Staff Profile

Roles and Responsibilities

Professor of Cerebrovascular Pathology (Neuropathology), personal chair appointed 1997

Lead PI, Newcastle Cognitive Function After Stroke (CogFAST) Longitudinal Study, MRC funded 2000-2015 

Head, Neurovascular Research Group (NRG), Translational and Clinical Research Institute

Past Co-ordinator, Newcastle NE ARUK Network Centre, Alzheimer's Research UK (ARUK)

Past Chairman/President, International Society for Vascular Behavioural and Cognitive Disorders (VasCog)

Adjunct Professor, Department of Human Anatomy, University of Nairobi, Kenya, 2019 - present

Adjunct Professor, IAMRAT, Faculty of Medicine, University of Ibadan, Ibadan, Nigeria, 2019 - present

Previous Positions

Associate Professor of Neurology, Neurosciences and Pathology, Case Western Reserve University, Cleveland, OH 44106, USA

Memberships

Royal College of Pathologists (Fellow), Society of Biology (Fellow), International Society for Vascular Behavioural and Cognitive Disorders (President and Secretary-General), British Neuroscience Association (past Hon Sec), International Brain Research Organisation (past member of Executive Committee)

Africa Task Force of the European Academy of Neurology and the ADCD speciality interest group of the World Federation of Neurology

Founder member of the African Stroke Organisation and the African Dementia Consortium

Honours and Awards

Gold medal from President Diouf of Senegal, appointed Officier L’Ordre National du Lion for services to promote research and teaching of neurosciences in Africa

Doctor of Science in Medicine, Newcastle University

Fellow of the Royal Society of Biology

Fellow of the Academy of Medical Sciences

Research Interests

Cerebrovascular diseases, Vascular Dementia, Alzheimer's disease, Post-Stroke Dementia

Current Work

Neuropathology and Neuroepidemiology of Cerebrovascular Diseases; CADASIL and Small Vessel Diseases of the Brain

Esteem Indicators

Chair, Networking Grants, Academy Medical Sciences, UK, 2023-2026.

Member, Centres of Excellence (CoE), Academy of Finland, Review panel, 2009-2012.

Member, Canadian Excellence Research Chairs (CERC) Review panel, Social Sciences and Humanities Research Council of Canada, 2008-2011.

Member, Scientific Advisory Board, Alzheimer's Research UK, 2000-2010, (2011, also Fellowships)

Member (and chair) Scientific Review panel, Fogarty NIH Brain Disorders Across the Life Span, 2003- 2011.

Member, MRC Clinical Pharmacology and Pathology Fellowships Board, 2009-2010.

Chair, Steering Group, MRC Brain Banks (Sudden death, HIV and CJD), Edinburgh, UK, 2007-2010.

Executive Committee, International Society of Neuropathology (ISN, Vienna), 2014- present; Chair, ISN Sub-committee on Training and Development, ISN, 2014- present;

Board Member, European Academy of Neurology (EAN) Task Force on Africa, 2008- present;

Chair, Global Networking Grants Panel, The Academy of Medical Sciences, UK, 2023-

Funding

Medical Research Council UK (MRC), Dunhill Medical Trust (UK), Alzheimer's Research UK (ARUK), National Institutes of Health (USA)

Neurovascular Research Group (NRG)

Interests: Increasing age is the strongest risk factor for cognitive dysfunction, which may result from primary cerebrovascular or neurodegenerative mechanisms, such as those involved in vascular dementia or Alzheimer’s disease (AD), or both. Like neurodegenerative disease, cerebrovascular disease (CVD) leads to high morbidity and mortality and is the second most common cause of dementia. Over the past 17 years, Prof Kalaria and his team in Newcastle have collected abundant evidence from epidemiological, genetic, clinical-pathological and animal studies to demonstrate the impact of systemic vascular and cerebrovascular diseases on cerebral neural processes and cognitive function. 

We have also contributed to diagnostic criteria guidelines for vascular dementia and vascular cognitive disorders (DSM V). The NRG has also built a reputation for students to publish at 2-3 peer-reviewed papers prior to completion of their doctoral studies. 

Potential Project(s) for students:

In collaboration with colleagues in Edinburgh and Japan (Kyoto and Osaka), the NRG has worked to share their expertise in human ageing, dementias and animal models (mice) of disease to probe mechanistic insights into the effects of altered brain perfusion and downstream consequences. Through these efforts, we have developed rigorous models in order to demonstrate how CVD causes nerve cell degeneration and affect dementia. 

The student will test the hypothesis that reduced brain perfusion in genetically altered mice, bred for their suitability to track specific modifications, leads to microvascular changes and subsequent damage to nerve cells, synapses and communication tracts between brain regions, which manifests as white matter disease. He/She will explore how reduced local cerebral blood flow (CBF) leads to neurodegeneration and culminates in cognitive impairment and dementia. Synaptic and dendritic structures are particularly vulnerable targets of ischaemic or hypoperfusive (oligaemic) insults, and likely contribute to cognitive impairment.

The student will also explore how improved perfusion through readily implemented interventions (physical exercise or active lifestyle) protects cortical (and strategic subcortical) structures from degeneration of their neuronal, synaptic, and microvascular network. This research will have impact on the global burden of dementia; identifying strategies, which will enable to reduce common dementing illnesses of old age.

The project is ideally suited to students from a physics based, mathematical or similar background, as they will join a team whose purpose will be to develop and refine the use of multiphoton (MP) laser imaging and its related technology to monitor CBF (laser speckle), blood rheology, perfusion across cerebral capillaries and assess synaptic/neuronal networks in live rodents. The data will be derived from a depth of ~900μm in specified regions of live mouse brains by the interaction of two photon collisions at the site of in vivo fluorochromes. This exciting project has only recently become possible due mainly to current understanding of multiphoton collision at increased tissue depth and the advent of innovative MP equipment design. The development of in vivo imaging using MP microscopy also affords a tremendous opportunity for the IoN and the Wellcome Trust Centre on Translation Research. 

Supervision of doctoral and MRes students and fellows (last 2 years):

Primary supervisor :

PhD/MD:15; MRes/MSci: 40

Most Recent Mentor and Supervisor Activity:

Mr Dan Jobson, MRes, PhD student 2022-, Newcastle University, Newcastle upon Tyne, UK

Dr Michael Ndung’u, BVM PhD student 2023-, University of Nairobi, Nairobi, Kenya

Dr Gan Han, MD PhD, Post-doctoral RA, CAV, Newcastle University, Newcastle upon Tyne, UK

Dr Yoshiki, Hase MD PhD, Fellow, Stroke Unit, RVI and Newcastle University, Newcastle upon Tyne, UK

Dr Stella-Maria Paddick, NU, Acad Med Sci Grant on Pilot HIV Study in Hai Tanzania-May 2018

Prof Rufus Aiknyemi, University of Ibadan, Nigeria,Newcastle University. FLAIR Fellowship, March 2019

Dr Nelson Manzanza, Newcastle University Angolan Government, PhD, Mol Mechanisms in LBD, 2018-2020

Postgraduate Teaching

BMS stage 2 - Biology of Ageing - Brain Ageing

MRes Medical and Molecular Biosciences. Scientific Basis of Neurological Disease module

MRes Ageing and Health module. Neuropathology Lectures

MRCPsych Parts I and II, Neuroanatomical localization and Neuropathology of Dementia 

