Staff Profile

Dr. von Zglinicki is a founding member of the basic ageing biology research at Newcastle. His principal research interest is in understanding the cellular and molecular signalling pathways connecting DNA damage responses (specifically emanating from dysfunctional telomeres) with mitochondrial function and metabolism, thus causing and maintaining cell senescence, and how these contribute to mammalian ageing. He was the first to discover oxidative stress and resulting DNA damage as a major cause of telomere shortening and to propose telomere length as a biomarker of ageing in humans. Dr. von Zglinicki chaired the 2004 Gordon Research Conference on Biology of Aging. He chaired the Scientific Advisory Board (SAB) of the Leibniz Institute for Environmental Medicine Dusseldorf (Germany) and is a member of the Mayo Clinic Robert and Arlene Kogod Center on Aging SAB. He is a Trustee of the Seneca Award for Ageing Research of the Industry Club Dusseldorf and serves on the editorial boards of Aging Cell, Aging (Albany) and other journals in the field. In 2017 he received the Lord Cohen of Birkenhead Medal for Services to Gerontology.

Area of expertise

• Biology of Ageing
• Cell senescence
• Telomeres
• Mitochondria

Google scholar: Click here.

• Articles

  • Riviere-Cazaux, C, Carlstrom, LP, Neth, BJ, Olson, IE, Rajani, K, Rahman, M, Ikram, S, Mansour, MA, Mukherjee, B, Warrington, AE, Short, SC, von Zglinicki, T, Brown, DA, Burma, S, Tchkonia, T, Schafer, MJ, Baker, DJ, Kizilbash, SH, Kirkland, JL, Burns, TC. An untapped window of opportunity for glioma: targeting therapy-induced senescence prior to recurrence. NPJ Precision Oncol 2023, 7.
  • Fielder E, Wan T, Alimohammadiha G, Ishaq A, Low E, Weigand BM, Kelly G, Parker C, Griffin B, Jurk D, Korolchuk V, von Zglinicki T, Miwa S. Short senolytic or senostatic interventions rescue progression of radiation-induced frailty and premature ageing in mice. eLife 2022, 11, e75492.
  • Rennie KJ, Witham M, Bradley P, Clegg A, Connolly S, Hancock HC, Hiu S, Marsay L, McDonald C, Robertson L, Simms L, Steel AJ, Steves CJ, Storey B, Wason J, Wilson N, von Zglinicki T, Sayer AAP. MET-PREVENT: metformin to improve physical performance in older people with sarcopenia and physical prefrailty/frailty - protocol for a double-blind, randomised controlled proof-of-concept trial. BMJ Open 2022, 12(7), e061823.
  • Granic A, Martin-Ruiz C, Rimmer L, Dodds RM, Robinson LA, Spyridopoulos I, Kirkwood TBL, von Zglinicki T, Sayer AA. Immunosenescence profiles of lymphocyte compartments and multiple long-term conditions (multimorbidity) in very old adults: The Newcastle 85+ Study. Mechanisms of Ageing and Development 2022, 208, 111739.
  • Ogrodnik M, Evans SA, Fielder E, Victorelli S, Kruger P, Salmonowicz H, Weigand BM, Patel AD, Pirtskhalava T, Inman CL, Johnson KO, Dickinson SL, Rocha A, Schafer MJ, Zhu Y, Allison DB, von Zglinicki T, LeBrasseur NK, Tchkonia T, Neretti N, Passos JF, Kirkland JL, Jurk D. Whole-body senescent cell clearance alleviates age-related brain inflammation and cognitive impairment in mice. Aging Cell 2021, 20(2), e13296.
  • Braude S, Holtze S, Begall S, Brenmoehl J, Burda H, Dammann P, del Marmol D, Gorshkova E, Henning Y, Hoeflich A, Hohn A, Jung T, Hamo D, Sahm A, Shebzukhov Y, Sumbera R, Miwa S, Vyssokikh MY, von Zglinicki T, Averina O, Hildebrandt TB. Surprisingly long survival of premature conclusions about naked mole-rat biology. Biological Reviews 2021, 96(2), 376-393.
  • Lagnado A, Leslie J, Ruchaud-Sparagano MH, Victorelli S, Hirsova P, Ogrodnik M, Collins AL, Grazia Vizioli M, Habiballa L, Saretzki G, Evans SA, Salmonowicz H, Hruby A, Geh D, Pavelko KD, Dolan D, Reeves HL, Grellscheid S, Wilson CH, Pandanaboyana S, Doolittle M, Von Zglinicki T, Oakley F, Gallage S, Wilson CL, Birch J, Carroll B, Chapman J, Heikenwalder M, Neretti N, Khosla S, Masuda CA, Tchkonia T, Kirkland JL, Jurk D, Mann DA, Passos JF. Neutrophils induce paracrine telomere dysfunction and senescence in ROS-dependent manner. The EMBO Journal 2021, 40(9), e106048.
  • Martin-Ruiz C, Williams-Gray CH, Yarnall AJ, Boucher JJ, Lawson RA, Wijeyekoon RS, Barker RA, Kolenda C, Parker C, Burn DJ, Von Zglinicki T, Saretzki G. Senescence and inflammatory markers for predicting clinical progression in Parkinson's disease-the ICICLE-PD study. Journal of Parkinson's Disease 2020, 10(1), 193-206.
