Staff Profile

Introduction

For a short video about recent research work we are doing, go to: https://www.youtube.com/watch?v=I-9XYyiqfLA

ResearchGate: Click here

Interested in Toxicology?

For information on the MRes course on Toxicology, please click on this link:

https://www.ncl.ac.uk/postgraduate/courses/degrees/toxicology-mres/#profile

Partner in the Erasmus ICTC project, see: http://www.itct.edu.eg/

Background

Research background in Toxicology and cytochromes P450. General interests are in the liver cell differentiation and liver disease.

Qualifications

BSc PhD

Memberships

British Toxicology Society (BTS).

Honours and Awards

British Association for the Study of the Liver – Young Investigator of the Year (2000).

Fellow of the British Toxicology Society (FBTS)

Research Interests

Liver Biology, Liver Fibrosis, Stem/Progenitor Cells and the Liver

Other Expertise

Pharmacology, Toxicology

Current Work

Role of the PXR in modulating liver fibrosis; developing imaging techniques for liver fibrosis; Hepatocyte differentiation.  Environment and liver disease.

See https://www.youtube.com/watch?v=Bd2N8HBwy7Q

Postgraduate Supervision

Currently 3 PhD Students - in Liver Biology and Disease.

Esteem Indicators

Guest Editor - Special issues for the journal Toxicology (2007-2010)

Elected to the British Association for the Study of the Liver Committee (2001-2004).

Member of the Scientific Sub-Committee of the British Toxicology Society (2003-2008).

Member of the Executive Committee of the British Toxicology Society (2009-2012).

Member of the ANS Panel, EFSA (2011-2018).

Member of the FAF Panel, EFSA (2020-present)

Associate Editor, Toxicology (2018-present)

Funding

Newton Mosharafa

Patents

Patent Application -Wright MC, Porter A. (13-10-2005). WO2005095453. Specific binding members against synaptophysin - a human antibody to hepatic stellate cells for targeting drugs / imaging agents for liver fibrosis treatment.

Undergraduate Teaching

Pharmacology PED2001

Toxicology PED3011

Postgraduate Teaching

MRes in Toxicology - Course co-ordinator - (MMB8032)

MRes Cell cycle control and cell signalling pathways in health and disease (PGY8003)

MRes Stem cells and regenerative medicine (MMB8022)

MRes in Medical & Molecular Biosciences (PGY8003)

