Staff Profile

Current Position

Newcastle University Academic Track (NUAcT) Fellowship, 2021-

Qualifications 

 BSc (Hons) Biomedical Science (Physiology), University of Aberdeen, 2000

PhD, University of Newcastle upon Tyne, 2004

Memberships

The Physiological Society

Royal Entomological Society

Endosymbiosis in Insects

• Crop pest insects (Hemiptera, aphids)
• Insect - microbe metabolic interdependency
• Nutrient handling at the endosymbiotic interface
• Novel nutrient transporters
• Transporter protein structure-function

Nutrient and Drug Transporters in Epithelia

• SLC solute carriers
• Amino acid and di/tripeptide transporters 
• H -coupled transporters
• Neurohormonal and nutrient regulation of transport
• Drug transport in the small intestine
• Intracellular pH regulation
• Nutrient and drug transporters in cancer

• Articles

  • Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA, Amarosi L, Anderson CMH, Beart PM, Broer S, Dawson PA, Gyimesi G, Hagenbuch B, Hammond JR, Hancox JC, Hershfinkel M, Inui K-I, Kanai Y, Kemp S, Kunji ERS, Stewart G, Tavoulari S, Thwaites DT, Verri T. The Concise Guide to PHARMACOLOGY 2023/24: Transporters. British Journal of Pharmacology 2023, 180(S2), S374-S469.
  • Duncan RP, Anderson CMH, Thwaites DT, Luetje CW, Wilson ACC. Co-option of a conserved host glutamine transporter facilitates aphid/Buchnera metabolic integration. Proceedings of the National Academy of Sciences USA 2023, 120(43), e2308448120.
  • Anderson CMH, Edwards N, Watson AK, Althaus M, Thwaites DT. Reshaping the Binding Pocket of the Neurotransmitter:Solute Symporter (NSS) Family Transporter SLC6A14 (ATB^0,+) Selectively Reduces Access for Cationic Amino Acids and Derivatives. Biomolecules 2022, 12(10), 1404.
  • Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Southan C, Davies JA, Amarosi L, Anderson CMH, Beart PM, Broer S, Dawson PA, Hagenbuch B, Hammond JR, Inui KI, Kanai Y, Kemp S, Stewart G, Thwaites DT, Verri T. THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Transporters. British Journal of Pharmacology 2021, 178(S1), S412-S513.
  • Feng H, Edwards N, Anderson CMH, Althaus M, Duncan RP, Hsu Y-C, Luetje CW, Price DRG, Wilson ACC, Thwaites DT. Trading amino acids at the aphid–Buchnera symbiotic interface. Proceedings of the National Academy of Sciences of the United States of America 2019, 116(32), 16003-16011.
  • Palazzolo L, Paravicini C, Laurenzi T, Adobati S, Saporiti S, Guerrini U, Gianazza E, Indiveri C, Anderson CMH, Thwaites DT, Eberini I. SLC6A14, a Pivotal Actor on Cancer Stage: When Function Meets Structure. SLAS Discovery 2019, 24(9), 928-938.
  • Edwards N, Anderson CMH, Conlon NJ, Watson AK, Hall RJ, Cheek TR, Embley TM, Thwaites DT. Resculpting the binding pocket of APC superfamily LeuT-fold amino acid transporters. Cellular and Molecular Life Sciences 2018, 75(5), 921-938.
  • Alexander SP, Benson HE, Faccenda E, Pawson AJ, Sharman JL, McGrath JC, Catterall WA, Spedding M, Peters JA, Harmar AJ, Abul-Hasn N, Anderson CM, Anderson CM, Araiksinen MS, Arita M, Arthofer E, Barker EL, Barratt C, Barnes NM, Bathgate R, Beart PM, Belelli D, Bennett AJ, Birdsall NJ, Boison D, Bonner TI, Brailsford L, Bröer S, Brown P, Calo G, Carter WG, Catterall WA, Chan SL, Chao MV, Chiang N, Christopoulos A, Chun JJ, Cidlowski J, Clapham DE, Cockcroft S, Connor MA, Cox HM, Cuthbert A, Dautzenberg FM, Davenport AP, Dawson PA, Dent G, Dijksterhuis JP, Dollery CT, Dolphin AC, Donowitz M, Dubocovich ML, Eiden L, Eidne K, Evans BA, Fabbro D, Fahlke C, Farndale R, Fitzgerald GA, Fong TM, Fowler CJ, Fry JR, Funk CD, Futerman AH, Ganapathy V, Gaisnier B, Gershengorn MA, Goldin A, Goldman ID, Gundlach AL, Hagenbuch B, Hales TG, Hammond JR, Hamon M, Hancox JC, Hauger RL, Hay DL, Hobbs AJ, Hollenberg MD, Holliday ND, Hoyer D, Hynes NA, Inui KI, Ishii S, Jacobson KA, Jarvis GE, Jarvis MF, Jensen R, Jones CE, Jones RL, Kaibuchi K, Kanai Y, Kennedy C, Kerr ID, Khan AA, Klienz MJ, Kukkonen JP, Lapoint JY, Leurs R, Lingueglia E, Lippiat J, Lolait SJ, Lummis SC, Lynch JW, MacEwan D, Maguire JJ, Marshall IL, May JM, McArdle CA, McGrath JC, Michel MC, Millar NS, Miller LJ, Mitolo V, Monk PN, Moore PK, Moorhouse AJ, Mouillac B, Murphy