Staff Profile
Dr Simon Tual-Chalot
Research Associate
- Email: simon.tual-chalot@ncl.ac.uk
- Personal Website: https://twitter.com/SimonTualChalot
- Address: Biosciences Institute
Theme Vascular Biology & Medicine
Faculty of Medical Sciences
Newcastle University
Central Parkway
Newcastle upon Tyne
NE1 3BZ
My research focusses on understanding the function of vascular cells in health and disease by combining fundamental vascular biology with method development.
Graduate student, University of Angers, France, 2008-2011
During my PhD, financed by a grant awarded by the French Ministry of Research, I revealed for the first time the importance of extracellular vesicles in driving the vascular dysfunction in diseases associated with hypoxia (Am J Respir Crit Care Med. 2010; Am J Pathol. 2012; Biochim Biophys Acta. 2014).
Post-doc, Arthur Lab, Newcastle University, 2012-2015
Supported by a Marie Curie fellowship, I first established the mandatory role of Alk1, a receptor for the TGF/BMP family, in the maintenance of vascular integrity (PLoS One. 2014) and then demonstrated the essential cardioprotective role of endoglin, Alk1 co-receptor, in cardiosphere derived cells after myocardial infarction (Stem Cell Reports. 2017). This work was highlighted in Horizon, the EU Research & Innovation Magazine. Within these studies, I optimised technologies and tools now widely used by the research community to assess angiogenesis in vivo (J Vis Exp. 2013) and vascular remodelling after myocardial infarction by imaging (Int J Cardiol Heart Vasc. 2016).
Post-doc, Arthur Lab, Newcastle University, 2015-2018
In this work, using funding obtained from the British Heart Foundation as Co-Investigator and my Young Investigator Award from Cure HHT, I have demonstrated for the first time how endoglin regulates the adult vasculature while its absence leads to a deleterious impact on heart function (Circ Res. 2020). In parallel, I contributed to deciphering the vascular senescence process in age-related cardiovascular diseases (EMBO. 2019; Aging Cell. 2019).
Post-doc, Stellos Lab, Newcastle University, October 2018-present
I am currently studying the role of RNA-based mechanisms in vascular endothelial cell homeostasis and disease.
Research Funding:
2020-2021 British Society for Research on Ageing consumable grant, £500
The Alzheimer’s disease Amyloid-beta hypothesis in vascular ageing
PI: Dr Simon Tual-Chalot
Biosciences Institute, Newcastle University, Newcastle Upon Tyne, UK
2015-2018 BHF project grant, £248,861
Endothelial endoglin is required to maintain normal cardiac function in adult life
PIs: Prof. Helen Arthur, Dr Simon Tual-Chalot and Prof. Michael Taggart
Institute of Genetic Medicine, Newcastle University, Newcastle Upon Tyne, UK
2015-2016 Young Investigator award from Cure HHT, £19,108
Role of endoglin in HHT and high output heart failure
PI: Dr Simon Tual-Chalot
Institute of Genetic Medicine, Newcastle University, Newcastle Upon Tyne, UK
2013-2015 Marie Curie Intra-European Fellowship, £231,283
Endoglin-mediated vascular regeneration to promote heart repair (VASC-GEN)
Fellow: Dr Simon Tual-Chalot
Institute of Genetic Medicine, Newcastle University, Newcastle Upon Tyne, UK
Honours and Awards:
2019 Best oral presentation prize runner up. British Atherosclerosis Society Annual Meeting, Oxford, UK
2019 Highest Scoring Abstract Basic Science. British Cardiovascular Society and the British Heart Foundation Annual Meeting, Manchester, UK
2019 Best oral presentation prize runner up. British Cardiovascular Research Society and the British Atherosclerosis Society Annual Meeting, Manchester, UK
2018 Best poster prize runner up. British Cardiovascular Research Society and the British Atherosclerosis Society Annual Meeting, Manchester, UK
2015 Young Investigator award from Cure HHT
2013 Marie Curie Intra-European Fellowship. Total Score of 95.2/100
2011 Best poster presentation prize. 27th Annual Meeting of the “Groupe de Réflexion sur la Recherche Cardiovasculaire”, Lyon, France
2009 Best oral presentation prize. 13th Annual Meeting of French Society of Pharmacology and Therapeutics, Marseille, France
Committee membership:
2020 Newcastle University Biosciences Institute Equality, Diversity and Inclusion Steering Committee
- Tual-Chalot S, Stellos K. Therapeutic potential of adenosine kinase inhibition in vascular disease. Cardiovascular research 2021, 117(2), 354-356.