• Articles

  • Hedya S, Charlton A, Leitch AC, Aljehani FA, Pinker B, Wright MC, Abdelghany TM. The methylimidazolium ionic liquid M8OI is a substrate for OCT1 and p-glycoprotein-1 in rat. Toxicology in Vitro 2023, 88, 105550.
  • Abdelghany TM, Hedya SA, De Santis C, Abd El-Rahman SS, Gill JH, Abdelkader NF, Wright MC. Potential for cardiac toxicity with methylimidazolium ionic liquids. Ecotoxicology and Environmental Safety 2023, 249, 114439.
  • Moulding S, Figueiredo R, Sewpaul A, Leitch A, Bates L, Wright M, Wilson C. Pregnane X Receptor Activation in Liver Perfusion. Transplantation Proceedings 2022, 54(3), 600-604.
  • Leitch AC, Ibrahim I, Abdelghany TM, Charlton A, Roper C, Vidler D, Palmer JM, Wilson C, Jones DE, Blain PG, Wright MC. The methylimidazolium ionic liquid M8OI is detectable in human sera and is subject to biliary excretion in perfused human liver. Toxicology 2021, 459, 152854.
  • Leitch AC, Abdelghany TM, Probert PM, Dunn MP, Meyer SK, Palmer JM, Cooke MP, Blake LI, Morse K, Rosenmai AK, Oskarsson A, Bates L, Figueiredo RS, Ibrahim I, Wilson C, Abdelkader NF, Jones DE, Blain PG, Wright MC. The toxicity of the methylimidazolium ionic liquids, with a focus on M8OI and hepatic effects. Food and Chemical Toxicology 2020, 136, 111069.
  • Leitch AC, Abdelghany TM, Charlton A, Grigalyte J, Oakley F, Borthwick LA, Reed L, Knox A, Reilly WJ, Agius L, Blain PG, Wright MC. Renal injury and hepatic effects from the methylimidazolium ionic liquid M8OI in mouse. Ecotoxicology and Environmental Safety 2020, 202, 110902.
  • Abdelghany TM, Leitch AC, Nevjestic I, Ibrahim I, Miwa S, Wilson C, Heutz S, Wright MC. Emerging risk from "environmentally-friendly" solvents: Interaction of methylimidazolium ionic liquids with the mitochondrial electron transport chain is a key initiation event in their mammalian toxicity. Food and Chemical Toxicology 2020, 145, 111593.
  • Young GR, Abdelghany TM, Leitch AC, Dunn MP, Blain PG, Lanyon C, Wright MC. Changes in the gut microbiota of mice orally exposed to methylimidazolium ionic liquids. PLoS ONE 2020, 15(3), 0229745.
  • Amer A, McColl K, Bouayyad S, Kanwar A, Sen G, French JJ, Wilson CH, Manas DM, Wright MC, White SA. The association of pregnane X receptor activation with outcomes after liver transplantation—A retrospective study. Clinical Transplantation 2019, 33(12), e13734.
  • Oskarsson A, Wright MC. Ionic Liquids: New Emerging Pollutants, Similarities with Perfluorinated Alkyl Substances (PFASs). Environmental Science & Technology 2019, 53(18), 10539-10541.
  • Alsaeedi F, Wilson R, Candlish C, Ibrahim I, Leitch AC, Abdelghany TM, Wilson C, Armstrong L, Wright MC. Expression of serine/threonine protein kinase SGK1F promotes an hepatoblast state in stem cells directed to differentiate into hepatocytes. PloS One 2019, 14(6), e0218135.
  • Leitch AC, Lakey AF, Hotham WE, Agius L, Kass GE, Blain PG, Wright MC. The ionic liquid 1-octyl-3-methylimidazolium (M8OI) is an activator of the human estrogen receptor alpha. Biochemical and Biophysical Research Communications 2018, 503(3), 2167-2178.
  • Probert PM, Leitch AC, Dunn MP, Meyer SK, Palmer JM, Abdelghany TM, Lakey AF, Cooke MP, Talbot H, Wills C, McFarlane W, Blake LI, Rosenmai AK, Oskarsson A, Figueiredo R, Wilson C, Kass GE, Jones DE, Blain PG, Wright MC. Identification of a xenobiotic as a potential environmental trigger in primary biliary cholangitis. Journal of Hepatology 2018, 69(5), 1123-1135.