PM, Neubig RR, Neumaier J, Niesler B, Obaidat A, Offermanns S, Ohlstein E, Panaro MA, Parsons S, Pertwee RG, Petersen J, Pin JP, Poyner DR, Prigent S, Prossnitz ER, Pyne NJ, Pyne S, Quigley JG, Ramachandran R, Richelson EL, Roberts RE, Roskoski R, Ross RA, Roth M, Rudnick G, Ryan RM, Said SI, Schild L, Sanger GJ, Scholich K, Schousboe A, Schulte G, Schulz S, Serhan CN, Sexton PM, Sibley DR, Siegel JM, Singh G, Sitsapesan R, Smart TG, Smith DM, Soga T, Stahl A, Stewart G, Stoddart LA, Summers RJ, Thorens B, Thwaites DT, Toll L, Traynor JR, Usdin TB, Vandenberg RJ, Villalon C, Vore M, Waldman SA, Ward DT, Willars GB, Wonnacott SJ, Wright E, Ye RD, Yonezawa A, Zimmermann M. The Concise Guide to PHARMACOLOGY 2013/14: Overview. British Journal of Pharmacology 2013, 170(8), 1449-1458.
  • Thwaites DT, Anderson CMH. The SLC36 family of proton-coupled amino acid transporters and their potential role in drug transport. British Journal of Pharmacology 2011, 164(7), 1802-1816.
  • Edwards N, Anderson CMH, Gatfield KM, Jevons MP, Ganapathy V, Thwaites DT. Amino acid derivatives are substrates or non-transported inhibitors of the amino acid transporter PAT2 (slc36a2). Biochimica et Biophysica Acta: Biomembranes 2011, 1808(1), 260-270.
  • Anderson CMH, Jevons M, Thangaraju M, Edwards N, Conlon NJ, Woods S, Ganapathy V, Thwaites DT. Transport of the Photodynamic Therapy Agent 5-Aminolevulinic Acid by Distinct H+-Coupled Nutrient Carriers Coexpressed in the Small Intestine. Journal of Pharmacology and Experimental Therapeutics 2010, 332(1), 220-228.
  • Anderson CMH, Thwaites DT. Hijacking solute carriers for proton-coupled drug transport. Physiology 2010, 25(6), 364-377.
  • Anderson CMH, Howard A, Walters JRF, Ganapathy V, Thwaites DT. Taurine uptake across the human intestinal brush-border membrane is via two transporters: H⁺-coupled PAT1 (SLC36A1) and Na⁺- and Cl^--dependent TauT (SLC6A6). Journal of Physiology 2009, 587(4), 731-744.
  • Anderson CMH, Ganapathy V, Thwaites DT. Human solute carrier SLC6A14 is the β-alanine carrier. Journal of Physiology 2008, 586(17), 4061-4067.
  • Anderson CMH, Thwaites DT. Regulation of intestinal hPepT1 (SLC15A1) activity by phosphodiesterase inhibitors is via inhibition of NHE3 (SLC9A3). Biochimica et Biophysica Acta: Biomembranes 2007, 1768(7), 1822-1829.
  • Thwaites DT, Anderson CMH. H⁺-coupled nutrient, micronutrient and drug transporters in the mammalian small intestine. Experimental Physiology 2007, 92(4), 603-619.
  • Thwaites DT, Anderson CMH. Deciphering the mechanisms of intestinal imino (and amino) acid transport: The redemption of SLC36A1. Biochimica et Biophysica Acta: Biomembranes 2007, 1768(2), 179-197.
  • Anderson CMH, Thwaites DT. Indirect regulation of the intestinal H⁺-coupled amino acid transporter hPAT1 (SLC36A1). Journal of Cellular Physiology 2005, 204(2), 604-613.
  • Anderson CMH, Grenade DS, Boll M, Foltz M, Wake KA, Kennedy DJ, Munck LK, Miyauchi S, Taylor PM, Campbell FC, Munck BG, Daniel H, Ganapathy V, Thwaites DT. H⁺/amino acid transporter 1 (PAT1) is the imino acid carrier: An intestinal nutrient/drug transporter in human and rat. Gastroenterology 2004, 127(5), 1410-1422.
  • Boll M, Foltz M, Anderson CMH, Oechsler C, Kottra G, Thwaites DT, Daniel H. Substrate recognition by the mammalian proton-dependent amino acid transporter PAT1. Molecular Membrane Biology 2003, 20(3), 261-269.
  • Chen Z, Fei Y-J Y, Anderson CMH, Wake K, Miyauchi S, Huang W, Thwaites DT, Ganapathy V. Structure, function and immunolocalization of a proton-coupled amino acid transporter (hPAT1) in the human intestinal cell line Caco-2. Journal of Physiology 2003, 546(2), 349-361.
  • Anderson CMH, Mendoza ME, Kennedy DJ, Raldua D, Thwaites DT. Inhibition of intestinal dipeptide transport by the neuropeptide VIP is an anti-absorptive effect via the VPAC₁ receptor in a human enterocyte-like cell line (Caco-2). British Journal of Pharmacology 2003, 138(4), 564-573.
  • Thwaites DT, Kennedy D, Raldua D, Anderson CMH, Mendoza ME, Bladen C, Simmons N. H⁺/dipeptide absorption across the human intestinal epithelium is controlled indirectly via a functional Na⁺/H⁺ exchanger. Gastroenterology 2002, 122(5), 1322-1333.

