Staff Profile
Dr Salman Razvi
Clinical Senior Lecturer/Consultant
- Email: salman.razvi@ncl.ac.uk
- Telephone: 0191 241 8838
- Address: Translational and Clinical Research Institute
Newcastle University
Centre for Life
Central Parkway
Newcastle upon Tyne
NE1 3BZ
My research focuses on ameliorating morbidity and mortality in people with thyroid diseases. As a clinically trained investigator, I am pursuing research questions on several different levels, from examining different treatments of thyroid disease and their effects on cardiovascular risk factors and diseases to investigating long-term natural history of thyroid disease in a population. Despite the day-to-day pressures I have been successful in developing and maintain an active research career including a number of nationally funded projects. The first was the British Thyroid Foundation funded study of assessing long-term outcomes in the survivors of the original Whickham cohort, the first community thyroid disease prevalence study. The second grant was the NIHR-RfPB funded trial (SORTED) to investigate lower dose levothyroxine in older hypothyroid individuals in relation to quality of life and cardiovascular risk factors. In addition, I obtained data from the General Practitioner Research Database (CPRD) via the MRC license to analyse outcomes of subclinical hypothyroidism, which provided real life data on the effects of treatment on cardiovascular events. These results were instrumental, in part, to the recommendations formulated by the European Thyroid Association (which I was a co-author on) that the age of an individual should be considered when deliberating treatment of subclinical hypothyroidism. Also, in association with colleagues from the British Thyroid Association, I studied the iodine status of schoolgirls, which discovered that there was significant iodine deficiency in the UK, and led to a review by the Scientific Advisory Committee on Nutrition.
In 2013, I successfully secured an NIHR Career Development Fellowship (CDF) award. The CDF had a significant and measurable impact on the quality and quantity of my research output. This was due to the shift in my focus from purely NHS work to being a clinical academic. As a consequence, my H index has increased to 32. Furthermore, my contribution to the peer review process has also seen me being ranked amongst the top reviewers (ranked at the 99th percentile on Publons).
My publications (currently >90, of which >60 are original research articles) focus mainly on the cardiovascular effects of thyroid hormones. I have edited a book (Thyroid and Heart, 2ndedition, Springer) and authored several book chapters (including two in the iconic textbook Werner & Ingbar’s The Thyroid 11th edition). I have been invited to give lectures at several international meetings including the American Thyroid Association, the European Thyroid Association and the National Institutes of Health. I have also been involved in training the next generation of researchers: supervised a clinical fellow who has recently submitted his PhD thesis and three students successfully through their Master’s degree. I regularly review grant applications for NIHR and MRC. In addition, I have been an examiner of PhD candidates overseas.
I continue to foster global collaborations with thyroid researchers as part of the Thyroid Studies Collaboration, which has led to several high impact publications relating thyroid dysfunction with important clinical outcomes such as cardiovascular events and mortality.
In addition, I also work with patient-led charities to help improve patients’ understanding of their condition. I work closely with the British Thyroid Foundation as their medical advisor. I am also involved in supporting research activity and delivery at a local and regional level in my role as R&D Director at Gateshead Health NHS Trust and also the Lead for Metabolic and Endocrine Research in the Local Clinical Research Network. I sit on the Executive committee of the British Thyroid Association, a professional organisation promoting research and interest in thyroidology. I am the Associate editor for Frontiers in Endocrinology and form the editorial panel of the journals Thyroid and Journal of Endocrinological Investigations.
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Articles
- Razvi S, Jabbar A, Addison C, Vernazza J, Syed A, Soran H, Leng O. Variation in the reference range limits of thyroid function tests and association with the prevalence of levothyroxine treatment. European Journal of Endocrinology 2023, 188(2), lvad016.
- Tee SuAnn, Tsatlidis V, Razvi S. The GLP-1 receptor agonist Exenatide reduces serum TSH by its effect on body weight in people with Type 2 Diabetes. Clinical Endocrinology 2023, Epub ahead of print.
- Howarth S, Sneddon G, Allinson KR, Razvi S, Mitchell AL, Pearce SHS. Replication of association at the LPP and UBASH3A loci in a UK autoimmune Addison's disease cohort. European Journal of Endocrinology 2023, 188(1).