  • Granic A, Martin-Ruiz C, Dodds RM, Robinson L, Spyridopoulos I, Kirkwood TBL, von Zglinicki T, Sayer AA. Immunosenescence profiles are not associated with muscle strength, physical performance and sarcopenia risk in very old adults: The Newcastle 85+ Study. Mechanisms of Ageing and Development 2020, 190, 111321.
  • Martin-Ruiz C, Hoffmann J, Shmeleva E, von Zglinicki T, Richardson G, Draganova L, Redgrave R, Collerton J, Arthur H, Keavney B, Spyridopoulos I. CMV-independent increase in CD27−CD28+ CD8+ EMRA T cells is inversely related to mortality in octogenarians. npj Aging and Mechanisms of Disease 2020, 6, 3.
  • Fielder E, Tweedy C, Wilson C, Oakley F, LeBeau FEN, Passos JF, Mann DA, von Zglinicki T, Jurk D. Anti-inflammatory treatment rescues memory deficits during aging in nfkb1−/− mice. Aging Cell 2020, 19(10), e13188.
  • Kucheryavenko O, Nelson G, von Zglinicki T, Korolchuk VI, Carroll B. The mTORC1-autophagy pathway is a target for senescent cell elimination. Biogerontology 2019, 20, 331–335.
  • da Silva PFL, Ogrodnik M, Kucheryavenko O, Glibert J, Miwa S, Cameron K, Ishaq A, Saretzki G, Nagaraja-Grellscheid S, Nelson G, von Zglinicki T. The bystander effect contributes to the accumulation of senescent cells in vivo. Aging Cell 2019, 18(1), e12848.
  • Palmer AK, Xu M, Zhu Y, Pirtskhalava T, Weivoda MM, Hachfeld CM, Prata LG, van Dijk TH, Verkade E, Casaclang-Verzosa G, Johnson KO, Cubro H, Doornebal EJ, Ogrodnik M, Jurk D, Jensen MD, Chini EN, Miller JD, Matveyenko A, Stout MB, Schafer MJ, White TA, Hickson LJ, Demaria M, Garovic V, Grande J, Arriaga EA, Kuipers F, von Zglinicki T, LeBrasseur NK, Campisi J, Tchkonia T, Kirkland JL. Targeting senescent cells alleviates obesity-induced metabolic dysfunction. Aging Cell 2019, 18(3), e12950.
  • Fielder E, Weigand M, Agneessens J, Griffin B, Parker C, Miwa S, von Zglinicki T. Sublethal whole-body irradiation causes progressive premature frailty in mice. Mechanisms of Ageing and Development 2019, 180, 63-69.
  • Bateson M, Aviv A, Bendix L, Benetos A, Ben-Shlomo Y, Bojesen SE, Cooper C, Cooper R, Deary IJ, Hagg S, Harris SE, Kark JD, Kronenberg F, Kuh D, Labat C, Martin-Ruiz CM, Meyer C, Nordestgaard BG, Penninx BWJH, Pepper GV, Revesz D, Said MA, Starr JM, Syddall H, Thomson WM, Van Der Harst P, Whooley M, Von Zglinicki T, Willeit P, Zhan Y, Nettle D. Smoking does not accelerate leucocyte telomere attrition: A meta-analysis of 18 longitudinal cohorts. Royal Society Open Science 2019, 6(6), 190420.
  • Ogrodnik M, Zhu Y, Langhi LGP, Tchkonia T, Krüger P, Fielder E, Victorelli S, Ruswhandi RA, Giorgadze N, Pirtskhalava T, Podgorni O, Enikolopov G, Johnson KO, Xu M, Inman C, Schafer M, Weigl M, Ikeno Y, Burns T, Passos JF, von Zglinicki T, Kirkland JL, Jurk D. Obesity-Induced Cellular Senescence Drives Anxiety And Impairs Neurogenesis. Cell Metabolism 2019, 29(5), 1061-1077.
  • Roger M, Fullard N, Costello L, Bradbury S, Markiewicz E, O'Reilly S, Darling N, Ritchie P, Maatta A, Karakesisoglou I, Nelson G, von Zglinicki T, Dicolandrea T, Isfort R, Bascom C, Przyborski S. Bioengineering the microanatomy of human skin. Journal of Anatomy 2019, 234(4), 438-455.
  • Nelson G, Kucheryavenko O, Wordsworth J, von Zglinicki T. The senescent bystander effect is caused by ROS-activated NF-κB signalling. Mechanisms of Ageing and Development 2018, 170, 30-36.
  • Ishaq A, Schroder J, Edwards N, von Zglinicki T, Saretzki G. Dietary restriction ameliorates age-related increase in DNA damage, senescence and inflammation in mouse adipose tissuey. Journal of Nutrition, Health and Aging 2018, 22(4), 555-561.
  • Langie SAS, Cameron KM, Ficz G, Oxley D, Tomaszewski B, Gorniak JP, Maas LM, Godschalk RWL, Van Schooten FJ, Reik W, Von Zglinicki T, Mathers JC. The Ageing Brain: Effects on DNA Repair and DNA Methylation in Mice. Genes 2017, 8(2), 75.
  • Carroll B, Nelson G, Rabanal-Ruiz Y, Kucheryavenko O, Dunhill-Turner NA, Chesterman CC, Zahari Q, Zhang T, Conduit SE, Mitchell CA, Maddocks ODK, Lovat P, von Zglinicki T, Korolchuk VI. Persistent mTORC1 signaling in cell senescence results from defects in amino acid and growth factor sensing. Journal of Cell Biology 2017, 216(7), 1949.
  • Korolchuk VI, Miwa S, Carroll B, von Zglinicki T. Mitochondria in cell senescence: Is mitophagy the weakest link?. EBioMedicine 2017, 21, 7-13.
