Staff Profile
Professor Simi Ali
Professor of Immunobiology
- Personal Website: http://www.ncl.ac.uk/biomedicine/research/groups/appliedimmuno.htm
- Address: Theme: Immunity and Inflammation
Translational and Clinical Research Institute
Faculty of Medical Sciences
3rd Floor Leech Building
Newcastle University
NE2 4HH
Roles and Responsibilities
I have held senior management responsibilities within the University and Institute and also serve on external Scientific Committees. For example:
Faculty Membership
Deputy Dean For Research and Innovation (2024-2027)
EPSRC Centre for Doctoral Training in Molecular Sciences for Medicine (MoSMed), (Co-director, lead for Faculty of Medical Sciences) January 2019-2026.
Member of MRes exam committee. (2007-present)
External Committees
Member of Northern Counties Kidney Research Fund Scientific Committee (2011-present)
Panel Member for National Athena SWAN (Equality Challenge Unit)
Past Membership
Member of Faculty Promotion Committee (2015-18)
Mentor for Faculty Future's Programme (2014-2020)
University appointed Governor for Royal Grammar School (2010-2018).
Member of Institute of Cellular Medicine Executive Board (2012-15)
Member of University Senate (2009-2012).
ICM Post-graduate coordinator (2004-2011).
ICM Athena SWAN lead (2011-2017)
Areas of expertise
Transplantation, Ischaemia reperfusion injury, ex vivo organ perfusion; endothelial permeability, Chemokines & their interaction with Glycosaminoglycans
Qualifications
1984 BSc Chemistry (1st Class Honours). AMU, Aligarh, India.
1986 MSc Biochemistry (1st Class). AMU, Aligarh, India.
1991 PhD Biochemistry. Central Drug Research Institute, Lucknow, India
Previous Positions
1990-91 Commonwealth Post-doctoral Fellow in Molecular Biology at UMIST, Manchester, UK.
1992-95 Post-doctoral Fellow at Department of Biological Sciences, University of Newcastle upon Tyne. Project funded by Biotechnology and Biological Sciences Research Council.
1995 (Sept) Lecturer in Molecular Biology of Organ Transplantation, Department of Surgery, University of Newcastle Upon Tyne. (Funded by Northern Counties Kidney Research Fund).
1999(Sept) Lecturer B, Department of Surgery (HEFCE funded)
2002 Senior Lecturer
2007 Reader in Immunobiology
2011 Professor of Molecular Immunology
Memberships
British Society of Immunology, British Transplantation Society
Honours and Awards
1. Award for Excellence in Science technology and Engineering (Muslim News)-Presented by: Rt Hon Ed Miliband MP, Leader of the Labour Party, London, March 2015.
2. Exhibition at Hatton's gallery on Inspirational Women of North East from 3rd October -20th December, 2013-I have been used as one of the examples. http://www.iwne.org/
3. I was awarded special recognition award by Roche Organ Transplantation research Fund for my contribution to research in Transplantation (cash award of 1000 Swiss Francs)-April 2011.
4. Member of Northern Counties Kidney Research Fund Scientific Sub-Committee.
5. Member of panel for ICM Grant Review System.
6. Regularly review grants for MRC, BBSRC, Cancer Research UK, British Heart Foundation, Wellcome, Asthma UK Foundation and Singapore Biomedical Research Council.
6. Institute of Cellular Medicine was awarded Athena SWAN silver award-June 2013 & 2016 (I was the academic lead for this application).
7. Editorial Board Member for
· Scientific Reports
· Mediators of Inflammation
Frontiers in Alloimmunity and Transplantation
Research Interests
My group has a strong background in understanding the mechanisms of inflammation following transplantation (PMID:36622452, 30794825). My recent work has demonstrated therapeutic potential of sphingosine-1-phosphate receptor agonism during IRI (PMID: 37446370).
I am also involved in development of methods to improve the quality of transplant organs (PMID:32506663, 34932895) and lead on an NIHR-EME (2023-26) exploring the underlying mechanistic pathways that confer statin induced organ protection in recipients.
I have contributed to 4 patents, including a recent application for use of bioreactor linked with ex vivo perfusion (P78261GB).
Research Roles
I currently supervise Post-doctoral Fellow, Research associate, PhD students, MD students and technician. I regularly take Mres and undergraduate project students.
I referee grants regularly from British Heart Foundation, BBSRC etc and have been appointed as examiner (internal/external) regularly for PhD as well as MD thesis. Furthermore, I am also involved in the annual assessment of PhD and MD students within the School/Faculty.