- Razvi S, Jabbar A, Bano A, Ingoe L, Carey P, Junejo S, Thomas H, Addison C, Austin D, Greenwood JP, Zaman AG. Triiodothyronine (T3), inflammation and mortality risk in patients with acute myocardial infarction. European Thyroid Journal 2022, 11(2), e210085.
- Abdalaziz A, Vanka R, Bartholomew P, Vennart N, Vernazza J, Stewart K, Tsatlidis V, Narayanan K, Weaver J, Razvi S. The prevalence and significance of non-uniform thyroid radio-isotope uptake in patients with Graves’ disease. Clinical Endocrinology 2022, Epub ahead of print.
- Alwan H, Villoz F, Feller M, Dullaart RPF, Bakker SJL, Peeters RP, Kavousi M, Bauer DC, Cappola AR, Yeap BB, Walsh JP, Brown SJ, Ceresini G, Ferrucci L, Gussekloo J, Trompet S, Iacoviello M, Moon JH, Razvi S, Bensenor IM, Azizi F, Amouzegar A, Valdés S, Colomo N, Wareham NJ, Jukema JW, Westendorp RGJ, Kim KW, Rodondi N, Giovane CD. Subclinical thyroid dysfunction and incident diabetes: a systematic review and an individual participant data analysis of prospective cohort studies. European Journal of Endocrinology 2022, (ePub ahead of Print).
- Perros P, Basu A, Boelaert K, Dayan C, Vaidya B, Williams GR, Lazarus JH, Hickey J, Drake WM, Crown A, Orme SM, Johnson A, Ray DW, Leese GP, Jones TH, Abraham P, Grossman A, Rees A, Razvi S, Gibb FW, Moran C, Madathil A, Zarkovic MP, Plummer Z, Jarvis S, Falinska A, Velusamy A, Sanderson V, Pariani N, Atkin SL, Syed AA, Sathyapalan T, Nag S, Gilbert J, Gleeson H, Levy MJ, Johnston C, Sturrock N, Bennett S, Mishra B, Malik I, Karavitaki N. Post-radioiodine Graves' management: the PRAGMA study. Clinical Endocrinology 2022, Epub ahead of print.
- Javaid U, Kennedy D, Addison C, Tsatlidis V, Razvi S. Frequency, Determinants and Costs of Thyroid Function Testing in a Laboratory serving a large Population. European Journal of Endocrinology 2022, epub ahead of print.
- Tharmapoopathy M, Thavarajah A, Kenny RPW, Pingitore A, Iervasi G, Dark J, Bano A, Razvi S. Efficacy and safety of Triiodothyronine (T3) treatment in Cardiac Surgery or Cardiovascular Diseases – a Systematic Review and Meta-analysis of Randomized Controlled Trials. Thyroid 2022, Epub ahead of print.
- RECOVERY Collaborative Group, Inc. The Newcastle Upon Tyne Hospitals NHS Foundation Trust, Hunter E, De Soyza A, Agbeko R, Baker K, Barr A, Cameron E, Campbell Hewson Q, Duncan C, Emonts M, Fenn A, Francis S, Glover Bengtsson J, Greenhalgh A, Hanrath A, Houghton K, Jerry D, Jones G, Kelly S, Lane N, Macfarlane J, McAlinden P, McCullagh I, McDonald S, Mohammed O, Obukofe R, Parker J, Patience A, Payne B, Price D, Razvi S, Robson S, Sanchez Gonzalez A, Stephenson E, Welton R, West S, Wong E, Yelnoorkar J. Casirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. The Lancet 2022, 399(10325), 665-676.
- Jabbar A, Ingoe L, Thomas H, Carey P, Junejo S, Addison C, Vernazza J, Austin D, Greenwood JP, Zaman A, Razvi S. Prevalence, Predictors and Outcomes of Thyroid Dysfunction in patients with Acute Myocardial Infarction: the ThyrAMI-1 Study. Journal of Endocrinological Investigation 2021, 44, 1209-1218.
- Razvi S, Arnott B, Teare D, Hiu S, OBrien N, Pearce SH. Multinational Survey of Treatment Practices of Clinicians Managing Subclinical Hypothyroidism in Older People in 2019. European Thyroid Journal 2021, 10(4), 330-338.