  • Fairhall EA, Leitch AC, Lakey AF, Abdelghany TM, Ibrahim I, Tosh D, Kass GE, Wilson C, Wright MC. HNF4alpha expression amplifies the glucocorticoid-induced conversion of a human pancreatic cell line to an hepatocyte-like cell. Biochemical and Biophysical Research Communications 2018, 503(3), 1633-1640.
  • Radwan MA, AlQuadeib BT, Siller L, Wright MC, Horrocks B. Oral administration of amphotericin B nanoparticles: antifungal activity, bioavailability and toxicity in rats. Drug Delivery 2017, 24(1), 40-50.
  • Meyer SK, Probert PME, Lakey AF, Axon AR, Leitch AC, Williams FM, Jowsey PA, Blain PG, Kass GEN, Wright MC. Hepatic effects of tartrazine (E 102) after systemic exposure are independent of oestrogen receptor interactions in the mouse. Toxicology Letters 2017, 273, 55-68.
  • Meyer SK, Probert PME, Lakey AK, Leitch A, Blake LI, Jowsey PA, Cooke MP, Blain PG, Wright MC. Environmental xenoestrogens super-activate a variant murine ER beta in cholangiocytes. Toxicological Sciences 2017, 156(1), 54-71.
  • Leitch AC, Probert PME, Shayman JA, Meyer SK, Kass GEN, Wright MC. B-13 progenitor-derived hepatocytes (B-13/H cells) model lipid dysregulation in response to drugs and chemicals. Toxicology 2017, 386, 120-132.
  • Probert PM, Palmer JM, Alhusainy W, Amer AO, Rietjens IMCM, White SA, Jones DE, Wright MC. Progenitor-derived hepatocyte-like (B-13/H) cells metabolise 1′-hydroxyestragole to a genotoxic species via a SULT2B1-dependent mechanism. Toxicology Letters 2016, 243, 98-110.
  • Richter M, Fairhall EA, Hoffmann SA, Tröbs S, Knöspel F, Probert PM, Oakley F, Stroux A, Wright MC, Zeilinger K. Pancreatic progenitor-derived hepatocytes are viable and functional in a 3D high density bioreactor culture system. Toxicology Research 2016, 5(1), 278-290.
  • Fairhall EA, Charles MA, Probert PM, Wallace K, Gibb J, Ravindan C, Soloman M, Wright MC. Pancreatic B-13 Cell Trans-Differentiation to Hepatocytes Is Dependent on Epigenetic-Regulated Changes in Gene Expression. PLoS ONE 2016, 11(3), e0150959.
  • Khadem F, Gao X, Mou Z, Jia P, Movasagh H, Onyilagha C, Wright MC, Uzonna JE. Hepatic stellate cells regulate liver specific immunity to visceral leishmaniasis through p110δ dependent induction of regulatory T cells in mice. Hepatology 2016, 63(2), 620-632.
  • Luli S, Di Paolo D, Perri P, Brignole C, Hill SJ, Brown H, Leslie J, Marshall HL, Wright MC, Mann DA, Ponzoni M, Oakley F. A new fluorescence-based optical imaging method to non-invasively monitor hepatic myofibroblasts in vivo. Journal of Hepatology 2016, 65(1), 75-83.
  • Thursz M, Forrest E, Roderick P, Day C, Austin A, O'Grady J, Ryder A, Allison M, Gleeson D, McCune A, Patch D, Wright M, Masson S, Richardson P, Hood S, MacGilchrist A, Grant A, Vale L, Mellor J, Stanton L, Bowers M, Ratcliffe I, Downs N, Kirkman S, Homer T, Ternent L, Deverill M. The clinical effectiveness and cost-effectiveness of STeroids or Pentoxifylline for Alcoholic Hepatitis (STOPAH): a 2x2 factorial, randomised controlled trial. Health Technology Assessment 2015, 19(102).
  • Amer AO, Probert PM, Dunn M, Knight M, Vallance AE, Flecknell PA, Oakley F, Cameron I, White SA, Blain PG, Wright MC. Sustained Isoprostane E2 Elevation, Inflammation and Fibrosis after Acute Ischaemia-Reperfusion Injury Are Reduced by Pregnane X Receptor Activation. PLoS ONE 2015, 10(8), e0136173.
