Staff Profile
Professor Nicola Pavese
Professor of Clinical Neuroscience
- Email: nicola.pavese@ncl.ac.uk
- Telephone: 0191 2081264
- Address: Clinical Ageing Research Unit
Newcastle University
Campus for Ageing & Vitality
Westgate Road
Newcastle upon Tyne NE4 5PL
Nicola Pavese, MD, PhD, FRCP, FEAN is Professor of Clinical Neuroscience and Director of the Clinical Ageing Research Unit at Newcastle University. He is also a Consultant Neurologist at The Newcastle upon Tyne Hospitals NHS Foundation Trust. He has more than 25 years’ experience in the treatment of patients with movement disorders and his clinical activity mainly focuses on the management of patients with advanced Parkinson’s disease, Dystonia and Essential Tremor treated with Deep Brain Stimulation.
He received his medical degree from Pisa University, Italy. After completing residency training in Neurology and subsequent training in Biochemistry and Clinical Chemistry at Pisa University, he moved to London where he achieved his PhD in Neuroimaging at Imperial College London. He had worked at the MRC Clinical Sciences Centre and Imperial College London before moving to Newcastle University.
My research involves the application of neuroimaging (Positron Emission Tomography and Magnetic Resonance Imaging) in neurodegenerative diseases to identify biomarkers of the pathological process and to elucidate the pathophysiological mechanisms responsible for the onset of specific symptoms such as dementia, depression, sleep problems, and fatigue, in patients with these conditions. My work has established for the first time that occurrence of fatigue and excessive daytime sleepiness in Parkinson’s disease are linked to definite deficits of the serotoninergic pathways in the brain which may lead to development of new drug targets and therapeutic strategies for these disabling symptoms. I have also worked extensively in the field of neuroinflammation in neurodegenerative disorders, and I currently leads an international collaboration with Aarhus University in Denmark and Barcelona University in Spain to investigate the occurrence of neuroinflammation in subjects at high risk of developing Parkinson’s disease and other parkinsonism, including patients with REM sleep behavior disorder.
I also act as Principal Investigator in several pharmaceutical sponsored clinical trials in patients with Parkinson’s disease and other parkinsonisms.
I have published over 160 reports including original articles, reviews, book chapters, and editorials.
- Stokholm MG, Iranzo A, Ostergaard K, Serradell M, Otto M, Svendsen KB, Garrido A, Vilas D, Borghammer P, Santamaria J, Moller A, Gaig C, Brooks DJ, Tolosa E, Pavese N. Assessment of neuroinflammation in patients with idiopathic rapid-eye-movement sleep behaviour disorder: A case-control study. The Lancet Neurology 2017, 16(10), 789-796.
- Strafella AP, Bohnen NI, Perlmutter JS, Eidelberg D, Pavese N, Van Eimeren T, Piccini P, Politis M, Thobois S, Ceravolo R, Higuchi M, Kaasinen V, Masellis M, Peralta MC, Obeso I, Pineda-Pardo JA, Cilia R, Ballanger B, Niethammer M, Stoessl JA. Molecular imaging to track Parkinson's disease and atypical parkinsonisms: New imaging frontiers. Movement Disorders 2017, 32(2), 181-192.
- Politis M, Sauerbier A, Loane C, Pavese N, Martin A, Corcoran B, Brooks DJ, Ray-Chaudhuri K, Piccini P. Sustained striatal dopamine levels following intestinal levodopa infusions in Parkinson's disease patients. Movement Disorders 2017, 32(2), 235-240.
- Pagano G, Molloy S, Bain PG, Rabiner EA, Chaudhuri KR, Brooks DJ, Pavese N. Sleep problems and hypothalamic dopamine D3 receptor availability in Parkinson disease. Neurology 2016, 87(23), 2451-2456.
- Woitalla D, Dunac A, Safavi A, Ceravolo MG, Gomez Esteban JC, Pavese N, Asgharnejad M, Joeres L, Schuller JC, Chaudhuri KR. A noninterventional study evaluating the effectiveness of rotigotine and levodopa combination therapy in younger versus older patients with Parkinson's disease. Expert Opinion on Pharmacotherapy 2018, 19(9), 937-945.