• Articles

  • Short E, Huckstepp RTR, Alavian K, Amoaku WMK, Barber TM, van Beek EJR, Benbow E, Bhandari S, Bloom P, Cota C, Chazot P, Christopher G, Demaria M, Erusalimsky JD, Ferenbach DA, Foster T, Gazzard G, Glassock R, Jamal N, Kalaria R, Kanamarlapudi V, Khan AH, Krishna Y, Leeuwenburgh C, van der Linde I, Lorenzini A, Maier AB, Medina RJ, Miotto CL, Mukherjee A, Mukkanna K, Murray JT, Nirenberg A, Palmer DB, Pawelec G, Reddy V, Rosa AC, Rule AD, Shiels PG, Sheridan C, Tree J, Tsimpida D, Venables ZC, Wellington J, Calimport SRG, Bentley BL. International Consortium to Classify Ageing-related Pathologies (ICCARP) senescence definitions: achieving international consensus. GeroScience 2025, epub ahead of print.
  • Kalailingam P, Ngan SC, Iyappan R, Nehchiri A, Mohd-Kahliab K-H, Lee BST, Sharma B, Machan R, Bo ST, Chambers ES, Fajardo VA, Macpherson REK, Liu J, Klentrou P, Tsiani EL, Lim KL, Su IH, Gao Y-G, Richar AM, Kalaria RN, Chen CP, Balion C, de Kleijn D, McCarthy NE, Sze SK. Immunotherapeutic targeting of aging-associated isoDGR motif in chronic lung inflammation. Aging Cell 2025, epub ahead of print.
  • Gravesteijn G, Rutten JW, Cerfontaine MN, Hack RJ, Liao Y-C, Jolly AA, Guey S, Hsu S-L, Park J-Y, Yuan Y, Kopczak A, Rifino N, Neilson SJ, Poggesi A, Shourav MMI, Saito S, Ishiyama H, Dominguez Mayoral A, Nogueira R, Muino E, Andersen P, De Stefano N, Santo G, Sukhonpanich N, Mele F, Park A, Lee JS, Rodriguez-Girondo M, Vonk SJJ, Brodtmann A, Borjesson-Hanson A, Pantoni L, Fernandez-Cadenas I, Silva AR, Montanaro VVA, Kalaria RN, Lopergolo D, Ihara M, Meschia JF, Muir KW, Bersano A, Pescini F, Duering M, Choi JC, Ling C, Kim H, Markus HS, Chabriat H, Lee Y-C, Lesnik Oberstein SAJ. Disease Severity Staging System for NOTCH3-Associated Small Vessel Disease, Including CADASIL. JAMA Neurology 2025, 82(1), 49-60.
  • Akinyemi RO, Tiwari HK, Srinivasasainagendra V, Akpa O, Sarfo FS, Akpalu A, Wahab K, Obiako R, Komolafe M, Owolabi L, Osaigbovo GO, Mamaeva OA, Halloran BA, Akinyemi J, Lackland D, Obiabo OY, Sunmonu T, Chukwuonye II, Arulogun O, Jenkins C, Adeoye A, Agunloye A, Ogah OS, Ogbole G, Fakunle A, Uvere E, Coker MM, Okekunle A, Asowata O, Diala S, Ogunronbi M, Adeleye O, Laryea R, Tagge R, Adeniyi S, Adusei N, Oguike W, Olowoyo P, Adebajo O, Olalere A, Oladele O, Yaria J, Fawale B, Ibinaye P, Oyinloye O, Mensah Y, Oladimeji O, Akpalu J, Calys-Tagoe B, Dambatta HA, Ogunniyi A, Kalaria R, Arnett D, Rotimi C, Ovbiagele B, Owolabi MO. Novel functional insights into ischemic stroke biology provided by the first genome-wide association study of stroke in indigenous Africans. Genome Medicine 2024, 16, 25.
  • Flack KA, Rainey ES, Urasa S, Koipapi S, Kalaria R, Howlett W, Mukaetova-Ladinska EB, Dekker M, Gray WK, Walker RW, Dotchin C, Mtwaile H, Lewis T, Stone LG, McNally R, Makupa PC, Paddick S-M. Lack of Association of Vascular Risk Factors with HIV-Associated Neurocognitive Disorders in cART-Treated Adults Aged ≥ 50 Years in Tanzania. Viruses 2024, 16(6), 819.
  • Askew KE, Beverley J, Sigfridsson E, Szymkowiak S, Emelianova K, Dando O, Hardingham GE, Duncombe J, Hennessy E, Koudelka J, Samarasekera N, Salman RA-S, Smith C, Tavares AAS, Gomez-Nicola D, Kalaria RN, McColl BW, Horsburgh K. Inhibiting CSF1R alleviates cerebrovascular white matter disease and cognitive impairment. GLIA 2024, 72(2), 375-395.
  • Hase Y, Jobson D, Cheong J, Gotama K, Maffei L, Hase M, Hamdan A, Ding R, Polivkoski T, Horsburgh K, Kalaria RN. Hippocampal capillary pericytes in post-stroke and vascular dementias and Alzheimer’s disease and experimental chronic cerebral hypoperfusion. Acta Neuropathologica Communications 2024, 12, 29.
  • Akinyemi RO, Griswold AJ, Coker M, Whitehead PL, Rajabli F, Akinwande KS, Diala S, Ogunronbi M, Scott K, Obiako R, Adams LD, Hamilton-Nelson KL, Wahab K, Mena PR, Akpalu AK, Kunkle BW, Sarfo FS, Vance JM, Okubadejo NU, Baiyewu O, Reitz C, Tosto G, Owolabi MO, Bush WS, Haines JL, Kalaria R, Byrd GS, Ogunniyi A, Pericak-Vance MA, African Dementia Consortium. Genetic architecture of Alzheimer’s disease in a West African Cohort: Insights from the READD - ADSP. Alzheimer's & Dementia 2024, 20(S1), e093308.
  • Shamputi D, Kaputu-Kalala-malu C, Vivalya BMN, Paddick S-M, Kalaria R. Challenges in evaluating cognitive impairment in diabetics in the Democratic Republic of the Congo / Desafios na avaliação da deficiência cognitiva em diabéticos na República Democrática do Congo. Dementia e Neuropsychologia 2024, 18, e20230082.
  • Waller R, Hase Y, Simpson JE, Heath PR, Wyles M, Kalaria RN, Wharton SB. Transcriptomic Profiling Reveals Discrete Poststroke Dementia Neuronal and Gliovascular Signatures. Translational Stroke Research 2023, 14(3), 383-396.
  • Jegede A, Balogun O, Olorunsogbon OF, Nichols M, Akinyemi J, Jenkins C, Ogunronbi M, Singh A, Obiako R, Wahab K, Bello A, Akpalu A, Sarfo FS, Owolabi LF, Ojebuyi B, Adigun M, Olujobi D, Musbahu R, Titiloye M, Afolami I, Calys-Tagoe B, Uvere E, Laryea R, Fakunle A, Adeleye O, Adesina D, Mensah N, Oguike W, Coleman N, Adeniyi S, Omotoso L, Asibey S, Melikam L, Yusuf J, Gbenga A, Mande A, Uthman M, Kalaria RN, Owolabi M, Ovbiagele B, Arulogun O, Akinyemi RO. Research participants' perception of ethical issues in stroke genomics and neurobiobanking research in Africa. medRxiv 2023. Submitted.
  • Magaki S, Chen Z, Severance A, Williams CK, Diaz R, Fang C, Khanlou N, Yong WH, Paganini-Hill A, Kalaria RN, Vinters HV, Fisher M. Neuropathy of microbleeds in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Journal of Neuropathology & Experimental Neurology 2023, 82(4), 333-344.
  • Kalailingam P, Mohd-Kahliab K-H, Ngan SC, Iyappan R, Melekh E, Lu T, Zien GW, Sharma B, Guo T, MacNeil AJ, MacPherson REK, Tsiani EL, O'Leary DD, Lim KL, Su IH, Gao Y-G, Richards AM, Kalaria RN, Chen CP, McCarthy NE, Sze SK. Immunotherapy targeting isoDGR-protein damage extends lifespan in a mouse model of protein deamidation. EMBO Molecular Medicine 2023, 15(12), e18526.
  • Panahi M, Hase Y, Gallart-Palau X, Mitra S, Watanabe A, Low RC, Yamamoto Y, Sepulveda-Falla D, Hainsworth AH, Ihara M, Sze SK, Viitanen M, Behbahani H, Kalaria RN. ER stress induced immunopathology involving complement in CADASIL: implications for therapeutics. Acta Neuropathologica Communications 2023, 11, 76.
  • Vinaiphat A, Pazhanchamy K, Jebamercy G, Ngan SC, Leow MK-S, Ho HH, Gao Y-G, Lim KL, Richards AM, De Kleijn DPV, Chen CP, Kalaria RN, Liu J, O'Leary DD, McCarthy NE, Sze SK. Endothelial Damage Arising from High Salt Hypertension Is Elucidated by Vascular Bed Systematic Profiling. Arteriosclerosis, Thrombosis, and Vascular Biology 2023, 43(3), 427-442.
  • Uvere EO, Nichols M, Ojebuyi BR, Isah SY, Calys-Tagoe B, Jenkins C, Obiako R, Owolabi L, Akpalu A, Sarfo FS, Ogunronbi O, Adigun M, Fakunle GA, Hamzat B, Laryea R, Uthman B, Akinyemi JO, Adeleye O, Melikam L, Balogun O, Sule A, Adeniyi S, Asibey SO, Oguike W, Olorunsogbon O, Singh A, Titiloye MA, Musbahu R, Wahab KW, Kalaria RN, Jegede AS, Owolabi MO, Ovbiagele B, Arulogun OS, Akinyemi RO. Capacity-Building for Stroke Genomic Research Data Collection: The African Neurobiobank Ethical, Legal, and Social Implications Project Experience. Biopreservation and Biobanking 2023, 21(2), 158-165.
  • Delgado J, Masoli J, Hase Y, Akinyemi R, Ballard C, Kalaria RN, Allan LM. Trajectories of cognitive change following stroke: Stepwise decline towards dementia in the elderly. Brain Communications 2022, 4(3), fcac129.
