Staff Profile
Paul Thompson
Research Assistant
- Email: paul.thompson2@ncl.ac.uk
- Personal Website: https://www.ncl.ac.uk/nuppa/
- Address: Biosciences Institute
Medical School
University of Newcastle upon Tyne
Framlington Place
Newcastle upon Tyne
NE2 4HH
Publications
- Maneiro M, Lence E, Sanz-Gaitero M, Otero JM, Van Raaij MJ, Thompson P, Hawkins AR, Gonzalez-Bello C. Hydroxylammonium derivatives for selective active-site lysine modification in the anti-virulence bacterial target DHQ1 enzyme. Organic Chemistry Frontiers 2019, 6(17), 3127-3135.
- Pernas M, Blanco B, Lence E, Thompson P, Hawkins AR, Gonzalez-Bello C. Synthesis of rigidified shikimic acid derivatives by ring-closing metathesis to imprint inhibitor efficacy against shikimate kinase enzyme. Organic Chemistry Frontiers 2019, 6(14), 2514-2528.
- Basle A, Hewitt L, Koh A, Lamb HK, Thompson P, Burgess JG, Hall MJ, Hawkins AR, Murray H, Lewis RJ. Crystal structure of NucB, a biofilm-degrading endonuclease. Nucleic Acids Research 2018, 46(1), 473-484.
- Wilkinson DJ, Habgood A, Lamb HK, Thompson P, Hawkins AR, Desilets A, Leduc R, Steinmetzer T, Hammami M, Lee MS, Craik CS, Watson S, Lin H, Milner JM, Rowan AD. Matriptase Induction of Metalloproteinase-Dependent Aggrecanolysis In Vitro and In Vivo: Promotion of Osteoarthritic Cartilage Damage by Multiple Mechanisms. Arthritis and Rheumatology 2017, 69(8), 1601–1611.
- Peon A, Robles A, Blanco B, Convertino M, Thompson P, Hawkins AR, Caflisch A, Gonzalez-Bello C. Reducing the Flexibility of Type II Dehydroquinase for Inhibition: A Fragment-Based Approach and Molecular Dynamics Study. ChemMedChem 2017, 12(18), 1512-1524.
- Wilkinson DJ, Desilets A, Lin H, Charlton S, Del Carmen Arques M, Falconer A, Bullock C, Hsu Y-C, Birchall K, Hawkins A, Thompson P, Ferrell WR, Lockhart J, Plevin R, Zhang Y, Blain E, Lin S-W, Leduc R, Milner JM, Rowan AD. The serine proteinase hepsin is an activator of pro-matrix metalloproteinases: Molecular mechanisms and implications for extracellular matrix turnover. Scientific Reports 2017, 7(1), 16693.
- Prado V, Lence E, Thompson P, Hawkins AR, Gonzalez-Bello C. Freezing the Dynamic Gap for Selectivity: Motion-Based Design of Inhibitors of the Shikimate Kinase Enzyme. Chemistry A European Journal 2016, 22(50), 17987-17999.
- Prado V, Lence E, Thompson P, Hawkins AR, Gonzalez-Bello C. Frontispiece: Freezing the Dynamic Gap for Selectivity: Motion-Based Design of Inhibitors of the Shikimate Kinase Enzyme. Chemistry - A European Journal 2016, 22(50).
- Prado V, Lence E, Vallejo JA, Beceiro A, Thompson P, Hawkins AR, Gonzalez-Bello C. Study of the Phosphoryl-Transfer Mechanism of Shikimate Kinase by NMR Spectroscopy. Chemistry: A European Journal 2016, 22(8), 2758-2768.
- Prado V, Lence E, Maneiro M, Vazquez-Ucha JC, Beceiro A, Thompson P, Hawkins AR, Gonzalez-Bello C. Targeting the Motion of Shikimate Kinase: Development of Competitive Inhibitors that Stabilize an Inactive Open Conformation of the Enzyme. Journal of Medicinal Chemistry 2016, 59(11), 5471-5487.
- Gonzalez-Bello C, Tizon L, Lence E, Otero JM, van Raaij MJ, Martinez-Guitian M, Beceiro A, Thompson P, Hawkins AP. Chemical Modification of a Dehydratase Enzyme Involved in Bacterial Virulence by an Ammonium Derivative: Evidence of its Active Site Covalent Adduct. Journal of the American Chemical Society 2015, 137(29), 9333-9343.
