Staff Profile

I am an NHIP Senior Clinical Fellow and Honorary Consultant based in the Translational and Clinical Research Institute at Newcastle University within the Immunity and Inflammation theme. Clinically I work as a consultant in Paediatric Respiratory Medicine at the Great North Children's Hospital and the Freeman Hospital in Newcastle upon Tyne where I work within the regional Paediatric Cystic Fibrosis and Sleep Services. I also have a general respiratory clinic where I see patients with a range of respiratory conditons.

My academic interests involve research investigating abnormal airway epithelial physiology in children who have chronic respiratory diseases such as cystic fibrosis.

Previous positions

• NIHR Clinical Lecturer, Newcastle University (2019-2022)
• Clinical Research Associate, Newcastle University (2015-2018)
• Paediatric Specialty Trainee, Northern Deanery, Newcastle (2010-2019)

Qualifications

MBBS, MRes, MRCPCH, PhD 

Roles and responsibilities

CF Trust Standards of Care Working Group (2023 -)

NIHR Reviewer Development Scheme (2020 to present)

UK Cystic Fibrosis Medical Association Paediatric Trainee Representative (2019 to present)

Newcastle University Ethics Committee Reviewer (2019 to present)

Editorial board member ‘Beat Asthma’ online resource (2017)

ALSG Newborn Life Support Instructor (2015 to present)

I am an NIHR ACL in Paediatric Respiratory Medicine and my research interests in cystic fibrosis and the development of relevant airway models to investigate the impact of dysfunctional airway epithelial ion transport and physiology in the cystic fibrosis airway. 

During my Wellcome Trust funded Clinical Research Training Fellowship I investigated the role of the alternative chloride channel, TMEM16A, as a therapeutic target for cystic fibrosis. During this PhD, I utilised differentiated primary airway epithelial cell culture models derived from children and applied these models to investigate ion transport using electrophysiological techniques. Since my PhD, I have been able to further my research within this field to further investigate abnormal ion transport processes in individuals with cystic fibrosis and how these vary within the nasal and bronchial airways and was awarded an Academy of Medical Sciences Starter Grant during my NIHR Clinical Lectureship to continue this work.

Awards

Academy of Medical Sciences Starter Grant for Clinical Lecturers (awarded 2021)

Wellcome Trust Institutional Strategic Support Fund (awarded 2019)

Wellcome Trust ISSF Broadening Our Horizons Scheme, North American Cystic Fibrosis Conference (awarded 2019)

Wellcome Trust Clinical Research Training Fellowship (awarded 2016)

British Paediatric Respiratory Society Travel Award, European Cystic Fibrosis Society Conference (awarded 2019)

In my clinical work, I am involved in teaching medical students and doctors in aspects of paediatrics and paediatric respiratory medicine. I am also a certified ALSG Newborn Life Support Instructor.

I have supervised students within the university including during summer studentships, undergraduate and postgraduate projects.

I am actively involved in structured teaching specifically with the undergraduate Biomedical Sciences and Physiology degree programmes.

I am also a personal tutor for the Masters of Clinical Research Programme.