  • Wright JR, Deen QFE, Stevenson A, Telford-Cooke LL, Parker C, Martin-Ruiz C, Steinert JR, Kalaria RN, Mukaetova-Ladinska EB. Plasma Myeloperoxidase as a Potential Biomarker of Patient Response to Anti-Dementia Treatment in Alzheimer's Disease. Journal of Alzheimer's Disease 2022, 89(4), 1483-1492.
  • Alfieri A, Koudelka J, Li M, Scheffer S, Duncombe J, Caporali A, Kalaria RN, Smith C, Shah AM, Horsburgh K. Nox2 underpins microvascular inflammation and vascular contributions to cognitive decline. Journal of Cerebral Blood Flow and Metabolism 2022, 42(7), 1176-1191.
  • Adigun M, Ojebuyi BR, Akinyemi J, Wahab K, Akpalu A, Sarfo FS, Owolabi LF, Musbahu R, Bello A, Obiako R, Ogunronbi M, Singh A, Nichols M, Jenkins C, Jegede A, Kalaria R, Owolabi M, Ovbiagele B, Arulogun O, Akinyemi R. Legal Implications of Stroke Biobanking and Genomics Research in Sub-Saharan Africa. Journal of Law and Medicine 2022, 29(2), 579-598.
  • Li M, Kitamura A, Beverley J, Koudelka J, Duncombe J, Lennen R, Jansen MA, Marshall I, Platt B, Wiegand UK, Carare RO, Kalaria RN, Iliff JJ, Horsburgh K. Impaired Glymphatic Function and Pulsation Alterations in a Mouse Model of Vascular Cognitive Impairment. Frontiers in Aging Neuroscience 2022, 13, 788519.
  • Adigun M, Ojebuyi BR, Akinyemi J, Wahab K, Akpalu A, Sarfo FS, Owolabi LF, Musbahu R, Bello A, Obiako R, Ogunronbi M, Singh A, Nichols M, Jenkins C, Jegede A, Kalaria R, Owolabi M, Ovbiagele B, Arulogun O, Akinyemi R. Human Rights Implications of Stroke Biobanking and Genomics Research in Sub-Saharan Africa. International Human Rights Law Review 2022, 11(1), 112-137.
  • Spooner R, Ranasinghe S, Urasa S, Yoseph M, Koipapi S, Mukaetova-Ladinska EB, Lewis T, Howlett W, Dekker M, Kisoli A, Gray WK, Walker RW, Dotchin CL, Kalaria R, Lwezuala B, Makupa PC, Akinyemi R, Paddick SM. HIV-Associated Neurocognitive Disorders: The First Longitudinal Follow-Up of a cART-Treated Cohort of Older People in Sub-Saharan Africa. Journal of Acquired Immune Deficiency Syndromes 2022, 90(2), 214-222.
  • Littau JL, Velilla L, Hase Y, Villalba-Moreno ND, Hagel C, Drexler D, Osorio Restrepo S, Villegas A, Lopera F, Vargas S, Glatzel M, Krasemann S, Quiroz YT, Arboleda-Velasquez JF, Kalaria R, Sepulveda-Falla D. Evidence of beta amyloid independent small vessel disease in familial Alzheimer's disease. Brain Pathology 2022, 32(6), e13097.
  • Hase Y, Ameen-Ali KE, Waller R, Simpson JE, Stafford C, Mahesh A, Ryan L, Pickering L, Bodman C, Hase M, Boche D, Horsburgh K, Wharton SB, Kalaria RN. Differential perivascular microglial activation in the deep white matter in vascular dementia developed post-stroke. Brain Pathology 2022, 32(6), e13101.
  • Singh A, Arulogun O, Akinyemi J, Nichols M, Calys-Tagoe B, Ojebuyi B, Jenkins C, Obiako R, Akpalu A, Sarfo F, Wahab K, Sunday A, Owolabi LF, Adigun M, Afolami I, Olorunsogbon O, Ogunronbi M, Melikam ES, Laryea R, Asibey S, Oguike W, Melikam L, Sule A, Titiloye MA, Yahaya IS, Bello A, Kalaria RN, Jegede A, Owolabi M, Ovbiagele B, Akinyemi R. Biological sample donation and informed consent for neurobiobanking: Evidence from a community survey in Ghana and Nigeria. PLoS ONE 2022, 17(8), e0267705.
  • Rajabli F, Beecham GW, Hendrie HC, Baiyewu O, Ogunniyi A, Gao S, Kushch NA, Lipkin-Vasquez M, Hamilton-Nelson KL, Young JI, Dykxhoorn DM, Nuytemans K, Kunkle BW, Wang L, Jin F, Liu X, Feliciano-Astacio BE, Alzheimer's Disease Sequencing Project AsDGC, Schellenberg GD, Dalgard CL, Griswold AJ, Byrd GS, Reitz C, Cuccaro ML, Haines JL, Pericak-Vance MA, Vance JM. A locus at 19q13.31 significantly reduces the ApoE ε4 risk for Alzheimer's Disease in African Ancestry. PLoS Genetics 2022, 18(7), e1009977.
  • Jobson DD, Hase Y, Clarkson AN, Kalaria RN. The role of the medial prefrontal cortex in cognition, ageing and dementia. Brain Communications 2021, 3(3), fcab125.
  • Adigun M, Ojebuyi BR, Akinyemi J, Wahab K, Akpalu A, Sarfo FS, Owolabi LF, Musbahu R, Bello A, Obiako R, Ogunronbi M, Singh A, Nichols M, Jenkins C, Jegede A, Kalaria R, Owolabi M, Ovbiagele B, Arulogun O, Akinyemi R. Symbolic legislation and the regulation of stroke biobanking and genomics research in Sub-Saharan Africa. Theory and Practice of Legislation 2021, 9(3), 404-424.
  • Yamamoto Y, Hase Y, Ihara M, Khundakar A, Roeber S, Duering M, Kalaria RN. Neuronal densities and vascular pathology in the hippocampal formation in CADASIL. Neurobiology of Aging 2021, 97, 33-40.
  • Ding R, Hase Y, Burke M, Foster V, Stevenson W, Polvikoski T, Kalaria RN. Loss with ageing but preservation of frontal cortical capillary pericytes in post-stroke dementia, vascular dementia and Alzheimer’s disease. Acta Neuropathologica Communications 2021, 9(1), 130.
  • Waller R, Narramore R, Simpson JE, Heath PR, Verma N, Tinsley M, Barnes J, Haris H, Henderson FE, Matthews FE, Richardson CD, Brayne C, Ince PG, Kalaria R, Wharton SB. Heterogeneity of cellular inflammatory responses in ageing white matter and relationship to Alzheimer's and small vessel disease pathologies. Brain Pathology 2021, 31(3), e12928.
  • Akinyemi R, Sarfo F, Abd-Allah F, Ogun Y, Belo M, Francis P, Mateus MB, Bateman K, Naidoo P, Charway-Felli A, Akpalu A, Wahab K, Napon C, Arulogun O, Ebenezer AA, Ekeng G, Scola G, Hamzat K, Zimba S, Ossou-Nguiet PM, Ademokoya J, Adebayo P, Ayele BA, Vaz DC, Ogbole G, Barasukan P, Melifonwu R, Onwuekwe I, Belson S, Damasceno A, Okubadejo N, Njamnshi AK, Ogeng'o J, Walker RW, Diop AG, Ogunniyi A, Kalaria R, Sandercock P, Davis S, Brainin M, Ovbiagele B, Owolabi M. Conceptual framework for establishing the African Stroke Organization. International Journal of Stroke 2021, 16(1), 93-99.
  • de Rojas I, Moreno-Grau S, Tesi N, Grenier-Boley B, et al. Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores. Nature Communications 2021, 12, 3417.
  • Akinyemi RO, Jenkins C, Nichols M, Singh A, Wahab K, Akpalu A, Sarfo FS, Owolabi LF, Obiako R, Akinyemi J, Ojebuyi B, Adigun M, Musbahu R, Bello A, Titiloye M, Calys-Tagoe B, Ogunronbi M, Uvere E, Laryea R, Fakunle A, Adeleye O, Olorunsogbon O, Ojo A, Adesina D, Mensah N, Oguike W, Coleman N, Mande A, Uthman M, Kalaria RN, Jegede A, Owolabi M, Ovbiagele B, Arulogun O. Unraveling the Ethical, Legal, and Social Implications of Neurobiobanking and Stroke Genomic Research in Africa: A Study Protocol of the African Neurobiobank for Precision Stroke Medicine ELSI Project. International Journal of Qualitative Methods 2020, 19, 1-13.
  • McFall A, Hietamies TM, Bernard A, Aimable M, Allan SM, Bath PM, Brezzo G, Carare RO, Carswell HV, Clarkson AN, Currie G, Farr TD, Fowler JH, Good M, Hainsworth AH, Hall C, Horsburgh K, Kalaria R, Kehoe P, Lawrence C, Macleod M, McColl BW, McNeilly A, Miller AA, Miners S, Mok V, O'Sullivan M, Platt B, Sena ES, Sharp M, Strangeward P, Szymkowiak S, Touyz RM, Trueman RC, White C, McCabe C, Work LM, Quinn TJ. UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment: questionnaire and workshop proceedings. Journal of Cerebral Blood Flow and Metabolism 2020, 40(7), 1402-1414.
  • Hase Y, Polvikoski TM, Firbank MJ, Craggs LJL, Hawthorne E, Platten C, Stevenson W, Deramecourt V, Ballard C, Kenny RA, Perry RH, Ince P, Carare RO, Allan LM, Horsburgh K, Kalaria RN. Small vessel disease pathological changes in neurodegenerative and vascular dementias concomitant with autonomic dysfunction. Brain Pathology 2020, 30(1), 191-202.
