Staff Profile

Qualifications

B.Sc. Combined (Hons) Biochem/Microbiology. University of Leeds

Ph.D. Membrane Transport. University of London 

Honours and Awards

Honorary membership of the Hungarian Gastroenterological Society with the Geza Hetenyi Memorial Medallion, in recognition of my contribution to Hungarian Gastroenterology (Awarded June 2011).

Invited to Buckingham Palace Garden Party in recognition of my work with the UK charity, Cystic Fibrosis Trust (May 2018)

Elected Fellow of The Physiological Society, July 2022.

Memberships

Elected member of The Physiological Society in 1992; Biophysical Society in 1993; American Physiological Society in 1995; Society of General Physiologists in 1996. Committee member of The Physiological Society and Chair of the Education and Information sub-committee (1997-2001). Member of the Meetings Advisory Committee of The Physiological Society 2003-2005

Convenor of the Epithelial and Membrane Transport Theme of the Physiological Society (2010- 2014)

Editor for Experimental Physiology (1999 - 2006).

Member of the Scientific Advisory Committee of the European Cystic Fibrosis Society (2016-2020).

Member of the Research and Medical Advisory Committee of the Cystic Fibrosis Trust (2001- 2004).

Member of the Steering Committee of the UK CF Microbiology Consortium (2005- 2008).

Deputy Chair of the Research Advisory Committee of the CF Trust (2004 - 2013).

Member of the Strategy Advisory Board of the CF Trust (2014-2020)

Chair of the Strategic Implementation Board of the CF Trust (2013 - 2020) 

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Research Interests

The major research interest of our lab is to understand the cellular mechanisms that orchestrate epithelial ion, fluid and mucus secretion in differentiated adult epithelial tissues, and how epithelial dysfunction impacts on the pathogenesis of chronic diseases such as cystic fibrosis, pancreatitis and COPD.

Epithelial ion (salt) transport is a fundamental function of all epithelial tissues and determines whole body fluid volume, blood pressure and acid-base balance, as well as regulating absorption and secretion of fluid and macromolecules such as digestive enzymes and mucus. Numerous diseases are caused by aberrant epithelial ion transport such as hypertension, cholera, polycystic kidney disease and cystic fibrosis, the most common, life-shortening, inherited disease in the white population. Understanding which transport proteins are involved, how they coordinate ion and fluid transport by the cell, and what goes wrong in disease is vitally important, not only for a better understanding of the biology of the system but also in developing new treatments to combat major diseases.      

Current projects are concerned with identifying novel-non CFTR based approaches to correct the basic defect in cystic fibrosis, as well as the role of CFTR in CF-related diabetes. These projects are funded by two Strategic Research Centre Grants from the CF Trust as well as a Clinical Fellowship from the Wellcome Trust. Other projects include; Role of CFTR in airways smooth muscle hyper-responsiveness (starts Sept 2016) regulation of CFTR by the luminal microenvironment, role of CFTR and SLC26A anion transporters in co-ordinating pancreatic and airway bicarbonate secretion; the effect of alcohol, bile acids and cigarette smoke exposure on CFTR and other ion transporters..

We use a multidisciplinary approach employing a range of molecular, biochemical and cell physiological techniques. Much of our work is conducted at the cellular level but employs native tissue, or primary epithelial cells, as much as possible.

Current research is being funded by The Cystic Fibrosis Trust

Research Expertise

Electrophysiology

Ion channel reconstitution

Fluorescent microscopy

Primary airway cell culture and differentiation

Stem cells and gene editing 

Undergraduate Teaching

Stage 1 Biomedical Science. PSC1002: Physiology - Cardiovascular Physiology Lectures

Stage 2 Biomedical Science. PSC2002: Membrane Transport and Cell Signalling in Health and Disease - Module leader and lectures on Epithelial ion transport, Cystic Fibrosis and Cell Signalling