Postgraduate Supervision
I have successfully supervised 28 PhD students (17 as lead supervisor and 11 as Co-supervisor).
Currently, I supervise 4 PhD students as a Primary research supervisor and 4 as co-supervisor. I also supervise 2 postdoctoral research associates, 4MRes/MSc students and 2 technicians.
Esteem Indicators
1. Merit award by Newcastle University in recognition of my achievements in Research and innovation and overall contribution to University (August 2022).
2. Award for Excellence in Science technology and Engineering (Muslim News)-Presented by Rt Hon Ed Miliband MP, Leader of the Labour Party, London, March 2015.
3. Exhibition at Hatton's gallery on Inspirational Women of North East from 3rd October -20th December, 2013-I have been used as one of the examples. http://www.iwne.org/
4. I was awarded special recognition award by Roche Organ Transplantation research Fund for my contribution to research in Transplantation (cash award of 1000 Swiss Francs)-April 2011.
5. Awarded Commonwealth Post-doctoral Fellowship, Manchester University, 1991.
Recent Presentation at Conference/invited talk/Awards to me & group members
· Oral presentation at European Society of Organ Transplantation (ESOT), 29 June-2 July'2025, London, UK.
· Oral presentation at the Transplantation Society 2024 meeting in Istanbul, Turkey (September 22-25)
· Invited speaker at European Chemokine and Cell Migration Conference (ECMC) September’2023, Belgium.
· Invited Speaker UK Proteoglycan meeting, Leeds, 12.01.2023.
· Invited speaker at British Transplant Research Unit Conference, Cambridge, UK, October’2022.
Group members:
• Jenny Gilmour (Post-doc), awarded Young Investigator Award by European Society for Heart and Lung Transplantation, January 2024.
• 4 group members short listed for oral presentation at British Transplantation Society, March 2024.
• Lu Wang: Oral presentation at BTS 2023. Hypothermic Oxygenated Perfusion to Improve Donor Heart Quality
• PhD student (Emily Thompson) awarded Medical Faculty Doctoral thesis award (2022).
• Emily Thompson won the Leonardo da Vinci award at the European Society of Transplantation. September 2019.
• Dr Thompson (my PhD student) received the Medawar medal from the British Transplantation Society, 2019.
• Tom Pither presented his work at Medawar Medal presentation during British Transplantation Society Annual Congress 2020.
Current Funding:
1. MRC. Repurposing existing Sphingosine-1-phosphate receptor modulators to reduce risk of primary graft dysfunction (PGD) after lung transplantation £405,493 (S Ali, A Fisher, J Dark). 1.09.2025-31.08.2028.
2. NIHR-EME. Examine the mechanisms in the potential downregulation of brain stem death induced proinflamatory responses by Simvastatin £340,000 (PI S Ali) 01.04.2023-31.03.2026.
3. BHF Non-clinical PhD Studentship. “Attenuation of damage to endothelium in transplanted heart by targeting the IL-6 /S1P signalling axis. (Simi Ali, £120,000, January 2025-Janurary 2028).
4. British Heart Foundation. Role of human amniotic epithelial cell derived extracellular vesicles in reducing ischaemia-reperfusion injury in human donor hearts. John Dark & Simi Ali, £164,000, 1.09.2024-31.08.2027.
5. NIHR-HTA. Statins in Organ Donor Management An evaluation of the benefits of giving a single dose of Simvastatin to brain-stem dead organ donors on outcomes in recipients of organs from the donor. £1,427,129. 1.10.2020-30.06.2026 (Co-Applicant, PI-John Dark).
6. Welcome 4ward North. Role of human amniotic epithelial cell derived extracellular vesicles in reducing ischaemia reperfusion injury in human donor lungs. CTRF awarded to Nick Chilvers. £210,000 1.08.2023-31.07.2025. (Supervisor).
7. MRC. Hollow-fiber bioreactor technology to explore mechanisms and delivery of cellular therapy during machine perfusion of donated human kidneys. CTRF awarded to Sam Tingle. £210,000. 1.08.2023-31.07.2026 (Supervisor).
8. NIHR-Blood and Transplant research Unit. Organ Donation and Transplantation £1,814,890 (Co-applicant, PI-Andrew Fisher) 1.04.2022-31.03.2027.