• Articles

  • Almulhem M, Harnett N, Graham S, Haq I, Visram S, Ward C, Brodlie M. Exploring the impact of elexacaftor-tezacaftor-ivacaftor treatment on opinions regarding airway clearance techniques and nebulisers: TEMPO a qualitative study in children with cystic fibrosis, their families and healthcare professionals. BMJ Open Respiratory Research 2022, 9, e001420.
  • Jackson RM, Hatton CF, Spegarova JS, Georgiou M, J Collin, E Stephenson, B Verdon, IJ Haq, R Hussain, JM Coxhead, H-S Mudhar, B Wagner, M Hasoon, T Davey, P Rooney, A Khan, C Ward, M Brodlie, M Haniffa, S Hambleton, L Armstrong, F Figueiredo, Queen R, Duncan CJ, Lako M. Conjunctival epithelial cells resist productive SARS-CoV-2 infection. Stem Cell Reports 2022, 17(7), 1699-1713.
  • Zainal Abidin N, Gardner AI, Robinson H, Haq IJ, Thomas MF, Brodlie M. Trends in nontuberculous mycobacteria infection in children and young people with cystic fibrosis. Journal of Cystic Fibrosis 2021, 20(5), 737-741.
  • Gardner AI, Wu Y, Verhaegh R, Liu Y, Wilker B, Soddemann M, Keitsch S, Edwards MJ, Haq IJ, Kamler M, Becker KA, Brodlie M, Gulbins E. Interferon regulatory factor 8 regulates expression of acid ceramidase and infection susceptibility in cystic fibrosis. Journal of Biological Chemistry 2021, 296, 100650.
  • Hatton CF, Botting RA, Duenas ME, Haq IJ, Verdon B, Thompson BJ, Spegarova JS, Gothe F, Stephenson E, Gardner AI, Murphy S, Scott J, Garnett JP, Carrie S, Powell J, Khan CMA, Huang L, Hussain R, Coxhead J, Davey T, Simpson AJ, Haniffa M, Hambleton S, Brodlie M, Ward C, Trost M, Reynolds G, Duncan CJA. Delayed induction of type I and III interferons mediates nasal epithelial cell permissiveness to SARS-CoV-2. Nature Communications 2021, 12(1), 7092.
  • Shteinberg M, Haq IJ, Polineni D, Davies JC. Cystic fibrosis. Lancet 2021, 397, 2195-2211.
  • Bain R, Cosgriff R, Zampoli M, Elbert A, Burgel P-R, Carr SB, Castaños C, Colombo C, Corvol H, Faro A, Goss CH, Gutierrez H, Jung A, Kashirskaya N, Marshall BC, Melo J, Mondejar-Lopez P, de Monestrol I, Naehrlich L, Padoan R, Dolores Pastor-Vivero M, Rizvi S, Salvatore M, Vicente Ribeiro Ferreira da Silva Filho L, Brownlee KG, Haq IJ, Brodlie M. Clinical characteristics of SARS-CoV-2 infection in children with cystic fibrosis: An international observational study. Journal of Cystic Fibrosis 2021, 20(1), 25-30.
  • Haq IJ, Althaus M, Gardner AI, Yeoh HY, Joshi U, Saint-Criq V, Verdon B, Townshend J, O'Brien C, Ben-Hamida M, Thomas M, Bourke S, van der Sluijs P, Braakman I, Ward C, Gray MA, Brodlie M. Clinical and molecular characterization of the R751L-CFTR mutation. American Journal of Physiology Lung Cellular and Molecular Physiology 2021.
  • Haq IJ, Althaus M, Gardner AI, Yeoh HY, Joshi U, Saint-Criq V, Verdon B, Townshend J, O'Brien C, Ben-Hamida M, Thomas M, Bourke S, van der Sluijs P, Braakman I, Ward C, Gray MA, Brodlie M. Clinical and molecular characterisation of the R751L-CFTR mutation. American Journal of Physiology Lung Cellular and Molecular Physiology 2021, 320(2), L288-L300.
  • Gardner AI, Haq IJ, Simpson AJ, Becker KA, Gallagher J, Saint-Criq V, Verdon B, Mavin E, Trigg A, Gray MA, Koulman A, McDonnell MJ, Fisher AJ, Kramer EL, Clancy JP, Ward C, Schuchman EH, Gulbins E, Brodlie M. Recombinant Acid Ceramidase Reduces Inflammation and Infection in Cystic Fibrosis. American Journal of Respiratory and Critical Care Medicine 2020, 202(8), 1133-1145.
  • Saint-Criq V, Haq IJ, Gardner AI, Garnett JP, Ward C, Brodlie M, Gray MA. Real-Time, Semi-Automated Fluorescent Measurement of the Airway Surface Liquid pH of Primary Human Airway Epithelial Cells. Journal of Visualized Experiements 2019, (148), e59815.
  • Haq IJ, Battersby AC, Eastham K, McKean M. Community acquired pneumonia in children. BMJ 2017, 356, j686.
  • Ibrahim SH, Turner MJ, Saint-Criq V, Garnett J, Haq IJ, Brodlie M, Ward C, Borgo C, Salvi M, Venerando A, Gray MA. CK2 is a key regulator of SLC₄A2- mediated Cl-/HCO₃- exchange in human airway epithelia. Pflügers Archiv - European Journal of Physiology 2017, 469(9), 1073-1091.
  • Zainal Abidin N, Haq IJ, Gardner AI, Brodlie M. Ataluren in cystic fibrosis: development, clinical studies and where are we now?. Expert Opinion on Pharmacotherapy 2017, 18(13), 1363-1371.
  • Haq IJ, Gray MA, Garnett JP, Ward C, Brodlie M. Airway surface liquid homeostasis in cystic fibrosis: pathophysiology and therapeutic targets. Thorax 2016, 71(3), 284-287.
  • Brodlie M, Haq IJ, Roberts K, Elborn JS. Targeted therapies to improve CFTR function in cystic fibrosis. Genome Medicine 2015, 7(1), 101.
  • Haq I, Gopalakaje S, Fenton AC, McKean MC, O'Brien C, Brodlie M. The evidence for high flow nasal cannula devices in infants. Paediatric Respiratory Reviews 2014, 15(2), 124-134.
  • Haq IJ, Steinberg LJ, Hoenig M, van der Burg M, Villa A, Cant AJ, Middleton PG, Gennery AR. GvHD-associated cytokine polymorphisms do not associate with Omenn syndrome rather than T-B- SCID in patients with defects in RAG genes. Clinical Immunology 2007, 124(2), 165-169.

• Book Chapter

  • Abidin NZ, Naples R, Powell S, Gabra H, De Rita F, McDonald L, Thomas MF, O'Brien CJ, Haq IJ, Tinnion R, Brodlie M. Tracheal disorders of the newborn. In: Sinha IP; Bhatt JM; Cleator A; Wallace H, ed. Respiratory Diseases of the Newborn Infant. Sheffield: European Respiratory Society, 2021, pp.147-163.

• Editorials

  • Haq I, Harris C, Taylor J, McKean MC, Brodlie M. Should we use montelukast in wheezy children?. Archives of Disease in Childhood 2017, 102(11), 997-998.
  • Haq IJ, Gardner A, Brodlie M. A multifunctional bispecific antibody against Pseudomonas aeruginosa as a potential therapeutic strategy. Annals of Translational Medicine 2016, 4(1), 12.

• Reviews

  • Haq I, Almulhem M, Soars S, Poulton D, Brodlie M. Precision Medicine Based on CFTR Genotype for People with Cystic Fibrosis. Pharmacogenomics and Personalized Medicine 2022, 15, 91-104.
  • Haq IJ, Parameswaran MC, Abidin NZ, Socas A, Gonzalez-Ciscar A, Gardner AI, Brodlie M. Modulator therapies for cystic fibrosis. Paediatrics and Child Health 2019, 29(4), 151-157.