Stage 3 Biomedical Science. CMB3000 - Undergraduate lab projects

• Articles

  • Lin JH, Gettings SM, Talbi K, Schreiber R, Taggart MJ, Preller M, Kunzelmann K, Althaus M, Gray MA. Pharmacological inhibitors of the cystic fibrosis transmembrane conductance regulator exert off-target effects on epithelial cation channels. Pflugers Archiv European Journal of Physiology 2023, 475, 167-179.
  • Delpiano L, Rodenburg LW, Burke M, Nelson G, Amatngalim GD, Beekman JM, Gray MA. Dynamic regulation of airway surface liquid pH by TMEM16A and SLC26A4 in cystic fibrosis nasal epithelia with rare mutations. Proceedings of the National Academy of Sciences of the United States of America 2023, 120(47), e2307551120.
  • Cuevas-Ocana S, Yang JY, Aushev M, Schlossmacher G, Bear CE, Hannan NRF, Perkins ND, Rossant J, Wong AP, Gray MA. A Cell-Based Optimised Approach for Rapid and Efficient Gene Editing of Human Pluripotent Stem Cells. International Journal of Molecular Sciences 2023, 24(12), 10266.
  • Jo S, Centeio R, Park J, Ousingsawat J, Jeon D-K, Talbi K, Schreiber R, Ryu K, Kahlenberg K, Somoza V, Delpiano L, Gray MA, Amaral MD, Railean V, Beekman JM, Rodenburg LW, Namkung W, Kunzelmann K. The SLC26A9 inhibitor S9-A13 provides no evidence for a role of SLC26A9 in airway chloride secretion but suggests a contribution to regulation of ASL pH and gastric proton secretion. FASEB Journal 2022, 36(11), e22534.
  • Saint-Criq V, Guequen A, Philp A, Villanueva S, Apablaza T, Fernandez-Moncada I, Mansilla A, Delpiano L, Ruminot I, Carrasco C, Gray MA, Flores CA. Inhibition of the sodium-dependent HCO₃ - transporter SLC4A4, produces a cystic fibrosis-like airway disease phenotype. eLife 2022, 11, e75871.
  • Rodenburg LW, Delpiano L, Railean V, Centeio R, Pinto MC, Smits SMA, van der Windt IS, van Hugten CFJ, van Beuningen SFB, Rodenburg RNP, van der Ent CK, Amaral MD, Kunzelmann K, Gray MA, Beekman JM, Amatngalim GD. Drug Repurposing for Cystic Fibrosis: Identification of Drugs That Induce CFTR-Independent Fluid Secretion in Nasal Organoids. International Journal of Molecular Sciences 2022, 23(20), 12657.
  • Saint-Criq V, Wang Y, Delpiano L, Lin J, Sheppard DN, Gray MA. Extracellular phosphate enhances the function of F508del-CFTR rescued by CFTR correctors. Journal of Cystic Fibrosis 2021, 20(5), 843-850.
  • Pereira C, Mazein A, Farinha CM, Gray MA, Kunzelmann K, Ostaszewski M, Balaur I, Amaral MD, Falcao AO. CyFi-MAP: an interactive pathway-based resource for cystic fibrosis. Scientific Reports 2021, 11(1), 22223.
  • Haq IJ, Althaus M, Gardner AI, Yeoh HY, Joshi U, Saint-Criq V, Verdon B, Townshend J, O'Brien C, Ben-Hamida M, Thomas M, Bourke S, van der Sluijs P, Braakman I, Ward C, Gray MA, Brodlie M. Clinical and molecular characterisation of the R751L-CFTR mutation. American Journal of Physiology Lung Cellular and Molecular Physiology 2021, 320(2), L288-L300.
  • Lin JH, Taggart M, Borthwick L, Fisher A, Brodlie M, Sassano MF, Tarran R, Gray MA. Acute cigarette smoke or extract exposure rapidly activates TRPA1-mediated calcium influx in primary human airway smooth muscle cells. Scientific Reports 2021, 11(1), 9643.
  • Gardner AI, Haq IJ, Simpson AJ, Becker KA, Gallagher J, Saint-Criq V, Verdon B, Mavin E, Trigg A, Gray MA, Koulman A, McDonnell MJ, Fisher AJ, Kramer EL, Clancy JP, Ward C, Schuchman EH, Gulbins E, Brodlie M. Recombinant Acid Ceramidase Reduces Inflammation and Infection in Cystic Fibrosis. American Journal of Respiratory and Critical Care Medicine 2020, 202(8), 1133-1145.
  • White MG, Maheshwari RR, Anderson SJ, Berlinguer-Palmini R, Jones C, Richardson SJ, Rotti PG, Armour SL, Ding Y, Krasnogor N, Engelhardt JF, Gray MA, Morgan NG, Shaw JAM. In situ analysis reveals that CFTR is expressed in only a small minority of β-cells in normal adult human pancreas. Journal of Clinical Endocrinology and Metabolism 2020, 105(5), 1366-1374.
  • Saint-Criq V, Delpiano L, Casement J, Onuora JC, Lin J, Gray MA. Choice of Differentiation Media Significantly Impacts Cell Lineage and Response to CFTR Modulators in Fully Differentiated Primary Cultures of Cystic Fibrosis Human Airway Epithelial Cells. Cells 2020, 9(9), 2137.
  • Saint-Criq V, Haq IJ, Gardner AI, Garnett JP, Ward C, Brodlie M, Gray MA. Real-Time, Semi-Automated Fluorescent Measurement of the Airway Surface Liquid pH of Primary Human Airway Epithelial Cells. Journal of Visualized Experiements 2019, (148), e59815.
  • Patel W, Moore PJ, Sassano MF, Lopes-Pacheco M, Aleksandrov AA, Amaral MD, Tarran R, Gray MA. Increases in cytosolic Ca²⁺ induce dynamin- and calcineurin-dependent internalisation of CFTR. Cellular and Molecular Life Sciences 2019, 76(5), 977-994.