  • AL-Quadeib BT, Radwan MA, Siller L, Horrocks B, Wright MC. Stealth Amphotericin B nanoparticles for oral drug delivery: In vitro optimization. Saudi Pharmaceutical Journal 2015, 23(3), 290-302.
  • Probert PM, Chung GW, Cockell SJ, Agius L, Mosesso P, White SA, Oakley F, Brown CD, Wright MC. Utility of B-13 Progenitor-Derived Hepatocytes in Hepatotoxicity and Genotoxicity Studies. Toxicological Sciences 2014, 137(2), 350-370.
  • Al-Quadeib BT, Radwan MA, Siller L, Mutch E, Horrocks B, Wright M, Alshaer A. Therapeutic monitoring of amphotericin B in Saudi ICU patients using UPLC MS/MS assay. Biomedical Chromatography 2014, 28(12), 1652-1659.
  • Fernandez JG, Rodriguez DA, Valenzuela M, Calderon C, Urzua U, Munroe D, Rosas C, Lemus D, Diaz N, Wright MC, Leyton L, Tapia JC, Quest AFG. Survivin expression promotes VEGF-induced tumor angiogenesis via PI3K/Akt enhanced β-catenin/Tcf-Lef dependent transcription. Molecular Cancer 2014, 13, 209.
  • Wilson CL, Mann J, Walsh M, Perrugoria MJ, Oakley F, Wright MC, Brignole C, Di Paolo D, Perri P, Ponzoni M, Karin M, Mann DA. Quiescent Hepatic Stellate Cells Functionally Contribute to the Hepatic Innate Immune Response via TLR3. PLoS One 2014, 9(1), e83391.
  • Probert PME, Ebrahimkhani MR, Oakley F, Mann J, Burt AD, Mann DA, Wright MC. A reversible model for periportal fibrosis and a refined alternative to bile duct ligation. Toxicology Research 2014, 3(2), 98-109.
  • Fairhall EA, Charles MA, Wallace K, Schwab CJ, Harrison CJ, Richter M, Hoffmann SA, Charlton KA, Zeilinger K, Wright MC. The B-13 hepatocyte progenitor cell resists pluripotency induction and differentiation to non-hepatocyte cells. Toxicology Research 2013, 2(5), 308-320.
  • O'Boyle G, Swidenbank I, Marshall H, Barker CE, Armstrong J, White SA, Fricker SP, Plummer R, Wright M, Lovat PE. Inhibition of CXCR4-CXCL12 chemotaxis in melanoma by AMD11070. British Journal of Cancer 2013, 108(8), 1634-1640.
  • Noormohamed MS, Kanwar A, Ray C, Wright MC, Cowie DE, Stamp S, Talbot D, Manas D, White SA. Extracorporeal membrane oxygenation for resuscitation of deceased cardiac donor livers for hepatocyte isolation. Journal of Surgical Research 2013, 183(2), e39-e48.
  • Fairhall EA, Wallace K, White SA, Huang GC, Shaw JA, Wright SC, Charlton KA, Burt AD, Wright MC. Adult human exocrine pancreas differentiation to hepatocytes – potential source of a human hepatocyte progenitor for use in toxicology research. Toxicology Research 2013, 2(1), 80-87.
  • Axon A, May FEB, Gaughan LE, Williams FM, Blain PG, Wright MC. Tartrazine and sunset yellow are xenoestrogens in a new screening assay to identify modulators of human oestrogen receptor transcriptional activity. Toxicology 2012, 298(1-3), 40-51.
  • Aguilar F, Crebelli R, Dusemund B, Galtier P, Gilbert J, Gott DM, Gundert-Remy U, König J, Lambré C, Leblanc J-C, Mortensen A, Mosesso P, Parent-Massin D, Stankovic I, Tobback P, Waalkens-Berendsen I, Woutersen R, Wright MC. Guidance for submission for food additive evaluations. EFSA Journal 2012, 10(7), 2760.
  • Ebrahimkhani MR, Oakley F, Murphy LB, Mann J, Moles A, Perugorria MJ, Ellis E, Lakey AF, Burt AD, Douglass A, Wright MC, White SA, Jaffre F, Maroteaux L, Mann DA. Stimulating healthy tissue regeneration by targeting the 5-HT_2B receptor in chronic liver disease. Nature Medicine 2011, 17(12), 1668-U189.
