U, Dewez JE, Emonts M, van der Flier M, de Groot R, Herberg J, Kohlmaier B, Lim E, Maconochie IK, Martinon-Torres F, Nieboer D, Nijman RG, Oostenbrink R, Pokorn M, Rivero Calle I, Strle F, Tsolia M, Vermont CL, Yeung S, Zavadska D, Zenz W, Levin M, Moll HA, on behalf of the PERFORM consortium. A NICE combination for predicting hospitalisation at the Emerge. A NICE combination for predicting hospitalisation at the Emergency Department: a European multicentre observational study of febrile children. The Lancet Regional Health 2021, 8, 100173.
  • Hagedoorn NH, Borensztajn DM, Nijman R, Balode A, von Both U, Carrol ED, Eleftheriou I, Emonts M, van der Flier M, de Groot R, Herberg J, Kohlmaier B, Lim E, Maconochie I, Martinon-Torres F, Nieboer D, Pokorn M, Strle F, Tsolia M, Yeung S, Zavadska D, Zenz W, Vermont C, Levin M, Moll HA, PERFORM consortium. Variation in antibiotic prescription rates in febrile children presenting to Emergency Departments across Europe (MOFICHE): a multicentre observational study. PLOS Medicine 2020, 17(8), e1003208.
  • Vergnano S, Bamford A, Bandi S, Chappel F, Demirjian A, Doerholt K, Emonts M, Antolin LF, Goenka A, Jones L, Herberg J, Hinds L, McGarrity O, Moriarty P, O'Riordan S, Patel M, Paulus S, Porter D, Stock K, Patel S. Paediatric Antimicrobial Stewardship Programmes in the UK's Regional Children's Hospitals. Journal of Hospital Infection 2020, 105(4), 736-740.
  • Lum SH, Selvarajah S, Deya-Martinez A, McNaughton P, Sobh A, Waugh S, Burton-Fanning S, Newton L, Gandy J, Nademi Z, Owens S, Williams E, Emonts M, Flood T, Cant A, Abinun M, Hambleton S, Gennery AR, Slatter M. Outcome of autoimmune cytopenia after hematopoietic cell transplantation in primary immunodeficiency. Journal of Allergy and Clinical Immunology 2020, 146(2), 406-416.
  • Lum SH, Anderson C, McNaughton P, Engelhardt K, MacKenzie B, Watson H, Al-Mousa H, Al-Herz W, Al-Saud B, Mohammed R, ALZahrani D, Alghamdi HA, Goronfolah L, Nademi Z, Habibolla S, Flinn AM, Shillitoe B, Owens S, Williams E, Emonts M, Hambleton S, Abinun M, Flood T, Cant A, Gennery AR, Slatter M. Improved transplant survival and long-term disease outcome in children with MHC class II deficiency. Blood 2020, 135(12), 954-973.
  • Warris A, Pana ZD, Oletto A, Lundin R, Castagnola E, Lehrnbecher T, Groll AH, Roilides E, Andersen CT, Arendrup MC, Arsenijevic VA, Bianchini S, von Both U, Chmelnik M, Controzzi T, Emonts M, Esposito S, Ferreras-Antolin L, Henriet S, Iosifidis E, Irwin A, Kopsidas J, Lagrou K, Lyall H, Casteleiro AM, Mesini A, Olbrich P, Paulus S, Lausch KR, Soler-Palacin P, Spyridis N, Strenger V, Theodoraki M, Wolfs T, EUROCANDY Study Group. Etiology and Outcome of Candidemia in Neonates and Children in Europe: An 11-year Multinational Retrospective Study. The Pediatric Infectious Disease Journal 2020, 39(2), 114-120.
  • RECOVERY Collaborative Group, Horby P, Mafham M, Linsell L, Bell JL, Staplin N, Emberson JR, Wiselka M, Ustianowski A, Elmahi E, Prudon B, Whitehouse T, Felton T, Williams J, Faccenda J, Underwood J, Baillie JK, Chappell LC, Faust SN, Jaki T, Jeffery K, Lim WS, Montgomery A, Rowan K, Tarning J, Watson JA, White NJ, Juszczak E, Haynes R, Landray MJ. Effect of Hydroxychloroquine in Hospitalized Patients with Covid-19. New England Journal of Medicine 2020, 383(21), 2030-2040.