  • Marklew AJ, Patel W, Moore PJ, Tan CD, Smith AJ, Sassano MF, Gray MA, Tarran R. Cigarette Smoke Exposure Induces Retrograde Trafficking of CFTR to the Endoplasmic Reticulum. Scientific Reports 2019, 9(1), 13655.
  • Delpiano L, Thomas JJ, Yates AR, Rice SJ, Gray MA, Saint-Criq V. Esomeprazole Increases Airway Surface Liquid pH in Primary Cystic Fibrosis Epithelial Cells. Frontiers in Pharmacology 2018, 9, 1462.
  • Ibrahim SH, Turner MJ, Saint-Criq V, Garnett J, Haq IJ, Brodlie M, Ward C, Borgo C, Salvi M, Venerando A, Gray MA. CK2 is a key regulator of SLC₄A2- mediated Cl-/HCO₃- exchange in human airway epithelia. Pflügers Archiv - European Journal of Physiology 2017, 469(9), 1073-1091.
  • Watson MJ, Lee SL, Marklew AJ, Gilmore RC, Gentzsch M, Sassano MF, Gray MA, Tarran R. The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Uses its C-Terminus to Regulate the A2B Adenosine Receptor. Scientific Reports 2016, 6, 27390.
  • Turner MJ, Saint-Criq V, Patel W, Ibrahim SH, Verdon B, Ward C, Garnett JP, Tarran R, Cann MJ, Gray MA. Hypercapnia Modulates cAMP Signalling and Cystic Fibrosis Transmembrane Conductance Regulator-dependent Anion and Fluid Secretion in Airway Epithelia. Journal of Physiology 2016, 594(6), 1643-1661.
  • Haq IJ, Gray MA, Garnett JP, Ward C, Brodlie M. Airway surface liquid homeostasis in cystic fibrosis: pathophysiology and therapeutic targets. Thorax 2016, 71(3), 284-287.
  • Broadbent SD, Ramjeesingh M, Bear CE, Argent BE, Linsdell P, Gray MA. The cystic fibrosis transmembrane conductance regulator is an extracellular chloride sensor. Pfluegers Archiv - European Journal of Physiology 2015, 467(8), 1783-1794.
  • Maleth J, Balazs A, Pallagi P, Balla Z, Kui B, Katona M, Judak L, Nemeth I, Kemeny LV, Rakonczay Z, Venglovecz V, Foldesi I, Peto Z, Somoracz A, Borka K, Perdomo D, Lukacs GL, Gray MA, Monterisi S, Zaccolo M, Sendler M, Mayerle J, Kuhn JP, Lerch MM, Sahin-Toth M, Hegyi P. Alcohol Disrupts Levels and Function of the Cystic Fibrosis Transmembrane Conductance Regulator to Promote Development of Pancreatitis. Gastroenterology 2015, 148(2), 427-439.e16.
  • Pallagi P, Balla Z, Singh AK, Dósa S, Iványi B, Kukor Z, Tóth A, Riederer B, Liu Y, Engelhardt R, Jármay K, Szabó A, Janovszky A, Perides G, Venglovecz V, Maléth J, Wittmann T, Takács T, Gray MA, Gácser A, Hegyi P, Seidler U, Rakonczay Z. The Role of Pancreatic Ductal Secretion in Protection Against Acute Pancreatitis in Mice. Critical Care Medicine 2014, 42(3).
  • Judak L, Hegyi P, Rakonczay Z, Maleth J, Gray MA, Venglovecz V. Ethanol and its non-oxidative metabolites profoundly inhibit CFTR function in pancreatic epithelial cells which is prevented by ATP supplementation. Pflügers Archiv - European Journal of Physiology 2014, 466(3), 549-562.
  • Garnett JP, Hickman E, Tunkamnerdthai O, Cuthbert AW, Gray MA. Protein phosphatase 1 coordinates CFTR-dependent airway epithelial HCO₃- secretion by reciprocal regulation of apical and basolateral membrane Cl--HCO₃- exchangers. British Journal of Pharmacology 2013, 168(8), 1946-1960.
  • Garnett JP, Gray MA, Tarran R, Brodlie M, Ward C, Baker EH, Baines DL. Elevated Paracellular Glucose Flux across Cystic Fibrosis Airway Epithelial Monolayers Is an Important Factor for Pseudomonas aeruginosa Growth. PLoS One 2013, 8(10), e76283.
  • Winpenny JP, Gray MA. The anoctamin (TMEM16) gene family: calcium-activated chloride channels come of age. Experimental Physiology 2012, 97(2), 175-176.
  • Cook ZC, Gray MA, Cann MJ. Elevated Carbon Dioxide Blunts Mammalian cAMP Signaling Dependent on Inositol 1,4,5-Triphosphate Receptor-mediated Ca2+ Release. Journal of Biological Chemistry 2012, 287(31), 26291-26301.
  • Pallagi P, Venglovecz V, Rakonczay Z, Borka K, Korompay A, Ozsvari B, Judak L, Sahin-Toth M, Geisz A, Schnur A, Maleth J, Takacs T, Gray MA, Argent BE, Mayerle J, Lerch MM, Wittmann T, Hegyi P. Trypsin Reduces Pancreatic Ductal Bicarbonate Secretion by Inhibiting CFTR Cl- Channels and Luminal Anion Exchangers. Gastroenterology 2011, 141(6), 2228-U413.
  • Venglovecz V, Hegyi P, Rakonczay Z, Tiszlavicz L, Nardi A, Grunnet M, Gray MA. Pathophysiological relevance of apical large-conductance Ca²⁺ -activated potassium channels in pancreatic duct epithelial cells. Gut 2011, 60(3), 361-369.
  • Garnett JP, Hickman E, Burrows R, Hegyi P, Tiszlavicz L, Cuthbert AW, Fong PY, Gray MA. Novel Role for Pendrin in Orchestrating Bicarbonate Secretion in Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)-expressing Airway Serous Cells. Journal of Biological Chemistry 2011, 286(47), 41069-41082.