9. Fight for sight. Limbal stem cell deficiency. £249,889 01.05.2022-30.04.2025.(Co-applicant, PI-Lyle Armstrong).
10. EPSRC, M Waring. EPSRC Centre for Doctoral Training in Molecular Sciences for Medicine. £6,916,264. (S Ali- Co-applicant and lead for Medical School awarded two studentship in my group~£240,000). 01.09.2019-31.08.2026.
11. ERC, Off-the-shelf hypoimmunogenic photoreceptors for treatment of blinding retinal disease.(Co-Applicant, PI M Lako) £2,116,789, 01.06.2023-31.05.2028.
Patents
- PCT/GB2005/002184 (Filing date: 3rd June 2005), non-GAG binding chemokine receptor agonists CCL7, which may be used to treat inflammatory conditions. (Ali S and Kirby JA).
- .Inventor on European patent application 07450189.1-2406, SDF-1 based glycosaminoglycan antagonists and method of using same. (Kungl A, Werner, I, Slingsby, J, Ali, S, Kirby, JA).
- Use of bioreactor linked with ex vivo perfusion (P78261GB).
Postgraduate Teaching
Mres Applied Immunobiology of Human Disease (20 credits) MMB8015, Strand leader: I designed this multi-disciplinary module, drawing upon the specialized expertise and research strengths of academic staff in Medical faculty in 2006. I stepped down from being a Module leader (2009/10) but I have retained the position of strand leader. This involves allocating the project to students stranding in AIB, nominating both external and internal examiners for the dissertation. Additionally, I give two lectures on the AIB module and also assess the oral presentations. (Marking includes essay, exam scripts and Mres thesis)
PGY805 MRes in Medical & Molecular Biosciences (Transplantation Sciences) (Lecture 2h, Course work/tutorial 5h)
Undergraduate Teaching
BMS 3007 RESEARCH IN BIOMEDICAL SCIENCES (Lecture 4h, course work 2h).
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Articles
- Tingle SJ, Connelly C, Glover EK, Stenberg B, Mcneill A, Kourounis G, Gibson BG, Mahendran B, Bates L, Cooper M, Pook R, Lee S, Brown ML, Figueiredo R, Marchbank KJ, Ali S, Sheerin N, Wilson CH, Thompson ER. Contrast-enhanced ultrasound to assess kidney quality during ex situ normothermic machine perfusion. Transplant International 2025. In Press.
- Li X, Rong K, Shi X. Situating artificial intelligence in organization: A human-machine relationship perspective. Journal of Digital Economy 2024, 2, 330-335.
- Figueiredo GS, Hogg J, Okonkwo A, Baylis OJ, Berry M, Ali S, Lako M, Figueiredo FC. Understanding Ocular Surface Inflammation in Tears Before and After Autologous Cultivated Limbal Epithelial Stem Cell Transplantation. Ophthalmology and Therapy 2023, 12, 1097–1107.
- Thompson S, Pang CY, Sepuru KM, Cambier S, Hellyer TP, Scott J, Simpson AJ, Proost P, Kirby JA, Rajarathnan K, Sheerin NS, Ali S. Nitration of Chemokine CXCL8 acts as a natural mechanism to limit acute inflammation. Cellular and Molecular Life Sciences 2023, 80, 35.
- Pither T, Wang L, Bates L, Morrison M, Charlton C, Griffiths C, Macdonald J, Bigley V, Mavridou M, Barsby J, Borthwick L, Dark J, Scott W, Ali S, Fisher AJ. Modeling the Effects of IL-1β-mediated Inflammation During Ex Vivo Lung Perfusion Using a Split Human Donor Model. Transplantation 2023, 107(10), 2179-2189.
- Wilkins GC, Gilmour J, Giannoudaki E, Kirby JA, Sheerin NS, Ali S. Dissecting the Therapeutic Mechanisms of Sphingosine-1-Phosphate Receptor Agonism during Ischaemia and Reperfusion. International Journal of Molecular Sciences 2023, 24(13), 11192.
- Thompson ER, Sewpaul A, Figuereido R, Bates L, Tingle SJ, Ferdinand JR, Situmorang GR, Ladak SS, Connelly CM, Hosgood SA, Nicholson ML, Clatworthy MR, Ali S, Wilson CH, Sheerin NS. MicroRNA antagonist therapy during normothermic machine perfusion of donor kidneys . American Journal of Transplantation 2022, 22(4), 1088-1100.
