Staff Profile

Roles and Responsibilities

Professor of Cerebrovascular Pathology (Neuropathology), personal chair appointed 1997

Lead PI, Newcastle Cognitive Function After Stroke (CogFAST) Longitudinal Study, MRC funded 2000-2010 

Director, Neurovascular Research Group (NRG), Institute of Neuroscience

Past Co-ordinator, Newcastle NE ARUK Network Centre,  Alzheimer's Research UK (ARUK)

Secretary-General, International Society for Vascular Behavioural and Cognitive Disorders (VasCog)

Previous Positions

Associate Professor of Neurology, Neurosciences and Pathology, Case Western Reserve University, Cleveland, OH 44106, USA

Memberships

Royal College of Pathologists (Fellow), Society of Biology (Fellow), International Society for Vascular Behavioural and Cognitive Disorders (Secretary-General), British Neuroscience Association (past Hon Sec), International Brain Research Organisation (past member of Executive Committee)

Honours and Awards

Gold medal from President Diouf of Senegal, appointed Officier L’Ordre National du Lion for services to promote research and teaching of neurosciences in Africa

Fellow of the Royal Society of Biology

Research Interests

Cerebrovascular diseases, Vascular Dementia, Alzheimer's disease, Post-Stroke Dementia

Current Work

Neuropathology of Cerebrovascular Disease; CADASIL and Small Vessel Diseases of the Brain

Esteem Indicators

Member, Centres of Excellence (CoE), Academy of Finland, Review panel, 2009-2012.

Member, Canadian Excellence Research Chairs (CERC) Review panel, Social Sciences and Humanities Research Council of Canada, 2008-2011.

Member, Scientific Advisory Board, Alzheimer's Research UK, 2000-2010, (2011, also Fellowships)

Member (and chair) Scientific Review panel, Fogarty NIH Brain Disorders Across the Life Span, 2003- 2011.

Member, MRC Clinical Pharmacology and Pathology Fellowships Board, 2009-2010.

Chair, Steering Group, MRC Brain Banks (Sudden death, HIV and CJD), Edinburgh, UK, 2007-2010.

Funding

Medical Research Council UK (MRC), Dunhill Medical Trust (UK), Alzheimer's Research UK (ARUK)

Neurovascular Research Group (NRG)

Interests: Increasing age is the strongest risk factor for cognitive dysfunction, which may result from primary cerebrovascular or neurodegenerative mechanisms, such as those involved in vascular dementia or Alzheimer’s disease (AD), or both. Like neurodegenerative disease, cerebrovascular disease (CVD) leads to high morbidity and mortality and is the second most common cause of dementia. Over the past 17 years, Prof Kalaria and his team in Newcastle have collected abundant evidence from epidemiological, genetic, clinical-pathological and animal studies to demonstrate the impact of systemic vascular and cerebrovascular diseases on cerebral neural processes and cognitive function. 

We have also contributed to diagnostic criteria guidelines for vascular dementia and vascular cognitive disorders (DSM V). The NRG has also built a reputation for students to publish at 2-3 peer-reviewed papers prior to completion of their doctoral studies. 

Potential Project(s) for students:

In collaboration with colleagues in Edinburgh and Japan (Kyoto and Osaka), the NRG has worked to share their expertise in human ageing, dementias and animal models (mice) of disease to probe mechanistic insights into the effects of altered brain perfusion and downstream consequences. Through these efforts, we have developed rigorous models in order to demonstrate how CVD causes nerve cell degeneration and affect dementia. 

The student will test the hypothesis that reduced brain perfusion in genetically altered mice, bred for their suitability to track specific modifications, leads to microvascular changes and subsequent damage to nerve cells, synapses and communication tracts between brain regions, which manifests as white matter disease. He/She will explore how reduced local cerebral blood flow (CBF) leads to neurodegeneration and culminates in cognitive impairment and dementia. Synaptic and dendritic structures are particularly vulnerable targets of ischaemic or hypoperfusive (oligaemic) insults, and likely contribute to cognitive impairment.

The student will also explore how improved perfusion through readily implemented interventions (physical exercise or active lifestyle) protects cortical (and strategic subcortical) structures from degeneration of their neuronal, synaptic, and microvascular network. This research will have impact on the global burden of dementia; identifying strategies, which will enable to reduce common dementing illnesses of old age.

The project is ideally suited to students from a physics based, mathematical or similar background, as they will join a team whose purpose will be to develop and refine the use of multiphoton (MP) laser imaging and its related technology to monitor CBF (laser speckle), blood rheology, perfusion across cerebral capillaries and assess synaptic/neuronal networks in live rodents. The data will be derived from a depth of ~900μm in specified regions of live mouse brains by the interaction of two photon collisions at the site of in vivo fluorochromes. This exciting project has only recently become possible due mainly to current understanding of multiphoton collision at increased tissue depth and the advent of innovative MP equipment design. The development of in vivo imaging using MP microscopy also affords a tremendous opportunity for the IoN and the Wellcome Trust Centre on Translation Research. 

Supervision of doctoral and MRes students and fellows (last 2 years):

Primary supervisor :

M Burke (PhD 2013), Elizabeth Gemmell (PhD 2014), R Akinyemi (PhD 2014), Felicity Dewhurst (MD 2013), V Foster (PhD 2015), Stella-Maria Paddick (MD 2015).