  • Zandstra J, Van de Geer A, Tanck MWT, Van Stijn-Bringas Dimitriades D, Aarts C, Dietz SM, Van Bruggen R, Schweintzger N, Zenz W, Emonts M, Zavadska D, Pokorn M, Usuf E, Moll H, Schlapbach LJ, Carrol E, Paulus SC, Tsolia M, Fink C, Yeung S, Shimizu C, Tremoulet A, Galassini R, Wright VJ, Martinon Torres F, Herberg J, Burns J, Levin ML, Kuijpers TW. Biomarkers for the discrimination of acute Kawasaki disease from infections in childhood. Frontiers in Pediatrics 2020, 8, 355.
  • Wang X, Nijman R, Camuzeaux S, Sands C, Jackson H, Kaforou M, Emonts M, Herberg JA, Maconochie I, Carrol ED, Paulus SC, Zenz W, Van der Flier M, de Groot R, Martinon-Torres F, Schlapbach LJ, Pollard AJ, Fink C, Kuijpers TT, Anderson S, Lewis MR, Levin M, McClure M, EUCLIDS consortium. Plasma lipid profiles discriminate bacterial from viral infection in febrile children. Scientific Reports 2019, 9(1), 17714.
  • van der Velden FJS, Battersby A, Pareja-Cebrian L, Ross Nicholas, Ball SL, Emonts M. Paediatric Focal Intracranial Suppurative Infection: a UK single-centre retrospective cohort study. BMC Pediatrics 2019, 19, 130.
  • Ferreras-Antolín L, Irwin A, Atra A, Dermirjian A, Drysdale S, Emonts M, McMaster P, Paulus S, Patel S, Kinsey S, Vergnano S, Whittaker E, Warris A. Neonatal Antifungal Consumption Is Dominated by Prophylactic Use; Outcomes From The Pediatric Antifungal Stewardship: Optimizing Antifungal Prescription Study. The Pediatric Infectious Disease Journal 2019, 38(12), 1219-1223.
  • Borghini L, Png E, Binder A, Wright VJ, Pinnock E, de Groot R, Hazelzet J, Emonts M, Van der Flier M, Schlapbach LJ, Anderson S, Secka F, Salas A, Fink C, Carrol ED, Pollard AJ, Coin LJ, Kuijpers TW, Martinon-Torres F, Zenz W, Levin M, Hibberd ML, Davila S, EUCLIDS consortium. Identification of regulatory variants associated with genetic susceptibility to meningococcal disease. Scientific Reports 2019, 9, 6966.
  • Borensztajn DM, Yeung S, Hagedoorn NN, Nijman R, Maconochie I, Dewez JE, Martinon-Torres F, Herberg J, Carrol ED, Lim E, Emonts M, Eleftheriou I, Tsolia M, de Groot R, van der Flier M, Kohlmaier B, Wendelin G, Zenz W, Strle F, Pokorn M, Balode A, Zavadska D, von Both U, Levin M, Moll HA, PERFORM consortium. Diversity in the Emergency care for febrile children in Europe. BMJ Paediatrics Open 2019, 3, e000456.
  • Willems E, Alkema W, Keizer-Garritsen J, Suppers A, van der Flier M, Philipsen RHLA, van den Heuvel LP, Volokhina E, van der Molen RG, Herberg JA, Levin M, Wright VJ, Ahout IML, Ferwerda G, Emonts M, Boeddha NP, Rivero-Calle I, Martinon Torres F, Wessels HJTC, de Groot R, van Gool AJ, Gloerich J, de Jonge MI. Biosynthetic homeostasis and resilience of the complement system in health and infectious disease. EBioMedicine 2019, 45, P303-313.