  • Granic A, Davies K, Martin-Ruiz C, Jagger C, Kirkwood TBL, von Zglinicki T, Sayer AA. Grip strength and inflammatory biomarker profiles in very old adults. Age and Ageing 2017, 46(6), 976-982.
  • Ogrodnik M, Miwa S, Tchkonia T, Tiniakos D, Wilson CL, Lahat A, Day CP, Burt A, Palmer A, Anstee QM, Nagaraja Grellscheid S, Hoeijmakers JHJ, Barnhoorn S, Mann DA, Bird TG, Vermeij WP, Kirkland JL, Passos JF, von Zglinicki T, Jurk D. Cellular senescence drives age-dependent hepatic steatosis. Nature Communications 2017, 8, 15691.
  • Stout MB, Steyn F, Jurczak MJ, Camporez JG, Zhu Y, Hawse JR, Jurk D, Palmer AK, Xu M, Pirtskhalava T, Evans GL, deSouzaSantos R, Frank AP, White TA, Monroe DG, Singh RJ, Casaclang-Verzosa G, Miller JD, Clegg DJ, LeBrasseur NK, vonZglinicki T, Shulman GI, Tchkonia T, Kirkland JL. 17α-Estradiol Alleviates Age-related Metabolic and Inflammatory Dysfunction in Male Mice Without Inducing Feminization. Journals of Gerontology Series A: Biological Sciences & Medical Sciences 2017, 72(1), 3-15.
  • Hewitt G, Carroll B, Sarallah R, Correia-Melo C, Ogrodnik M, Nelson G, Otten EG, Manni D, Antrobus R, Morgan BA, von Zglinicki T, Jurk D, Seluanov A, Gorbunova V, Johansen T, Passos JF, Korolchuk VI. SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair. Autophagy 2016, 12(10), 1917-1930.
  • Correia-Melo C, Marques FDM, Anderson R, Hewitt G, Hewitt R, Cole J, Carroll BM, Miwa S, Birch J, Merz A, Rushton MD, Charles M, Jurk D, Tait SWG, Czapiewski R, Greaves L, Nelson G, Bohlooly-Y M, Rodriguez-Cuenca S, Vidal-Puig A, Mann D, Saretzki G, Quarato G, Green DR, Adams PD, von Zglinicki T, Korolchuk VI, Passos JF. Mitochondria are required for pro-ageing features of the senescent phenotype. EMBO Journal 2016, 35(7), 724-742.
  • Harris SE, Marioni RE, Martin-Ruiz C, Pattie A, Gow AJ, Cox SR, Corley J, von Zglinicki T, Starr JM, Deary IJ. Longitudinal telomere length shortening and cognitive and physical decline in later life: The Lothian Birth Cohorts 1936 and 1921. Mechanisms of Ageing and Development 2016, 154, 43-48.
  • Miwa S, Czapiewski R, Wan TF, Bell A, Hill KN, von Zglinicki T, Saretzki G. Decreased mTOR signalling reduces mitochondrial ROS in brain via accumulation of the telomerase protein TERT within mitochondria. Aging 2016, 8(10), 2551-2567.
  • Vistoli G, Treumann A, von Zglinicki T, Miwa S. Data from molecular dynamics simulations in support of the role of human CES1 in the hydrolysis of Amplex Red. Data in Brief 2016, 6, 865-870.
  • Spyridopoulos I, Martin-Ruiz C, Hilkens C, Yadegarfar ME, Isaacs J, Jagger C, Kirkwood T, von Zglinicki T. CMV-seropositivity and T-cell senescence predict increased cardiovascular mortality in octogenarians - results from the Newcastle 85+ study. Aging Cell 2016, 15(2), 389-392.
  • Miwa S, Treumann A, Bell A, Vistoli G, Nelson G, Hay S, von Zglinicki T. Carboxylesterase converts Amplex red to resorufin: Implications for mitochondrial H₂O₂ release assays. Free Radical Biology and Medicine 2016, 90, 173-183.
  • Granic A, Hill TR, Kirkwood TBL, Davies K, Collerton J, Martin-Ruiz C, von Zglinicki T, Saxby BK, Wesnes KA, Collerton D, Mathers JC, Jagger C. Serum 25-hydroxyvitamin D and cognitive decline in the very old: The Newcastle 85+ study. European Journal of Neurology 2015, 22(1), 106-e7.
  • Martin-Ruiz CM, Baird D, Roger L, Boukamp P, Krunic D, Cawthon R, Dokter MM, vanderHarst P, Bekaert S, deMeyer T, Roos G, Svenson U, Codd V, Samani NJ, McGlynn L, Shiels PG, Pooley KA, Dunning AM, Cooper R, Wong A, Kingston A, von Zglinicki T. Reproducibility of telomere length assessment: an international collaborative study. International Journal of Epidemiology 2015, 44(5), 1673-1683.
  • Hoffmann J, Shmeleva EV, Boag SE, Fiser K, Bagnall A, Murali S, Dimmick I, Pircher H, Martin-Ruiz C, Egred M, Keavney B, von Zglinicki T, Das R, Todryk S, Spyridopoulos I. Myocardial Ischemia and Reperfusion Leads to Transient CD8 Immune Deficiency and Accelerated Immunosenescence in CMV-Seropositive Patients. Circulation Research 2015, 116(1), 87-98.
  • Arai Y, Martin-Ruiz CM, Takayama M, Abe Y, Takebayashi T, Koyasu S, Suematsu M, Hirose N, von Zglinicki T. Inflammation, But Not Telomere Length, Predicts Successful Ageing at Extreme Old Age: A Longitudinal Study of Semi-supercentenarians. EBioMedicine 2015, 2(10), 1549-1558.