Secondary supervisor:

Kirsty McAlleese (PhD 2014), Laura Barratt (PhD 2014), S McParland (PhD 2015)

MRes students:

Jennifer Horn (MRes 2014); Phoebe J Meyer (MRes 2013), Georgia Raey-Robinson (MRes 2013), R Fenwick (MRes 2013), S Tiwari (MRes 2013). Secondary; Natalie Shek (MRes 2014), M Li (MRes 2014), Noreen Ishaq (MRes 2014)

Vacation Scholarships:

J Eklid (2014), Shobana Analapakhan (2014)

Postdoctoral fellows:

Dr Lucy Craggs (UK), Dr Yoshiki Hase (Japan), Dr Rufus Akinyemi (Nigeria)

Postgraduate Teaching

MRes Medical and Molecular Biosciences. Scientific Basis of Neurological Disease module

MRes Ageing and Health module.  Neuropathology Lectures

MRCPsyh Parts I and II, Neuroanatomical localization and Neuropathology of Dementia 

• Sachdev P, Kalaria R, O'Brien J, Skoog I, Alladi S, Black SE, Blacker D, Blazer DG, Chen C, Chui H, Ganguli M, Jellinger K, Jeste DV, Pasquier F, Paulsen J, Prins N, Rockwood K, Roman G, Scheltens P. Diagnostic Criteria for Vascular Cognitive Disorders: A VASCOG Statement. Alzheimer Disease & Associated Disorders 2014, 28(3), 206-218.
• Gemmell E, Tam E, Allan L, Hall R, Khundakar A, Oakley AE, Thomas A, Deramecourt V, Kalaria RN. Neuron Volumes in Hippocampal Subfields in Delayed Poststroke and Aging-Related Dementias. Journal of Neuropathology and Experimental Neurology 2014, 73(4), 305-311.
• Burke MJC, Nelson L, Slade JY, Oakley AE, Khundakar AA, Kalaria RN. Morphometry of the hippocampal microvasculature in post-stroke and age-related dementias. Neuropathology and Applied Neurobiology 2014, 40(3), 284-295.
• Datta A, Qian J, Chong R, Kalaria RN, Francis P, Lai MKP, Chen CP, Sze SK. Novel pathophysiological markers are revealed by iTRAQ-based quantitative clinical proteomics approach in vascular dementia. Journal of Proteomics 2014, 99, 54-67.
• Lam SM, Wang Y, Duan X, Wenk MR, Kalaria RN, Chen CP, Lai MKP, Shui G. The brain lipidomes of subcortical ischemic vascular dementia and mixed dementia. Neurobiology of Aging 2014, 35(10), 2369-2381.
• Ihara M, Kalaria RN. Understanding and preventing the development of post-stroke dementia. Expert Review of Neurotherapeutics 2014, 14(9), 1067-1077.
• Craggs LJL, Yamamoto Y, Ihara M, Fenwick R, Burke M, Oakley AE, Roeber S, Duering M, Kretzschmar H, Kalaria RN. White matter pathology and disconnection in the frontal lobe in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Neuropathology and Applied Neurobiology 2014, 40(5), 591-602.
• Rannikmae K, Kalaria RN, Greenberg SM, Chui HC, Schmitt FA, Samarasekera N, Al-ShahiSalman R, Sudlow CL. APOE associations with severe CAA-associated vasculopathic changes: collaborative meta-analysis. Journal of Neurology, Neurosurgery & Psychiatry 2014, 85, 300-305.
• Yamamoto Y, Craggs LJL, Watanabe A, Booth T, Attems J, Low RWC, Oakley AE, Kalaria RN. Brain Microvascular Accumulation and Distribution of the NOTCH3 Ectodomain and Granular Osmiophilic Material in CADASIL. Journal of Neuropathology and Experimental Neurology 2013, 72(5), 416-431.
• Craggs LJL, Oakley A, Kalaria R. CADASIL: Intracytoplasmic Granular Osmiophilic Material Deposits Are Pseudoinclusions Reply. Journal of Neuropathology and Experimental Neurology 2013, 72(8), 801-803.
• Paddick S-M, Longdon AR, Kisoli A, Dotchin C, Gray WK, Dewhurst F, Chaote P, Kalaria R, Jusabani AM, Walker R. Dementia prevalence estimates in sub-Saharan Africa: comparison of two diagnostic criteria. Global Health Action 2013, 6, 19646.
• Kalaria RN, Ihara M. Dementia: Vascular and neurodegenerative pathways - will they meet?. Nature Reviews Neurology 2013, 9(9), 487-488.
• Allan LM, Rowan EN, Thomas AJ, Polvikoski JT, O'Brien JT, Kalaria RN. Long-term incidence of depression and predictors of depressive symptoms in older stroke survivors. British Journal of Psychiatry 2013, n/a, n/a.
• Craggs LJL, Hagel C, Kuhlenbaeumer G, Borjesson-Hanson A, Andersen O, Viitanen M, Kalimo H, McLean CA, Slade JY, Hall R, Oakley AE, Yamamoto Y, Deramecourt V, Kalaria RN. Quantitative vascular pathology and phenotyping familial and sporadic cerebral small vessel diseases. Brain Pathology 2013, 23(5), 547-557.
• Hawkes CA, Gatherer M, Sharp MM, Dorr A, Yuen HM, Kalaria R, Weller RO, Carare RO. Regional differences in the morphological and functional effects of aging on cerebral basement membranes and perivascular drainage of amyloid- from the mouse brain. Aging Cell 2013, 12(2), 224-236.