- Tee SA, Devine K, Potts A, Javaid U, Razvi S, Quinton R, Roberts G, Leech NJ. Iatrogenic hypoglycaemia following glucose-insulin infusions for the treatment of hyperkalaemia. Clinical Endocrinology 2021, 94(2), 176-182.
- Barr CE, Njoku K, Hotchkies L, Ryan NAJ, Wan YL, Davies DA, Razvi S, Crosbie EJ. Does Clinical and Biochemical Thyroid Dysfunction Impact on Endometrial Cancer Survival Outcomes? A Prospective Database Study. Cancers 2021, 13(21), 5444.
- Foo O, Hiu S, Teare D, Syed AA, Razvi S. A Global Country Level Analysis of The Relationship between Obesity and COVID-19 Cases and Mortality. Diabetes Obesity and Metabolism 2021, 23(12), 2697-2706.
- Bano A, Chaker L, Muka T, Mattace-Raso FUS, Bally LH, Franco O, Peeters RP, Razvi S. Thyroid function and the risk of fibrosis of the liver, heart and lung in humans: A systematic review and meta-analysis. Thyroid 2020, 30(6), 806-820.
- Razvi S, Leng O, Jabbar A, Bano A, Ingoe L, Addison C, Thomas H, Carey P, Junejo S, Austin D, Greenwood JP, Zaman A. Sample Timing, Diagnosis of Subclinical Thyroid Dysfunction and Mortality in Acute Myocardial Infarction: ThyrAMI1 Study. Journal of Clinical Endocrinology and Metabolism 2020, 105(4), e1299–e1306.
- Razvi S, Oliver R, Moore J, Beeby A. Exposure of hospital healthcare workers to the novel coronavirus (SARS-CoV-2). Clinical Medicine 2020, 20(6), e238-e240.
- Jabbar A, Ingoe L, Junejo S, Carey P, Addison C, Thomas H, Parikh JD, Austin D, Hollingsworth KG, Stocken DD, Pearce SHS, Greenwood JP, Zaman A, Razvi S. Effect of levothyroxine on left ventricular ejection fraction in patients with subclinical hypothyroidism and acute myocardial infarction: a randomized clinical trial. JAMA: The Journal of the American Medical Association 2020, 324(3), 249-258.
- Razvi S, Ryan V, Ingoe L, Pearce SH, Wilkes S. Age-related serum Thyroid Stimulating Hormone Reference range in Older Patients treated with Levothyroxine: a Randomized Controlled Feasibility Trial (SORTED 1). European Thyroid Journal 2020, 9, 40-48.
- Pearce SHS, Dayan C, Wraith DC, Barrell K, Olive N, Jansson L, Walker-Smith T, Carnegie C, Martin KF, Boelaert K, Gilbert J, Higham CE, Muller I, Murray RD, Perros P, Razvi S, Vaidya B, Wernig F, Kahaly GJ. Antigen-Specific Immunotherapy with Thyrotropin Receptor Peptides in Graves' Hyperthyroidism: A Phase I Study. Thyroid 2019, 29(7), 1003-1011.
- Razvi S, Korevaar TIM, Taylor PN. Trends, Determinants and Associations of Treated Hypothyroidism in the United Kingdom, 2005-2014 . Thyroid 2018, 29(2), 174-182.
- Ingoe LE, Hickey J, Pearce S, Rapley T, Razvi S, Wilkes S, Hrisos S. Older patients' experience of primary hypothyroidism: A qualitative study. Health Expectations 2018, 21(3), 628-635.
- Dew R, King K, Okosieme OE, Pearce SH, Donovan G, Taylor PN, Hickey J, Dayan CM, Leese G, Razvi S, Wilkes S. Attitudes and perceptions of health professionals towards management of hypothyroidism in general practice: a qualitative interview study. BMJ Open 2018, 8, e019970.
- Lane LC, Allinson KR, Campbell K, Bhatnagar I, Ingoe L, Razvi S, Cheetham T, Cordell HJ, Pearce SH, Mitchell AL. Analysis of BAFF gene polymorphisms in UK Graves' disease patients. Clinical Endocrinology 2018, 90(1), 170-174.