  • Wallace K, Long Q, Fairhall EA, Charlton KA, Wright MC. Serine/threonine protein kinase SGK1 in glucocorticoid-dependent transdifferentiation of pancreatic acinar cells to hepatocytes. Journal of Cell Science 2011, 124(3), 405-413.
  • Wallace K, Cowie DE, Konstantinou DK, Hill SJ, Tjelle TE, Axon A, Koruth M, White SA, Carlsen H, Mann DA, Wright MC. The PXR is a drug target for chronic inflammatory liver disease. Journal of Steroid Biochemistry and Molecular Biology 2010, 120(2-3), 137-148.
  • Gieling RG, Elsharkawy AM, Caamano JH, Cowie DE, Wright MC, Ebrahimkhani MR, Burt AD, Mann J, Raychaudhuri P, Liou HC, Oakley F, Mann DA. The c-Rel Subunit of Nuclear Factor-κB Regulates Murine Liver Inflammation, Wound-Healing, and Hepatocyte Proliferation. Hepatology 2010, 51(3), 922-931.
  • Wallace K, Marek CJ, Hoppler S, Wright MC. Glucocorticoid-dependent transdifferentiation of pancreatic progenitor cells into hepatocytes is dependent on transient suppression of WNT signalling. Journal of Cell Science 2010, 123(12), 2102-2109.
  • Wallace K, Flecknell PA, Burt AD, Wright MC. Disrupted Pancreatic Exocrine Differentiation and Malabsorption in Response to Chronic Elevated Systemic Glucocorticoid. American Journal of Pathology 2010, 177(3), 1225-1232.
  • Marek CJ, Wallace K, Durward E, Koruth M, Leel V, Leiper LJ, Wright MC. Low affinity glucocorticoid binding site ligands as potential anti-fibrogenics. Comparative Hepatology 2009, 8(1), -.
  • Wallace K, Marek CJ, Currie RA, Wright MC. Exocrine pancreas trans-differentiation to hepatocytes-A physiological response to elevated glucocorticoid in vivo. Journal of Steroid Biochemistry and Molecular Biology 2009, 116(1-2), 76-85.
  • Douglass A, Wallace K, Koruth M, Barelle C, Porter AJ, Wright MC. Targeting liver myofibroblasts: a novel approach in anti-fibrogenic therapy. Hepatology International 2008, 2(4), 405-415.
  • Hagens WI, Beljaars L, Mann DA, Wright MC, Julien B, Lotersztajn S, Reker-Smit C, Poelstra K. Cellular targeting of the apoptosis-inducing compound gliotoxin to fibrotic rat livers. Journal of Pharmacology and Experimental Therapeutics 2008, 324(3), 902-910.
  • Douglass A, Wallace K, Parr R, Park J, Durward E, Broadbent I, Barelle C, Porter A, Wright MC. Antibody-targeted myofibroblast apoptosis reduces fibrosis during sustained liver injury. Journal of Hepatology 2008, 49(1), 88-98.
  • Marek CJ, Tucker SJ, Koruth M, Wallace K, Wright MC. Expression of CYP2S1 in human hepatic stellate cells. FEBS Letters 2007, 581(4), 781-786.
  • Wright MC. The impact of pregnane X receptor activation on liver fibrosis. Biochemical Society Transactions 2006, 34(6), 1119-1123.
  • Haughton EL, Tucker SJ, Marek CJ, Durward E, Leel V, Bascal Z, Monaghan T, Koruth M, Collie-Duguid E, Mann DA, Trim JE, Wright MC. Pregnane X Receptor Activators Inhibit Human Hepatic Stellate Cell Transdifferentiation In Vitro. Gastroenterology 2006, 131(1), 194-209.
  • Marek CJ, Tucker SJ, Konstantinou DK, Elrick LJ, Haefner D, Sigalas C, Murray GI, Goodwin B, Wright MC. Pregnenolone 16α carbonitrile inhibits rodent liver fibrogenesis via PXR-dependent and PXR-independent mechanisms. Biochemical Journal 2005, 387(3), 601-608.