- Lambrinoudaki I, Delialis D, Georgiopoulos G, Tual-Chalot S, Vlachogiannis NI, Patras R, Aivalioti E, Armeni E, Augoulea A, Tsoltos N, Soureti A, Stellos K, Stamatelopoulos K. Circulating Amyloid Beta 1-40 Is Associated with Increased Rate of Progression of Atherosclerosis in Menopause: A Prospective Cohort Study. Thrombosis and Haemostasis 2021, 121(05), 650-658.
- Dookun E, Walaszczyk A, Redgrave R, Palmowski P, Tual Chalot S, Suwana A, Chapman J, Jirkovsky E, Donastorg Sosa L, Gill E, Yausep O, Santin Y, Mialet Perez J, Owens WA, Grieve D, Spyridopoulos I, Taggart M, Arthur HM, Passos JF, Richardson GD. Clearance of senescent cells during cardiac ischemia-reperfusion injury improves recovery. Aging Cell 2020, 19(10), e13249.
- Dookun E, Walaszczyk A, Redgrave R, Palmowski P, Tual Chalot S, Suwana A, Chapman J, Jirkovsky E, Donastorg Sosa L, Gill E, Yausep O, Santin Y, Mialet Perez J, Owens WA, Grieve D, Spyridopoulos I, Taggart M, Arthur HM, Passos JF, Richardson GD. Clearance of senescent cells during cardiac ischemia–reperfusion injury improves recovery. Aging Cell 2020, 19(10), e13249.
- Tual-Chalot S, García-Collado M, Redgrave RE, Singh E, Davison B, Park C, Lin H, Luli S, Jin Y, Wang Y, Lawrie A, Jakobsson L, Arthur HM. Loss of endothelial Endoglin promotes high-output heart failure through peripheral arteriovenous shunting driven by VEGF signalling. Circulation Research 2020, 126(2), 243-257.
- Stakos DA, Stamatelopoulos K, Bampatsias D, Sachse M, Zormpas E, Vlachogiannis NI, Tual-Chalot S, Stellos K. The Alzheimer's Disease Amyloid-Beta Hypothesis in Cardiovascular Aging and Disease: JACC Focus Seminar. Journal of the American College of Cardiology 2020, 75(8), 952-967.
- Mareti A, Kritsioti C, Georgiopoulos G, Vlachogiannis NI, Delialis D, Sachse M, Sopova K, Koutsoukis A, Kontogiannis C, Patras R, Tual-Chalot S, Koureas A, Gatsiou A, Stellos K, Stamatelopoulos K. Cathepsin B expression is associated with arterial stiffening and atherosclerotic vascular disease. European Journal of Preventive Cardiology 2019, 27(19), 2288-2291.
- Bailey KE, MacGowan GA, Tual-Chalot S, Phillips L, Mohun TJ, Henderson DJ, Arthur HM, Bamforth SD, Phillips HM. Disruption of embryonic ROCK signalling reproduces the sarcomeric phenotype of Hypertrophic Cardiomyopathy. JCI Insight 2019, 4(8), e125172.
- Anderson R, Lagnado A, Maggiorani D, Walaszczyk A, Dookun E, Chapman J, Birch J, Salmonowicz H, Ogrodnik M, Jurk D, Proctor C, Correia-Melo C, Victorelli S, Fielder E, Berlinguer-Palmini R, Owens WA, Greaves L, Kolsky K, Parini A, Douin-Echinard V, LeBrasseur N, Arthur H, Tual-Chalot S, Schafer M, Roos C, Miller J, Robertson N, Mann J, Adams P, Tchkonia T, Kirkland J, Mialet-Perez J, Richardson GD, Passos J. Length‐independent telomere damage drives post‐mitotic cardiomyocyte senescence. The EMBO Journal 2019, 38(5), e100492.
- Dookun E, Walaszczyk A, Redgrave R, Tual-Chalot S, Yausep O, Chapman J, Anderson R, Spyridopoulos I, Owens A, Arthur H, Passos J, Richardson G. Navitoclax eliminates senescence attenuating remodelling and improving outcome to cardiac ischemia-reperfusion injury. In: Senescence Symposium. 2019, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, UK.