  • Holly AC, Grellscheid S, van de Walle P, Dolan D, Pilling LC, Daniels DJ, von Zglinicki T, Ferrucci L, Melzer D, Harries LW. Comparison of senescence-associated miRNAs in primary skin and lung fibroblasts. Biogerontology 2015, 16(4), 423-434.
  • Mitnitski A, Collerton J, Martin-Ruiz C, Jagger C, von Zglinicki T, Rockwood K, Kirkwood TBL. Age-related frailty and its association with biological markers of ageing. BMC Medicine 2015, 13, 161.
  • Granic A, Aspray T, Hill T, Davies K, Collerton J, Martin-Ruiz C, von Zglinicki T, Kirkwood TB, Mathers JC, Jagger C. 25-hydroxyvitamin D and increased all-cause mortality in very old women: the Newcastle 85+ study. Journal of Internal Medicine 2015, 277(4), 456-467.
  • Miwa S, Jow H, Baty K, Johnson A, Czapiewski R, Saretzki G, Treumann A, von Zglinicki T. Low abundance of the matrix arm of complex I in mitochondria predicts longevity in mice. Nature Communications 2014, 5, 3837.
  • Baylis D, Ntani G, Edwards MH, Syddall HE, Bartlett DB, Dennison EM, Martin-Ruiz C, von Zglinicki T, Kuh D, Lord JM, Aihie Sayer A, Cooper C. Inflammation, telomere length, and grip strength: a 10-year longitudinal study. Calcified Tissue International 2014, 95(1), 54-63.
  • Gardner M, Bann D, Wiley L, Cooper R, Hardy R, Nitsch D, Martin-Ruiz C, Shiels P, Sayer AA, Barbieri M, Bekaert S, Bischoff C, Brooks-Wilson A, Chen W, Cooper C, Christensen K, De Meyer T, Deary I, Der G, Roux AD, Fitzpatrick A, Hajat A, Halaschek-Wiener J, Harris S, Hunt SC, Jagger C, Jeon HS, Kaplan R, Kimura M, Lansdorp P, Li CY, Maeda T, Mangino M, Nawrot TS, Nilsson P, Nordfjall K, Paolisso G, Ren F, Riabowol K, Robertson T, Roos G, Staessen JA, Spector T, Tang N, Unryn B, van der Harst P, Woo J, Xing C, Yadegarfar ME, Park JY, Young N, Kuh D, von Zglinicki T, Ben-Shlomo Y, Halcyon Study Team. Gender and telomere length: Systematic review and meta-analysis. Experimental Gerontology 2014, 51, 15-27.
  • Dalle Pezze P, Nelson G, Otten EG, Korolchuk VI, Kirkwood TBL, von Zglinicki T, Shanley DP. Dynamic Modelling of Pathways to Cellular Senescence Reveals Strategies for Targeted Interventions. PLoS Computational Biology 2014, 10(8), e1003728.
  • Jurk D, Wilson C, Passos J, Oakley F, Correia-Melo C, Greaves L, Saretzki G, Fox C, Lawless C, Anderson R, Hewitt G, Pender SLF, Fullard N, Nelson G, Mann J, van de Sluis B, Mann DA, von Zglinicki T. Chronic inflammation induces telomere dysfunction and accelerates ageing in mice. Nature Communications 2014, 5, 4172.
  • Bennaceur K, Atwill M, Al Zhrany N, Hoffmann J, Keavney B, Breault D, Richardson G, von Zglinicki T, Saretzki G, Spyridopoulos I. Atorvastatin induces T cell proliferation by a telomerase reverse transcriptase (TERT) mediated mechanism. Atherosclerosis 2014, 236(2), 312-320.
  • Anderson KN, Catt M, Collerton J, Davies K, von Zglinicki T, Kirkwood TBL, Jagger C. Assessment of sleep and circadian rhythm disorders in the very old: the Newcastle 85+ Cohort Study. Age and Ageing 2014, 43(1), 57-63.
  • Collerton J, Gautrey HE, van Otterdijk SD, Davies K, Martin-Ruiz C, von Zglinicki T, Kirkwood TBL, Jagger C, Mathers JC, Strathdee G. Acquisition of aberrant DNA methylation is associated with frailty in the very old: findings from the Newcastle 85+Study. Biogerontology 2014, 15(4), 317-328.
  • Gorniak JP, Cameron KM, Waldron KJ, von Zglinicki T, Mathers JC, Langie SAS. Tissue differences in BER-related incision activity and non-specific nuclease activity as measured by the comet assay. Mutagenesis 2013, 28(6), 673-681.
  • Gavriilidis C, Miwa S, von Zglinicki T, Taylor RW, Young DA. Mitochondrial dysfunction in osteoarthritis is associated with down-regulation of superoxide dismutase 2. Arthritis & Rheumatism 2013, 65(2), 378-387.
  • Collerton J, Ashok D, Martin-Ruiz C, Pyle A, Hudson G, Yadegarfar M, Davies K, Jagger C, von Zglinicki T, Kirkwood T, Chinnery P. Frailty and mortality are not influenced by mitochondrial DNA haplotypes in the very old. Neurobiology of Aging 2013, 34(12), 2889.e1-2889.e4.
  • Hewitt G, Von Zglinicki T, Passos JF. Cell sorting of young and senescent cells. Methods in Molecular Biology 2013, 1048, 31-47.
  • Brain JG, Robertson H, Thompson EH, Humphreys E, Gardner A, Booth TA, Jones DEJ, Afford SC, von Zglinicki T, Burt AD, Kirby JA. Biliary Epithelial Senescence and Plasticity in Acute Cellular Rejection. American Journal of Transplantation 2013, 13(7), 1688-1702.