  • Oakley F, Meso M, Iredale JP, Green K, Marek CJ, Zhou X, May MJ, Millward-Sadler H, Wright MC, Mann DA. Inhibition of Inhibitor of κB Kinases Stimulates Hepatic Stellate Cell Apoptosis and Accelerated Recovery From Rat Liver Fibrosis. Gastroenterology 2005, 128(1), 108-120.
  • Elrick LJ, Leel V, Blaylock MG, Duncan L, Drever MR, Strachan G, Charlton KA, Koruth M, Porter AJ, Wright MC. Generation of a monoclonal human single chain antibody fragment to hepatic stellate cells - a potential mechanism for targeting liver anti-fibrotic therapeutics. Journal of Hepatology 2005, 42(6), 888-896.
  • Orr JG, Leel V, Cameron GA, Marek CJ, Haughton EL, Elrick LJ, Trim JE, Hawksworth GM, Halestrap AP, Wright MC. Mechanism of Action of the Antifibrogenic Compound Gliotoxin in Rat Liver Cells. Hepatology 2004, 40(1), 232-242.
  • Leel V, Elrick LJ, Solares J, Ingram N, Charlton KA, Porter AJ, Wright MC. Identification of a truncated ratp28-related protein expressed in kidney. Biochemical and Biophysical Research Communications 2004, 316(3), 872-877.
  • Marek CJ, Cameron GA, Elrick LJ, Hawksworth GM, Wright MC. Generation of hepatocytes expressing functional cytochromes P450 from a pancreatic progenitor cell line in vitro. Biochemical Journal 2003, 370(3), 763-769.
  • Vincent KJ, Jones E, Arthur MJ, Smart DE, Trim J, Wright MC, Mann DA. Regulation of E-box DNA binding during in vivo and in vitro activation of rat and human hepatic stellate cells. Gut 2001, 49(5), 713-719.
  • Wright MC, Issa R, Smart DE, Trim N, Murray GI, Primrose JN, Arthur MJ, Iredale JP, Mann DA. Gliotoxin Stimulates the Apoptosis of Human and Rat Hepatic Stellate Cells and Enhances the Resolution of Liver Fibrosis in Rats. Gastroenterology 2001, 121(3), 685-698.
  • Trim JE, Samra SK, Arthur MJ, Wright MC, McAulay M, Beri R, Mann DA. Upstream tissue inhibitor of metalloproteinases-1 (TIMP-1) element-1, a novel and essential regulatory DNA motif in the human TIMP-1 gene promoter, directly interacts with a 30-kDa nuclear protein. Journal of Biological Chemistry 2000, 275(9), 6657-63.
  • Hodgkinson CP, Wright MC, Paine AJ. Fibronectin mediated hepatocyte shape change reprograms cytochrome P450 2C11 gene expression via an integrin signalled induction of ribonuclease activity. Molecular Pharmacology 2000, 58(5), 976-981.
  • Harvey JL, Paine AJ, Maurel P, Wright MC. Effect of the Adrenal 11-beta Hydroxylase Inhibitor Metyrapone on Human Hepatic Cytochrome P-450 gene Expression: Induction of Cytochrome P-450 3A4. Drug Metabolism and Disposition 2000, 28(1), 96-101.
  • Goodship J, Gill H, Carter J, Jackson A, Splitt M, Wright M. Autozygosity mapping of a Seckel Syndrome Locus to chromosome 3q22.1-q24. American Journal of Human Genetics 2000, 67(2), 498-503.
  • Elsharkawy AM, Wright MC, Hay RT, Arthur MJ, Hughes T, Bahr MJ, Degitz K, Mann DA. Persistent activation of nuclear factor-kappaB in cultured rat hepatic stellate cells involves the induction of potentially novel Rel-like factors and prolonged changes in the expression of IkappaB family proteins. Hepatology 1999, 30(3), 761-769.
  • Bahr MJ, Vincent KJ, Arthur MJ, Fowler AV, Smart DE, Wright MC, Clark IM, Benyon RC, Iredale JP, Mann DA. Control of the tissue inhibitor of metalloproteinases-1 promoter in culture-activated rat hepatic stellate cells: regulation by activator protein-1 DNA binding proteins. Hepatology 1999, 29(3), 839-848.

