Staff Profile

Introduction

I manage the Electron Microscopy Research Services unit which provides an electron microscopy service to students and researchers throughout the University as well as to companies and individuals both nationally and internationally

Training Courses

Transmission EM

Training packages are available for researchers which will reduce costs in the long term.

The TEM course is held over 3 days and covers ultra-microtomy and use of the transmission electron microscope. The course can be tailored to suit the individual.

Scanning EM

This is for groups who may have a high throughput of samples to be analysed. Once competent, the researchers would be allowed to use the microscope themselves.

School workshops  

We welcome visits from key stage 5 pupils and their teachers to the electron microscopy laboratory at Newcastle University's Medical School. During their 1.5-2 hour visit they will learn how specimens are prepared for both scanning and transmission EM and see the electron microscopes in action. Visits are suitable for both year 12 and year 13, though numbers are restricted (min 7, max 14).

• Faitg J, Lacefield C, Davey T, White K, Laws R, Kosmidis S, Reeve AK, Kandel ER, Vincent AE, Picard M. 3D neuronal mitochondrial morphology in axons, dendrites, and somata of the aging mouse hippocampus. Cell Reports 2021, 36, 108509.
• Mather MW, Verdon B, Botting RA, Engelbert J, Delpiano L, Xu X, Hatton C, Davey T, Lisgo S, Yates P, Dawe N, Bingle CD, Haniffa M, Powell J, Ward C. Development of a physiological model of human middle ear epithelium. Laryngoscope Investigative Otolaryngology 2021, 6(5), 1167-1174.
• Dorgau B, Georgiou M, Chaudhary A, Molina MM, Collin J, Queen R, Hilgen G, Davey T, Hewitt P, Schmitt M, Kustermann S, Pognan F, Steel DH, Sernagor E, Armstrong L, Lako M. Human retinal organoids provide a suitable tool for toxicological investigations – a comprehensive validation using drugs and compounds affecting retina. Stem Cell Translational Medicine 2021. In Press.
• Kattner N, Dyson N, Bury Y, Tiniakos D, White K, Davey T, Eliasson L, Tindale L, Wagner B, Honkanen-Scott MM, Doyle J, Ploeg RJ, Shaw JAM, Scott III WE. Development and validation of a quantitative electron microscopy score to assess acute cellular stress in the human exocrine pancreas. Journal of Pathology: Clinical Research 2020, 7(2), 173-187.
• Faitg J, Davey T, Turnbull DM, White K, Vincent AE. Mitochondrial morphology and function: two for the price of one!. Journal of Microscopy 2020, 278(2), 89-106.
• Spendiff S, Howarth R, McMacken G, Davey T, Quinlan K, O'Connor E, Slater C, Hettwer S, Mader A, Roos A, Horvath R, Lochmuller H. Modulation of the Acetylcholine Receptor Clustering Pathway Improves Neuromuscular Junction Structure and Muscle Strength in a Mouse Model of Congenital Myasthenic Syndrome. Frontiers in Molecular Neuroscience 2020, 13, 594220.
• Bury Y, Kattner K, Dyson N, Jones C, Ness T, Coulthard R, Davey T, Eliasson L, Honkanen-Scott M, Doyle J, Ploeg R, Klöppel G, Tiniakos D, Shaw J, Scott W. Standardized pathology reporting in donor pancreata within the quality and safety in organ donation (QUOD) tissue bank: a new resource for pancreatic research. In: European Congress of Pathology. 2020. In Preparation.
• Vincent AE, White K, Davey T, Philips J, Ogden RT, Lawless C, Warren C, Hall MG, Ng YS, Falkous G, Holden T, Deehan D, Taylor RW, Turnbull DM, Picard M. Quantitative 3D Mapping of the Human Skeletal Muscle Mitochondrial Network. Cell Reports 2019, 26(4), 996-1009.e4.