  • Golightly A, Boys RJ, Cameron KM, von Zglinicki T. The effect of late onset, short-term caloric restriction on the core temperature and physical activity in mice. Journal of the Royal Statistical Society: Series C (Applied Statistics) 2012, 61(5), 733-751.
  • Tsolou A, Nelson G, Trachana V, Chondrogianni N, Saretzki G, von Zglinicki T, Gonos ES. The 19S proteasome subunit Rpn7 stabilizes DNA damage foci upon genotoxic insult. IUBMB Life 2012, 64(5), 432-442.
  • Harris SE, Martin-Ruiz C, vonZglinicki T, Starr JM, Deary IJ. Telomere length and aging biomarkers in 70-year-olds: the Lothian Birth Cohort 1936. Neurobiology of Aging 2012, 33(7), 1486.e3-1486.e8.
  • Verma S, Tachtatzis P, Penrhyn-Lowe S, Scarpini C, Jurk D, von Zglinicki T, Coleman N, Alexander GJ. Sustained telomere length in hepatocytes and cholangiocytes with increasing age in normal liver. Hepatology 2012, 56(4), 1510-1520.
  • Lisanti S, von Zglinicki T, Mathers JC. Standardization and quality controls for the methylated DNA immunoprecipitation technique. Epigenetics 2012, 7(6), 615-625.
  • Jurk D, Wang C, Miwa S, Maddick M, Korolchuk V, Tsolou A, Gonos ES, Thrasivoulou C, Saffrey JM, Cameron K, von Zglinicki T. Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response. Aging Cell 2012, 11(6), 996-1004.
  • Passos JF, von Zglinicki T. Mitochondrial dysfunction and cell senescence - skin deep into mammalian aging. Aging 2012, 4(2), 74-75.
  • Hoffmann J, Fiser K, Weaver J, Dimmick I, Loeher M, Pircher H, Martin-Ruiz C, Veerasamy M, Keavney B, von Zglinicki T, Spyridopoulos I. High-Throughput 13-Parameter Immunophenotyping Identifies Shifts in the Circulating T-Cell Compartment Following Reperfusion in Patients with Acute Myocardial Infarction. PLoS one 2012, 7(10), e47155.
  • Collerton J, Martin-Ruiz C, Davies K, Hilkens CM, Isaacs J, Kolenda C, Parker C, Dunn M, Catt M, Jagger C, von Zglinicki T, Kirkwood TB. Frailty and the role of inflammation, immunosenescence and cellular ageing in the very old: Cross-sectional findings from the Newcastle 85+ Study. Mechanisms of Ageing and Development 2012, 133(6), 456-466.
  • Pearce MS, Mann KD, Martin-Ruiz C, Parker L, White M, von Zglinicki T, Adams J. Childhood Growth, IQ and Education as Predictors of White Blood Cell Telomere Length at Age 49-51 Years: The Newcastle Thousand Families Study. PLoS One 2012, 7(7), e40116.
  • Lawless C, Jurk D, Gillespie CS, Shanley D, Saretzki G, von Zglinicki T, Passos JF. A Stochastic Step Model of Replicative Senescence Explains ROS Production Rate in Ageing Cell Populations. PLoS One 2012, 7(2), e32117.
  • Nelson G, Wordsworth J, Wang CF, Jurk D, Lawless C, Martin-Ruiz C, von Zglinicki T. A senescent cell bystander effect: senescence-induced senescence. Aging Cell 2012, 11(2), 345-349.
  • Den Elzen WPJ, Martin-Ruiz C, von Zglinicki T, Westendorp RGJ, Kirkwood TBL, Gussekloo J. Telomere length and anaemia in old age: results from the Newcastle 85-plus Study* and the Leiden 85-plus Study. Age and Ageing 2011, 40(4), 494-500.
  • Langie SAS, Cameron KM, Waldron KJ, Fletcher KPR, von Zglinicki T, Mathers JC. Measuring DNA repair incision activity of mouse tissue extracts towards singlet oxygen-induced DNA damage: a comet-based in vitro repair assay. Mutagenesis 2011, 26(3), 461-471.
  • Cameron KM, Golightly A, Miwa S, Speakman J, Boys R, von Zglinicki T. Gross energy metabolism in mice under late onset, short term caloric restriction. Mechanisms of Ageing and Development 2011, 132(4), 202-209.
  • Pekovic V, Gibbs-Seymour I, Markiewicz E, Alzoghaibi F, Benham AM, Edwards R, Wenhert M, von Zglinicki T, Hutchison CJ. Conserved cysteine residues in the mammalian lamin A tail are essential for cellular responses to ROS generation. Aging Cell 2011, 10(6), 1067-1079.
  • Jagger C, Collerton JC, Davies K, Kingston A, Robinson LA, Eccles MP, von Zglinicki T, Martin-Ruiz C, James OFW, Kirkwood TBL, Bond J. Capability and dependency in the Newcastle 85+ cohort study. Projections of future care needs. BMC Geriatrics 2011, 11, 21.