  • Ding R, Hase Y, Ameen-Ali KE, Ndung'u M, Stevenson W, Barsby J, Gourlay R, Akinyemi T, Akinyemi R, Uemura MT, Polvikoski T, Mukaetova-Ladinska E, Ihara M, Kalaria RN. Loss of capillary pericytes and the blood–brain barrier in white matter in poststroke and vascular dementias and Alzheimer’s disease. Brain Pathology 2020, 30(6), 1087-1101.
  • Stevenson W, Hase Y, Wilson E, Hollins A, Hase M, Ennaceur A, Craggs L, Ihara M, Horsburgh K, Kalaria RN. Long-term effects of experimental carotid stenosis on hippocampal infarct pathology, neurons and glia and amelioration by environmental enrichment. Brain Research Bulletin 2020, 163, 72-83.
  • Panahi M, Rodriguez PR, Fereshtehnejad S-M, Arafa D, Bogdanovic N, Winblad B, Cedazo-Minguez A, Rinne J, Darreh-Shori T, Hase Y, Kalaria RN, Viitanen M, Behbahani H. Insulin-Independent and Dependent Glucose Transporters in Brain Mural Cells in CADASIL. Frontiers in Genetics 2020, 11, 1022.
  • Fowler JH, Kalaria RN. Connecting to motor recovery after stroke. Brain Communications 2020, 2(2), fcaa067.
  • Hase Y, Ding R, Harrison G, Hawthorne E, King A, Gettings S, Platten C, Stevenson W, Craggs LJL, Kalaria RN. White matter capillaries in vascular and neurodegenerative dementias. Acta Neuropathologica Communications 2019, 7(1), 16.
  • Takahashi Y, Saito S, Yamamoto Y, Uehara T, Yokota C, Sakai G, Nishida N, Takahashi R, Kalaria RN, Toyoda K, Nagatsuka K, Ihara M, Friedland R. Visually-rated medial temporal lobe atrophy with lower educational history as a quick indicator of amnestic cognitive impairment after stroke. Journal of Alzheimer's Disease 2019, 67(2), 621-629.
  • Akinyemi RO, Owolabi MO, Ihara M, Damasceno A, Ogunniyi A, Dotchin C, Paddick S-M, Ogeng'o J, Walker R, Kalaria RN. Stroke, cerebrovascular diseases and vascular cognitive impairment in Africa. Brain Research Bulletin 2019, 145, 97-108.
  • Lo JW, Crawford JD, Desmond DW, Godefroy O, Jokinen H, Mahinrad S, Bae H-J, Lim J-S, Kohler S, Douven E, Staals J, Chen C, Xu X, Chong EJ, Akinyemi RO, Kalaria RN, Ogunniyi A, Barbay M, Roussel M, Lee B-C, Srikanth VK, Moran C, Kandiah N, Chander RJ, Sabayan B, Jukema JW, Melkas S, Erkinjuntti T, Brodaty H, Bordet R, Bombois S, Henon H, Lipnicki DM, Kochan NA, Sachdev PS, for the Stroke and Cognition (STROKOG) Collaboration. Profile of and risk factors for poststroke cognitive impairment in diverse ethnoregional groups. Neurology 2019, 93(24), E2257-E2271.
  • Akinyemi R, Ojagbemi A, Akinyemi J, Salami A, Olopade F, Farombi T, Nweke M, Uvere E, Aridegbe M, Balogun J, Ogbole G, Jegede A, Kalaria R, Ogunniyi A, Owolabi M, Arulogun O. Gender differential in inclination to donate brain for research among Nigerians: the IBADAN Brain Bank Project. Cell and Tissue Banking 2019, 20, 297–306.
  • Graham C, Santiago-Mugica E, Abdel-All Z, Li M, McNally R, Kalaria RN, Mukaetova-Ladinska EB. Erythrocytes as Biomarkers for Dementia: Analysis of Protein Content and Alpha-Synuclein. Journal of Alzheimer's Disease 2019, 71(2), 569-580.
  • McDonald MW, Black SE, Copland DA, Corbett D, Dijkhuizen RM, Farr TD, Jeffers MS, Kalaria RN, Karayanidis F, Leff AP, Nithianantharajah J, Pendlebury S, Quinn TJ, Clarkson AN, O'Sullivan MJ. Cognition in Stroke Rehabilitation and Recovery Research: Consensus-Based Core Recommendations From the Second Stroke Recovery and Rehabilitation Roundtable. Neurorehabilitation and Neural Repair 2019, 33(11), 943-950.
  • McDonald MW, Black SE, Copland DA, Corbett D, Dijkhuizen RM, Farr TD, Jeffers MS, Kalaria RN, Karayanidis F, Leff AP, Nithianantharajah J, Pendlebury S, Quinn TJ, Clarkson AN, O'Sullivan MJ. Cognition in stroke rehabilitation and recovery research: Consensus-based core recommendations from the second Stroke Recovery and Rehabilitation Roundtable. International Journal of Stroke 2019, 14(8), 774-782.
  • Hase Y, Polvikoski TM, Ihara M, Hase M, Zafar R, Stevenson W, Allan LM, Ennaceur A, Horsburgh K, Gallart-Palau X, Sze SK, Kalaria RN. Carotid artery disease in post-stroke survivors and effects of enriched environment on stroke pathology in a mouse model of carotid artery stenosis. Neuropathology and Applied Neurobiology 2019, 45(7), 681-697.
  • Gallart-Palau X, Serra A, Hase Y, Tan CF, Chen CP, Kalaria RN, Sze SK. Brain-derived and circulating vesicle profiles indicate neurovascular unit dysfunction in early Alzheimer’s disease. Brain Pathology 2019, 29(5), 593-605.
  • Rajani RM, Ratelade J, Domenga-Denier V, Hase Y, Kalimo H, Kalaria RN, Joutel A. Blood brain barrier leakage is not a consistent feature of white matter lesions in CADASIL. Acta Neuropathologica Communications 2019, 7, 187.
  • Smith AR, Smith RG, Burrage J, Troakes C, Al-Sarraj S, Kalaria RN, Sloan C, Robinson AC, Mill J, Lunnon K. A cross-brain regions study of ANK1 DNA methylation in different neurodegenerative diseases. Neurobiology of Aging 2019, 74, 70-76.
  • Hase Y, Craggs L, Hase M, Stevenson W, Slade J, Chen A, Liang D, Ennaceur A, Oakley A, Ihara M, Horsburgh K, Kalaria RN. The effects of environmental enrichment on white matter pathology in a mouse model of chronic cerebral hypoperfusion. Journal of Cerebral Blood Flow and Metabolism 2018, 38(1), 151-165.
  • Horsburgh K, Wardlaw JM, van Agtmael T, Allan SM, Ashford MLJ, Bath PM, Brown R, Berwick J, Cader MZ, Carare RO, Davis JB, Duncombe J, Farr TD, Fowler JH, Goense J, Granata A, Hall CN, Hainsworth AH, Harvey A, Hawkes CA, Joutel A, Kalaria RN, Kehoe PG, Lawrence CB, Lockhart A, Love S, Macleod MR, Macrae IM, Markus HS, McCabe C, McColl BW, Meakin PJ, Miller A, Nedergaard M, O'Sullivan M, Quinn TJ, Rajani R, Saksida LM, Smith C, Smith KJ, Touyz RM, Trueman RC, Wang T, Williams A, Williams SCR, Work LM. Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology. Clinical Science 2018, 132(8), 851-868.
  • Hase Y, Chen A, Bates LL, Craggs LJL, Yamamoto Y, Gemmell E, Oakley AE, Korolchuk VI, Kalaria RN. Severe white matter astrocytopathy in CADASIL. Brain Pathology 2018, 28(6), 832-843.
  • Skrobot OA, Black SE, Chen C, DeCarli C, Erkinjuntti T, Ford GA, Kalaria RN, O'Brien J, Pantoni L, Pasquier F, Roman GC, Wallin A, Sachdev P, Skoog I, VICCCS group, Ben-Shlomo Y, Passmore AP, Love S, Kehoe PG. Progress toward standardized diagnosis of vascular cognitive impairment: Guidelines from the Vascular Impairment of Cognition Classification Consensus Study. Alzheimer's and Dementia 2018, 14(3), 280-292.
  • Uemura MT, Ihara M, Maki T, Nakagomi T, Kaji S, Uemura K, Matsuyama T, Kalaria RN, Kinoshita A, Takahashi R. Pericyte-derived bone morphogenetic protein 4 underlies white matter damage after chronic hypoperfusion. Brain Pathology 2018, 28(4), 521-535.
  • Nakaoku Y, Oishi N, Hase Y, Hase M, Saito S, Mitsueda T, Matsui M, Toyoda K, Nagatsuka K, Kalaria RN, Fukuyama H, Ihara M, Takahashi R. Montreal Cognitive Assessment score correlates with regional cerebral blood flow in post-stroke patients. Clinical Neurology and Neurosurgery 2018, 174, 68-74.
  • Skrobot OA, O'Brien J, Black S, Chen C, DeCarli C, Erkinjuntti T, Ford GA, Kalaria RN, Pantoni L, Pasquier F, Roman GC, Wallin A, Sachdev P, Skoog I, Ben-Shlomo Y, Passmore AP, Love S, Kehoe PG. The Vascular Impairment of Cognition Classification Consensus Study. Alzheimer's and Dementia 2017, 13(6), 624-633.
  • Manousopoulou A, Gatherer M, Smith C, Nicoll JAR, Woelk CH, Johnson M, Kalaria R, Attems J, Garbis SD, Carare RO. Systems proteomic analysis reveals that clusterin and tissue inhibitor of metalloproteinases 3 increase in leptomeningeal arteries affected by cerebral amyloid angiopathy. Neuropathology and Applied Neurobiology 2017, 43(6), 492-504.