- Bano A, Gan E, Addison C, Narayanan K, Weaver JU, Tsatlidis V, Razvi S. Age may influence the impact of TRAbs on thyroid function and relapse-risk in patients with Graves’ disease. Journal of Clinical Endocrinology and Metabolism 2018, 104(5), 1378-1385.
- Jabbar A, Pingitore A, Pearce SHS, Zaman A, Iervasi G, Razvi S. Thyroid hormones and cardiovascular disease. Nature Reviews Cardiology 2017, 14, 39-55.
- Ingoe L, Phipps N, Armstrong G, Rajagopal A, Kamali F, Razvi S. Prevalence of treated hypothyroidism in the community: Analysis from general practices in North-East England with implications for the United Kingdom. Clinical Endocrinology 2017, 87(6), 860-864.
- Dew R, King K, Okosieme OE, Pearce S, Donovan G, Taylor P, Leese G, Hickey J, Razvi S, Dayan C, Wilkes S. Patients' attitudes and perceptions towards treatment of hypothyroidism in general practice: an in-depth qualitative interview study. BJGP Open 2017, 1(2), BJGP-2017-0125.
- Dew R, Okosieme O, Dayan C, Eligar V, Khan I, Razvi S, Pearce S, Wilkes S. Clinical, behavioural and pharmacogenomic factors influencing the response to levothyroxine therapy in patients with primary hypothyroidism-protocol for a systematic review. Systematic Reviews 2017, 6(1), 60.
- Razvi S, Ingoe L, Ryan V, Pearce SHS, Wilkes S. Study of Optimal Replacement of Thyroxine in the Elderly (SORTED) - results from the feasibility randomised controlled trial. Thyroid Research 2016, 9(1), 1-9.
- Jabbar A, Razvi S. Thyroid disease and vascular risk. Clinical Medicine 2014, 14(Suppl. 6), s29-s32.
- Razvi S, Shakoor A, Vanderpump M, Weaver JU, Pearce SHS. The influence of age on the relationship between subclinical hypothyroidism and ischemic heart disease: A metaanalysis. Journal of Clinical Endocrinology and Metabolism 2008, 93(8), 2998-3007.
- McMillan C, Bradley C, Razvi S, Weaver J. Evaluation of new measures of the impact of hypothyroidism on quality of life and symptoms: The ThyDQoL and ThySRQ. Value in Health 2008, 11(2), 285-294.
- Razvi S, Ingoe L, Keeka G, Oates C, McMillan C, Weaver JU. The beneficial effect of L-thyroxine on cardiovascular risk factors, endothelial function, and quality of life in subclinical hypothyroidism: Randomized, crossover trial. Journal of Clinical Endocrinology and Metabolism 2007, 92(5), 1715-1723.
- Razvi S, Vaidya B, Perros P, Pearce SHS. What is the evidence behind the evidence-base? The premature death of block-replace antithyroid drug regimens for Graves' disease. European Journal of Endocrinology 2006, 154(6), 783-786.
- McMillan C, Bradley C, Razvi S, Weaver J. Psychometric evaluation of a new questionnaire measuring treatment satisfaction in hypothyroidism: The ThyTSQ. Value in Health 2006, 9(2), 132-139.
- Razvi S, McMillan CV, Weaver JU. Instruments used in measuring symptoms, health status and quality of life in hypothyroidism: A systematic qualitative review. Clinical Endocrinology 2005, 63(6), 617-624.
- Razvi S, Ingoe LE, McMillan CV, Weaver JU. Health status in patients with sub-clinical hypothyroidism. European Journal of Endocrinology 2005, 152(5), 713-717.
- Razvi S, Basu A, McIntyre EA, Wahid ST, Bartholomew PH, Weaver JU. Low failure rate of fixed dose 400 MBq131I with pre-treatment with Carbimazole for thyrotoxicosis; The Gateshead protocol. Nuclear Medicine Communications 2004, 25(7), 675-682.
- Razvi S, Basu A, McIntyre EA, Wahid ST, Bartholomew PH, Weaver JU. Low failure rate of fixed administered activity of 400 MBq 131I with pre-treatment with carbimazole for thyrotoxicosis: The Gateshead protocol. Nuclear Medicine Communications 2004, 25(7), 675-682.