- Rogowski A, Briggs JA, Mortimer JC, Tryfona T, Terrapon N, Lowe EC, Baslé A, Morland C, Day AM, Zheng H, Rogers TE, Thompson P, Hawkins AR, Yadav MP, Henrissat B, Martens EC, Dupree P, Gilbert HJ, Bolam DN. Glycan complexity dictates microbial resource allocation in the large intestine. Nature Communications 2015, 6, 7481.
- Tizon L, Maneiro M, Peon A, Otero JM, Lence E, Poza S, van Raaij MJ, Thompson P, Hawkins AR, Gonzalez-Bello C. Irreversible covalent modification of type I dehydroquinase with a stable Schiff base. Organic & Biomolecular Chemistry 2015, 13(3), 706-716.
- Blanco B, Sedes A, Peon A, Otero JM, van Raaij MJ, Thompson P, Hawkins AR, Gonzalez-Bello C. Exploring the Water-Binding Pocket of the Type II Dehydroquinase Enzyme in the Structure-Based Design of Inhibitors. Journal of Medicinal Chemistry 2014, 57(8), 3494-3510.
- Maneiro M, Peon A, Lence E, Otero JM, Van Raaij MJ, Thompson P, Hawkins AR, Gonzalez-Bello C. Insights into substrate binding and catalysis in bacterial type I dehydroquinase. Biochemical Journal 2014, 462, 415-424.
- Nichols CE, Lamb HK, Thompson P, Omari KE, Lockyer M, Charles I, Hawkins AR, Stammers DK. Crystal structure of the dimer of two essential Salmonella typhimurium proteins, YgjD and YeaZ and calorimetric evidence for the formation of a ternary YgjD-YeaZ-YjeE complex. Protein Science 2013, 22(5), 628-640.
- Martin S, Lamb HK, Brady C, Lefkove B, Bonner MY, Thompson P, Lovat PE, Arbiser JL, Hawkins AR, Redfern CPF. Inducing apoptosis of cancer cells using small-molecule plant compounds that bind to GRP78. British Journal of Cancer 2013, 109(2), 433-443.
- Piggott MA, Perry EK, Marshall EF, McKeith IG, Johnson M, Melrose HL, Court JA, Lloyd S, Fairbairn A, Brown A, Thompson P, Perry RH. Nigrostriatal dopaminergic activities in dementia with Lewy bodies in relation to neuroleptic sensitivity: Comparisons with Parkinson's disease. Biological Psychiatry 1998, 44(8), 765-774.
- Ballard C, Mckeith I, Harrison R, O'Brien J, Thompson P, Lowery K, Perry R, Ince P. Aspects of dementia. A detailed phenomenological comparison of complex visual hallucinations in dementia with Lewy bodies and Alzheimer's disease. International Psychogeriatrics 1997, 9(4), 381-388.
- Morris CM, Massey HM, Benjamin R, Leake A, Broadbent C, Griffiths M, Lamb H, Brown A, Ince PG, Tyrer S, Thompson P, McKeith IG, Edwardson JA, Perry RH, Perry EK. Molecular biology of APO E alleles in Alzheimer's and non-Alzheimer's dementias. In: Meeting on New Trends in the Diagnosis and Therapy of Non-Alzheimer's Dementia. 1996, Vienna, Austria: Springer Wien.
- Perry EK, Marshall E, Thompson P, McKeith IG, Collerton D, Fairbairn AF, Ferrier IN, Irving D, Perry RH. Monoaminergic activities in Lewy body dementia: relation to hallucinosis and extrapyramidal features. Journal of Neural Transmission. Parkinson's Disease and Dementia Section 1993, 6(3), 167-177.
- Perry EK, McKeith I, Thompson P, Marshall E, Kerwin J, Jabeen S, Edwardson JA, Ince P, Blessed G, Irving D, Perry RH. Topography, extent, and clinical relevance of neurochemical deficits in dementia of Lewy body type, Parkinson's disease, and Alzheimer's disease. Annals of the New York Academy of Sciences 1991, 640, 197-202.