  • Sachdev PS, Lo JW, Crawford JD, Mellon L, Hickey A, Williams D, Bordet R, Mendyk A-M, Gele P, Deplanque D, Bae H-J, Lim J-S, Brodtmann A, Werden E, Cumming T, Kohler S, Verhey FRJ, Dong Y-H, Tan HH, Chen C, Xin X, Kalaria RN, Allan LM, Akinyemi RO, Ogunniyi A, Klimkowicz-Mrowiec A, Dichgans M, Wollenweber FA, Zietemann V, Hoffmann M, Desmond DW, Linden T, Blomstrand C, Fagerberg B, Skoog I, Godefroy O, Barbay M, Roussel M, Lee B-C, Yu K-H, Wardlaw J, Makin SJ, Doubal FN, Chappell FM, Srikanth VK, Thrift AG, Donnan GA, Kandiah N, Chander RJ, Lin X, Cordonnier C, Moulin S, Rossi C, Sabayan B, Stott DJ, Jukema JW, Melkas S, Jokinen H, Erkinjuntti T, Mok VCT, Wong A, Lam BYK, Leys D, Henon H, Bombois S, Lipnicki DM, Kochan NA, Sachdev PS, Lo JW, Crawford JD, Lipnicki DM, Kochan NA, Mellon L, Hickey A, Williams D, Bordet R, Mendyk A-M, Gele P, Deplanque D, Bae H-J, Lim J-S, Brodtmann A, Werden E, Cumming T, Kohler S, Verhey FRJ, Dong Y-H, Xu J, Chen C, Kalaria RN, Allan LM, Akinyemi R, Ogunniyi A, Kalariai RN, Klimkowicz-Mrowiec A, Dichgans M, Wollenweber FA, Zietemann V, Hoffmann M, Desmond DW, Linden T, Blomstrand C, Fagerberg B, Skoog I, Godefroy O, Barbay M, Roussel M, Lee B-C, Yu K-H, Lim J-S, Wardlaw J, Makin SJ, Doubal FN, Chappell FM, Srikanth VK, Thrift AG, Donnan GA, Kandiah N, Chander RJ, Lin X, Cordonnier C, Moulin S, Rossi C, Sabayan B, Stott DJ, Jukema JW, Melkas S, Jokinen H, Erkinjuntti T, Mok VCT, Wong A, Lam BYK, Leys D, Henon H, Bombois S, Sachdev P. STROKOG (stroke and cognition consortium): An international consortium to examine the epidemiology, diagnosis, and treatment of neurocognitive disorders in relation to cerebrovascular disease. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring 2017, 7, 11-23.
  • Akinyemi RO, Allan LM, Oakley A, Kalaria RN. Hippocampal neurodegenerative pathology in post-stroke dementia compared to other dementias and aging controls. Frontiers in Neuroscience 2017, 11, 717.
  • Hase Y, Craggs L, Hase M, Stevenson W, Slade J, Lopez D, Mehta R, Chen A, Liang D, Oakley A, Ihara M, Horsburgh K, Kalaria RN. Effects of environmental enrichment on white matter glial responses in a mouse model of chronic cerebral hypoperfusion. Journal of Neuroinflammation 2017, 14(1), 81.
  • Skrobot OA, Attems J, Esiri M, Hortobágyi, T, Ironside JW, Kalaria RN, King A, Lammie GA, Mann D, Neal J, Ben-Shlomo Y, Kehoe PG, Love S. Vascular cognitive impairment neuropathology guidelines (VCING): the contribution of cerebrovascular pathology to cognitive impairment. Brain 2016, 139(11), 2957-2969.
  • Khan A, Kalaria RN, Corbett A, Ballard C. Update on Vascular Dementia. Journal of Geriatric Psychiatry and Neurology 2016, 29(5), 281-301.
  • Kalaria RN, Akinyemi R, Ihara M. Stroke injury, cognitive impairment and vascular dementia. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2016, 1862(5), 915-925.
  • McAleese KE, Alafuzoff I, Charidimou A, De Reuck J, Grinberg LT, Hainsworth AH, Hortobagyi T, Ince P, Jellinger K, Gao J, Kalaria RN, Kovacs GG, Kovari E, Love S, Popovic M, Skrobot O, Taipa R, Thal DR, Werring D, Wharton SB, Attems J. Post-mortem assessment in vascular dementia: advances and aspirations. BMC Medicine 2016, 14, 129.
  • Akinyemi RO, Owolabi MO, Oyeniyi T, Ovbiagele B, Arnett DK, Tiwari HK, Walker RW, Ogunniyi A, Kalaria RN, SIREN group of H3Africa Consortium. Neurogenomics in Africa: Perspectives, progress, possibilities and priorities. Journal of the Neurological Sciences 2016, 366, 213-223.
  • Lee JH, Francis PT, Ballard CG, Aarsland D, Kalaria RN, Wong PTH, Chen CP, Lai MKP. Muscarinic M1 Receptor Coupling to G-protein is Intact in Parkinson's Disease Dementia. Journal of Parkinsons Disease 2016, 6(4), 733-739.
  • Chen AQ, Oakley AE, Monteiro M, Tuomela K, Allan LM, Mukaetova-Ladinska EB, O'Brien JT, Kalaria RN. Multiplex analyte assays to characterize different dementias: brain inflammatory cytokines in poststroke and other dementias. Neurobiology of Aging 2016, 38, 56-67.
  • Dichgans M, Wardlaw J, Smith E, Zietemann V, Seshadri S, Sachdev P, Biessels GJ, Fazekas F, Benavente O, Pantoni L, De Leeuw F, Norrving B, Matthews P, Chen C, Mok V, During M, Whiteley W, Shuler K, Alonso A, Black SE, Brayne C, Chabriat H, Cordonnier C, Doubal F, Duzel E, Ewers M, Frayne R, Hachinski V, Ikram MA, Jessen F, Jouvent E, Linn J, O'Brien J, van Oostenbrugge R, Malik R, Mazoyer B, Schmidt R, Sposato LA, Stephan B, Swartz RH, Vernooij M, Viswanathan A, Werring D, Abe K, Allan L, Arba F, Bae HJ, Bath PMW, Bordet R, Breteler M, Choi S, Deary I, DeCarli C, Ebmeier K, Feng L, Greenberg SM, Ihara M, Kalaria R, Kim S, Lim JS, Lindley RI, Mead G, Murray A, Quinn T, Ritchie C, Sacco R, Salman RA, Sprigg N, Sudlow C, Thomas A, van Boxtel M, van der Grond J, van der Lugt A, Yang YH, VISTA Collaboration, METACOHORTS Consortiums. METACOHORTS for the study of vascular disease and its contribution to cognitive decline and neurodegeneration: An initiative of the Joint Programme for Neurodegenerative Disease Research. Alzheimer's & Dementia 2016, 12(12), 1235-1249.
  • Kitamura A, Saito S, Maki T, Oishi N, Ayaki T, Hattori Y, Yamamoto Y, Urushitani M, Kalaria RN, Fukuyama H, Horsburgh K, Takahashi R, Ihara M. Gradual cerebral hypoperfusion in spontaneously hypertensive rats induces slowly evolving white matter abnormalities and impairs working memory. Journal of Cerebral Blood Flow and Metabolism 2016, 36(9), 1592-1602.
  • Hattori Y, Enmi J, Iguchi S, Saito S, Yamamoto Y, Tsuji M, Nagatsuka K, Kalaria RN, Iida H, Ihara M. Gradual Carotid Artery Stenosis in Mice Closely Replicates Hypoperfusive Vascular Dementia in Humans. Journal of the American Heart Association 2016, 5(2).
  • Gallart-Palau X, Lee BST, Adav SS, Qian J, Serra A, Park JE, Lai MKP, Chen CP, Kalaria RN, Sze SK. Gender differences in white matter pathology and mitochondrial dysfunction in Alzheimer's disease with cerebrovascular disease. Molecular Brain 2016, 9(1), 27.
  • Chen A, Akinyemi RO, Hase Y, Firbank MJ, Ndung'u MN, Foster V, Craggs LJL, Washida K, Okamoto Y, Thomas AJ, Polvikoski TM, Allan LM, Oakley AE, O'Brien JT, Horsburgh K, Ihara M, Kalaria RN. Frontal white matter hyperintensities, clasmatodendrosis and gliovascular abnormalities in ageing and post-stroke dementia. Brain 2016, 139(1), 242-258.
  • Keable A, Fenna K, Yuen HM, Johnston DA, Smyth NR, Smith C, Salman RAS, Samarasekera N, Nicoll JAR, Attems J, Kalaria RN, Weller RO, Carare RO. Deposition of amyloid β in the walls of human leptomeningeal arteries in relation to perivascular drainage pathways in cerebral amyloid angiopathy. Biochimica et Biophysica Acta - Molecular Basis of Disease 2016, 1862(5), 1037-1046.
  • Craggs L, Taylor J, Slade JY, Chen A, Hagel C, Kuhlenbaeumer G, Borjesson-Hanson A, Viitanen M, Kalimo H, Deramecourt V, Oakley AE, Kalaria RN. Clusterin/Apolipoprotein J immunoreactivity is associated with white matter damage in cerebral small vessel diseases. Neuropathology and Applied Neurobiology 2016, 42(2), 194-209.
  • Skrobot OA, McKnight AJ, Passmore PA, Seripa D, Mecocci P, Panza F, Kalaria R, Wilcock G, Munafo M, Erkinjuntti T, Karhunen P, Pessi T, Martiskainen M, Love S, Kehoe PG, Genetic Environm Risk Alzheimer's. A Validation Study of Vascular Cognitive Impairment Genetics Meta-Analysis Findings in an Independent Collaborative Cohort. Journal of Alzheimer's Disease 2016, 53(3), 981-989.