- Walaszczyk A, Dookun E, Redgrave R, Tual-Chalot A, Spyridopoulos I, Owens A, Arthur HM, Passos JF, Richardson GD. Pharmacological clearance of senescent cells improves survival and recovery in aged mice following acute myocardial infarction. Aging Cell 2019, 18(3), e12945.
- Dorn LE, Tual-Chalot S, Stellos K, Accornero F. RNA epigenetics and cardiovascular diseases. Journal of Molecular and Cellular Cardiology 2019, 129, 272-280.
- Yausep Oliver, Dookun E, Walaszczyk A, Redgrave R, Tual-Chalot S, Chapman J, Anderson R, Spyridopoulos I, Owens A, Arthur H, Passos J, Richardson G. The Effects of Senolytics on Murine Cardiac Function and Morphology Post-Ischemia Reperfusion Injury. In: 24th ASEAN Federation Cardiology Congress (24th AFCC) 28th Annual Scientific Meeting of the Idonesian Heart Association (28th ASMIHA). 2019, Faculty of Medicine, University of Indonesia, Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia.
- Dookun ER, Walaszczyk A, Redgrave R, Tual-Chalot S, Yausep O, Spyridopoulos I, Owens A, Arthur H, Passos J, Richardson GD. Accumulation of cardiomyocyte senescence following ischaemia-reperfusion injury (IRI); a potential therapeutic target?. In: BAS/BSCR Spring Meeting 2018. 2018, Manchester, UK: Heart.
- Dookun E, Walaszczyk A, Redgrave R, Tual-Chalot S, Yausep O, Chapman J, Anderson R, Spyridopoulos I, Owens A, Arthur H, Passos J, Richardson G. Cardiomyocyte Senescence accumulates following Myocardial Infarction and Ischaemia-Reperfusion Injury. In: 26th Northern Cardiovascular Research Group Meeting. 2018, Newcastle upon Tyne.
- Thalgott JH, Dos-Santos-Luis D, Hosman AE, Martin S, Lamande N, Bracquart D, Srun S, Galaris G, de Boer HC, Tual-Chalot S, Kroon S, Arthur HM, Cao Y, Snijder RJ, Disch F, Mager JJ, Rabelink TJ, Mummery CL, Raymond K, Lebrin F. Decreased Expression of Vascular Endothelial Growth Factor Receptor 1 Contributes to the Pathogenesis of Hereditary Hemorrhagic Telangiectasia Type 2. Circulation 2018, 138(23), 2698-2712.
- Walaszczyk A, Dookun ER, Redgrave R, Tual-Chalot S, Anderson R, Spyridopoulos I, Owens A, Arthur H, Passos J, Richardson GD. Senescence as a therapeutic target for myocardial ageing. In: BAS/BSCR Spring Meeting 2018. 2018, Manchester, UK: Heart.
- Gallardo-Vara E, Tual-Chalot S, Botella LM, Arthur HM, Bernabeu C. Soluble endoglin regulates expression of angiogenesis-related proteins and induction of arteriovenous malformations in a mouse model of hereditary hemorrhagic telangiectasia. Disease Models & Mechanisms 2018, 11(9), dmm034397.
- Redgrave RE, Tual-Chalot S, Davison BJ, Singh E, Hall D, Amirrasouli MM, Gilchrist D, Medvinsky A, Arthur HM. Cardiosphere-Derived Cells Require Endoglin for Paracrine-Mediated Angiogenesis. Stem Cell Reports 2017, 8(5), 1287-1298.
- Tual-Chalot S, Davison B, Redgrave R, Arthur H. Loss of Endothelial Endoglin Leads to Heart Failure. In: BCS Annual Conference: Prediction and Prevention. 2016, Manchester, UK: BMJ Publishing Group.
- Anderson R, TualChalot S, Redgrave R, Dodds R, Owens WA, Saretzki G, Arthur H, vonZglinicki T, Passos JF, Richardson GD. The role of cardiomyocyte senescence and regeneration in Ageing. In: British Microcirculation Society 66th Annual Meeting. 2016, Newcastle upon Tyne, UK: BMS.
- Redgrave RE, Tual-Chalot S, Davison BJ, Greally E, Santibanez-Koref M, Schneider JE, Blamire AM, Arthur HM. Using MRI to predict future adverse cardiac remodelling in a male mouse model of myocardial infarction. IJC Heart & Vasculature 2016, 11, 29-34.