  • Martin Ruiz C, Jagger C, Kingston A, Collerton J, Catt M, Davies K, Dunn M, Hilkens C, Keavney B, Pearce S, den Elzen W, Talbot D, Wiley L, Bond J, Mathers J, Eccles M, Robinson L, James O, Kirkwood T, von Zglinicki T. Assessment of a large panel of candidate biomarkers of ageing in the Newcastle 85+ study. Mechanisms of Ageing and Development 2011, 132(10), 496-502.
  • Neganova I, Vilella F, Atkinson SP, Lloret M, Passos JF, von Zglinicki T, O'Connor JE, Burks D, Jones R, Armstrong L, Lako M. An Important Role for CDK2 in G1 to S Checkpoint Activation and DNA Damage Response in Human Embryonic Stem Cells. Stem Cells 2011, 29(4), 651-659.
  • Lawless C, Wang CF, Jurk D, Merz A, von Zglinicki T, Passos JF. Quantitative assessment of markers for cell senescence. Experimental Gerontology 2010, 45(10), 772-778.
  • Passos JF, Nelson G, Wang CF, Richter T, Simillion C, Proctor CJ, Miwa S, Olijslagers S, Hallinan J, Wipat A, Saretzki G, Rudolph KL, Kirkwood TBL, von Zglinicki T. Feedback between p21 and reactive oxygen production is necessary for cell senescence. Molecular Systems Biology 2010, 6(1), 347.
  • Jagger C, Collerton J, Robinson L, Eccles MP, Kingston A, von Zglinicki T, Kirkwood T, Bond J. Disability and dependency: How much care is in the community? [abstract]. Gerontologist 2010, 50(s1), 375-375.
  • Miwa S, Lawless C, von Zglinicki T. Correction of radiolabel pulse-chase data by a mathematical model: application to mitochondrial turnover studies. Biochemical Society Transactions 2010, 38, 1322-1328.
  • Kirkwood T, Martin-Ruiz C, Jagger C, Collerton J, Kingston A, von Zglinicki T. Biomarkers of ageing and their relationship to disability and cognition [abstract]. Gerontologist 2010, 50, 375.
  • Wang CF, Maddick M, Miwa S, Jurk D, Czapiewski R, Saretzki G, Langie SAS, Godschalk RWL, Cameron K, von Zglinicki T. Adult-onset, short-term dietary restriction reduces cell senescence in mice. Aging 2010, 2(9), 555-566.
  • Ksiazek K, Mikula-Pietrasik J, Olijslagers S, Jörres A, Von Zglinicki T, Witowski J. Vulnerability to oxidative stress and different patterns of senescence in human peritoneal mesothelial cell strains. American Journal of Physiology: Regulatory Integrative and Comparative Physiology 2009, 296(2), R374-R382.
  • Birket MJ, Passos JF, von Zglinicki T, Birch-Machin MA. The Relationship between the Aging- and Photo-Dependent T414G Mitochondrial DNA Mutation with Cellular Senescence and Reactive Oxygen Species Production in Cultured Skin Fibroblasts. Journal of Investigative Dermatology 2009, 129(6), 1361-1366.
  • Hapangama DK, Turner MA, Drury JA, Quenby S, Hart A, Maddick M, Martin-Ruiz C, von Zglinicki T. Sustained replication in endometrium of women with endometriosis occurs without evoking a DNA damage response. Human Reproduction 2009, 24(3), 687-696.
  • Collerton J, Davies K, Jagger C, Kingston A, Bond J, Eccles M, Robinson L, Martin-Ruiz C, Von Zglinicki T, James O, Kirkwood T. Health and disease in 85 year olds: Baseline findings from the Newcastle 85+ cohort study. British Medical Journal 2009, 339, b4904.
  • Wang CF, Jurk D, Maddick M, Nelson G, Martin-Ruiz C, von Zglinicki T. DNA damage response and cellular senescence in tissues of aging mice. Aging Cell 2009, 8(3), 311-323.
  • Nelson G, Buhmann M, von Zglinicki T. DNA damage foci in mitosis are devoid of 53BP1. Cell Cycle 2009, 8(20), 3379-3383.
  • Ahmed S, Passos JF, Birket MJ, Beckmann T, Brings S, Peters HH, Birch-Machin MA, von Zglinicki TW, Saretzki GC. Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress. Journal of Cell Science 2008, 121(7), 1046-1053.
  • Miwa S, Lawless C, von Zglinicki T. Mitochondrial turnover in liver is fast in vivo and is accelerated by dietary restriction: application of a simple dynamic model. Aging Cell 2008, 7(6), 920-923.
  • Passos JF, Saretzki G, Ahmed S, Nelson G, Richter T, Peters H, Wappler I, Birket MJ, Harold G, Schaeuble K, Birch-Machin MA, Kirkwood TBL, von Zglinicki T. Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence. PLoS Biology 2007, 5(5), 1138-1151.
  • Choudhury AR, Ju Z, Djojosubroto MW, Schienke A, Lechel A, Schaetzlein S, Jiang H, Stepczynska A, Wang C, Buer J, Lee H-W, Von Zglinicki T, Ganser A, Schirmacher P, Nakauchi H, Rudolph KL. Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation. Nature Genetics 2007, 39(1), 99-105.
  • Martin-Ruiz C, Dickinson HO, Keys B, Rowan E, Kenny RA, von Zglinicki T. Telomere length predicts poststroke mortality, dementia, and cognitive decline. Annals of Neurology 2006, 60(2), 174-180.