  • Borthwick LA, Botha P, Verdon B, Brodlie MJ, Gardner A, Bourn D, Johnson GE, Gray MA, Fisher AJ. Is CFTR-delF508 Really Absent from the Apical Membrane of the Airway Epithelium?. PLoS One 2011, 6(8).
  • Hug MJ, Clarke LL, Gray MA. How to measure CFTR-dependent bicarbonate transport: from single channels to the intact epithelium. Methods in Molecular Biology 2011, 741(5), 489-509.
  • Ko SBH, Yamamoto A, Azuma S, Song HZ, Kamimura K, Nakakuki M, Gray MA, Becq F, Ishiguro H, Goto H. Effects of CFTR gene silencing by siRNA or the luminal application of a CFTR activator on fluid secretion from guinea-pig pancreatic duct cells. Biochemical and Biophysical Research Communications 2011, 410(4), 904-909.
  • Brodlie M, McKean MC, Johnson GE, Perry JD, Nicholson A, Verdon B, Gray MA, Dark JH, Pearson JP, Fisher AJ, Corris PA, Lordan J, Ward C. Primary bronchial epithelial cell culture from explanted cystic fibrosis lungs. Experimental Lung Research 2010, 36(2), 101-110.
  • Park HW, Nam JH, Kim JY, Namkung W, Yoon JS, Lee JS, Kim KS, Venglovecz V, Gray MA, Kim KH, Lee MG. Dynamic Regulation of CFTR Bicarbonate Permeability by [Cl^-]_i and Its Role in Pancreatic Bicarbonate Secretion. Gastroenterology 2010, 139(2), 620-631.
  • Townsend PD, Holliday PM, Fenyk S, Hess KC, Gray MA, Hodgson DRW, Cann MJ. Stimulation of Mammalian G-protein-responsive Adenylyl Cyclases by Carbon Dioxide. Journal of Biological Chemistry 2009, 284(2), 784-791.
  • Treharne KJ, Xu Z, Chen JH, Best OG, Cassidy DM, Gruenert DC, Hegyi P, Gray MA, Sheppard DN, Kunzelmann K, Mehta A. Inhibition of Protein Kinase CK2 Closes the CFTR Cl- Channel, but has no Effect on the Cystic Fibrosis Mutant Delta F508-CFTR CFTR. Cellular Physiology and Biochemistry 2009, 24(5-6), 347-360.
  • Ignáth I, Hegyi P, Venglovecz V, Székely CA, Carr G, Hasegawa M, Inoue M, Takács T, Argent BE, Gray MA, Rakonczay Z. CFTR Expression But Not Cl- Transport Is Involved in the Stimulatory Effect of Bile Acids on Apical Cl-/HCO3- Exchange Activity in Human Pancreatic Duct Cells. Pancreas 2009, 38(8), 921-929.
  • Linley JE, Boese SH, Simmons NL, Gray MA. A Voltage-Dependent Ca2+ Influx Pathway Regulates the Ca2+-Dependent Cl- Conductance of Renal IMCD-3 Cells. Journal of Membrane Biology 2009, 230(2), 57-68.
  • Venglovecz V, Rakonczay Jr Z, Ozsvari B, Takacs T, Lonovics J, Varro A, Gray MA, Argent BE, Hegyi P. Effects of bile acids on pancreatic ductal bicarbonate secretion in guinea pig. Gut 2008, 57(8), 1102-1112.
  • Rakonczay Jr Z, Hegyi P, Hasegawa M, Inoue M, You J, Iida A, Ignáth I, Alton EWFW, Griesenbach U, Óvári G, Vág J, Da Paula AC, Crawford RM, Varga G, Amaral MD, Mehta A, Lonovics J, Argent BE, Gray MA. CFTR gene transfer to human cystic fibrosis pancreatic duct cells using a Sendai virus vector. Journal of Cellular Physiology 2008, 214(2), 442-455.
  • Ferrari S, Griesenbach U, Iida A, Farley R, Wright AM, Zhu J, Munkonge FM, Smith SN, You J, Ban H, Inoue M, Chan M, Singh C, Verdon B, Argent BE, Wainwright B, Jeffery PK, Geddes DM, Porteous DJ, Hyde SC, Gray MA, Hasegawa M, Alton EWFW. Sendai virus-mediated CFTR gene transfer to the airway epithelium. Gene Therapy 2007, 14(19), 1371-1379.
  • Linley JE, Simmons NL, Gray MA. Extracellular zinc stimulates a calcium-activated chloride conductance through mobilisation of intracellular calcium in renal inner medullary collecting duct cells. Pflugers Archiv European Journal of Physiology 2007, 453(4), 487-495.
  • Sheppard DN, Hwang T-C, Gray MA. The physiology of anion transport: Tales of the bizarre and unexpected. Experimental Physiology 2006, 91(1), 121-122.
  • Griesenbach U, Kitson C, Garcia SE, Farley R, Singh C, Somerton L, Painter H, Smith RL, Gill DR, Hyde SC, Chow Y-H, Hu J, Gray M, Edbrooke M, Ogilvie V, MacGregor G, Scheule RK, Cheng SH, Caplen NJ, Alton EWFW. Inefficient cationic lipid-mediated siRNA and antisense oligonucleotide transfer to airway epithelial cells in vivo. Respiratory Research 2006, 7, 26.
  • Rakonczay Jr Z, Fearn A, Hegyi P, Boros I, Gray MA, Argent BE. Characterization of H+ and HCO3- transporters in CFPAC-1 human pancreatic duct cells. World Journal of Gastroenterology 2006, 12(6), 885-895.
  • Hegyi P, Rakonczay Jr Z, Tiszlavicz L, Varro A, Toth A, Racz G, Varga G, Gray MA, Argent BE. Protein kinase C mediates the inhibitory effect of substance P on HCO 3- secretion from guinea pig pancreatic ducts. American Journal of Physiology: Cell Physiology 2005, 288(5), C1030-C1041.
  • Heygi P, Ordog B, Rakonczai Jr Z, Takacs T, Lonovics J, Szabolcs A, Sari R, Toth A, Papp JG, Varro A, Kovacs MK, Gray MA, Argent BE, Boldogkoi Z. Effect of herpesvirus infection on pancreatic duct cell secretion. World Journal of Gastroenterology 2005, 11(38), 5997-6002.