• Carare RO, Hawkes CA, Jeffrey M, Kalaria RN, Weller RO. Review: Cerebral amyloid angiopathy, prion angiopathy, CADASIL and the spectrum of protein elimination failure angiopathies (PEFA) in neurodegenerative disease with a focus on therapy. Neuropathology and Applied Neurobiology 2013, 39(6), 593-611.
• Mukaetova-Ladinska EB, Andras A, Milne J, Abdel-All Z, Bohr I, Jaros E, Perry RH, Honer WG, Cleghorn A, Doherty J, McIntosh G, Perry EK, Kalaria RN, McKeith IG. Synaptic proteins and choline acetyltransferase loss in visual cortex in dementia with Lewy bodies. Journal of Neuropathology and Experimental Neurology 2013, 72(1), 53-60.
• Akinyemi R, Mukaetova-Ladinska E, Attems J, Ihara M, Kalaria RN. Vascular Risk Factors and Neurodegeneration in Ageing related Dementias: Alzheimer's Disease and Vascular Dementia. Current Alzheimer Research 2013, 10(6), 642-653.
• Kalaria RN, Perry RH, O'Brien J, Jaros E. Atheromatous disease in small intracerebral vessels, microinfarcts and dementia. Neuropathology and Applied Neurobiology 2012, 38(5), 505-508.
• Ndung'u M, Hartig W, Wegner F, Mwenda JM, Low RWC, Akinyemi RO, Kalaria RN. Cerebral amyloid beta(42) deposits and microvascular pathology in ageing baboons. Neuropathology and Applied Neurobiology 2012, 38(5), 487-499.
• Okamoto Y, Yamamoto T, Kalaria RN, Senzaki H, Maki T, Hase Y, Kitamura A, Washida K, Yamada M, Ito H, Tomimoto H, Takahashi R, Ihara M. Cerebral hypoperfusion accelerates cerebral amyloid angiopathy and promotes cortical microinfarcts. Acta Neuropathologica 2012, 123(3), 381-394.
• Kalaria RN, Mukaetova-Ladinska EB. Delirium, dementia and senility. Brain 2012, 135(9), 2582-2584.
• Kalaria RN, Akinyemi R, Ihara M. Does vascular pathology contribute to Alzheimer changes?. Journal of the Neurological Sciences 2012, 322(1-2), 141-147.
• Huey ED, Ferrari R, Moreno JH, Jensen C, Morris CM, Potocnik F, Kalaria RN, Tierney M, Wassermann EM, Hardy J, Grafman J, Momeni P. FUS and TDP43 genetic variability in FTD and CBS. Neurobiology of Aging 2012, 33(5), 1016.e9–1016.e17.
• Gemmell E, Bosomworth H, Allan L, Hall R, Khundakar A, Oakley AE, Deramecourt V, Polvikoski TM, O'Brien JT, Kalaria RN. Hippocampal Neuronal Atrophy and Cognitive Function in Delayed Poststroke and Aging-Related Dementias. Stroke 2012, 43(3), 808-814.
• Mukaetova-Ladinska EB, Abdel-All Z, Andrade J, McNally RJ, James PW, Kalaria RN, O'Brien JT. Increase in platelet immunoglobulin in Alzheimer's disease is lowered following cholinesterase inhibitor treatment: preliminary results. Journal of Alzheimer's Disease 2012, 32(2), 431-436.
• Ekonomou A, Johnson M, Perry RH, Perry EK, Kalaria RN, Minger SL, Ballard CG. Increased neural progenitors in individuals with cerebral small vessel disease. Neuropathology and Applied Neurobiology 2012, 38(4), 344-353.
• Lax NZ, Pienaar IS, Reeve AK, Hepplewhite PD, Jaros E, Taylor RW, Kalaria RN, Turnbull DM. Microangiopathy in the cerebellum of patients with mitochondrial DNA disease. Brain 2012, 135(6), 1736-1750.
• Firbank MJ, Allan LM, Burton EJ, Barber R, O'Brien JT, Kalaria RN. Neuroimaging predictors of death and dementia in a cohort of older stroke survivors. Journal of Neurology, Neurosurgery and Psychiatry 2012, 83(3), 263-267.
• Giwa MO, Williams J, Elderfield K, Jiwa NS, Bridges LR, Kalaria RN, Markus HS, Esiri MM, Hainsworth AH. Neuropathologic evidence of endothelial changes in cerebral small vessel disease. Neurology 2012, 78(3), 167-174.
• Mukaetova-Ladinska EB, Abdel-All Z, Dodds S, Andrade J, AlvesdaSilva J, Kalaria RN, O'Brien JT. Platelet immunoglobulin and amyloid precursor protein (APP) as potential peripheral biomarkers for Alzheimer’s Disease. Findings from a pilot study. Age and Ageing 2012, 41(3), 408-412.
• Lopes MA, Firbank MJ, Widdrington M, Blamire AM, Kalaria RN, O'Brien JT. Post-stroke dementia: the contribution of thalamus and basal ganglia changes. International Psychogeriatrics 2012, 24(4), 568-576.
• Kitamura A, Fujita Y, Oishi N, Kalaria RN, Washida K, Maki T, Okamoto Y, Hase Y, Yamada M, Takahashi J, Ito H, Tomimoto H, Fukuyama H, Takahashi R, Ihara M. Selective white matter abnormalities in a novel rat model of vascular dementia. Neurobiology of Aging 2012, 33(5), 1012.e25.
• Deramecourt V, Slade JY, Oakley AE, Perry RH, Ince PG, Maurage CA, Kalaria RN. Staging and natural history of cerebrovascular pathology in dementia. Neurology 2012, 78(14), 1043-1050.
• Narayan SK, Gorman G, Kalaria RN, Ford GA, Chinnery PF. The minimum prevalence of CADASIL in northeast England. Neurology 2012, 78(13), 1025-1027.