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Editorials
- Razvi S, Duntas L, Biondi B. Editorial: Treatment of Subclinical Thyroid Dysfunction in Patients with Comorbidities. Frontiers in Endocrinology 2023, 14, 1141612.
- Gan EH, Razvi S. The role of local thyroid hormone perturbation in hippocampal sclerosis dementia - commentary on a multi-modality study. Gland Surgery 2017, 6(6), 604-607.
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Letters
- Razvi S, Peeters R, Pearce SHS. Thyroid Hormone Therapy for Subclinical Hypothyroidism [Comment & Response]. JAMA - Journal of the American Medical Association 2019, 321(8), 804-805.
- Taylor P, Razvi S, Muller I, Wass J, Dayan C, Chatterjee K, Boelaert K. Liothyronine cost and prescriptions in England. The Lancet Diabetes and Endocrinology 2019, 7(1), 11-12.
- Razvi S, Pearce SHS. Subclinical Hypothyroidism and Cardiovascular Disease Reply. Archives of Internal Medicine 2012, 172(19), 1523-1524.
- Weaver JU, Razvi S. Dose of anti-thyroid drugs can effect remission in grave's disease. Endocrine Journal 2005, 52(1), 159-.
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Note
- Razvi S, Pearce SHS. Do antithyroid drugs influence outcome after radioiodine therapy for hyperthyroidism?. Nature Clinical Practice Endocrinology and Metabolism 2007, 3(9), 628-629.
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Reviews
- Urgatz B, Razvi S. Subclinical hypothyroidism, outcomes and management guidelines: a narrative review and update of recent literature. Current Medical Research and Opinion 2023, 39(3), 351-365.
- Chaker L, Razvi S, Bensenor IM, Azizi F, Pearce EN, Peeters RP. Hypothyroidism. Nature Reviews Disease Primers 2022, 8(30).
- Gottwald-Hostalek U, Razvi S. Getting the levothyroxine (LT4) dose right for adults with hypothyroidism: opportunities and challenges in the use of modern LT4 preparations. Current Medical Research and Opinion 2022, Epub ahead of print.
- Leng O, Razvi S. Treatment of subclinical hypothyroidism: assessing when treatment is likely to be beneficial. Expert Review of Endocrinology and Metabolism 2021, 16(2), 73-86.
- Alijla F, Buttia C, Reichlin T, Razvi S, Minder B, Wilhelm M, Muka T, Franco OH, Bano A. Association of diabetes with atrial fibrillation types: a systematic review and meta-analysis. Cardiovascular Diabetology 2021, 20(1), 230.
- Kwok S, Adam S, Hoong Ho J, Iqbal Z, Turkington P, Razvi S, Le Roux CW, Soran H, Syed AA. Obesity: A critical risk factor in the COVID‐19 pandemic. Clinical Obesity 2020, 10(6), e12403.
- Razvi S, Mrabeti S, Luster M. Managing symptoms in hypothyroid patients on adequate levothyroxine: a narrative review. Endocrine Connections 2020, 9(11), R241-R250.
- Razvi S, Hostalek U. Therapeutic challenges in the application of serum thyroid stimulating hormone testing in the management of patients with hypothyroidism on replacement thyroid hormone therapy: a review. Current Medical Research and Opinion 2019, 35(7), 1215-1220.
- Jonklaas J, Razvi S. Reference intervals in the diagnosis of thyroid dysfunction: treating patients not numbers. The Lancet Diabetes and Endocrinology 2019, 7(6), 473-483.
- Razvi S. Novel uses of thyroid hormones in cardiovascular conditions. Endocrine 2019, 66(1), 115–123.
- Leng O, Razvi S. Hypothyroidism in the older population. Thyroid Research 2019, 12(2).
- Razvi S, Bhana S, Mrabeti S. Challenges in Interpreting Thyroid Stimulating Hormone Results in the Diagnosis of Thyroid Dysfunction. Journal of Thyroid Research 2019, 4106816.
- Razvi S, Jabbar A, Pingitore A, Danzi S, Biondi B, Klein I, Peeters R, Zaman A, Iervasi G. Thyroid Hormones and Cardiovascular Function and Diseases. Journal of the American College of Cardiology 2018, 71(16), 1781-1796.