- Marsh SA, Park C, Redgrave RE, Singh E, Draganova L, Boag SE, Spray L, Ali S, Spyridopoulos I, Arthur HM. Rapid fall in circulating non-classical monocytes in ST elevation myocardial infarction patients correlates with cardiac injury. FASEB Journal 2021, 35(5), e21604.
- Thompson ER, Bates L, Ibrahim IK, Sewpaul A, Stenberg B, McNeill A, Figueiredo R, Girdlestone T, Wilkins GC, Tingle SJ, Scott WE, Lamos H, Mellor AL, Roobrouck VD, Ting AE, Hosgood SA, Nicholson ML, Fisher AJ, Ali S, Sheerin NS, Wilson CH. Novel delivery of cellular therapy to reduce ischaemia reperfusion injury in kidney transplantation. American Journal of Transplantation 2021, 21(4), 1402-1414.
- Jordan NP, Tingle SJ, Shuttleworth VG, Cooke K, Redgrave RE, Singh E, Glover EK, Tajuddin HBA, Kirby JA, Arthur HM, Ward C, Sheerin NS, Ali S. MiR-126-3p Is Dynamically Regulated in Endothelial-to-Mesenchymal Transition during Fibrosis. International Journal of Molecular Sciences 2021, 22(16), 8629.
- Del Molino Del Barrio I, Meeson A, Cooke K, Malki MI, Barron-Millar B, Kirby JA, Ali S. Contribution of heparan sulphate binding in CCL21-mediated migration of breast cancer cells. Cancers 2021, 13(14), 3462.
- Coelho-Lima J, Mohammed A, Cormack S, Jones S, Ali A, Panahi P, Barter M, Bagnall A, Ali S, Young D, Spyridopoulos I. Kinetics Analysis of Circulating MicroRNAs Unveils Markers of Failed Myocardial Reperfusion. Clinical Chemistry 2020, 66(1), 247-256.
- Wang L, MacGowan GA, Ali S, Dark JH. Ex situ heart perfusion: The past, the present, and the future. Journal of Heart and Lung Transplantation 2020, 40(1), 69-86.
- Tingle SJ, Sewpaul A, Bates L, Thompson ER, Shuttleworth V, Figueiredo R, Ibrahim IK, Ali S, Wilson C, Sheerin NS. Dual microRNA blockade increases expression of antioxidant protective proteins; implications for ischaemia reperfusion injury. Transplantation 2020, 104(9), 1853-1861.
- Ladak SS, Roebuck E, Powell J, Fisher AJ, Ward C, Ali S. The role of miR-200b-3p in modulating TGF-β1 induced injury in human bronchial epithelial cells. Transplantation 2019, 103(11), 2275-2286.
- Ferreras L, Moles A, Situmorang G, el Masri R, Wilson I, Cooke K, Thompson E, Kusche-Gullberg M, Vivès M, Sheerin N, Ali S. Heparan sulfate in chronic kidney diseases: exploring the role of 3-O-sulfation. Biochimica et Biophysica Acta (BBA) - General Subjects 2019, 1863(5), 839-848.
- Martinez-Burgo B, Cobb S, Pohl E, Kashanin D, Paul T, Kirby JA, Sheerin N, Ali S. A C-terminal CXCL8 peptide based on chemokine-glycosaminoglycan interactions reduces neutrophil adhesion and migration during inflammation. Immunology 2019, 157(2), 173-184.
- Aldhahrani A, Powell J, Ladak S, Ali M, Ali S, Verdon B, Pearson J, Ward C. The Potential Role of Bile Acids in Acquired Laryngotracheal Stenosis. The Laryngoscope 2018, 128(9), 2029-2033.
- Glover EK, Jordan N, Sheerin NS, Ali S. Regulation of Endothelial-to-Mesenchymal Transition by MicroRNAs in Chronic Allograft Dysfunction. Transplantation 2018, 103(4), e64-e73.
- Coelho-Lima J, Mohammed A, Cormack S, Jones S, Das R, Egred M, Panahi P, Ali S, Spyridopoulos I. Overcoming Heparin-Associated RT-qPCR Inhibition and Normalization Issues for microRNA Quantification in Patients with Acute Myocardial Infarction. Thrombosis and Haemostasis 2018, 118(7), 1257-1269.
- del Molino del Barrio I, Wilkins GC, Meeson A, Ali S, Kirby JA. Breast Cancer: An Examination of the Potential of ACKR3 to Modify the Response of CXCR4 to CXCL12. International Journal of Molecular Sciences 2018, 19(11), 3592.