• Research Dataset/Database

  • Anderson CMH, Thwaites DT. SLC36 family of proton-coupled amino acid transporters in GtoPdb v.2023.1. 2023. IUPHAR/BPS Guide to Pharmacology CITE.

• Reviews

  • Anderson CM, Thwaites DT. SLC36 family of proton-coupled amino acid transporters in GtoPdb v.2021. IUPHAR/BPS Guide to Pharmacology CITE 2021, 2021(3).
  • Thwaites DT, Verri T. SLC15 family of peptide transporters in GtoPdb v.2021.3. IUPHAR/BPS Guide to Pharmacology CITE 2021, 2021(3).
  • Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA, Anderson CMH, Bröer S, Dawson P, Hagenbuch B, Hammond JR, Hancox J, Inui KI, Kanai Y, Kemp S, Thwaites DT, Verri T. THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Transporters. British Journal of Pharmacology 2019, 176 (Suppl 1), S397-S493.
  • Anderson CMH, Thwaites DT. SLC36 family of proton-coupled amino acid transporters (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE 2019, 2019(4).
  • Alexander SP, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, Spedding M, Striessnig J, Davies JA, Abbracchio MP, Aldrich R, Al-Hosaini K, Arumugam TV, Attali B, Bäck M, Barnes NM, Bathgate R, Beart PM, Becirovic E, Bettler B, Biel M, Birdsall NJ, Blaho V, Boison D, Bräuner-Osborne H, Bröer S, Bryant C, Burnstock G, Calo G, Catterall WA, Ceruti S, Chan SL, Chandy KG, Chazot P, Chiang N, Chun JJ, Chung JJ, Clapham DE, Clapp L, Connor MA, Cox HM, Davies P, Dawson PA, Decaen P, Dent G, Doherty P, Douglas SD, Dubocovich ML, Fong TM, Fowler CJ, Frantz A, Fuller P, Fumagalli M, Futerman AH, Gainetdinov RR, Gershengorn MA, Goldin A, Goldstein S, Goudet C, Gregory K, Grissmer S, Gundlach AL, Hagenbuch B, Hamann J, Hammond JR, Hancox JC, Hanson J, Hanukoglu I, Hay DL, Hobbs AJ, Hollenberg AN, Holliday ND, Hoyer D, Ijzerman AP, Inui KI, Irving AJ, Ishii S, Jacobson KA, Jan LY, Jarvis MF, Jensen R, Jockers R, Kaczmarek LK, Kanai Y, Karnik S, Kellenberger S, Kemp S, Kennedy C, Kerr ID, Kihara Y, Kukkonen J, Larhammar D, Leach K, Lecca D, Leeman S, Leprince J, Lolait SJ, Macewan D, Maguire JJ, Marshall F, Mazella J, Mcardle CA, Michel MC, Miller LJ, Mitolo V, Mizuno H, Monk PN, Mouillac B, Murphy PM, Nahon JL, Nerbonne J, Nichols CG, Norel X, Offermanns S, Palmer LG, Panaro MA, Papapetropoulos A, Perez-Reyes E, Pertwee RG, Pintor S, Pisegna JR, Plant LD, Poyner DR, Prossnitz ER, Pyne S, Ramachandran R, Ren D, Rondard P, Ruzza C, Sackin H, Sanger G, Sanguinetti MC, Schild L, Schiöth H, Schulte G, Schulz S, Segaloff DL, Serhan CN, Singh KD, Slesinger PA, Snutch TP, Sobey CG, Stewart G, Stoddart LA, Summers RJ, Szabo C, Thwaites D, Toll L, Trimmer JS, Tucker S, Vaudry H, Verri T, Vilargada JP, Waldman SA, Ward DT, Waxman SG, Wei AD, Willars GB, Wong SS, Woodruff TM, Wulff H, Ye RD, Yung Y, Zajac JM. The Concise Guide to PHARMACOLOGY 2017/18: Overview. British Journal of Pharmacology 2017, 174(S1), S1-S16.