Staff Profile
Dr Mojgan Reza
Research Associate
- Email: mojgan.reza@ncl.ac.uk
- Address: Wolfson Childhood Cancer Research Centre
Translational and Clinical Research Institute
Faculty of Medical Sciences
Newcastle University
Herschel Building, Level 6
Newcastle Upon Tyne
NE1 7RU, United Kingdom
Background
Academic background
- PhD in Medical Genetics, Newcastle University
Areas of expertise
- Cell- and molecular biology
- Leukaemia
- Muscular dystrophy
Google scholar: Click here.
Research
Acute myeloid leukaemia (AML) is a heterogeneous malignant disease of the bone marrow and peripheral blood. The RUNX1/ETO fusion gene is the most frequent chromosomal rearrangement in childhood AML. To date, the mainstream treatments are genotoxic and the mechanisms underlying drug resistance are poorly understood.
Using genome wide CRISPR/Cas9 screening and subsequent next generation sequencing, we identify potential novel target genes and pathways which may play an important role in AML. Furthermore we test drug combinations that target these genes and pathways.
Our ultimate aim is to develop drug combinations to improve outcome for young patients and maximise their quality of life, to reduce the side effects of treatment and the long-term sequelae, to increase survival rates for children with relapse and to minimise the emergence of drug resistance.
Teaching
Supervision of Undergraduate and MRes students
Publications
- Martinez-Soria N, McKenzie L, Draper J, Ptasinska A, Issa H, Potluri S, Blair HJ, Pickin A, Isa A, Chin PS, Tirtakusuma R, Coleman D, Nakjang S, Assi S, Forster V, Reza M, Law E, Berry P, Mueller D, Elder A, Bomken SN, Pal D, Allan JM, Veal GJ, Cockerill PN, Wichmann C, Vormoor J, Lacaud G, Bonifer C, Heidenreich O. The Oncogenic Transcription Factor RUNX1/ETO Corrupts Cell Cycle Regulation to Drive Leukemic Transformation. Cancer Cell 2018, 34(4), 626-642.e8.
- Lourbakos A, Yau N, De Bruijn P, Hiller M, Kozaczynska K, Jean-Baptiste R, Reza M, Wolterbeek R, Koeks Z, Ayoglu B, De Klerk D, Campion G, Zaharieva I, Nadarajah VD, Nilsson P, Al-Khalili Szigyarto C, Muntoni F, Lochmuller H, Verschuuren JJ, Goemans N, Tulinius M, Niks EH, De Kimpe S, Aartsma-Rus A, T'Hoen PAC, Spitali P. Evaluation of serum MMP-9 as predictive biomarker for antisense therapy in Duchenne. Scientific Reports 2017, 7, 17888.
- Reza M, Cox D, Phillips L, Johnson D, Manoharan V, Grieves M, Davis B, Roos A, Morgan J, Hanna MG, Muntoni F, Lochmuller H. MRC Centre Neuromuscular Biobank (Newcastle and London): Supporting and facilitating rare and neuromuscular disease research worldwide. Neuromuscular Disorders 2017, 27(11), 1054-1064.
- Meng JH, Counsell JR, Reza M, Laval SH, Danos O, Thrasher A, Lochmuller H, Muntoni F, Morgan JE. Autologous skeletal muscle derived cells expressing a novel functional dystrophin provide a potential therapy for Duchenne Muscular Dystrophy. Scientific Reports 2016, 6, 19750.
- Roos A, Cox D, Reza M, Guglieri M, Straub V, Lochmuller H. MRC biobank Newcastle - A five-year review of the John Walton Muscular Dystrophy Research Centre experience. In: 21st International Congress of the World Muscle Society. 2016, Granada, Spain: Elsevier.
- Reza M, Laval SH, Roos A, Carr S, Lochmuller H. Optimization of Internally Deleted Dystrophin Constructs. Human Gene Therapy Methods 2016, 27(5), 174-186.
- Mora M, Angelini C, Bignami F, Bodin AM, Crimi M, Di Donato JH, Felice A, Jaeger C, KarCagi V, LeCam Y, Lynn S, Meznaric M, Moggio M, Monaco L, Politano L, de la Paz MP, Saker S, Schneiderat P, Ensini M, Garavaglia B, Gurwitz D, Johnson D, Muntoni F, Puymirat J, Reza M, Voit T, Baldo C, Bricarelli FD, Goldwurm S, Merla G, Pegoraro E, Renieri A, Zatloukal K, Filocamo M, Lochmuller H. The EuroBioBank Network: 10 years of hands-on experience of collaborative, transnational biobanking for rare diseases. European Journal of Human Genetics 2015, 23(9), 1116-1123.