  • Tchkonia T, Giorgadze N, Pirtskhalava T, Thomou T, De Ponte M, Koo A, Forse RA, Chinnappan D, Martin-Ruiz C, Von Zglinicki T, Kirkland JL. Fat depot-specific characteristics are retained in strains derived from single human preadipocytes. Diabetes 2006, 55(9), 2571-2578.
  • Armstrong L, Saretzki G, Peters H, Wappler I, Evans J, Hole N, Von Zglinicki T, Lako M. Overexpression of telomerase confers growth advantage, stress resistance, and enhanced differentiation of ESCs toward the hematopoietic lineage. Stem Cells 2005, 23(4), 516-529.
  • Martin-Ruiz C, Saretzki G, Petrie J, Ladhoff J, Jeyapalan J, Wei W, Sedivy J, Von Zglinicki T. Stochastic Variation in Telomere Shortening Rate Causes Heterogeneity of Human Fibroblast Replicative Life Span. Journal of Biological Chemistry 2004, 279(17), 17826-17833.
  • Saretzki G, Murphy MP, von Zglinicki T. MitoQ counteracts telomere shortening and elongates lifespan of fibroblasts under mild oxidative stress. Aging Cell 2003, 2(2), 141-143.
  • Davies, B.R., Steele, I.A., Edmondson, R.J., Zwolinski, S.A., Saretzki, G., Von Zglinicki, T., O'Hare, M.J. Immortalisation of human ovarian surface epithelium with telomerase and temperature-senstitive SV40 large T antigen. Experimental Cell Research 2003, 288(2), 390-402.
  • Serra V, Von Zglinicki T, Lorenz M, Saretzki G. Extracellular superoxide dismutase is a major antioxidant in human fibroblasts and slows telomere shortening. Journal of Biological Chemistry 2003, 278(9), 6824-6830.
  • D'Adda Di Fagagna F, Reaper PM, Clay-Farrace L, Fiegler H, Carr P, Von Zglinicki T, Saretzki G, Carter NP, Jackson SP. A DNA damage checkpoint response in telomere-initiated senescence. Nature 2003, 426(6963), 194-198.
  • Saretzki G, Ludwig A, Von Zglinicki T, Runnebaum IB. Ribozyme-mediated telomerase inhibition induces immediate cell loss but not telomere shortening in ovarian cancer cells. Cancer Gene Therapy 2001, 8(10), 827-834.
  • Ludwig A, Saretzki G, Holm PS, Tiemann F, Lorenz M, Emrich T, Harley CB, von Zglinicki T. Ribozyme cleavage of telomerase mRNA sensitizes breast epithelial cells to inhibitors of topoisomerase. Cancer Research 2001, 61(7), 3053-3061.
  • Sitte N, Merker K, Grune T, Von Zglinicki T. Lipofuscin accumulation in proliferating fibroblasts in vitro: An indicator of oxidative stress. Experimental Gerontology 2001, 36(3), 475-486.
  • von Zglinicki T, Serra V, Lorenz M, Saretzki G, Lenzen-Grossimlighaus R, Gessner R, Risch A, Steinhagen-Thiessen E. Short telomeres in patients with vascular dementia: An indicator of low antioxidative capacity and a possible risk factor?. Laboratory Investigation 2000, 80(11), 1739-1747.
  • Toussaint O, Medrano EE, Von Zglinicki T. Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes. Experimental Gerontology 2000, 35(8), 927-945.
  • von Zglinicki T, Pilger R, Sitte N. Accumulation of single-strand breaks is the major cause of telomere shortening in human fibroblasts. Free Radical Biology and Medicine 2000, 28(1), 64-74.
  • Saretzki G, Sitte N, Merkel U, Wurm RE, von Zglinicki T. Telomere shortening triggers a p53-dependent cell cycle arrest via accumulation of G-rich single stranded DNA fragments. Oncogene 1999, 18(37), 5148-5158.
  • Muller A, Saretzki G, von Zglinicki T. Telomerase inhibition by induced expression of antisense RNA. Advances in Experimental Medicine & Biology 1998, 451, 23-26.
  • Saretzki G, Feng J, von Zglinicki T, Villeponteau B. Similar gene expression pattern in senescent and hyperoxic-treated fibroblasts. Journals of Gerontology Series A-Biological Sciences & Medical Sciences 1998, 53, B438-B442.
  • Petersen S, Saretzki G, von Zglinicki T. Preferential accumulation of single-stranded regions in telomeres of human fibroblasts. Experimental Cell Research 1998, 239(1), 152-160.
  • Sitte N, Saretzki G, von Zglinicki T. Accelerated telomere shortening in fibroblasts after extended periods of confluency. Free Radical Biology & Medicine 1998, 24, 885-893.
  • von Zglinicki T, Sitte N, Merkel U, Saretzki G. Regulation of telomere length under oxidative stress. Journal of Molecular Medicine 1997, 75, 414.
  • von Zglinicki T, Saretzki G, Docke W, Lotze C. Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: a model for senescence?. Experimental Cell Research 1995, 220, 186-193.