• Allan LM, Rowan EN, Firbank MJ, Thomas AJ, Parry SW, Polvikoski TM, O'Brien JT, Kalaria RN. Long term incidence of dementia, predictors of mortality and pathological diagnosis in older stroke survivors. Brain 2011, 134(12), 3716-3727.
• Smith AR, Smith RG, Burrage J, Troakes C, Al-Sarraj S, Kalaria RN, Sloan C, Robinson AC, Mill J, Lunnon K. A cross-brain regions study of ANK1 DNA methylation in different neurodegenerative diseases. Neurobiology of Aging 2019, 74, 70-76.
• Gallart-Palau X, Serra A, Hase Y, Tan CF, Chen CP, Kalaria RN, Sze SK. Brain-derived and circulating vesicle profiles indicate neurovascular unit dysfunction in early Alzheimer’s disease. Brain Pathology 2019, 29(5), 593-605.
• Hase Y, Polvikoski TM, Ihara M, Hase M, Zafar R, Stevenson W, Allan LM, Ennaceur A, Horsburgh K, Gallart-Palau X, Sze SK, Kalaria RN. Carotid artery disease in post-stroke survivors and effects of enriched environment on stroke pathology in a mouse model of carotid artery stenosis. Neuropathology and Applied Neurobiology 2019, 45(7), 681-697.
• Graham C, Santiago-Mugica E, Abdel-All Z, Li M, McNally R, Kalaria RN, Mukaetova-Ladinska EB. Erythrocytes as Biomarkers for Dementia: Analysis of Protein Content and Alpha-Synuclein. Journal of Alzheimer's Disease 2019, 71(2), 569-580.
• Kalaria RN, Hase Y. Neurovascular Ageing and Age-Related Diseases. In: J. Robin Harris and Viktor I. Korolchuk, ed. Biochemistry and Cell Biology of Ageing: Part II Clinical Science. Singapore: Springer, 2019, pp.477-499.
• Kalaria RN, Hase Y, Ihara M. The rise and rise of cerebral small vessel disease: Implications for vascular cognitive impairment and dementia. Future Neurology 2019, 14(2), 1-4.
• Sweeney MD, Montagne A, Sagare AP, Nation DA, Schneider LS, Chui HC, Harrington MG, Pa J, Law M, Wang DJJ, Jacobs RE, Doubal FN, Ramirez J, Black SE, Nedergaard M, Benveniste H, Dichgans M, Iadecola C, Love S, Bath PM, Markus HS, Salman RA, Allan SM, Quinn TJ, Kalaria RN, Werring DJ, Carare RO, Touyz RM, Williams SCR, Moskowitz MA, Katusic ZS, Lutz SE, Lazarov O, Minshall RD, Rehman J, Davis TP, Wellington CL, Gonzalez HM, Yuan C, Lockhart SN, Hughes TM, Chen CLH, Sachdev P, O'Brien JT, Skoog I, Pantoni L, Gustafson DR, Biessels GJ, Wallin A, Smith EE, Mok V, Wong A, Passmore P, Barkof F, Muller M, Breteler MMB, Roman GC, Hamel E, Seshadri S, Gottesman RF, van Buchem MA, Arvanitakis Z, Schneider JA, Drewes LR, Hachinski V, Finch CE, Toga AW, Wardlaw JM, Zlokovic BV. Vascular dysfunction—The disregarded partner of Alzheimer's disease. Alzheimer's and Dementia 2019, 15(1), 158-167.
• Hase Y, Ding R, Harrison G, Hawthorne E, King A, Gettings S, Platten C, Stevenson W, Craggs LJL, Kalaria RN. White matter capillaries in vascular and neurodegenerative dementias. Acta Neuropathologica Communications 2019, 7(1), 16.
• Nakaoku Y, Oishi N, Hase Y, Hase M, Saito S, Mitsueda T, Matsui M, Toyoda K, Nagatsuka K, Kalaria RN, Fukuyama H, Ihara M, Takahashi R. Montreal Cognitive Assessment score correlates with regional cerebral blood flow in post-stroke patients. Clinical Neurology and Neurosurgery 2018, 174, 68-74.
• Uemura MT, Ihara M, Maki T, Nakagomi T, Kaji S, Uemura K, Matsuyama T, Kalaria RN, Kinoshita A, Takahashi R. Pericyte-derived bone morphogenetic protein 4 underlies white matter damage after chronic hypoperfusion. Brain Pathology 2018, 28(4), 521-535.
• Skrobot OA, Black SE, Chen C, DeCarli C, Erkinjuntti T, Ford GA, Kalaria RN, O'Brien J, Pantoni L, Pasquier F, Roman GC, Wallin A, Sachdev P, Skoog I, VICCCS group, Ben-Shlomo Y, Passmore AP, Love S, Kehoe PG. Progress toward standardized diagnosis of vascular cognitive impairment: Guidelines from the Vascular Impairment of Cognition Classification Consensus Study. Alzheimer's and Dementia 2018, 14(3), 280-292.
• Horsburgh K, Wardlaw JM, van Agtmael T, Allan SM, Ashford MLJ, Bath PM, Brown R, Berwick J, Cader MZ, Carare RO, Davis JB, Duncombe J, Farr TD, Fowler JH, Goense J, Granata A, Hall CN, Hainsworth AH, Harvey A, Hawkes CA, Joutel A, Kalaria RN, Kehoe PG, Lawrence CB, Lockhart A, Love S, Macleod MR, Macrae IM, Markus HS, McCabe C, McColl BW, Meakin PJ, Miller A, Nedergaard M, O'Sullivan M, Quinn TJ, Rajani R, Saksida LM, Smith C, Smith KJ, Touyz RM, Trueman RC, Wang T, Williams A, Williams SCR, Work LM. Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology. Clinical Science 2018, 132(8), 851-868.
