Staff Profile

Introduction

I am an Academic Clinician / Physician-Researcher and an Honorary Consultant Physician at Newcastle upon Tyne Hospitals NHS Foundation Trust. My interests are in both early (discovery) and late (first into man – clinical implementation) translational gaps.

I lead a group looking at bacteria, chronic lung infections and use both basic science approaches and clinical trials activity to tackle these.

I led a successful bid for a MRC Partnership grant in a multicentre approach to Bronchiectasis and have set up the UK national registry in bronchiectasis "BRONCH-UK" 2014-2017 with further funding from the US COPD foundation

I also lead a clinical trials unit based at Freeman Hospital which has globally leading recruitment rates.  My particular interest in respiratory clinical trials means I am heavily involved in investigator led and commercial/industry trials of new therapies in bronchiectasis and COPD. I have undertaken UK Chief Investigator roles and recently started International lead investigator roles. These activities map to my role as National Specialty lead for the NIHR National Respiratory group working for the UK National Institute for Health research Clinical trials network . 

Both areas of work map to my interest in pulmonary infections and how patients treatment need tailored to help. A focus on Gram negative infections in Cystic Fibrosis formed part of my early (PhD) research. Lipopolysaccharide (LPS) biological activity and LPS structure to function correlation has formed part of more recent work. I also research inflammatory pathways, biomarkers and am developing in vitro models for studying these. I was VC of a multinational COST action in Cystic fibrosis pathogens (COST action BM1003) and led a consensus approach to developing an International reference panel of Pseudomonas strains.

My clinical services map to the above themes with increasing interests in managing both severe Bronchiectasis and COPD. I run a service in endobronchial lung volume techniques for severe emphysema and am developing services for alpa-1-antitrypsin deficiency. I have supported acute COVID care during the pandemic. As part of the national response to tackle COVID I have participated in the National Institute for Health Research Urgent public Health prioritisation (UPH) panel.

I have been local lead for COVID 19 research RECOVERY trial and a lead for ACCORD studies. I serve on the PHOS-COVID working group and Chief investigator for an ACCORD program on complement inhibition. I have served on the steering committees of RECOVERY RS (ventilation in COVID) and EMBARC European Registry. I am CI for the 30T sponsored anti viral trial in COPD/ Bronchiectasis. I have supported big pharma in advisory boards and trials steering committees to help develop new medicines in Bronchiectasis and COPD

Outline of Research Interests

My main interest is in pulmonary infections, their consequences and how to manage patients with such infections better.

A focus on Gram negative infections in Cystic Fibrosis has formed part of my early research. Lipopolysaccharide (LPS) biological activity and LPS structure to function correlation has formed part of more recent work. Clinical research in bronchiectasis and severe smoking related lung disease (COPD) is underway in collaboration with many clinical and academic colleagues;

Collaborations 

1. BRONCH-UK 9 Bronchiectasis centres across the UK plus 5 academic experts from other disciplines
2. Lipopolysaccharide and Peptidoglycan; Prof Molinaro Naples, Prof W Vollmer & Dr CMA Khan, Newcastle
3. Pseudomonas biology and reference panel/ cross infection: Prof Craig Winstanley Liverpool,  Dr S MacClean Dublin
4. Bronchiectasis network- EMBARC- a European network for bronchiectasis- in set up
5. Bronchiectasis severity index group- S Aliberti, Milano, L DuPont/ P Goeminne Leuven Belgium, J Chalmers Dundee, A Hill Edinburgh
6. Biogerontology; J Passos and T vonZglinicki, Newcastle
7. Microbiome and Phages-  C van der Gast, NERC, UK  & S Cummings, C Lanyon & D Smith Northumbria University
8. Bronchiectasis and Rheumatoid group - L Perry, P Eggleton Exeter University, P Venables Oxford
9. Neutrophils and Bronchiectasis- J Simpson & J Isaacs
10. Pseudomonas and epithelial Dysfunction- AJ Fisher, L Borthwick

Collaborations with Industry & SMEs are not listed but enquiries welcome

Current Work

1. Structure and biological activity of LPS extracted from pathogens infecting patients with a variety of respiratory conditions (Cystic Fibrosis, Bronchiectasis and COPD).
2. Identifying "at risk" groups such as those with Bronchiectasis and comorbid Rheumatoid arthritis / applying prognostic scoring indices 
3. Biomarkers of disease activity
4. Airway pathogens virulence, microbiome and bacteriophages
5. Accelerated aging and the lung "Inflammaging"
6. COVID-19 Research and clinical trials
   

Current Grants

1. I am the lead applicant on the £700K MRC Funded Partnership grant in bronchiectasis "Bronch -UK" starts October 2014
2. I am a co-applicant on the 2.2MHealth Technology Assessment grant TWICS trial  https://w3.abdn.ac.uk/hsru/twics/
3. I cowrote and am Vice Chair  of the EU Cost action BM1003 (EU500,000)
4. I supervise 3 PhD students funded via the NIHR and MRC 
5. Industry funding of over £100,000 on Bronchiectasis projects
6. NIHR HTA DIBS trial of Inhaled therapy in bronchiectasis 2020-2024
   

Prior grants

Wellcome Clinical Training Fellowship 2001-2003 (work led to 4 publications) Funded £138,000
HEFCE award £250,000 2007-2012

GSK investigator led grant £10K 2008
FFC Charity grant £24,000 2009 3 prior publications

Newcastle Hospital Special Trustees 2005-2006
(2 Publications) Funded £38,000
I co-supervised a technician continuing research themes from the Wellcome Trust grant.