- Stokholm MG, Iranzo A, Østergaard K, Serradell M, Otto M, Svendsen KB, Garrido A, Vilas D, Parbo P, Borghammer P, Santamaria J, Møller A, Gaig C, Brooks DJ, Tolosa E, Pavese N. Extrastriatal monoaminergic dysfunction and enhanced microglial activation in idiopathic rapid eye movement sleep behaviour disorder. Neurobiology of Disease 2018, 115, 9-16.
- Strafella AP, Bohnen NI, Pavese N, Vaillancourt DE, van Eimeren T, Politis M, Tessitore A, Ghadery C, Lewis S. Imaging Markers of Progression in Parkinson's Disease. Movement Disorders Clinical Practice 2018, 5(6), 567-663.
- Knudsen K, Fedorova TD, Hansen AK, Sommerauer M, Otto M, Svendsen KB, Nahimi A, Stokholm MG, Pavese N, Beier CP, Brooks DJ, Borghammer P. In vivo staging of pathology in REM Sleep Behaviour Disorder – a multi-modality imaging case-control study. Lancet Neurology 2018, 17(7), 618-628.
- Pavese N. Is neuromelanin the imaging biomarker for the early diagnosis of Parkinson's disease that we were looking for?. Parkinsonism & Related Disorders 2019, 58, 1-2.
- Pavese N, Tai YF. Nigrosome imaging and neuromelanin sensitive MRI in diagnostic evaluation of parkinsonism. Movement Disorders Clinical Practice 2018, 5(2), 131-140.
- Maxan A, Mason S, Saint-Pierre M, Smith E, Ho A, Harrower T, Watts C, Tai Y, Pavese N, Savage JC, Tremblay ME, Gould P, Rosser AE, Dunnett SB, Piccini P, Barker RA, Cicchetti F. Outcome of cell suspension allografts in a patient with Huntington’s disease. Annals of Neurology 2018, 84(6), 950-956.
- Lee JY, Lao-Kaim NP, Pasquini J, Deuschl G, Pavese N, Piccini P. Pallidal dopaminergic denervation and rest tremor in early Parkinson’s disease: PPMI cohort analysis. Parkinsonism & Related Disorders 2018, 51, 101-104.
- Thevathasan W, Debu B, Aziz T, Bloem BR, Blahak C, Butson C, Czernecki V, Foltynie T, Fraix V, Grabli D, Joint C, Lozano AM, Okun MS, Ostrem J, Pavese N, Schrader C, Tai C-H, Krauss JK, Moro E. Pedunculopontine nucleus deep brain stimulation in Parkinson's disease: A clinical review. Movement Disorders 2018, 33(1), 10-20.
- Xu Z, Arbizu J, Pavese N. PET Molecular Imaging in Atypical Parkinsonism. International Review of Neurobiology 2018, 142, 3-36.
- Pasquini J, Ceravolo R, Qamhawi Z, Lee JY, Deuschl G, Brooks DJ, Bonuccelli U, Pavese N. Progression of tremor in early stages of Parkinson’s disease: a clinical and neuroimaging study . Brain 2018, 141(3), 811-821.
- Angeles P, Tai Y, Pavese N, Wilson S, Vaidyanathan R. Automated assessment of symptom severity changes during deep brain stimulation (DBS) therapy for Parkinson's disease. In: IEEE International Conference on Rehabilitation Robotics (ICORR). 2017, London, UK: IEEE Computer Society.
- Arshad Q, Bonsu A, Lobo R, Fluri A-S, Sheriff R, Bain P, Pavese N, Bronstein AM. Biased numerical cognition impairs economic decision-making in Parkinson's disease. Annals of Clinical and Translational Neurology 2017, 739-748.