• Akinyemi RO, Owolabi MO, Ihara M, Damasceno A, Ogunniyi A, Dotchin C, Paddick S-M, Ogeng'o J, Walker R, Kalaria RN. Stroke, cerebrovascular diseases and vascular cognitive impairment in Africa. Brain Research Bulletin 2019, 145, 97-108.
• Hase Y, Craggs L, Hase M, Stevenson W, Slade J, Chen A, Liang D, Ennaceur A, Oakley A, Ihara M, Horsburgh K, Kalaria RN. The effects of environmental enrichment on white matter pathology in a mouse model of chronic cerebral hypoperfusion. Journal of Cerebral Blood Flow and Metabolism 2018, 38(1), 151-165.
• Hase Y, Horsburgh K, Ihara I, Kalaria RN. White matter degeneration in vascular and other ageing-related dementias. Journal of Neurochemistry 2018, 144(5), 617-633.
• Duncombe J, Kitamura A, Hase Y, Ihara M, Kalaria RN, Horsburgh K. Chronic cerebral hypoperfusion: a key mechanism leading to vascular cognitive impairment and dementia. Closing the translational gap between rodent models and human vascular cognitive impairment and dementia. Clinical Science 2017, 131(19), 2451-2468.
• Hase Y, Craggs L, Hase M, Stevenson W, Slade J, Lopez D, Mehta R, Chen A, Liang D, Oakley A, Ihara M, Horsburgh K, Kalaria RN. Effects of environmental enrichment on white matter glial responses in a mouse model of chronic cerebral hypoperfusion. Journal of Neuroinflammation 2017, 14(1), 81.
• Akinyemi RO, Allan LM, Oakley A, Kalaria RN. Hippocampal neurodegenerative pathology in post-stroke dementia compared to other dementias and aging controls. Frontiers in Neuroscience 2017, 11, 717.
• Skrobot OA, Attems J, Esiri M, Hortobagyi T, Ironside JW, Kalaria RN, King A, Lammie GA, Mann D, Neal J, Ben-Shlomo Y, Kehoe PG, Love S. Reply: Atherosclerosis and vascular cognitive impairment neuropathological guideline. Brain 2017, 140(2), e13-e13.
• Sachdev PS, Lo JW, Crawford JD, Mellon L, Hickey A, Williams D, Bordet R, Mendyk A-M, Gele P, Deplanque D, Bae H-J, Lim J-S, Brodtmann A, Werden E, Cumming T, Kohler S, Verhey FRJ, Dong Y-H, Tan HH, Chen C, Xin X, Kalaria RN, Allan LM, Akinyemi RO, Ogunniyi A, Klimkowicz-Mrowiec A, Dichgans M, Wollenweber FA, Zietemann V, Hoffmann M, Desmond DW, Linden T, Blomstrand C, Fagerberg B, Skoog I, Godefroy O, Barbay M, Roussel M, Lee B-C, Yu K-H, Wardlaw J, Makin SJ, Doubal FN, Chappell FM, Srikanth VK, Thrift AG, Donnan GA, Kandiah N, Chander RJ, Lin X, Cordonnier C, Moulin S, Rossi C, Sabayan B, Stott DJ, Jukema JW, Melkas S, Jokinen H, Erkinjuntti T, Mok VCT, Wong A, Lam BYK, Leys D, Henon H, Bombois S, Lipnicki DM, Kochan NA, Sachdev PS, Lo JW, Crawford JD, Lipnicki DM, Kochan NA, Mellon L, Hickey A, Williams D, Bordet R, Mendyk A-M, Gele P, Deplanque D, Bae H-J, Lim J-S, Brodtmann A, Werden E, Cumming T, Kohler S, Verhey FRJ, Dong Y-H, Xu J, Chen C, Kalaria RN, Allan LM, Akinyemi R, Ogunniyi A, Kalariai RN, Klimkowicz-Mrowiec A, Dichgans M, Wollenweber FA, Zietemann V, Hoffmann M, Desmond DW, Linden T, Blomstrand C, Fagerberg B, Skoog I, Godefroy O, Barbay M, Roussel M, Lee B-C, Yu K-H, Lim J-S, Wardlaw J, Makin SJ, Doubal FN, Chappell FM, Srikanth VK, Thrift AG, Donnan GA, Kandiah N, Chander RJ, Lin X, Cordonnier C, Moulin S, Rossi C, Sabayan B, Stott DJ, Jukema JW, Melkas S, Jokinen H, Erkinjuntti T, Mok VCT, Wong A, Lam BYK, Leys D, Henon H, Bombois S, Sachdev P. STROKOG (stroke and cognition consortium): An international consortium to examine the epidemiology, diagnosis, and treatment of neurocognitive disorders in relation to cerebrovascular disease. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring 2017, 7, 11-23.
• Manousopoulou A, Gatherer M, Smith C, Nicoll JAR, Woelk CH, Johnson M, Kalaria R, Attems J, Garbis SD, Carare RO. Systems proteomic analysis reveals that clusterin and tissue inhibitor of metalloproteinases 3 increase in leptomeningeal arteries affected by cerebral amyloid angiopathy. Neuropathology and Applied Neurobiology 2017, 43(6), 492-504.
• Skrobot OA, O'Brien J, Black S, Chen C, DeCarli C, Erkinjuntti T, Ford GA, Kalaria RN, Pantoni L, Pasquier F, Roman GC, Wallin A, Sachdev P, Skoog I, Ben-Shlomo Y, Passmore AP, Love S, Kehoe PG. The Vascular Impairment of Cognition Classification Consensus Study. Alzheimer's and Dementia 2017, 13(6), 624-633.
• Hainsworth AH, Allan SM, Boltze J, Cunningham C, Farris C, Head E, Ihara M, Isaacs JD, Kalaria RN, Lesnik Oberstein SAMJ, Moss MB, Nitzsche B, Rosenberg GA, Rutten JW, Salkovic-Petrisic M, Troen AM. Translational models for vascular cognitive impairment: A review including larger species. BMC Medicine 2017, 15(1), 16.