• Conference Proceedings (inc. Abstracts)

  • McConnell A, O'Boyle G, Wright M, Plummer R, Lovat P. Targeting mitogen-activated protein kinase kinase to prevent CXCR₄-CXCL₁₂ chemotaxis in cutaneous melanoma. In: Annual Meeting of the British Association of Dermatologists. 2015, Glasgow, UK: Wiley-Blackwell Publishing Ltd.
  • Amer A, Vallance A, Mccoll K, Kanwar A, Wright M, White S. Reducing the risk of early allograft dysfunction in liver transplant recipients by activation of the pregnane x receptor (PXR). In: 17th Congress of the European Society for Organ Transplantation. 2015, Brussels, Belgium: Wiley-Blackwell.
  • Luli S, Di Paolo D, Wilson C, Wright MC, Brown H, Ponzoni M, Mann D, Oakley F. Non-invasive fluorescent imaging of liver fibrosis and response to therapy in mice. In: The Liver Meeting 2015: 66th Annual Meeting of the American Association for the Study of Liver Diseases. 2015, San Francisco: John Wiley & Sons, Inc.
  • Amer A, Vallance A, Wright M, White S. Activation of the pregnane X receptor (PXR) reduces the risk of early allograft dysfunction following liver transplantation. In: 2nd Digestive Disorders Federation Conference 2015. 2015, London, UK: BMJ Group.
  • Charles M, Wallace K, Probert P, Oakley F, Wright M. THE glucocorticoid-dependent conversion of the B-13 progenitor cell into hepatocyte-like (B-13/H) cells is dependent on a short exposure to glucocorticoid and epigenetic alterations. In: 50th Congress of the European Societies of Toxicology (EUROTOX). 2014, Edinburgh: Elsevier Ireland.
  • Meyer S, Axon A, Jowsey P, Williams F, Blain P, Wright M. Tartrazine is not an activator of the mouse oestrogen ER alpha and ER beta receptors. In: 50th Congress of the European Societies of Toxicology (EUROTOX). 2014, Edinburgh: Elsevier Ireland.
  • Probert P, Alhusainy W, Rietjens I, Wright M. Progenitor-derived hepatocyte-like (B-13/H) cells metabolise 1 ' hydroxyestragole to a genotoxic species - An animal donor-free in vitro screen for phase II activated genotoxins. In: 50th Congress of the European-Societies-of-Toxicology. 2014, Edinburgh, SCOTLAND: Elsevier Ireland Ltd.
  • Probert P, Oakley F, Tosh D, Wright M. Improving expression levels of transporters in progenitor-derived hepatocyte-like (B-13/H) cells. In: 50th Congress of the European Societies of Toxicology (EUROTOX). 2014, Edinburgh, SCOTLAND: Elsevier Ireland Ltd.
  • Fairhall E, Wallace K, Wright M. Co-culture of B-13 hepatocyte progenitors with liver myofibroblasts promotes progenitor WNT signalling repression in response to glucocorticoids and enhances their transdifferentiation towards hepatocyte-like cells. In: 50th Congress of the European Societies of Toxicology (EUROTOX). 2014, Edinburgh: Elsevier Ireland.
  • Luli S, Hill S, Wilson CL, Wright MC, Mann DA, Oakley F. A simple fluorescence based method to non-invasively image liver fibrosis. In: The International Liver Congress 2014: 49th Annual Meeting of the European Association for the Study of the Liver. 2014, London: Elsevier BV.
  • Fairhall EA, Schwab C, Harrison C, Charlton KA, Wallace K, Wright MC. The Hepatic Progenitor B-13 Cell Line Engrafts into the Mouse Liver and Transdifferentiates in Vivo. In: 48th Annual meeting of the European Association for the Study of the Liver. 2013, Amsterdam, The Netherlands: Elsevier.
  • Probert PME, Ebrahimkhani MR, Oakley F, Burt AD, Mann DA, Wright MC. Methapyrilene Treatment is a Refined Alternative to Bile Duct Ligation as a Model of Reproducible and Reversible Periportal Fibrosis in the Rat. In: 48th Annual meeting of the European Association for the Study of the Liver. 2013, Amsterdam, Netherlands: Elsevier BV.
  • Richter M, Fairhall EA, Hoffmann SA, Fruhwald J, Wright MC, Zeilinger K. Dexamethasone induced hepatic differentiation of rat pancreatic progenitor cells (B-13) in a 3D multicompartment bioreactor system. In: International Liver Congress 2013: 48th Annual meeting of the European Association for the Study of the Liver. 2013, Amsterdam, The Netherlands: Elsevier BV.
  • Oakley F, Murphy L, Wright M, Mann D. Stimulation of liver regeneration and amelioration of fibrosis by antagonism of a 5-HT2B/ERK/JUND/TGF beta 1 signally pathway in hepatic stellate cell. In: Journal of Hepatology: 46th Annual Meeting of the European Association for the Study of the Liver (EASL). 2011, Berlin, Germany: Elsevier BV.

• Editorial

  • Wright M. British Toxicology Society Special Reviews 2010. Toxicology 2010, 278(3), 249.

• Reviews

  • Probert PME, Meyer SK, Alsaeedi F, Axon AA, Fairhall EA, Wallace K, Charles M, Oakley F, Jowsey PA, Blain PG, Wright MC. An expandable donor-free supply of functional hepatocytes for toxicology. Toxicology Research 2015, 4(2), 203-222.
  • Wallace K, Fairhall EA, Charlton KA, Wright MC. AR42J-B-13 cell: An expandable progenitor to generate an unlimited supply of functional hepatocytes. Toxicology 2010, 278(3), 277-287.
  • Wallace K, Burt A, Wright M. Liver fibrosis. Biochemical Journal 2008, 411(1), 1-18.
  • Axon A, Cowie DE, Mann DA, Wright MC. A mechanism for the anti-fibrogenic effects of the pregnane X receptor (PXR) in the liver: Inhibition of NF-κB?. Toxicology 2008, 246(1), 40-44.