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Staff Profile

Dr Valeria Di Leo

Research Associate

  • Address: Mitochondrial Research Group
    Translational and Clinical Research Institute
    Faculty of Medical Sciences
    Newcastle University
    4th Floor Cookson Building
    Framlington Place
    NE2 4HH
Background

I am a Research Associate within the Mitochondrial Research Group. I investigate the effects of resistance exercise training on neuromuscular disease patients, with a particular focus on Myotonic Dystrophy type 1 and Mitochondrial Myopathy.


Associate in Translational Medicine (Neuromuscular Disorders) in Newcastle University (UK)

PhD in Translational Medicine in (Neuromuscular Disorders) in Newcastle University (UK)

Erasmus traineeship within the John Walton Muscular Dystrophy Research Centre, in Newcastle University (UK)

Master degree in Functional Genomics in Trieste University (IT)

Bachelor degree in Medical and Pharmaceutical Biotechnology in Bari University (IT)

 

ResearchGate: https://www.researchgate.net/profile/Valeria_Di_Leo

LinkedIn: www.linkedin.com/in/valeria-di-leo-85b70712a

Research

My research focuses on the effects of resistance exercise training on mitochondrial dysfunction on both Mitochondrial Myopathy and Myotonic Dystrophy type 1 patients, aiming to identify some key signature targets for the future development of exercise mimetic drugs for the treatment of mitochondrial dysfunction.

Publications

  • Articles

    • Topf A, Cox D, Zaharieva IT, Di Leo V, Sarparanta J, Jonson PH, Sealy IM, Smolnikov A, White RJ, Vihola A, Savarese M, Merteroglu M, Wali N, Laricchia KM, Venturini C, Vroling B, Stenton SL, Cummings BB, Harris E, Marini-Bettolo C, Diaz-Manera J, Henderson M, Barresi R, Duff J, England EM, Patrick J, Al-Husayni S, Biancalana V, Beggs AH, Bodi I, Bommireddipalli S, Bonnemann CG, Cairns A, Chiew M-T, Claeys KG, Cooper ST, Davis MR, Donkervoort S, Erasmus CE, Fassad MR, Genetti CA, Grosmann C, Jungbluth H, Kamsteeg E-J, Lornage X, Loscher WN, Malfatti E, Manzur A, Marti P, Mongini TE, Muelas N, Nishikawa A, O'Donnell-Luria A, Ogonuki N, O'Grady GL, O'Heir E, Paquay S, Phadke R, Pletcher BA, Romero NB, Schouten M, Shah S, Smuts I, Sznajer Y, Tasca G, Taylor RW, Tuite A, Van den Bergh P, VanNoy G, Voermans NC, Wanschitz JV, Wraige E, Yoshimura K, Oates EC, Nakagawa O, Nishino I, Laporte J, Vilchez JJ, MacArthur DG, Sarkozy A, Cordell HJ, Udd B, Busch-Nentwich EM, Muntoni F, Straub V. Digenic inheritance involving a muscle-specific protein kinase and the giant titin protein causes a skeletal muscle myopathy. Nature Genetics 2024, 56, 395–407.
    • Vincent AE, Chen C, Gomes TB, Di Leo V, Laalo T, Pabis K, Capaldi R, Marusich MF, McDonald D, Filby A, Fuller A, Lehmann Urban D, Zierz S, Deschauer M, Turnbull D, Reeve AK, Lawless C. A stagewise response to mitochondrial dysfunction in mitochondrial DNA maintenance disorders. Biochimica et Biophysica Acta - Molecular Basis of Disease 2024, 1870(5), 167131.

  • Review