• Skrobot OA, McKnight AJ, Passmore PA, Seripa D, Mecocci P, Panza F, Kalaria R, Wilcock G, Munafo M, Erkinjuntti T, Karhunen P, Pessi T, Martiskainen M, Love S, Kehoe PG, Genetic Environm Risk Alzheimer's. A Validation Study of Vascular Cognitive Impairment Genetics Meta-Analysis Findings in an Independent Collaborative Cohort. Journal of Alzheimer's Disease 2016, 53(3), 981-989.
• Carare RO, Kalaria R. Cerebrovascular pathology: the dark side of neurodegeneration. Acta Neuropathologica 2016, 131(5), 641-643.
• Craggs L, Taylor J, Slade JY, Chen A, Hagel C, Kuhlenbaeumer G, Borjesson-Hanson A, Viitanen M, Kalimo H, Deramecourt V, Oakley AE, Kalaria RN. Clusterin/Apolipoprotein J immunoreactivity is associated with white matter damage in cerebral small vessel diseases. Neuropathology and Applied Neurobiology 2016, 42(2), 194-209.
• Keable A, Fenna K, Yuen HM, Johnston DA, Smyth NR, Smith C, Salman RAS, Samarasekera N, Nicoll JAR, Attems J, Kalaria RN, Weller RO, Carare RO. Deposition of amyloid β in the walls of human leptomeningeal arteries in relation to perivascular drainage pathways in cerebral amyloid angiopathy. Biochimica et Biophysica Acta - Molecular Basis of Disease 2016, 1862(5), 1037-1046.
• Hase Y, Craggs L, Stevenson W, Hase M, Slade J, Oakley A, Ihara M, Horsburgh K, Kalaria R. Effects of environmental enrichment/physical exercise on white matter integrity and stroke injury in a mouse model of chronic cerebral jypoperfusion. In: 25th European Stroke Conference. 2016, Venice, Italy: S. Karger AG.
• Chen A, Akinyemi RO, Hase Y, Firbank MJ, Ndung'u MN, Foster V, Craggs LJL, Washida K, Okamoto Y, Thomas AJ, Polvikoski TM, Allan LM, Oakley AE, O'Brien JT, Horsburgh K, Ihara M, Kalaria RN. Frontal white matter hyperintensities, clasmatodendrosis and gliovascular abnormalities in ageing and post-stroke dementia. Brain 2016, 139(1), 242-258.
• Gallart-Palau X, Lee BST, Adav SS, Qian J, Serra A, Park JE, Lai MKP, Chen CP, Kalaria RN, Sze SK. Gender differences in white matter pathology and mitochondrial dysfunction in Alzheimer's disease with cerebrovascular disease. Molecular Brain 2016, 9(1), 27.
• Hattori Y, Enmi J, Iguchi S, Saito S, Yamamoto Y, Tsuji M, Nagatsuka K, Kalaria RN, Iida H, Ihara M. Gradual Carotid Artery Stenosis in Mice Closely Replicates Hypoperfusive Vascular Dementia in Humans. Journal of the American Heart Association 2016, 5(2).
• Kitamura A, Saito S, Maki T, Oishi N, Ayaki T, Hattori Y, Yamamoto Y, Urushitani M, Kalaria RN, Fukuyama H, Horsburgh K, Takahashi R, Ihara M. Gradual cerebral hypoperfusion in spontaneously hypertensive rats induces slowly evolving white matter abnormalities and impairs working memory. Journal of Cerebral Blood Flow and Metabolism 2016, 36(9), 1592-1602.
• Dichgans M, Wardlaw J, Smith E, Zietemann V, Seshadri S, Sachdev P, Biessels GJ, Fazekas F, Benavente O, Pantoni L, De Leeuw F, Norrving B, Matthews P, Chen C, Mok V, During M, Whiteley W, Shuler K, Alonso A, Black SE, Brayne C, Chabriat H, Cordonnier C, Doubal F, Duzel E, Ewers M, Frayne R, Hachinski V, Ikram MA, Jessen F, Jouvent E, Linn J, O'Brien J, van Oostenbrugge R, Malik R, Mazoyer B, Schmidt R, Sposato LA, Stephan B, Swartz RH, Vernooij M, Viswanathan A, Werring D, Abe K, Allan L, Arba F, Bae HJ, Bath PMW, Bordet R, Breteler M, Choi S, Deary I, DeCarli C, Ebmeier K, Feng L, Greenberg SM, Ihara M, Kalaria R, Kim S, Lim JS, Lindley RI, Mead G, Murray A, Quinn T, Ritchie C, Sacco R, Salman RA, Sprigg N, Sudlow C, Thomas A, van Boxtel M, van der Grond J, van der Lugt A, Yang YH, VISTA Collaboration, METACOHORTS Consortiums. METACOHORTS for the study of vascular disease and its contribution to cognitive decline and neurodegeneration: An initiative of the Joint Programme for Neurodegenerative Disease Research. Alzheimer's & Dementia 2016, 12(12), 1235-1249.
• Chen AQ, Oakley AE, Monteiro M, Tuomela K, Allan LM, Mukaetova-Ladinska EB, O'Brien JT, Kalaria RN. Multiplex analyte assays to characterize different dementias: brain inflammatory cytokines in poststroke and other dementias. Neurobiology of Aging 2016, 38, 56-67.
• Lee JH, Francis PT, Ballard CG, Aarsland D, Kalaria RN, Wong PTH, Chen CP, Lai MKP. Muscarinic M1 Receptor Coupling to G-protein is Intact in Parkinson's Disease Dementia. Journal of Parkinsons Disease 2016, 6(4), 733-739.