  • Secka F, Herberg JA, Sarr I, Darboe S, Sey G, Saidykhan M, Wathuo M, Kaforou M, Antonio M, Roca A, Zaman SMA, Cebey-López M, Boeddha NP, Paulus S, Kohlfürst DS, Emonts M, Zenz W, Carrol ED, de Groot R, Schlapbach L, Martinon-Torres F, Bojang K, Levin M, van der Flier M, Anderson ST, on behalf of the EUCLIDS consortium. Bacteremia in childhood life-threatening infections in urban Gambia: EUCLIDS in West Africa. Open Forum Infectious Diseases 2019, 6(9), ofz332.
  • Hoppenbrouwers T, Boeddha N, Driessen GJ, Emonts M, Hazelzet JA, de Maat MP. Neutrophil extracellular traps in children with meningococcal sepsis. Pediatric Critical Care Medicine 2018, 19(6), e286-e291.
  • Boeddha NP, Schlapbach LJ, Driessen GJ, Herberg JA, Rivero-Calle I, Cebey-Lopez M, Klobassa DS, Philipsen R, de Groot R, Inwald DP, Nadel S, Paulus S, Pinnock E, Secka F, Anderson ST, Agbeko RS, Berger C, Fink CG, Carrol ED, Zenz W, Levin M, van der Flier M, Martinon-Torres F, Hazelzet JA, Emonts M. Mortality and morbidity in community-acquired sepsis in European pediatric intensive care units: A prospective cohort study from the European Childhood Life-threatening Infectious Disease Study (EUCLIDS). Critical Care 2018, 22(1), 143.
  • Martinon-Tores F, Salas A, Rivero I, Cebey-Lopez M, Pardo-Seco J, Herber J, Boeddha NP, Emonts M, Zenz W, Carrol ED, Van der Flier M, Levin M, EUCLIDS Consortium. Life-threatening infections in children in Europe – a prospective cohort study (The EUCLIDS Project). The Lancet Child & Adolescent Health 2018, 2(6), 404-414.
  • Emonts M, Waalewijn H, Colbers A, Pickering A, Burger D. First reported use of zidovudine for prevention of perinatal HIV transmission in a premature neonate on extra corporal membrane oxygenation. AIDS 2018, 32(14), 2084-2085.
  • Schrier L, Hadjipanayis A, DelTorso S, Stiris T, Emonts M, Dornbusch HJ. European Antibiotic Awareness Day 2017: training the next generation of health care professionals in antibiotic stewardship. European Journal of Pediatrics 2018, 177(2), 279-283.
  • de Haan N, Boeddha NP, Ekinci E, Reiding KR, Emonts M, Hazelzet JA, Wuhrer M, Driessen GJ. Differences in IgG Fc Glycosylation are Associated with Outcome of Pediatric Meningococcal Sepsis. mBio 2018, 9(3), e00546-18.
  • Morillo-Gutierrez B, Waugh S, Pickering A, Flood T, Emonts M. Emerging (val)ganciclovir resistance during treatment of congenital CMV infection: A case report and review of the literature. BMC Pediatrics 2017, 17, 181.
  • de Graaf H, Sukhtankar P, Arch B, Ahmad N, Lees A, Bennett A, Spowart C, Hickey H, Jeanes A, Armon K, Riordan A, Herberg J, Hackett S, Gamble C, Shingadia D, Pallett A, Clarke SC, Henman P, Emonts M, Sharland M, Finn A, Pollard AJ, Powell C, Marsh P, Ballinger C, Williamson PR, Clarke NMP, Faust SN. Duration of intravenous antibiotic therapy for children with acute osteomyelitis or septic arthritis: A feasibility study. Health Technology Assessment 2017, 21(48), 1-198.
  • Engert A, Balduini C, Brand A, Coiffier B, Cordonnier C, Döhner H, deWit TD, Eichinger S, Fibbe W, Green T, deHaas F, Iolascon A, Jaffredo T, Rodeghiero F, Salles G, Schuringa JJ, other authors. The European Hematology Association Roadmap for European Hematology Research. A Consensus Document. Haematologica 2016, 101(2), 115-208.