• Vincent AE, Rosa HS, Pabis K, Lawless C, Chen C, Grünewald A, Rygiel K, Rocha MC, Reeve AK, Falkous G, Perissi V, White K, Davey T, Petrof BJ, Sayer AA, Cooper C, Deehan D, Taylor RW, Turnbull DM, Picard M. Subcellular origin of mitochondrial DNA deletions in human skeletal muscle. Annals of Neurology 2018, 84(2), 289-301.
• Hall EA, Nahorski MS, Murray LM, Shaheen R, Perkins E, Dissanayake KN, Kristaryanto Y, Jones RA, Vogt J, Rivagorda M, Handley MT, Mali GR, Quidwai T, Soares DC, Keighren MA, McKie L, Mort RL, Gammoh N, Garcia-Munoz A, Davey T, Vermeren M, Walsh D, Budd P, Aligianis IA, Faqeih E, Quigley AJ, Jackson IJ, Kulathu Y, Jackson M, Ribchester RR, von Kriegsheim A, Alkuraya FS, Woods CG, Maher ER, Mill P. PLAA Mutations Cause a Lethal Infantile Epileptic Encephalopathy by Disrupting Ubiquitin-Mediated Endolysosomal Degradation of Synaptic Proteins. American Journal of Human Genetics 2017, 100(5), 706-724.
• Oláhová M, Thompson K, Hardy SA, Barbosa IA, Besse A, Anagnostou ME, White K, Davey T, Simpson MA, Champion M, Enns G, Schelley S, Lightowlers RN, Chrzanowska-Lightowlers ZMA, McFarland R, Deshpande C, Bonnen PE, Taylor RW. Pathogenic variants in HTRA2 cause an early-onset mitochondrial syndrome associated with 3-methylglutaconic aciduria. Journal of Inherited Metabolic Disease 2017, 40(1), 121-130.
• McGorum BC, Scholes S, Milne EM, Eaton SL, Wishart TM, Poxton IR, Moss S, Wernery U, Davey T, Harris JB, Pirie RS. Equine grass sickness, but not botulism, causes autonomic and enteric neurodegeneration and increases soluble N-ethylmaleimide-sensitive factor attachment receptor protein expression within neuronal perikarya. Equine Veterinary Journal 2016, 48(6), 786-791.
• Vincent AE, Ng YS, White K, Davey T, Mannella C, Falkous G, Feeney C, Schaefer AM, McFarland R, Gorman GS, Taylor RW, Turnbull DM, Picard M. The Spectrum of Mitochondrial Ultrastructural Defects in Mitochondrial Myopathy. Scientific Reports 2016, 6, 30610.
• Speight RA, Davey T, White K, Kirby JA, Mansfield JC. Activation of the bile acid receptor, farnesoid-x receptor, maintains gut epithelial cell morphology, possibly via inhibition of myosin light chain kinase expression. In: 2nd Digestive Disorders Federation Conference 2015. 2015, London, UK: BMJ Group.
• Hall EA, Keighren M, Ford MJ, Davey T, Jarman AP, Smith LB, Jackson IJ, Mill P. Acute Versus Chronic Loss of Mammalian Azi1/Cep131 Results in Distinct Ciliary Phenotypes. PLoS Genetics 2013, 9(12), e1003928.
• Dunican DS, Cruickshanks HA, Suzuki M, Semple CA, Davey T, Arceci RJ, Greally J, Adams IR, Meehan RR. Lsh regulates LTR retrotransposon repression independently of Dnmt3b function. Genome Biology 2013, 14(10), R146.
• Zhou YS, Webb S, Lettice L, Tardif S, Kilanowski F, Tyrrell C, MacPherson H, Semple F, Tennant P, Baker T, Hart A, Devenney P, Perry P, Davey T, Barran P, Barratt CL, Dorin JR. Partial Deletion of Chromosome 8 β-defensin Cluster Confers Sperm Dysfunction and Infertility in Male Mice. PLoS Genetics 2013, 9(10), e1003826.
• Harris JB, Scott-Davey T. Secreted Phospholipases A₂ of Snake Venoms: Effects on the Peripheral Neuromuscular System with Comments on the Role of Phospholipases A₂ in Disorders of the CNS and Their Uses in Industry. Toxins 2013, 5(12), 2533-2571.
• Hart AJ, Hodgson WC, Scott-Davey T, Harris JB. Neuromuscular toxicology of the venom of Collett's snake (Pseudechis colletti): A histopathological study. Muscle and Nerve 2011, 43(4), 552-559.
• Hart A, Scott-Davey T, Harris J. Venom of Collett's snake (Pseudechis colletti) blocks the binding of α-bungarotoxin to acetylcholine receptors at chick but not human neuromuscular junctions: A histochemical study. Toxicon 2008, 52(5), 647-650.