- Parbo P, Ismail R, Hansen K, Mårup F, Gottrup H, Braendgaard H, Eriksson B, Eskildsen S, Lund T, Tietze A, Edison P, Pavese N, Stokholm M, Borghammer P, Hinz R, Aanerud J, Brooks DJ. Brain inflammation accompanies amyloid in a majority of mild cognitive impairment cases due to Alzheimer’s disease. Brain 2017, 140(7), 2002-2011.
- Weintraub D, Simuni T, Caspell-Garcia C, Coffey C, Lasch S, Siderowf A, Aarsland D, Barone P, Burn D, Chahine LM, Eberling J, Espay AJ, Foster ED, Leverenz JB, Litvan I, Richard I, Troyer MD, Hawkins KA, Marek K, Jennings D, Tanner C, Kieburtz K, Poewe W, Mollenhauer B, Foroud T, Galasko D, Sherer T, Chowdhury S, Frasier M, Kopil C, Arnedo V, Rudolph A, Seibyl J, Mendick S, Schuff N, Caspell C, Uribe L, Foster E, Gloer K, Yankey J, Toga A, Berlin D, Casalin P, Malferrari G, Trojanowski J, Shaw L, Russell D, Factor S, Hogarth P, Standaert D, Hauser R, Jankovic J, Stern M, Chahine L, Frank S, Seppi K, Shill H, Berg D, Mari Z, Pavese N, Espay A, Devoto J, Rowe D, Brandabur M, Alcalay R, Tolosa E, York M, Leary L, Riordan C, Rees L, Portillo A, Lenahan A, Williams K, Guthrie S, Rawlins A, Harlan S, Hunter C, Tran B, Thomas C-A, James R, Sprenger F, Willeke D, Obradov S, Mule J, Gauss K, Fontaine D, Shah B, Ranola M, Sims JR. Cognitive Performance and Neuropsychiatric Symptoms in Early, Untreated Parkinson's Disease. Movement Disorders 2015, 30(7), 919-927.
- Simpson B, Pavese N, Ramlackhansingh A, Breen D, Barker R, Burn D, Brooks D. Clinical and Cognitive Correlates of Brain Inflammation in Parkinson Disease: A PET Study. In: NEUROLOGY. 2013, 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA: LIPPINCOTT WILLIAMS & WILKINS.
- Grover VPB, Pavese N, Koh SB, Wylezinska M, Saxby BK, Gerhard A, Forton DM, Brooks DJ, Thomas HC, Taylor-Robinson SD. Cerebral microglial activation in patients with hepatitis c: in vivo evidence of neuroinflammation. Journal of Viral Hepatitis 2012, 19(2), E89-E96.
- Tilley BS, Smith C, Pavese N, Attems J. Rare histotype of sporadic Creutzfeldt-Jakob disease, clinically suspected as corticobasal degeneration. BMJ Case Reports 2019, 12(3), e228305.
- van Eimeren T, Antonini A, Berg D, Bohnen N, Ceravolo R, Drzezga A, Hoglinger GU, Higuchi M, Lehericy S, Lewis S, Monchi O, Nestor P, Ondrus M, Pavese N, Peralta MC, Piccini P, Pineda-Pardo JA, Rektorova I, Rodriguez-Oroz M, Rominger A, Seppi K, Stoessl AJ, Tessitore A, Thobois S, Kaasinen V, Wenning G, Siebner HR, Strafella AP, Rowe JB. Neuroimaging biomarkers for clinical trials in atypical parkinsonian disorders: Proposal for a Neuroimaging Biomarker Utility System. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring 2019, 11, 301-309.
- Durcan R, Wiblin L, Lawson RA, Khoo TK, Yarnall AJ, Duncan GW, Brooks DJ, Pavese N, Burn DJ. Prevalence and duration of non‐motor symptoms in prodromal Parkinson's disease. European Journal of Neurology 2019, 26(7), 979-985.
- Pasquini J, Ceravolo R, Brooks DJ, Bonuccelli U, Pavese N. Progressive loss of raphe nuclei serotonin transporter in early Parkinson’s disease: a longitudinal 123I-FP-CIT SPECT study. Parkinsonism & Related Disorders 2019, 77, 170-175.