• Book Chapter

  • Kalaria RN, Hase Y. Neurovascular Ageing and Age-Related Diseases. In: J. Robin Harris and Viktor I. Korolchuk, ed. Biochemistry and Cell Biology of Ageing: Part II Clinical Science. Singapore: Springer, 2019, pp.477-499.

• Editorials

  • Kalaria RN, Markus H, O'Brien J. VasCog 2021 virtual report and abstracts. Cerebral Circulation - Cognition and Behavior 2024, 6, 100149.
  • Wallin A, Alladi S, Black SE, Chen C, Greenberg SM, Gustafson D, Isaacs JD, Jokinen H, Kalaria R, Mok V, Pantoni L, Pasquier F, Roman GC, Rosenberg GA, Schmidt R, Smith EE, Hainsworth AH. What does aducanumab treatment of Alzheimer's disease mean for research on vascular cognitive disorders?. Cerebral Circulation - Cognition and Behavior 2022, 3, 100044.
  • Carare RO, Kalaria R. Cerebrovascular pathology: the dark side of neurodegeneration. Acta Neuropathologica 2016, 131(5), 641-643.

• Letters

  • Akinyemi RO, Owolabi MO, Okubadejo N, Ogunniyi A, Kalaria RN. The African Dementia Consortium. The Lancet Neurology 2023, 22(1), 28-29.
  • Skrobot OA, Attems J, Esiri M, Hortobagyi T, Ironside JW, Kalaria RN, King A, Lammie GA, Mann D, Neal J, Ben-Shlomo Y, Kehoe PG, Love S. Reply: Atherosclerosis and vascular cognitive impairment neuropathological guideline. Brain 2017, 140(2), e13-e13.