- Boczonadi V, Muller JS, Pyle A, Munkley J, Dor T, Quartararo J, Ferrero I, Karcagi V, Giunta M, Polvikoski T, Birchall D, Princzinger A, Cinnamon Y, Lutzkendorf S, Piko H, Reza M, Florez L, Santibanez-Koref M, Griffin H, Schuelke M, Elpeleg O, Kalaydjieva L, Lochmuller H, Elliott DJ, Chinnery PF, Edvardson S, Horvath R. EXOSC8 mutations alter mRNA metabolism and cause hypomyelination with spinal muscular atrophy and cerebellar hypoplasia. Nature Communications 2014, 5, 4287.
- Lourbakos A, Hiller M, Kozaczynska K, Baptiste RJ, Reza M, Niks E, Koeks Z, de Klerk D, Wolterbeek R, Campion G, Nadarajah VD, Szigyarto CA, Calissano M, Muntoni F, Lochmuller H, Verschuuren JJGM, Goemans N, Tulinius M, de Kimpe S, Aartsma-Rus A, 't Hoen PAC, Spitali P. MMP-9 serum levels increase over time in Duchenne muscular dystrophy patients and decrease upon treatment with drisapersen. In: ESGCT and NVGCT Collaborative Congress. 2014, The Hauge, The Netherlands: Mary Ann Liebert, Inc. Publishers.
- Almalki A, Alston CL, Parker A, Simonic I, Mehta SG, He LP, Reza M, Oliveira JMA, Lightowlers RN, McFarland R, Taylor RW, Chrzanowska-Lightowlers ZMA. Mutation of the human mitochondrial phenylalanine-tRNA synthetase causes infantile-onset epilepsy and cytochrome c oxidase deficiency. Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease 2014, 1842(1), 56-64.
- Spendiff S, Reza M, Murphy JL, Gorman G, Blakely EL, Taylor RW, Horvath R, Campbell G, Newman J, Lochmüller H, Turnbull DM. Mitochondrial DNA deletions in muscle satellite cells: implications for therapies. Human Molecular Genetics 2013, 22(23), 4739-4747.
- Reza M, Laval SH, Counsell J, Muntoni F, Morgan J, Lochmuller H. Optimised dystrophin mini-constructs for gene delivery. In: 18th International Congress of the World Muscle Society. 2013, California, USA: Elsevier.
- Reza M, Johnson D, Cox D, Laval S, Chaouch A, Barresi R, Morgan J, Bushby K, Straub V, Muntoni F, Lochmuller H. MRC NMD Centre Biobank: An overview. In: United Kingdom Neuromuscular Translational Research Conference. 2012, Newcastle upon Tyne, UK: Elsevier Ltd.
- Spendiff S, Horvath R, Lochmüller H, Reza M, Murphy JL, Taylor RW, Turnbull DM. Mitochondrial DNA mutations in satellite cells. In: UK Neuromuscular Translational Research Conference. 2011, London: Neuromuscular Disorders: Pergamon.
- Dick E, Matsa E, Bispham J, Reza M, Guglieri M, Staniforth A, Watson S, Kumari R, Lochmuller H, Young L, Darling D, Denning C. Two new protocols to enhance the production and isolation of human induced pluripotent stem cell lines. Stem Cell Research 2011, 6(2), 158-167.
- Spendiff S, Horvath R, Murphy JL, Taylor RW, Reza M, Lochmuller H, Turnbull DM. Finding the missing gap - mitochondrial DNA deletions in muscle stem cells. In: United Kingdom Neuromuscular Translational Research Conference 2010. 2010, Oxford: Neuromuscular Disorders, Elsevier.
- Johnson D, Reza M, Morgan JE, Barresi R, Lochmuller H, Muntoni F. MRC NMD Biobank service: an overview. In: United Kingdom Neuromuscular Translational Research Conference. 2010, Oxford: Neuromuscular Disorders, Elsevier.
- Charlton R, Henderson M, Richards J, Hicks D, Reza M, Straub V, Lochmuller H, Bushby K, Barresi R. Chain-specific antibody testing of collagen VI: An additional pre-screening strategy for the diagnosis of Bethlem myopathy. In: Neuromuscular Disorders: 14th International Congress of the World Muscle Society. 2009, Geneva, Switzerland: Elsevier Ltd.