Staff Profile
Research
I am interested in the discovery, biosynthesis, function, and mode of action of microbial natural products for therapeutic purposes. For these studies I use a combination of natural product chemistry, microbiology, molecular biology, and biochemistry.
Publications
- Dashti Y, Nakou IT, Mullins A, Webster G, Mahenthiralingam E, Challis GL. Discovery and biosynthesis of bolagladins: unusual lipodepsipeptides from clinical Burkholderia gladioli isolates. Angewandte Chemie 2020, 59(48), 21553-21561.
- Nakou IT, Jenner M, Dashti Y, RomeroCanelon I, Masschelein J, Mahenthiralingam E, Challis GL. Genomics-driven discovery of a novel glutarimide antibiotic from Burkholderia gladioli reveals an unusual polyketide synthase chain release mechanism. Angewandte Chemie 2020, 59(51), 23145-23153.
- Zabala D, Song L, Dashti Y, Challis GL, Salas JA, Méndez C. Heterologous reconstitution of the biosynthesis pathway for 4-demethyl-premithramycinone, the aglycon of antitumor polyketide mithramycin. Microbial Cell Factories 2020, 19, 111.
- Jenner M, Jian X, Dashti Y, Masschelein J, Hobson C, Roberts DM, Jones C, Harris S, Parkhill J, Raja HA, Oberlies NH, Pearce CJ, Mahenthiralingam E, Challis GL. An unusual Burkholderia gladioli double chain-initiating nonribosomal peptide synthetase assembles ‘fungal’ icosalide antibiotics. Chemical Science 2019, 10, 5489-5494.
- Heidarian S, Mohammadipanah F, Maghsoudlou A, Dashti Y, Challis GL. Anti-microfouling Activity of Glycomyces sediminimaris UTMC 2460 on Dominant Fouling Bacteria of Iran Marine Habitats. Frontiers in Microbiology 2019, 9, 3148.
- Dashti Y, Hobson C, Mazraati Tajabadi F, Rezadoost H. Phytochemical investigation of Iphiona aucheri. Structural revision of donine. Chemistry of Natural Compounds 2019, 55, 902–907.
- Mazraati Tajabadi F, Pouwer RH, Liu M, Dashti Y, Campitelli MR, Murtaza M, Mellick GD, Wood SA, Jenkins ID, Quinn RJ. Design and synthesis of natural product inspired libraries based on the three-dimensional (3D) cedrane scaffold: toward the exploration of 3D biological space. Journal of Medicinal Chemistry 2018, 61(15), 6609-6628.
- Dashti Y, Grkovic T, Abdelmohsen UR, Hentschel U, Quinn RJ. Actinomycetes metabolome induction/suppression with N-acetylglucosamine. Journal of Natural Products 2017, 80(4), 828–836.
- Dashti Y, Vial ML, Wood SA, Mellick GD, Roullier C, Quinn RJ. Kororamide B, a brominated alkaloid from the bryozoan Amathia tortuosa and its effects on Parkinson's disease cells. Tetrahedron 2015, 71(41), 7879-7884.
- Dashti Y, Grkovic T, Quinn RJ. Predicting natural products value, an exploration of anti-TB drug space. Natural Product Reports 2014, 31(8), 990-998.
- Dashti Y, Grkovic T, Ramadan Abdelmohsen U, Hentschel U, Quinn R. Production of induced secondary metabolites by a co-culture of sponge-associated actinomycetes Actinokineospora sp. EG49 and Nocardiopsis sp. RV163. Marine Drugs 2014, 12(5), 3046-3059.
- Salehi P, Mazraati Tajabadi F, Younesi H, Dashti Y. Optimization of lead and nickel biosorption by Cystoseira trinodis (brown algae) using Response Surface Methodology (RSM). CLEAN-Soil, Air, Water 2014, 42(3), 243-250.
- Salehi P, Dashti Y, Mazraati Tajabadi F, safidkon F, Rabiei R. Structural and compositional characteristics of a sulfated galactan polysaccharide from the red algae Gracilariopsis persica. Carbohydrate Polymers 2011, 83(4), 1570-1574.