  • Hegyi P, Ordog B, Rakonczai Z, Takacs T, Lonovics J, Szabolcs A, Sari R, Toth A, Papp JG, Varro A, Kovacs MK, Gray MA, Argent BE, Boldogkoi Z. Effect of herpesvirus infection on pancreatic duct cell secretion. WORLD JOURNAL OF GASTROENTEROLOGY 2005, 11(38), 5997-6002.
  • Sheppard DN, Gray MA, Gong X, Sohma Y, Kogan I, Benos DJ, Scott-Ward TS, Chen J-H, Li H, Cai Z, Gupta J, Li C, Ramjeesingh M, Berdiev BK, Ismailov II, Bear CE, Hwang T-C, Linsdell P, Hug MJ. The patch-clamp and planar lipid bilayer techniques: Powerful and versatile tools to investigate the CFTR Cl- channel. Journal of Cystic Fibrosis 2004, 3(Suppl. 2), 101-108.
  • Wright AM, Gong X, Verdon B, Linsdell P, Mehta A, Riordan JR, Argent BE, Gray MA. Novel regulation of cystic fibrosis transmembrane conductance regulator (CFTR) channel gating by external chloride. Journal of Biological Chemistry 2004, 279(40), 41658-41663.
  • Davidson DJ, Gray MA, Kilanowski FM, Tarran R, Randell SH, Sheppard DN, Argent BE, Dorin JR. Murine epithelial cells: Isolation and culture. Journal of Cystic Fibrosis 2004, 3(2), 59-62.
  • Hegyi P, Rakonczay Jr Z, Gray MA, Argent BE. Measurement of Intracellular pH in Pancreatic Duct Cells: A New Method for Calibrating the Fluorescence Data. Pancreas 2004, 28(4), 427-434.
  • Boese SH, Aziz O, Simmons NL, Gray MA. Kinetics and regulation of a Ca²⁺-activated Cl^- conductance in mouse renal inner medullary collecting duct cells. American Journal of Physiology - Renal Physiology 2004, 286(4), F682-F692.
  • Gray MA. Bicarbonate secretion: It takes two to tango. Nature Cell Biology 2004, 6(4), 292-294.
  • Hegyi P, Gray MA, Argent BE. Substance P inhibits bicarbonate secretion in guinea pig panceatic ducts by modulating an anion exchanger. Gastroenterology 2003, 124(4), A439-A439.
  • Hegyi P, Gray MA, Argent BE. Substance P inhibits bicarbonate secretion from guinea pig pancreatic ducts by modulating an anion exchanger. American Journal of Physiology - Cell Physiology 2003, 285(2), C268-C276.
  • Fong P, Argent BE, Guggino WB, Gray MA. Characterization of vectorial chloride transport pathways in the human pancreatic duct adenocarcinoma cell line HPAF. American Journal of Physiology - Cell Physiology 2003, 285(2), C433-C445.
  • Gray M, Aziz O. Role of capacitative calcium entry in secretion by A549 epithelial cells [abstract]. FASEB Journal 2002, 16(4), A411-A411.
  • Tarran R, Loewen ME, Paradiso AM, Olsen JC, Gray MA, Argent BE, Boucher RC, Gabriel SE. Regulation of murine airway surface liquid volume by CFTR and Ca2+-activated Cl- conductances. Journal of General Physiology 2002, 120(3), 407-418.
  • Gray MA. Designer pharmacotherapy for the treatment of cystic fibrosis. British Journal of Pharmacology 2002, 137(4), 411-412.
  • Sayer JA, Stewart GS, Boese SH, Gray MA, Pearce SHS, Goodship THJ, Simmons NL. The voltage-dependent of Cl- channel ClC-5 and plasma membrane Cl- conductances of mouse renal collecting duct cells (mIMCD-3). Journal of Physiology 2001, 536(3), 769-783.
  • Stewart GS, Glanville M, Aziz O, Simmons NL, Gray MA. Regulation of an outwardly rectifying chloride conductance in renal epithelial cells by external and internal calcium. Journal of Membrane Biology 2001, 180(1), 49-64.
  • Gray MA, O'Reilly C, Winpenny J, Argent B. Functional interactions of HCO3- with cystic fibrosis transmembrane conductance regulator. Journal of the Pancreas 2001, 2(4 (suppl.)), 207-211.
  • Dormer RL, Derand R, McNeilly CM, Mettey Y, Bulteau-Pignoux L, Metaye T, Vierfond JM, Gray MA, Galietta LJV, Morris MR, Pereira MMC, Doull IJM, Becq F, McPherson MA. Correction of delF508-CFTR activity with benzo(c)quinolizinium compounds through facilitation of its processing in cystic fibrosis airway cells. Journal of Cell Science 2001, 114(22), 4073-4081.
  • Sohma Y, Gray MA, Imai Y, Argent BE. 150 mM HCO₃^- - How does the pancreas do it? Clues from computer modelling of the duct cell. Journal of the Pancreas 2001, 2(suppl. 4), 198-202.
  • Boese SH, Glanville M, Gray MA, Simmons NL. The swelling-activated anion conductance in the mouse renal inner medullary collecting duct cell line mIMCD-K2. Journal of Membrane Biology 2000, 177(1), 51-64.
  • Tarran R, Argent BE, Gray MA. Regulation of a hyperpolarization-activated chloride current in murine respiratory ciliated cells. Journal of Physiology 2000, 524(2), 353-364.
  • Sohma Y, Gray MA, Imai Y, Argent BE. Hco3- Transport in a mathematical model of the pancreatic ductal epithelium. Journal of Membrane Biology 2000, 176(1), 77-100.