• Akinyemi RO, Owolabi MO, Oyeniyi T, Ovbiagele B, Arnett DK, Tiwari HK, Walker RW, Ogunniyi A, Kalaria RN, SIREN group of H3Africa Consortium. Neurogenomics in Africa: Perspectives, progress, possibilities and priorities. Journal of the Neurological Sciences 2016, 366, 213-223.
• Kalaria JN. Neuropathological diagnosis of vascular cognitive impairment and vascular dementia with implications for Alzheimer’s disease. Acta Neuropathologica 2016, 131(5), 659-685.
• McAleese KE, Alafuzoff I, Charidimou A, De Reuck J, Grinberg LT, Hainsworth AH, Hortobagyi T, Ince P, Jellinger K, Gao J, Kalaria RN, Kovacs GG, Kovari E, Love S, Popovic M, Skrobot O, Taipa R, Thal DR, Werring D, Wharton SB, Attems J. Post-mortem assessment in vascular dementia: advances and aspirations. BMC Medicine 2016, 14, 129.
• Kalaria RN, Akinyemi R, Ihara M. Stroke injury, cognitive impairment and vascular dementia. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2016, 1862(5), 915-925.
• Khan A, Kalaria RN, Corbett A, Ballard C. Update on Vascular Dementia. Journal of Geriatric Psychiatry and Neurology 2016, 29(5), 281-301.
• Skrobot OA, Attems J, Esiri M, Hortobagyi T, Ironside J, Kalaria RN, King A, Lammie GA, Mann D, Neal J, Ben-Shlomo Y, Kehoe PG, Love S. Vascular Cognitive Impairment Neuropathology Guidelines (VCING) - a UK multi-centre consensus study. In: 117th Meeting of the British Neuropathological Society. 2016, London, UK: Wiley-Blackwell Publishing Ltd.
• Skrobot OA, Attems J, Esiri M, Hortobágyi, T, Ironside JW, Kalaria RN, King A, Lammie GA, Mann D, Neal J, Ben-Shlomo Y, Kehoe PG, Love S. Vascular cognitive impairment neuropathology guidelines (VCING): the contribution of cerebrovascular pathology to cognitive impairment. Brain 2016, 139(11), 2957-2969.
• Chen A, Bates LL, Hase Y, Slade JY, Oakley AE, Kalaria RN. White matter clasmatodendrosis and gliovascular abnormalities in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). In: 117th Meeting of the British Neuropathological Society Royal College of Physicians. 2016, London, UK: Wiley-Blackwell Publishing Ltd.
• Ahmed-Jushuf F, Jiwa N, Arwani A, Bridges L, Kalaria R, Esiri M, Hainsworth A. Age-dependent vascular endothelial growth factor receptor-2 in arterial smooth muscle cells in deep grey matter. In: UK Stroke Forum 2015 Conference. 2015, Liverpool, UK: Sage Publications Ltd.
• Pienaar IS, Lee CH, Elson JL, McGuinness L, Gentleman SM, Kalaria RN, Dexter DT. Deep-brain stimulation associates with improved microvascular integrity in the subthalamic nucleus in Parkinson's disease. Neurobiology of Disease 2015, 74, 392–405.
• Chen A, Akinyemi RO, Washida K, Foster V, Firbank MJ, Oakley AE, Okamoto Y, O'Brien JT, Allan LM, Ihara M, Kalaria RN. Frontal white matter clasmatodendrosis and cognitive dysfunction in the elderly. In: 116th Meeting of the British Neuropathological Society Institute of Child Health. 2015, London, UK: Wiley-Blackwell Publishing Ltd.
• Holland PR, Searcy JL, Salvadores N, Scullion G, Chen GQ, Lawson G, Scott F, Bastin ME, Ihara M, Kalaria R, Wood ER, Smith C, Wardlaw JM, Horsburgh K. Gliovascular disruption and cognitive deficits in a mouse model with features of small vessel disease. Journal of Cerebral Blood Flow & Metabolism 2015, 35(6), 1005-1014.
• Manousopoulou A, Smith C, Nicoll JAR, Attems J, Kalaria R, Johnston HE, Woelk CH, Weller RO, Garbis SD, Carare RO. Global proteomic profiling of brain leptomeningeal arteries from patients with cerebral amyloid angiopathy reveals novel therapeutic targets. In: 116th Meeting of the British Neuropathological Society. 2015, London, UK: Wiley-Blackwell.
• Craggs LJL, Fenwick R, Oakley AE, Ihara M, Kalaria RN. Immunolocalization of platelet-derived growth factor receptor-β (PDGFR-β) and pericytes in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Neuropathology and Applied Neurobiology 2015, 41(4), 557-570.
• Akinyemi RO, Firbank M, Ogbole GI, Allan LM, Owolabi MO, Akinyemi JO, Yusuf BP, Ogunseyinde O, Ogunniyi A, Kalaria RN. Medial temporal lobe atrophy, white matter hyperintensities and cognitive impairment among African stroke survivors. BMC Research Notes 2015, 8, 625.
• Mukaetova-Ladinska EB, Abdel-All Z, Andrade J, da Silva JA, O'Brien JT, Kalaria RN. Plasma and platelet clusterin ratio is altered in Alzheimer's disease patients with distinct neuropsychiatric symptoms: findings from a pilot study. International Journal of Geriatric Psychiatry 2015, 30(4), 368-375.