- Andreasson ASI, Borthwick LA, Gillespie C, Jiwa K, Scott J, Henderson P, Mayes J, Romano R, Roman M, Ali S, Fildes JE, Marczin N, Dark JH, Fisher AJ, on behalf of the DEVELOP-UK Investigators. The role of interleukin-1β as a predictive biomarker and potential therapeutic target during clinical ex vivo lung perfusion. Journal of Heart and Lung Transplantation 2017, 36(9), 985-995.
- Andreasson ASI, Karamanou DM, Gillespie CS, Özalp F, Butt T, Hill P, Jiwa K, RWalden H, Green NJ, Borthwick LA, Clark SC, Pauli H, Gould KF, Corris PA, Ali S, Dark JH, Fisher AJ. Profiling inflammation and tissue injury markers in perfusate and bronchoalveolar lavage fluid during human ex vivo lung perfusion. European Journal of Cardio-thoracic Surgery 2017, 51(3), 577-586.
- Barker CE, Thompson S, O'Boyle G, Lortat-Jacob H, Sheerin NS, Ali S, Kirby JA. CCL2 nitration is a negative regulator of chemokine-mediated inflammation. Scientific Reports 2017, 7, 44384.
- Shaharuddin B, Ahmad S, MdLatar N, Ali S, Meeson A. A Human Corneal Epithelial Cell Line Model for LimbalStem Cell Biology and Limbal Immunobiology. Stem Cells Translational Medicine 2017, 6(3), 761-766.
- Shaharuddin B, Osei-Bempong C, Ahmad S, Rooney P, Ali S, Oldershaw R, Meeson A. Human limbal mesenchymal stem cells express ABCB5 and can grow on amniotic membrane. Regenerative Medicine 2016, 11(3), 273-286.
- Hjortø GM, Larsen O, Steen A, Daugvilaite V, Berg C, Fares S, Hansen M, Ali S, Rosenkilde MM. Differential CCR7 Targeting in Dendritic Cells by Three Naturally Occurring CC-Chemokines. Frontiers in Immunology 2016, 7, 568.
- Singh Dang T, Willet JDP, Griffin HR, Morgan NV, O'Boyle G, Arkwright PD, Hughes SM, Abinun M, Tee LJ, Barge D, Engelhardt KR, Jackson M, Cant AJ, Maher ER, Santibanez Koref M, Reynard LN, Ali S, Hambleton S. Defective Leukocyte Adhesion and Chemotaxis Contributes to Combined Immunodeficiency in Humans with Autosomal Recessive MST1 Deficiency. Journal of Clinical Immunology 2016, 36(2), 117-122.
- Gschwandtner M, Trinker MU, Hecher B, Adage T, Ali S, Kungl AJ. Glycosaminoglycan silencing by engineered CXCL12 variants. FEBS Letters 2015, 589(19), 2819-2824.
- Alhasan AA, Spielhofer J, Kusche-Gullberg M, Kirby JA, Ali S. Role of 6-O-Sulfated Heparan Sulfate in Chronic Renal Fibrosis. Journal of Biological Chemistry 2014, 289(29), 20295-20306.
- Shaharuddin B, Harvey I, Ahmad S, Ali S, Meeson A. Characterisation of Human Limbal Side Population Cells Isolated Using an Optimised Protocol From an Immortalised Epithelial Cell Line and Primary Limbal Cultures. Stem Cell Reviews and Reports 2014, 10(2), 240-250.
- Douglass A, Meeson AP, Overbeck-Zubrzycka D, Brain JG, Bennett MR, Lamb CA, Lennard TWJ, Browell D, Ali S, Kirby JA. Breast cancer metastasis: demonstration that FOXP3 regulates CXCR4 expression and the response to CXCL12. The Journal of Pathology 2014, 234(1), 74-85.
- Pekalski M, Jenkinson SE, Willet JDP, Poyner EFM, Alhamidi AH, Robertson H, Ali S, Kirby JA. Renal allograft rejection: Examination of delayed differentiation of Treg and Th17 effector T cells. Immunobiology 2013, 218(3), 303-310.
- Willet JDP, Pichitsiri W, Jenkinson SE, Brain JG, Wood K, Alhasan AA, Spielhofer J, Robertson H, Ali S, Kirby JA. Kidney transplantation: analysis of the expression and T cell-mediated activation of latent TGF-β. Journal of Leukocyte Biology 2013, 93(4), 471-478.