  • O'Reilly CM, Winpenny JP, Argent BE, Gray MA. Cystic fibrosis transmembrane conductance regulator currents in guinea pig pancreatic duct cells: Inhibition by bicarbonate ions. Gastroenterology 2000, 118(6), 1187-1196.
  • O'Reilly CM, Winpenny JP, Argent BE, Gray MA. Cystic fibrosis transmembrane conductance regulator currents in guinea pig pancreatic duct cells: inhibition by bicarbonate ions. Gastroenterology 2000, 118(6), 1187-1196.
  • Boese SH, Glanville M, Aziz O, Gray MA, Simmons NL. Ca2+ and cAMP-activated Cl- conductances mediate Cl- secretion in a mouse renal inner medullary collecting duct cell line. Journal of Physiology 2000, 523(2), 325-338.
  • Kose H, Boese SH, Glanville M, Gray MA, Brown CDA, Simmons NL. Bradykinin regulation of salt transport across mouse inner medullary collecting duct epithelium involves activation of a Ca2+ -dependent Cl- conductance. British Journal of Pharmacology 2000, 131(8), 1689-1699.
  • Gray M, O'Reilly C, Winpenny J, Argent B. Anion interactions with CFTR and consequences for HCO3- transport in secretory epithelia. Journal of Korean Medical Science 2000, 15, S12-S15.
  • Becq F, Mettey Y, Gray MA, Galietta LJV, Dormer RL, Merten M, Metaye T, Chappe V, Marvingt-Mounir C, Zegarra-Moran O, Tarran R, Bulteau L, Derand R, Pereira MMC, McPherson MA, Rogier C, Joffre M, Argent BE, Sarrouilhe D, Kammouni W, Figarella C, Verrier B, Gola M, Vierfond J-M. Development of substituted benzo[c]quinolizinium compounds as novel activators of the cystic fibrosis chloride channel. Journal of Biological Chemistry 1999, 274(39), 27415-27425.
  • Adair J, Argent BE, Gray MA. ATP-induced [CA2+]i oscillations in a human pancreatic duct cell line (HPAF). Journal of Physiology 517P 96P 1999.
  • Stewart GS, Glanville M, Gray MA, Simmons NL. ATP stimulates a chloride conductance in the mIMCD-3 cell line. The FASEB Journal 1999, 13(4), A70-A70.
  • Boese SH, Simmons NL, Gray MA. ATP and forskolin stimulate transepithelial Cl- secretion in mouse renal inner medullary collecting duct cells (mIMCD-K2) by activation of distinct Cl- conductances. The Journal of Physiology 1999, (supplement), 515P 162P.
  • Adair J, Stephenson D, Kappler TG, Gray MA, Argent BE. Anion secretion and intracellular calcium concentration in a human pancreatic duct cell line (HPAF). Journal of Physiology 1999, 29P.
  • Boese SH, Glanville M, Gray MA, Simmons NL. A Ca2+-activated Cl- conductance is expressed at the apical membrane of mouse renal inner medullary collecting duct cells (mIMCD-K2). The Journal of Physiology 1999, 517P.
  • Winpenny JP, Harris A, Hollingsworth MA, Argent BE, Gray MA. Calcium-activated chloride-conductance in a pancreatic adenocarcinoma cell line of ductal origin (HPAF) and in freshly isolated human pancreatic duct cells. Pflugers Archiv European Journal of Physiology 1998, 435(6), 796-803.
  • Winpenny J.P., Harris A., Hollingworth M.A., Argent B.E. and Gray M.A. Calcium-activated chloride conductance in a pancreatic adenocarcinoma cell line of ductal origin (HPAF) and in freshly isolated human pancreatic duct cells. Pflugers Archiv 1998, 435, 796-803.
  • Winpenny JP, Harris A, Hollingsworth MA, Argent BE, Gray MA. Calcium-activated chloride conductance in a pancreatic adenocarcinoma cell line of ductal origin (HPAF) and in freshly isolated human pancreatic duct cells. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY 1998, 435(6), 796-803.
  • Tarran R., Gray M.A., Evans M.J., Colledge W.H., Ratcliff R. and Argent B.E. Basal chloride currents in murine airway epithelial cells. Modulation by CFTR. American Journal of Physiology 1998, 274, C904-C913.
  • Sohma Y., Harris A., Argent B.E. and Gray M.A. A novel type of internal barium block of a maxi-K+ channel from human vas deferens epithelial cells. Biophysical Journal 1998, 74, 199-209.
  • Winpenny JP, Mathews CJ, Verdon B, Wardle CJC, Chambers JA, Harris A, Argent BE, Gray MA. Volume sensitive chloride currents in primary cultures of human fetal vas deferens epithelial cells. Pflugers Archiv European Journal of Physiology 1996, 432(4), 644-654.
  • Sohma Y., Harris A., Wardle C.J.C., Argent B.E. and Gray M.A. Two barium binding sites on a maxi-K+ channel from human vas deferens epithelial cells. Biophysical Journal 1996, 70, 1316-1325.
  • Shindo M., Simmons N.L. and Gray M.A. Characterisation of whole cell chloride conductances in a mouse inner medullary collecting duct cell line mIMCD-3. Journal of Membrane Biology 1996, 149, 21-31.
  • Sohma Y, Gray MA, Imai Y, Argent BE. A mathematical model of the pancreatic ductal epithelium. Journal of Membrane Biology 1996, 154(1), 53-67.