• Notes

  • Maestre G, Carrillo M, Kalaria R, Acosta D, Adams L, Adoukonou T, Akinwande K, Akinyemi J, Akinyemi R, Akpa O, Alladi S, Allegri R, Arizaga R, Arshad F, Arulogun O, Babalola D, Baiyewu O, Bak T, Bellaj T, Boshe J, Brayne C, Brodie-Mends D, Brown R, Cahn J, Cyrille N, Damasceno A, de Silva R, de Silva R, Djibuti M, Dreyer AJ, Ellajosyula R, Farombi T, Fongang B, Forner S, Friedland R, Garza N, Gbessemehlan A, Georgiou E, Gouider R, Govia I, Grinberg L, Guerchet M, Gugssa S, Gumikiriza-Onoria JL, Gustafson D, Hogervorst E, Hornberger M, Ibanez A, Ihara M, Ismail O, Issac T, Jonsson L, Kaputu C, Karanja W, Karungi J, Tshala-Katumbay D, Kunkle B, Lee JH, Leroi I, Lewis R, Livingston G, Lopera F, Lwere K, Manes F, Mbakile-Mahlanza L, Mena P, Miller B, Millogo A, Mohamed A, Musyimi C, Mutiso V, Nakasujja N, Ndetei D, Nightingale S, Njamnshi AK, Novotni G, Nyamayaro P, Nyame S, Ogeng'o J, Ogunniyi A, Okada De Oliveira M, Okubadejo N, Orrell M, Orunmuyi A, Owolabi M, Paddick S, A Pericak-Vance M, Pirtosek Z, Potocnik F, Preston B, Raman R, Ranchod K, Rizig M, Rosselli M, Deepa R, Roy U, Salokhiddinov M, Sano M, Sarfo F, Satizabal CL, Sepulveda-Falla D, Seshadri S, Sexton C, Skoog I, St George-Hyslop P, Suemoto C, Tanner J, Thapa P, Toure K, Ucheagwu V, Udeh-Momoh C, Valcour V, Vance J, Varghese M, Vera J, Walker R, Weidner W, Sebastian W, Whitehead Gay P, Zetterberg H, Zewde Y. The Nairobi Declaration—Reducing the burden of dementia in low- and middle-income countries (LMICs): Declaration of the 2022 Symposium on Dementia and Brain Aging in LMICs. Alzheimer's and Dementia 2023, 19(3), 1105-1108.
  • de Rojas I, Moreno-Grau S, Tesi N, Grenier-Boley B, Andrade V, Jansen IE, Pedersen NL, Stringa N, Zettergren A, Hernandez I, Montrreal L, Antunez C, Antonell A, Tankard RM, Bis JC, Sims R, Bellenguez C, Quintela I, Gonzalez-Perez A, Calero M, Franco-Macias E, Macias J, Blesa R, Cervera-Carles L, Menendez-Gonzalez M, Frank-Garcia A, Royo JL, Moreno F, Huerto Vilas R, Baquero M, Diez-Fairen M, Lage C, Garcia-Madrona S, Garcia-Gonzalez P, Alarcon-Martin E, Valero S, Sotolongo-Grau O, Ullgren A, Naj AC, Lemstra AW, Benaque A, Perez-Cordon A, Benussi A, Rabano A, Padovani A, Squassina A, de Mendonca A, Arias Pastor A, Kok AAL, Meggy A, Pastor AB, Espinosa A, Corma-Gomez A, Martin Montes A, Sanabria A, DeStefano AL, Schneider A, Haapasalo A, Kinhult Stahlbom A, Tybjaerg-Hansen A, Hartmann AM, Spottke A, Corbaton-Anchuelo A, Rongve A, Borroni B, Arosio B, Nacmias B, Nordestgaard BG, Kunkle BW, Charbonnier C, Abdelnour C, Masullo C, Martinez Rodriguez C, Munoz-Fernandez C, Dufouil C, Graff C, Ferreira CB, Chillotti C, Reynolds CA, Fenoglio C, Van Broeckhoven C, Clark C, Pisanu C, Satizabal CL, Holmes C, Buiza-Rueda D, Aarsland D, Rujescu D, Alcolea D, Galimberti D, Wallon D, Seripa D, Grunblatt E, Dardiotis E, Duzel E, Scarpini E, Conti E, Rubino E, Gelpi E, Rodriguez-Rodriguez E, Duron E, Boerwinkle E, Ferri E, Tagliavini F, Kucukali F, Pasquier F, Sanchez-Garcia F, Mangialasche F, Jessen F, Nicolas G, Selbaek G, Ortega G, Chene G, Hadjigeorgiou G, Rossi G, Spalletta G, Giaccone G, Grande G, Binetti G, Papenberg G, Hampel H, Bailly H, Zetterberg H, Soininen H, Karlsson IK, Alvarez I, Appollonio I, Giegling I, Skoog I, Saltvedt I, Rainero I, Rosas Allende I, Hort J, Diehl-Schmid J, Van Dongen J, Vidal J-S, Lehtisalo J, Wiltfang J, Thomassen JQ, Kornhuber J, Haines JL, Vogelgsang J, Pineda JA, Fortea J, Popp J, Deckert J, Buerger K, Morgan K, Fliessbach K, Sleegers K, Molina-Porcel L, Kilander L, Weinhold L, Farrer LA, Wang L-S, Kleineidam L, Farotti L, Parnetti L, Tremolizzo L, Hausner L, Benussi L, Froelich L, Ikram MA, Deniz-Naranjo MC, Tsolaki M, Rosende-Roca M, Lowenmark M, Hulsman M, Spallazzi M, Pericak-Vance MA, Esiri M, Bernal Sanchez-Arjona M, Dalmasso MC, Martinez-Larrad MT, Arcaro M, Nothen MM, Fernandez-Fuertes M, Dichgans M, Ingelsson M, Herrmann MJ, Scherer M, Vyhnalek M, Kosmidis MH, Yannakoulia M, Schmid M, Ewers M, Heneka MT, Wagner M, Scamosci M, Kivipelto M, Hiltunen M, Zulaica M, Alegret M, Fornage M, Roberto N, van Schoor NM, Seidu NM, Banaj N, Armstrong NJ, Scarmeas N, Scherbaum N, Goldhardt O, Hanon O, Peters O, Skrobot OA, Quenez O, Lerch O, Bossu P, Caffarra P, Dionigi Rossi P, Sakka P, Mecocci P, Hoffmann P, Holmans PA, Fischer P, Riederer P, Yang Q, Marshall R, Kalaria RN, Mayeux R, Vandenberghe R, Cecchetti R, Ghidoni R, Frikke-Schmidt R, Sorbi S, Hagg S, Engelborghs S, Helisalmi S, Botne Sando S, Kern S, Archetti S, Boschi S, Fostinelli S, Gil S, Mendoza S, Mead S, Ciccone S, Djurovic S, Heilmann-Heimbach S, Riedel-Heller S, Kuulasmaa T, Del Ser T, Lebouvier T, Polak T, Ngandu T, Grimmer T, Bessi V, Escott-Price V, Giedraitis V, Deramecourt V, Maier W, Jian X, Pijnenburg YAL, Kehoe PG, Garcia-Ribas G, Sanchez-Juan P, Pastor P, Perez-Tur J, Pinol-Ripoll G, Lopez de Munain A, Garcia-Alberca JM, Bullido MJ, Alvarez V, Lleo A, Real LM, Mir P, Medina M, Scheltens P, Holstege H, Marquie M, Saez ME, Carracedo A, Amouyel P, Schellenberg GD, Williams J, Seshadri S, van Duijn CM, Mather KA, Sanchez-Valle R, Serrano-Rios M, Orellana A, Tarraga L, Blennow K, Huisman M, Andreassen OA, Posthuma D, Clarimon J, Boada M, van der Flier WM, Ramirez A, Lambert J-C, van der Lee SJ, Ruiz A. Erratum: Author Correction: Common variants in Alzheimer's disease and risk stratification by polygenic risk scores (Nature communications (2021) 12 1 (3417)). Nature Communications 2023, 14(1), 716.
  • Mok VCT, Pendlebury S, Wong A, Alladi S, Au L, Bath PM, Biessels GJ, Chen C, Cordonnier C, Dichgans M, Dominguez J, Gorelick PB, Kim S, Kwok T, Greenberg SM, Jia J, Kalaria R, Kivipelto M, Naegandran K, Lam LCW, Lam BYK, Lee ATC, Markus HS, O'Brien J, Pai M-C, Pantoni L, Sachdev P, Senanarong V, Skoog I, Smith EE, Srikanth V, Suh G-H, Wardlaw J, Ko H, Black SE, Scheltens P. Erratum to: Tackling challenges in care of Alzheimer's disease and other dementias amid the COVID-19 pandemic, now and in the future (Alzheimer's & Dementia, (2020), 16, 11, (1571-1581), 10.1002/alz.12143). Alzheimer's and Dementia 2021, 17(5), 906-907.
  • Sweeney MD, Montagne A, Sagare AP, Nation DA, Schneider LS, Chui HC, Harrington MG, Pa J, Law M, Wang DJJ, Jacobs RE, Doubal FN, Ramirez J, Black SE, Nedergaard M, Benveniste H, Dichgans M, Iadecola C, Love S, Bath PM, Markus HS, Salman RA, Allan SM, Quinn TJ, Kalaria RN, Werring DJ, Carare RO, Touyz RM, Williams SCR, Moskowitz MA, Katusic ZS, Lutz SE, Lazarov O, Minshall RD, Rehman J, Davis TP, Wellington CL, Gonzalez HM, Yuan C, Lockhart SN, Hughes TM, Chen CLH, Sachdev P, O'Brien JT, Skoog I, Pantoni L, Gustafson DR, Biessels GJ, Wallin A, Smith EE, Mok V, Wong A, Passmore P, Barkof F, Muller M, Breteler MMB, Roman GC, Hamel E, Seshadri S, Gottesman RF, van Buchem MA, Arvanitakis Z, Schneider JA, Drewes LR, Hachinski V, Finch CE, Toga AW, Wardlaw JM, Zlokovic BV. Vascular dysfunction—The disregarded partner of Alzheimer's disease. Alzheimer's and Dementia 2019, 15(1), 158-167.