- Saleki M, Colgin N, Kirby JA, Cobb SL, Ali S. Evaluation of two cyclic di-peptides as inhibitors of CCL2 induced chemotaxis. MedChemComm 2013, 4(5), 860-864.
- Naemi FMA, Carter V, Kirby JA, Ali S. Anti-Donor HLA Class I Antibodies: Pathways to Endothelial Cell Activation and Cell-Mediated Allograft Rejection. Transplantation 2013, 96(3), 258-266.
- Mavin E, Ahmed SS, O'Boyle G, Turner B, Douglass S, Collin M, Ali S, Dickinson A, Wang X-N. Regulatory T Cells Inhibit CD8+ T-Cell Tissue Invasion in Human Skin Graft-Versus-Host Reactions. Transplantation 2012, 94(5), 456-464.
- Swan DJ, Kirby JA, Ali S. Post-Transplant Immunosuppression: Regulation of the Efflux of Allospecific Effector T Cells from Lymphoid Tissues. PLoS One 2012, 7(9), e45548.
- O'Boyle G, Fox CR, Walden HR, Willet JD, Mavin ER, Hine DW, Palmer JM, Barker CE, Lamb CA, Ali S, Kirby JA. Chemokine receptor CXCR3 agonist prevents human T-cell migration in a humanized model of arthritic inflammation. Proceedings of the National Academy of Sciences 2012, 109(12), 4598-4603.
- O'Boyle G, Ali S, Kirby JA. Chemokines in transplantation: what can atypical receptors teach us about anti-inflammatory therapy?. Transplantation Reviews 2011, 25(4), 136-144.
- Naemi FMA, Ali S, Kirby JA. Antibody-mediated allograft rejection: The emerging role of endothelial cell signalling and transcription factors. Transplantation Immunology 2011, 25(2-3), 96-103.
- Ali S, O'Boyle G, Hepplewhite P, Tyler JR, Robertson H, Kirby JA. Therapy with Nonglycosaminoglycan-Binding Mutant CCL7: A Novel Strategy to Limit Allograft Inflammation. American Journal of Transplantation 2010, 10(1), 47-58.
- Bradford L, Marshall H, Robertson H, Kirby JA, Graham G, Ali S, O'Boyle G. Cardiac Allograft Rejection: Examination of the Expression and Function of the Decoy Chemokine Receptor D6. Transplantation 2010, 89(11), 1411-1416.
- Newton P, O'Boyle G, Jenkins Y, Ali S, Kirby JA. T cell extravasation: Demonstration of synergy between activation of CXCR3 and the T cell receptor. Molecular Immunology 2009, 47(2-3), 485-492.
- O'Boyle G, Mellor P, Kirby JA, Ali S. Anti-inflammatory therapy by intravenous delivery of non-heparan sulfate-binding CXCL12. FASEB Journal 2009, 23(11), 3906-3916.
- Al-Hamidi A, Pekalski M, Robertson H, Ali S, Kirby JA. Renal allograft rejection: The contribution of chemokines to the adhesion and retention of αE(CD103)β7 integrin-expressing intratubular T cells. Molecular Immunology 2008, 45(15), 4000-4007.
- Ali S, Jenkins Y, Kirkley M, Dagkalis A, Manivannan A, Crane IJ, Kirby JA. Leukocyte extravasation: An immunoregulatory role for α-L-Fucosidase?. Journal of Immunology 2008, 181(4), 2407-2413.
- Mellor, P., Harvey, J., Murphy, K, Pye, D., O'Boyle, G, Lennard, T.W.J., Kirby, J., Ali, S. Modulatory effects of heparin and short-length oligosaccharides of heparin on the metastasis and growth of LMD MDA-MB 231 breast cancer cells in vivo. British Journal of Cancer 2007, 97(6), 761-768.
- Harvey, J., Mellor, P., Eldaly, H., Lennard, T.W.J., Kirby, J., Ali, S. Inhibition of CXCR4-mediated breast cancer metastasis: A potential role for heparinoids?. Clinical Cancer Research 2007, 13(5), 1562-1570.
- Ali S, Lazennec G. Chemokines: Novel targets for breast cancer metastasis. Cancer and Metastasis Reviews 2007, 26(3-4), 401-420.
- O'Boyle G, Brain JG, Kirby JA, Ali S. Chemokine-mediated inflammation: Identification of a possible regulatory role for CCR2. Molecular Immunology 2007, 44(8), 1954-1963.
- Ali S, Malik G, Burns A, Robertson H, Kirby JA. Renal transplantation: Examination of the regulation of chemokine binding during acute rejection. Transplantation 2005, 79(6), 672-679.