• Book Chapters

  • Fong P, Gray MA. Orchestration of vectorial chloride transport by epithelia. In: Pusch, M, ed. Chloride Movements Across Cellular Membranes. London: Elsevier Science, 2007, pp.329-368.
  • Argent BE, Gray MA, Steward MC, Case RM. Cell physiology of pancreatic ducts. In: Johnson, LR, ed. Physiology of the Gastrointestinal Tract. San Diego: Elsevier, 2006, pp.1371-1396.
  • Boese SH, Gray MA, Simmons NL. Volume-dependent and -independent activated anion conductances and their interaction in the renal inner medullary collecting duct (IMCD). In: Lauf, P., Adragna, N, ed. Cell Volume and Signaling. New York: Springer, 2005, pp.109-118.
  • Boese S, Sayer J, Stewart G, Glanville M, Gray MA, Simmons NL. Renal expression of Ca2+-activated Cl- channels. In: Fuller, C.M, ed. Calcium-Activated Chloride Channels. Amsterdam & London: Academic Press, 2002, pp.283-307.
  • Gray MA, Winpenny JP, Verdon B, O'Reilly CM, Argent BE. Properties and role of calcium-activated chloride channels in pancreatic duct cells. In: Fuller, C.M, ed. Calcium-Activated Chloride Channels. Maryland Heights, Missouri, USA: Academic Press, 2002, pp.231-256.