- Tual-Chalot S, Davison BJ, Yin Y, Redgrave RE, Jakobsson L, Arthur HM. Endoglin is required to maintain normal cardiac function in adult life. In: 11th HHT International Scientific Conference. 2015, Captiva, FL, USA: Springer.
- Tual-Chalot S, Oh SP, Arthur HM. Mouse models of hereditary hemorrhagic telangiectasia: recent advances and future challenges. Frontiers in Genetics 2015, 6, 25.
- Tual-Chalot S, Gagnadoux F, Trzepizur W, Priou P, Andriantsitohaina R, Martinez MC. Circulating microparticles from obstuctive sleep apnea syndrome patients induce endothelin-mediated angiogenesis. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2014, 1842(2), 202-207.
- Tual-Chalot S, Mahmoud M, Allinson KR, Redgrave RE, Zhai ZH, Oh SP, Fruttiger M, Arthur HM. Endothelial Depletion of Acvrl1 in Mice Leads to Arteriovenous Malformations Associated with Reduced Endoglin Expression. PLoS One 2014, 9(6), e98646.
- Tual-Chalot S, Redgrave R, Oh P, Arthur HM. Endothelial expression of endoglin and Acvrl1 are required for normal vascular patterning during developmental angiogenesis and for maintaining adult vessel integrity. In: Development Vascular Biology and Genetics Workshop VI and Vascular Inflammation Work organized by NAVBO. 2014, Monterey, CA, USA: Springer.
- Tual-Chalot S, Allinson KR, Fruttiger M, Arthur HM. Whole Mount Immunofluorescent Staining of the Neonatal Mouse Retina to Investigate Angiogenesis In vivo. Journal of Visualized Experiments 2013, 77, 1-5.
- Tual-Chalot S, Fatoumata K, Priou P, Trzepizur W, Gaceb A, Contreras C, Prieto D, Martinez MC, Gagnadoux F, Andriantsitohaina R. Circulating microparticles from patients with obstructive sleep apnea enhance vascular contraction: mandatory role of the endothelium. American Journal of Pathology 2012, 181(4), 1473-1482.
- López-Andrés N, Tesse A, Regnault V, Louis H, Cattan V, Thornton SN, Labat C, Kakou A, Tual-Chalot S, Faure S, Challande P, Osborne-Pellegrin M, Martínez MC, Lacolley P, Andriantsitohaina R. Increased microparticle production and impaired microvascular endothelial function in aldosterone-salt-treated rats: protective effects of polyphenols. PLoS One 2012, 7(7), e39235.
- Jeanneteau J, Hibert P, Martinez MC, Tual-Chalot S, Tamareille S, Furber A, Andriantsitohaina R, Prunier F. Microparticle release in remote ischemic conditioning mechanism. American Journal of Physiology: Heart and Circulatory Physiology 2012, 303(7), H871-H877.
- Rottner M, Tual-Chalot S, Mostefai HA, Andriantsitohaina R, Freyssinet JM, Martínez MC. Increased oxidative stress induces apoptosis in human cystic fibrosis cells. PLoS One 2011, 6(9), e24880.
- Martinez MC, Tual-Chalot S, Leonetti D, Andriantsitohaina R. Microparticles: targets and tools in cardiovascular disease. Trends in Pharmacological Sciences 2011, 32(11), 659-665.
- Tual-Chalot S, Leonetti D, Andriantsitohaina R, Martínez MC. Microvesicles: intercellular vectors of biological messages. Molecular Interventions 2011, 11(2), 88-94.
- Trzepizur W, Priou P, Paris A, Nardi J, Tual-Chalot S, Meslier N, Urban T, Andriantsitohaina R, Martinez MC, Gagnadoux F. Nocturnal release of leukocyte-derived microparticles in males with obstructive sleep apnoea. European Respiratory Journal 2011, 37(5), 1293-1295.
- Tual-Chalot S, Guibert C, Muller B, Savineau JP, Andriantsitohaina R, Martinez MC. Circulating microparticles from pulmonary hypertensive rats induce endothelial dysfunction. American Journal of Respiratory and Critical Care Medicine 2010, 182(2), 261-268.
- Benameur T, Tual-Chalot S, Andriantsitohaina R, Martínez MC. PPARα is essential for microparticle-induced differentiation of mouse bone marrow-derived endothelial progenitor cells and angiogenesis. PLoS One 2010, 5(8), e12392.