- Ali S, Robertson H, Wain JH, Isaacs JD, Malik G, Kirby JA. A non-glycosaminoglycan-binding variant of CC chemokine ligand 7 (monocyte chemoattractant protein-3) antagonizes chemokine-mediated inflammation. Journal of Immunology 2005, 175(2), 1257-1266.
- Hardy LA, Booth TA, Lau EK, Handel TM, Ali S, Kirby JA. Examination of MCP-1 (CCL2) partitioning and presentation during transendothelial leukocyte migration. Laboratory Investigation 2004, 84(1), 81-90.
- Robertson H, Ali S, McDonnell BJ, Burt AD, Kirby JA. Chronic Renal Allograft Dysfunction: The Role of T Cell-Mediated Tubular Epithelial to Mesenchymal Cell Transition. Journal of the American Society of Nephrology 2004, 15(2), 390-397.
- Wong WK, Robertson H, Carroll H, Ali S, Kirby JA. Tubulitis in renal allograft rejection: role of TGFb and IL-15 in development and maintenance of CD103+T cells. Transplantation 2003, 75(4), 505-514.
- Rao JN, Clark SC, Ali S, Kirby J, Flecknell PA, Dark JH. Improvements in lung compliance after pulmonary transplantation: Correlation with interleukin 8 expression. European Journal of Cardio-thoracic Surgery 2003, 23(4), 497-502.
- Carter NM, Ali S, Kirby JA. Endothelial inflammation: The role of differential expression of N-deacetylease/N-sulphotransferase enzymes in alteration of the immunological properties of heparan sulphate. Journal of Cell Science 2003, 116(17), 3591-3600.
- Carter N, Ali S, Kirby JA. Endothelial inflammation: the role of differential expression of N-deacetylase/N-sulphotransferase enzymes in alteration of the immunological properties of heparan sulphate. Journal of Cell Science 2003, 116(7), 3591.
- Wain JH, Kirby JA, Ali S. Leucocyte chemotaxis: Examination of mitogen-activated protein kinase and phosphoinositide 3-kinase activation by Monocyte Chemoattractant Proteins-1, -2, -3 and -4. Clinical and Experimental Immunology 2002, 127(3), 436-444.
- Ali S, Fritchley SJ, Chaffey BT, Kirby JA. Contribution of the putative heparan sulfate-binding motif BBXB of RANTES to transendothelial migration. Glycobiology 2002, 12(9), 535-543.
- Ali S, Palmer ACV, Fritchley SJ, Maley Y, Kirby JA. Multimerization of monocyte chemoattractant protein-1 is not required for glycosaminoglycan-dependent transendothelial chemotaxis. Biochemical Journal 2001, 358(3), 737-745.
- Carroll HP, Ali S, Kirby JA. Accelerating the induction of Fas-mediated T cell apoptosis: A strategy for transplant tolerance?. Clinical and Experimental Immunology 2001, 126(3), 589-597.
- Ali S, Palmer ACV, Banerjee B, Fritchley SJ, Kirby JA. Examination of the function of RANTES, MIP-1α, and MIP-1β following interaction with heparin-like glycosaminoglycans. Journal of Biological Chemistry 2000, 275(16), 11721-11727.
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Conference Proceedings (inc. Abstracts)
- Figueiredo G, Hogg J, Okonkwo A, Stocken D, Ali S, Lako M, Figueiredo F. Understanding ocular surface inflammation in tears before and after ex vivo expanded autologous limbal stem cell transplantation. In: ARVO Annual Meeting 2016. 2016, Seattle Washington USA: ARVO.
- Thompson S, Redgrave R, Kirby J, Arthur H, Ali S. Modulation of wound healing post-myocardial infarction. In: British Society for Immunology Annual Congress. 2014, Brighton, UK: Wiley-Blackwell.
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Editorial
- Ali S, Sheerin NS. Biomarkers of acute injury: predicting the long-term outcome after transplantation. Kidney International 2013, 84(6), 1072-1074.
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Letters
- O'Boyle G, Ali S, Kirby JA. Comment on "CXCL19 causes heterologous desensitization of CXCL12-mediated memory T cell activation". Journal of Immunology 2013, 191(2), 525.
- Nilsson J, Ali S, Harvey I, Kirby J, Meeson A. Stem cell therapy: a role for CXCR4 in homing bone marrow side population cells to areas of myocardial damage. International Journal of Cardiology 2010, 145(3), 554-555.