  • Herberg JA, Kaforou M, Wright VJ, Shailes H, Eleftherohorinou H, Hoggart CJ, Cebey-Lopez M, Carter MJ, Janes VA, Gormley S, Shimizu C, Tremoulet AH, Barendregt AM, Salas AS, Kanegaye J, Pollard AJ, Faust SN, Patel S, Kuijpers T, Martinon-Torres F, Burns JC, Coin LJM, Levin M, for the IRIS Consortium. Diagnostic Test Accuracy of a 2-Transcript Host RNA Signature for Discriminating Bacterial vs Viral Infection in Febrile Children. JAMA 2016, 316(8), 835-845.
  • Boeddha NP, Driessen GJ, Cnossen MH, Hazelzet JA, Emonts M. Circadian Variation of Plasminogen-Activator-Inhibitor-1 Levels in Children with Meningococcal Sepsis. PLOS One 2016, 11(11), e0167004.
  • Herberg J, Emonts M, Jacobs M, Riordan A. UK preparedness for children with Ebola infection. Archives of Disease in Childhood 2015, 100(5), 421-423.
  • Reynolds B, Hambleton S, Dammann D, Lambert H, Emonts M. Troublesome Thai travels. Archives of Disease in Childhood Education and Practice Edition 2015, 100(3), 166-167.
  • de Velde F, Emonts M, Verbruggen S, van der Sijs H. High tobramycin serum concentrations after tobramycin inhalation in a child with renal failure. Journal of Antimicrobial Chemotherapy 2014, 69(11), 3163-3164.

• Book Chapter

  • Emonts M, Pareja-Cebrian L, Skinner R. Infection. In: Simon Bailey and Rod Skinner, ed. Paediatric Haematology and Oncology. Oxford: Oxford University Press, 2022.

• Letter

  • Ramnarayan P, Mitting R, Whittaker E, Marcolin M, O'Regan C, Sinha R, Bennett A, Moustafa M, Tickner N, Gilchrist M, Kershaw A, Rampling T, NHS England Airborne High Consequence Infectious Diseases Network. Neonatal Monkeypox Virus Infection. New England Journal of Medicine 2022, 387, 1618-1620.

• Reviews

  • Cordonnier C, Ljungman P, Cesaro S, Hirsch HH, Maschmeyer G, Von Lilienfeld-Toal M, Vehreschild M, Mikulska M, Emonts M, Gennery AR, Neofytos D, Bochud P-Y, Einsele H, Maertens J. The EHA Research Roadmap: Infections in Hematology. HemaSphere 2021, 5(12), e662-e662.
  • Harwood R, Allin B, Jones CE, Whittaker E, Ramnarayan P, Ramanan AV, Kaleem M, Tulloh R, Peters MJ, Almond S, Davis PJ, Levin M, Tometzki A, Faust SN, Knight M, Kenny S, Agbeko R, Aragon O, Baird J, Bamford A, Bereford M, Bharucha T, Brogan P, Butler K, Carroll E, Cathie K, Chikermane A, Christie S, Clark M, Deri A, Doherty C, Drysdale S, Duong P, Durairaj S, Emonts M, Evans J, Fraser J, Hackett S, Hague R, Heath P, Herberg J, Ilina M, Jay N, Kelly D, Kerrison C, Kraft J, Leahy A, Linney M, Lyall H, McCann L, McMaster P, Miller O, O'Riordan S, Owens S, Pain C, Patel S, Pathan N, Pauling J, Porter D, Prendergast A, Ravi K, Riorden A, Roderick M, Scholefield BR, Semple MG, Sen E, Shackley F, Sinha I, Tibby S, Verganano S, Welch SB, Wilkinson N, Wood M, Yardley I. A national consensus management pathway for paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS): results of a national Delphi process. The Lancet Child and Adolescent Health 2021, 5(2), 133-141.
  • Boeddha NP, Emonts M, Cnossen MH, deMaat MP, Leebeek FW, Driessen GJ, Hazelzet JA. Gene variations in the protein C and fibrinolytic pathway: relevance for severity and outcome in paediatric sepsis. Seminars in Thrombosis and Hemostasis 2017, 43(1), 36-47.