• Book Chapters

  • Nelson G, von Zglinicki T. Chapter 14, Monitoring DNA Damage During Cell Senescence. In: Galluzzi, L., Vitale, I., Kepp, O., Kroemer, G, ed. Cell Senescence: Methods and Protocols. London: Springer ; Humana Press, 2013, pp.197-213.
  • von Zglinicki T. Telomeric damage in aging. In: von Zglincki, T, ed. Aging at the Molecular Level. Dordrecht, Netherlands: Kluwer Academic, 2003, pp.121-130.
  • Sitte N, von Zglinicki T. Free radical production and antioxidant defence: A primer. In: von Zglinicki, T, ed. Aging at the Molecular Level. Dordrecht, Netherlands: Kluwer Academic, 2003, pp.1-10.
  • von Zglinicki T, Saretzki G. Regeneration der Telomeren als Basis zellulaerer Immortalitaet. In: Sames, K, ed. Medizinische Regeneration und Tissue Engineering. Landsberg: Ecomed, 2000, pp.IV.4.1 - IV.4.9.
  • Sitte N, Saretzki G, von Zglinicki T. Sauerstoffradikalbedingte Telomeren-verkuerzung ist der Ausloeser der Seneszenz in Zellkulturen. In: R. M. Schuetz;W. Ries;H. P. Tews, ed. Altern in Gesundheit und Krankheit. Melsungen: Bibliomed Medizinische Verlagsgesellschaft, 1997, pp.229-234.

• Edited Book

  • von Zglinicki T, ed. Aging at the Molecular Level. Dordrecht: Springer, 2003.

• Editorials

  • Skinner R, von Zglinicki T. Accelerated Aging in Bone Marrow Transplant Survivors. JAMA Oncology 2016, 2(10), 1267-1268.
  • Spyridopoulos I, von Zglinicki T. Telomere length predicts cardiovascular disease. British Medical Journal 2014, 349, g4373.
  • Von Zglinicki T. Telomeres, telomerase and the cancer cell: An introduction. Cancer Letters 2003, 194(2), 137-138.
  • von Zglinicki T. Oxidative stress shortens telomeres. Trends in Biochemical Sciences 2002, 27(7), 339-344.

• Letter

  • Von Zglinicki T, Petrie J, Kirkwood TBL. Telomere-driven replicative senescence is a stress response [2]. Nature Biotechnology 2003, 21(3), 229-230.

• Note

  • Martin-Ruiz CM, Baird D, Roger L, Boukamp P, Krunic D, Cawthon R, Dokter MM, van der Harst P, Bekaert S, De Meyer T, Roos G, Svenson U, Codd V, Samani NJ, McGlynn L, Shiels PG, Pooley KA, Dunning AM, Cooper R, Wong A, Kingston A, Von Zglinicki T. Corrigendum to "Reproducibility of Telomere Length Assessment - An International Collaborative Study" [International Journal of Epidemiology 2014, doi: 10.1093/ije/dyu191]. International Journal of Epidemiology 2015, 44(5), 1749-1754.

• Patent

  • von Zglinicki T, Ludwig A, Saretzki G. Ribozymes inhibiting the catalytic subunit of human telomerase (hTERT). Germany & International, DE199039615, INT10003356, 1999.

• Reviews

  • Miwa S, Kashyap S, Chini E, von Zglinicki T. Mitochondrial dysfunction in cell senescence and aging. Journal of Clinical Investigation 2022, 132(13), e158447.
  • Von Zglinicki T, Wan T, Miwa S. Senescence in Post-Mitotic Cells: A Driver of Aging?. Antioxidants and Redox Signaling 2021, 34(4), 308-323.
  • Low E, Alimohammadiha G, Smith LA, Costello LF, Przyborski SA, von Zglinicki T, Miwa S. How good is the evidence that cellular senescence causes skin ageing?. Ageing Research Reviews 2021, 71, 101456.
  • Short S, Fielder E, Miwa S, von Zglinicki T. Senolytics and senostatics as adjuvant tumour therapy. EBioMedicine 2019, 41, 683-692.
  • Gorgoulis V, Adams PD, Alimonti A, Bennett DC, Bischof O, Bishop C, Campisi J, Collado M, Evangelou K, Ferbeyre G, Gil J, Hara E, Krizhanovsky V, Jurk D, Maier AB, Narita M, Niedernhofer L, Passos JF, Robbins PD, Schmitt CA, Sedivy J, Vougas K, von Zglinicki T, Zhou D, Serrano M, Demaria M. Cellular Senescence: Defining a Path Forward. Cell 2019, 179(4), 813-827.
  • Fielder E, Von Zglinicki T, Jurk D. The DNA Damage Response in Neurons: Die by Apoptosis or Survive in a Senescence-Like State?. Journal of Alzheimer's Disease 2017, 60(s1), S107-S131.
  • Tchkonia T, Morbeck D, Von Zglinicki T, Van Deursen J, Lustgarten J, Scrable H, Khosla S, Jensen M, Kirkland J. Fat tissue, aging, and cellular senescence. Aging Cell 2010, 9(5), 667-684.