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Notes
- del Molino del Barrio I, Wilkins GC, Meeson A, Ali S, Kirby JA. Correction to: Breast Cancer: An Examination of the Potential of ACKR3 to Modify the Response of CXCR4 to CXCL12 (International Journal of Molecular Sciences, (2018), 19, 11, (3592), 10.3390/ijms19113592). International Journal of Molecular Sciences 2023, 24(23), 17108.
- Hjorto GM, Larsen O, Steen A, Daugvilaite V, Berg C, Fares S, Hansen M, Ali S, Rosenkilde MM. Differential CCR7 targeting in Dendritic Cells by three naturally occurring CC-Chemokines (vol 7, 568, 2016). Frontiers in Immunology 2017, 8, 89.
- Dang TS, Willet JDP, Griffin HR, Morgan NV, O'Boyle G, Arkwright PD, Hughes SM, Abinun M, Tee LJ, Barge D, Engelhardt KR, Jackson M, Cant AJ, Maher ER, Koref MS, Reynard LN, Ali S, Hambleton S. Erratum to: Defective Leukocyte Adhesion and Chemotaxis Contributes to Combined Immunodeficiency in Humans with Autosomal Recessive MST1 Deficiency (vol 36, pg 117, 2016). Journal of Clinical Immunology 2016, 36(3), 336-337.
- Douglass S, Ali S, Meeson AP, Browell D, Kirby JA. Erratum to: The role of FOXP3 in the development and metastatic spread of breast cancer (vol 31, pg 843, 2012). Cancer and Metastasis Reviews 2013, 32(3-4), 763-763.
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Reviews
- Thompson ER, Connelly C, Ali S, Sheerin N, Wilson C. Cell therapy during machine perfusion. Transplant International 2021, 34(1), 49-58.
- Griffiths C, Scott III WE, Ali S, Fisher AJ. Normothermic machine perfusion: a platform to assess and treat donor organs ex-situ with novel therapeutics prior to transplantation. QJM: An International Journal of Medicine 2020. In Press.
- Thompson S, Martinez-Burgo B, Sepuru KM, Rajarathnam K, Kirby JA, Sheerin NS, Ali S. Regulation of chemokine function: The roles of GAG-binding and post-translational nitration. International Journal of Molecular Sciences 2017, 18(8), 1692.
- del Barrio ID, Kirby J, Ali S. The Role of Chemokine and Glycosaminoglycan Interaction in Chemokine-Mediated Migration In Vitro and In Vivo. Methods in Enzymolgy 2016, 570, 309-333.
- Ladak SS, Ward C, Ali S. The potential role of microRNAs in lung allograft rejection. Journal of Heart and Lung Transplantation 2016, 35(5), 550-9.
- Ferreras L, Sheerin NS, Kirby J, Ali S. Mechanisms of renal graft chronic injury and progression to interstitial fibrosis. Current Transplantation Reports 2015, 2, 259-268.
- Barker CE, Ali S, O'Boyle G, Kirby JA. Transplantation and inflammation: implications for the modification of chemokine function. Immunology 2014, 143(2), 138-145.
- Shaharuddin B, Ahmad S, Meeson A, Ali S. Immunological Properties of Ocular Surface and Importance of Limbal Stem Cells for Transplantation. Stem Cells Translational Medicine 2013, 2(8), 614-624.
- Douglass S, Ali S, Meeson AP, Browell D, Kirby JA. The role of FOXP3 in the development and metastatic spread of breast cancer. Cancer and Metastasis Reviews 2012, 31(3-4), 843-854.
- Swan DJ, Kirby JA, Ali S. Vascular biology: the role of sphingosine 1-phosphate in both the resting state and inflammation. Journal of Cellular and Molecular Medicine 2010, 14(9), 2211-2222.
- Ali S, O'Boyle G, Mellor P, Kirby JA. An apparent paradox: Chemokine receptor agonists can be used for anti-inflammatory therapy. Molecular Immunology 2007, 44(7), 1477-1482.
- Ali S, Hardy LA, Kirby JA. Transplant immunobiology: A crucial role for heparan sulfate glycosaminoglycans?. Transplantation 2003, 75(11), 1773-1782.
- Dowsland, M., Harvey, J., Lennard, T.W.J., Kirby, J.A., Ali, S. Chemokines and breast cancer: A gateway to revolutionary targeted cancer treatments?. Current Medicinal Chemistry 2003, 10(7), 579-592.