• Reviews

  • Kalaria R, Maestre G, Mahinrad S, Acosta DM, Akinyemi RO, Alladi S, Allegri RF, Arshad F, Babalola DO, Baiyewu O, Bak TH, Bellaj T, Brodie-Mends DK, Carrillo MC, Celestin K-K-M, Damasceno A, de Silva RK, de Silva R, Djibuti M, Dreyer AJ, Ellajosyula R, Farombi TH, Friedland RP, Garza N, Gbessemehlan A, Georgiou EE-Z, Govia I, Grinberg LT, Guerchet M, Gugssa SA, Gumikiriza-Onoria JL, Hogervorst E, Hornberger M, Ibanez A, Ihara M, Issac TG, Jonsson L, Karanja WM, Lee JH, Leroi I, Livingston G, Manes FF, Mbakile-Mahlanza L, Miller BL, Musyimi CW, Mutiso VN, Nakasujja N, Ndetei DM, Nightingale S, Novotni G, Nyamayaro P, Nyame S, Ogeng'o JA, Ogunniyi A, de Oliveira MO, Okubadejo NU, Orrell M, Paddick S-M, Pericak-Vance MA, Pirtosek Z, Potocnik FCV, Raman R, Rizig M, Rosselli M, Salokhiddinov M, Satizabal CL, Sepulveda-Falla D, Seshadri S, Sexton CE, Skoog I, George-Hyslop PHS, Suemoto CK, Thapa P, Udeh-Momoh CT, Valcour V, Vance JM, Varghese M, Vera JH, Walker RW, Zetterberg H, Zewde YZ, Ismail O. The 2022 symposium on dementia and brain aging in low- and middle-income countries: Highlights on research, diagnosis, care, and impact. Alzheimer's and Dementia 2024, 20(6), 4290-4314.
  • Kalaria RN, Akinyemi RO, Paddick S-M, Ihara M. Current perspectives on prevention of vascular cognitive impairment and promotion of vascular brain health. Expert Review of Neurotherapeutics 2024, 24(1), 25-44.
  • Lam BYK, Cai Y, Akinyemi R, Biessels GJ, van den Brink H, Chen C, Cheung CW, Chow KN, Chung HKH, Duering M, Fu ST, Gustafson D, Hilal S, Hui VMH, Kalaria R, Kim S, Lam MLM, de Leeuw FE, Li ASM, Markus HS, Marseglia A, Zheng H, O'Brien J, Pantoni L, Sachdev PS, Smith EE, Wardlaw J, Mok VCT. The global burden of cerebral small vessel disease in low- and middle-income countries: A systematic review and meta-analysis. International Journal of Stroke 2023, 18(1), 15-27.
  • Yassine HN, Self W, Kerman BE, Santoni G, Navalpur Shanmugam N, Abdullah L, Golden LR, Fonteh AN, Harrington MG, Graff J, Gibson GE, Kalaria R, Luchsinger JA, Feldman HH, Swerdlow RH, Johnson LA, Albensi BC, Zlokovic BV, Tanzi R, Cunnane S, Samieri C, Scarmeas N, Bowman GL. Nutritional metabolism and cerebral bioenergetics in Alzheimer's disease and related dementias. Alzheimer's and Dementia 2023, 19(3), 1041-1066.
  • Adewale BA, Coker MM, Ogunniyi A, Kalaria RN, Akinyemi RO. Biomarkers and Risk Assessment of Alzheimer's Disease in Low- and Middle-Income Countries. Journal of Alzheimer's Disease 2023, 95(4), 1339-1349.
  • Fang C, Magaki SD, Kim RC, Kalaria RN, Vinters HV, Fisher M. Arteriolar neuropathology in cerebral microvascular disease. Neuropathology and Applied Neurobiology 2023, 49(1), e12875.
  • Ballerini C, Njamnshi AK, Juliano SL, Kalaria RN, Furlan R, Akinyemi RO. Non-Communicable Neurological Disorders and Neuroinflammation. Frontiers in Immunology 2022, 13, 834424.
  • Akinyemi RO, Yaria J, Ojagbemi A, Guerchet M, Okubadejo N, Njamnshi AK, Sarfo FS, Akpalu A, Ogbole G, Ayantayo T, Adokonou T, Paddick S-M, Ndetei D, Bosche J, Ayele B, Damas A, Coker M, Mbakile-Mahlanza L, Ranchod K, Bobrow K, Anazodo U, Damasceno A, Seshadri S, Pericak-Vance M, Lawlor B, Miller BL, Owolabi M, Baiyewu O, Walker R, Gureje O, Kalaria RN, Ogunniyi A. Dementia in Africa: Current evidence, knowledge gaps, and future directions. Alzheimer's and Dementia 2022, 18(4), 790-809.
  • Santiago-Mujika E, Luthi-Carter R, Giorgini F, Kalaria RN, Mukaetova-Ladinska EB. Tubulin and Tubulin Posttranslational Modifications in Alzheimer’s Disease and Vascular Dementia. Frontiers in Aging Neuroscience 2021, 13, 730107.
  • Ruchoux M-M, Kalaria RN, Roman GC. The pericyte: A critical cell in the pathogenesis of CADASIL. Cerebral Circulation - Cognition and Behavior 2021, 2, 100031.
  • Akinyemi RO, Ovbiagele B, Adeniji OA, Sarfo FS, Abd-Allah F, Adoukonou T, Ogah OS, Naidoo P, Damasceno A, Walker RW, Ogunniyi A, Kalaria RN, Owolabi MO. Stroke in Africa: profile, progress, prospects and priorities. Nature Reviews Neurology 2021, 17(10), 634-656.
  • Kalaria RN, Sepulveda-Falla D. Cerebral Small Vessel Disease in Sporadic and Familial Alzheimer Disease. American Journal of Pathology 2021, 191(11), 1888-1905.
  • Blevins BL, Vinters HV, Love S, Wilcock DM, Grinberg LT, Schneider JA, Kalaria RN, Katsumata Y, Gold BT, Wang DJJ, Ma SJ, Shade LMP, Fardo DW, Hartz AMS, Jicha GA, Nelson KB, Magaki SD, Schmitt FA, Teylan MA, Ighodaro ET, Phe P, Abner EL, Cykowski MD, Van Eldik LJ, Nelson PT. Brain arteriolosclerosis. Acta Neuropathologica 2021, 141(1), 1-24.
  • Manzanza NDO, Sedlackova L, Kalaria RN. Alpha-Synuclein Post-translational Modifications: Implications for Pathogenesis of Lewy Body Disorders. Frontiers in Aging Neuroscience 2021, 13, 690293.
  • Mok VCT, Pendlebury S, Wong A, Alladi S, Au L, Bath PM, Biessels GJ, Chen C, Cordonnier C, Dichgans M, Dominguez J, Gorelick PB, Kim S, Kwok T, Greenberg SM, Jia J, Kalaria R, Kivipelto M, Naegandran K, Lam LCW, Lam BYK, Lee ATC, Markus HS, O'Brien J, Pai M-C, Pantoni L, Sachdev P, Skoog I, Smith EE, Srikanth V, Suh G-H, Wardlaw J, Ko H, Black SE, Scheltens P. Tackling challenges in care of Alzheimer's disease and other dementias amid the COVID-19 pandemic, now and in the future. Alzheimer's and Dementia 2020, 16(11), 1571-1581.
  • Kalaria RN, Hase Y, Ihara M. The rise and rise of cerebral small vessel disease: Implications for vascular cognitive impairment and dementia. Future Neurology 2019, 14(2), 1-4.
  • Gallart-Palau X, Tan LM, Serra A, Gao Y, Ho HH, Richards AM, Kandiah N, Chen CP, Kalaria RN, Sze SK. Degenerative protein modifications in the aging vasculature and central nervous system: A problem shared is not always halved. Ageing Research Reviews 2019, 53, 100909.
  • Akinyemi RO, Salami A, Akinyemi J, Ojagbemi A, Olopade F, Coker M, Farombi T, Nweke M, Arulogun O, Jegede A, Owolabi M, Kalaria RN, Ogunniyi A. Brain banking in low and middle-income countries: Raison D'être for the Ibadan Brain Ageing, Dementia And Neurodegeneration (IBADAN) Brain Bank Project. Brain Research Bulletin 2019, 145, 136-141.
  • Hase Y, Horsburgh K, Ihara I, Kalaria RN. White matter degeneration in vascular and other ageing-related dementias. Journal of Neurochemistry 2018, 144(5), 617-633.
  • Hainsworth AH, Allan SM, Boltze J, Cunningham C, Farris C, Head E, Ihara M, Isaacs JD, Kalaria RN, Lesnik Oberstein SAMJ, Moss MB, Nitzsche B, Rosenberg GA, Rutten JW, Salkovic-Petrisic M, Troen AM. Translational models for vascular cognitive impairment: A review including larger species. BMC Medicine 2017, 15(1), 16.
  • Duncombe J, Kitamura A, Hase Y, Ihara M, Kalaria RN, Horsburgh K. Chronic cerebral hypoperfusion: a key mechanism leading to vascular cognitive impairment and dementia. Closing the translational gap between rodent models and human vascular cognitive impairment and dementia. Clinical Science 2017, 131(19), 2451-2468.
  • Kalaria JN. Neuropathological diagnosis of vascular cognitive impairment and vascular dementia with implications for Alzheimer’s disease. Acta Neuropathologica 2016, 131(5), 659-685.