• Hattori Y, Okamoto Y, Nagatsuka K, Takahashi R, Kalaria RN, Kinoshita M, Ihara M. SIRT1 attenuates severe ischemic damage by preserving cerebral blood flow. NeuroReport 2015, 26(3), 113-117.
• Akinyemi RO, Ovbiagele B, Akpalu A, Jenkins C, Sagoe K, Owolabi L, Sarfo F, Obiako R, Gebreziabher M, Melikam E, Warth S, Arulogun O, Lackland D, Ogunniyi A, Tiwari H, Kalaria RN, Arnett D, Owolabi MO, SIREN, H3Africa Consortium. Stroke genomics in people of African ancestry: charting new paths. Cardiovascular Journal of Africa 2015, 26(2 Suppl. 1), S39-S49.
• Mukaetova-Ladinska EB, Li M, Kalaria RN. Tau protein, ischemic injury and vascular dementia. Future Neurology 2015, 10(6), 559-575.
• Mukaetova-Ladinska EB, Abdel-All Z, Mugica ES, Li M, Craggs LJ, Oakley AE, Honer WG, Kalaria RN. Tau proteins in the temporal and frontal cortices in patients with vascular dementia. Journal of Neuropathology & Experimental Neurology 2015, 72(2), 148-157.
• Gallart-Palau X, Serra A, Qian J, Chen CP, Kalaria RN, Sze SK. Temporal lobe proteins implicated in synaptic failure exhibit differential expression and deamidation in vascular dementia. Neurochemistry International 2015, 80, 87-98.
• Paddick SM, Kalaria RN, Mukaetova-Ladinska EB. The prevalence and clinical manifestations of delirium in sub-Saharan Africa: A systematic review with inferences. Journal of the Neurological Sciences 2015, 348(1-2), 6-17.
• Banik A, Brown RE, Bamburg J, Lahiri DK, Khurana D, Friedland RP, Chen W, Ding Y, Mudher A, Padjen AL, Mukaetova-Ladinska E, Ihara M, Srivastava S, Srivastava MVP, Masters CL, Kalaria RN, Anand A. Translation of Pre-Clinical Studies into Successful Clinical Trials for Alzheimer's Disease: What are the Roadblocks and How Can They Be Overcome?. Journal of Alzheimer's Disease 2015, 47(4), 815-843.
• Mukaetova-Ladinska EB, Abdel-All Z, Craggs LJL, Oakley AE, Honer WG, Kalaria RN. Brain tau in ischaemic injury and vascular dementia. In: Meeting of the British Neuropathological Society. 2014, Institute of Child Health, London, UK: Wiley-Blackwell Publishing Ltd.
• Mulugeta E, Vallortigara J, Francis PT, Hye A, Kalaria RN, Perry EK, Lovestone S, Ballard CG. Dynamin protein in stroke and vascular dementia. Neuroscience Letters 2014, 563, 118-122.
• Washida K, Ihara M, Kalaria RN. Glial activation and white matter change in baboon brain with chronic cerebral hypoperfusion. In: 9th World Stroke Congress. 2014, Istanbul, Turkey: Wiley-Blackwell Publishing.
• Adav SS, Qian J, Ang YL, Kalaria RN, Lai MKP, Chen CP, Sze SK. ITRAQ quantitative clinical proteomics revealed role of Na⁺K⁺-ATPase and its correlation with deamidation in vascular dementia. Journal of Proteome Research 2014, 13(11), 4635-4646.
• Kalaria RN, Attems J. Microvascular Pathology. In: Michael J. Aminoff and Robert B. Daroff, ed. Encyclopedia of the Neurological Sciences. Elsevier Inc, 2014, pp.21-25.
• Craggs LJL, Yamamoto Y, Deramecourt V, Kalaria RN. Microvascular Pathology and Morphometrics of Sporadic and Hereditary Small Vessel Diseases of the Brain. Brain Pathology 2014, 24(5), 495-509.
• Maki T, Okamoto Y, Carare RO, Hase Y, Hattori Y, Hawkes CA, Saito S, Yamamoto Y, Terasaki Y, Ishibashi-Ueda H, Taguchi A, Takahashi R, Miyakawa T, Kalaria RN, Lo EH, Arai K, Ihara M. Phosphodiesterase III inhibitor promotes drainage of cerebrovascular beta-amyloid. Annals of Clinical and Translational Neurology 2014, 1(8), 519-533.
• Akinyemi RO, Allan L, Ogunniyi A, Kalaria RN. Profile and determinants associated with vascular cognitive impairment in African stroke survivors: The CogFAST - Nigeria study. In: 9th World Stroke Congress. 2014, Istanbul, Turkey: Wiley-Blackwell Publishing.
• Akinyemi RO, Allan L, Owolabi MO, Akinyemi JO, Ogbole G, Ajani A, Firbank M, Ogunniyi A, Kalaria RN. Profile and determinants of vascular cognitive impairment in African stroke survivors: The CogFAST Nigeria Study. Journal of the Neurological Sciences 2014, 346(1-2), 241-249.
• Foster V, Oakley AE, Slade JY, Hall R, Polvikoski TM, Burke M, Thomas AJ, Khundakar A, Allan LM, Kalaria RN. Pyramidal neurons of the prefrontal cortex in post-stroke, vascular and other ageing-related dementias. Brain 2014, 137(9), 2509-2521.
• Hattori Y, Okamoto Y, Maki T, Yamamoto Y, Oishi N, Yamahara K, Nagatsuka K, Takahashi R, Kalaria RN, Fukuyama H, Kinoshita M, Ihara M. Silent Information Regulator 2 Homolog 1 Counters Cerebral Hypoperfusion Injury by Deacetylating Endothelial Nitric Oxide Synthase. Stroke 2014, 45(11), 3403-3411.