• Conference Proceedings (inc. Abstracts)

  • Hegyi P, Rakonczay Jr Z, Tiszlavicz L, Varro A, Toth A, Racz G, Varga G, Gray MA, Argent BE. SLC26 transporters and the inhibitory control of pancreatic ductal bicarbonate secretion. In: Epithelial Anion Transport: The Role of the SLC26 Transporters Family. 2006, London, UK: John Wiley & Sons.
  • Rakonczay Z, Fearn A, Hegyi P, Gray MA, Argent BE. Characterization of H⁺ and HCO₃^- transporters in CFPAC-1 human pancreatic duct cells. In: 37th European Pancreatic Club Meeting. 2005, Graz, Austria.
  • Aldridge PD, Gray MA, Hirst BH, Khan CMA. Who's talking to whom? Epithelial-bacterial pathogen interactions. In: International Symposium on Epithelial-Bacterial Pathogen Interactions. 2004, Newcastle upon Tyne, UK: Molecular Microbiology: Wiley-Blackwell.
  • Ferrari S, Griesenbach U, Farley R, Munkonge F, Smith SN, Singh C, You J, Tokusumi T, Iida A, Wainwright B, Gray M, Wright A, Verdon B, Argent B, Geddes DM, Hasegawa M, Alton EWFW. Recombinant sendai virus mediates CFTR gene transfer to airway epithelium both in vitro and in vivo. In: Journal of Gene Medicine: 1st Annual Conference of the British Society for Gene Therapy. 2004, Oxford, UK: John Wiley & Sons, Inc.

• Editorial

  • Gray MA. Primary cilia and regulation of renal Na+ transport. Focus on "Heightened epithelial Na+ channel-mediated Na+ absorption in a murine polycystic kidney disease model epithelium lacking apical monocilia". American Journal of Physiology - Cell Physiology 2006, 290(4), C947-C949.

• Letters

  • Kemeny LV, Hegyi P, Rakonczay Z, Borka K, Korompay A, Gray MA, Argent BE, Venglovecz V. Substance P Inhibits Pancreatic Ductal Bicarbonate Secretion via Neurokinin Receptors 2 and 3 in the Guinea Pig Exocrine Pancreas. Pancreas 2011, 40(5), 793-795.
  • Hegyi P, Rakonczay Z Jr, Farkas K, Venglovecz V, Ozsvari B, Seidler U, Gray MA, Argent BE. Controversies in the role of SLC26 anion exchangers in pancreatic ductal bicarbonate secretion. Pancreas 2008, 37(2), 232-234.

• Notes

  • Delpiano L, Gray MA. Location, location, location: lessons from airway epithelial anion channels. Journal of Physiology 2019, 597(24).
  • Gray MA. Designer pharmacotherapy for the treatment of cystic fibrosis: Commentary on Zegarra-Moran et al. British Journal of Pharmacology 2002, 137(4), 411-412.

• Reviews

  • Saint-Criq V, Gray MA. Role of CFTR in epithelial physiology. Cellular and Molecular Life Sciences 2017, 74(1), 93-115.
  • Hegyi P, Wilschanski M, Muallem S, Lukacs GL, Sahin-Toth M, Uc A, Gray MA, Rakonczay Z, Maleth J. CFTR: A New Horizon in the Pathomechanism and Treatment of Pancreatitis. Reviews of Physiology, Biochemistry and Pharmacology Vol. 170 2016, 170, 37-66.
  • Venglovecz V, Rakonczay Z, Gray MA, Hegyi P. Potassium channels in pancreatic duct epithelial cells: their role, function and pathophysiological relevance. Pflügers Archiv - European Journal of Physiology 2015, 467(4), 625-640.
  • Gray MA. CFTR is a mechanosensitive anion channel: a real stretch?. Cell Science 2010, 7(1), 1-7.
  • Fong P, Gray MA. Orchestration of Vectorial Chloride Transport by Epithelia. Advances in Molecular and Cell Biology 2006, 38, 329-368.
  • Boese S, Sayer J, Stewart G, Glanville M, Gray MA, Simmons NL. Renal expression of Ca2+-activated Cl- channels. Current Topics in Membranes 2002, 53, 283-307.
  • Gray MA, Winpenny JP, Verdon B, O'Reilly CM, Argent BE. Properties and role of calcium-activated chloride channels in pancreatic duct cells. Current Topics in Membranes 2002, 53, 231-256.