Higher Education Council For England Senior Lecturer Award
5 Year Tenure University of Newcastle
Funded £250,000 over 5 years towards wages. This post is complemented with a 50% clinical component funded by Newcastle upon Tyne Hospitals Trust (multiple publications).

Research Roles

1. Principal Investigator (bench and trials roles),
2. National/ Global Chief Investigator 

Postgraduate Supervision

The post-graduate supervision of research candidates started in October 2007. Three MRES students have completed to merit/distinction levels and publications arisen through this

4 PhD students completed

Esteem Indicators

3M Pharmaceuticals Small Airways Research Prize 1999
University of Newcastle, School of Medicine Annual Research presentation, First prize, 2000
Wellcome Trust Clinical Training Fellowship,Sep 2001 - October 2003
British Lung Foundation Young Investigator of the Year 2003
One of two national HECFE award winners in Respiratory Medicine 2007

VC of COST BM1003 a European network 2010-14

National Industry lead for NIHR specialty group 2012-date

Deputy Chair of NIHR national Respiratory specialty group 2011-4

Industrial Relevance

Significant input into UK clinical trials by recruitment at Sir William Leech Trials Centre.
Prior UK Chief Investigator duties undertaken
Facilitated Industrial contact with UKCRN adoption process improving trials throughput
Co supervisor to Wellcome Translational PhD student part funded by AstraZeneca

Keywords

Cystic Fibrosis, microbiology, bronchiectasis, lipopolysaccharide, virulence, Pseudomonas aeruginosa, Burkholderia, cepacia, cenocepacia, COPD, COVID-19, Coronavirus

Undergraduate Teaching

Prior MRES student supervision / cosupervision Syba Sunny, S Maloney, J Birch
Prior 3 Biology honours undergraduates B Johnson, K Laws and I Laher

Postgraduate Teaching Prior and Current

1. Academic clinical fellow Dr H Jary
2. CoSupervisor to Dr L Moisey
3. Lead supervisor to Jodie Birch MRC MRES/PhD
4. Co Supervisor to Dr M McDonell/ M Friel
5. Lead Supervisor for K Heslop (NIHR PhD Fellow)
6. Lead supervisor to K Hester (NIHR PhD Fellow) 
7. Lead supervisor Chris Cole (PhD)
8. Lead supervisor to Paul McCallion (NIHR PCAF fellow)
9. Lead Supervisor to Jen Murphy/ Butler (NIHR PCAF fellow)

• Articles

  • Pollock J, Polverino E, Dhar R, Dimakou K, Traversi L, Bossios A, Haworth C, Loebinger MR, De Soyza A, Vendrell M, Burgel PR, Mertsch P, McDonnell MJ, Skgrat S, Maiz-Carro L, Sibila O, Van Der Eerden M, Kauppi P, Hill AT, Wilson R, Milenkovic B, Menendez R, Murris M, Crichton ML, Borecki S, Obradovic D, Irfan M, Eshenkulova V, Nowinski A, Amorim A, Torres A, Lorent N, Welte T, Blasi F, Van Braeckel E, Altenburg J, Shteinberg M, Boersma W, Elborn JS, Aliberti S, Ringshausen FC, Goeminne P, Chalmers JD. Use of inhaled corticosteroids in bronchiectasis: data from the European Bronchiectasis Registry (EMBARC). Thorax 2025, 80(6), 358-368.
  • Ong WH, Ireland P, Ho CK, Fowkes R, Madhu Y, Davidson R, Kaiser K, George K, Rodger J, Armstrong A, Messer B, Tedd H, Lane N, De Soyza A. Transcutaneous CO2 Measurement in an Adult Long-Term Ventilation (LTV) Service. Journal of Clinical Medicine 2025, 14(12), 4137.
  • Sibila O, Stobo J, Perea L, Gao Y-H, Xu J-F, Lind H, Viligorska K, Spinou A, Polverino E, Ringshausen FC, Vendrell M, Burgel P-R, Haworth CS, Loebinger MR, Lorent N, Dhar R, Choi H, Chotirmall SH, De Soyza A, Hurst JR, Brown JS, van der Eerden M, Kauppi P, Johnson ED, Mendez R, Dimakou K, Bossios A, Torres A, Blasi F, Shteinberg M, Elborn SJ, Goeminne PC, Aliberti S, Jayaram L, Karalus N, Taylor SL, Martin ML, Burr LD, Wong C, Terpstra L, Altenburg J, Boersma W, Chalmers JD. Symptoms, risk of future exacerbations, and response to long-term macrolide treatment in bronchiectasis: an observational study. The Lancet Respiratory Medicine 2025, 13(10), 911-920.
  • De Soyza A, Goodwin VA, Roberts K, Masoli J, Mathews J, Wilding J, Nestor G, Bower P. Rising to the challenges of research in multiple long-term conditions: health and social care research ecosystem approaches. BMJ Open 2025, 15(9), e096206.
  • Chalmers JD, Burgel P-R, Daley CL, De Soyza A, Haworth CS, Mauger D, Loebinger MR, McShane PJ, Ringshausen FC, Blasi F, Shteinberg M, Mange K, Teper A, Fernandez C, Zambrano M, Fan C, Zhang X, Metersky ML. Phase 3 Trial of the DPP-1 Inhibitor Brensocatib in Bronchiectasis. New England Journal of Medicine 2025, 392(16), 1569-1581.
  • McCallion P, Bradley JM, Lewis A, Robinson L, Lally J, De Soyza A. Improving shared decision-making in bronchiectasis. BMJ Open Respiratory Research 2025, 12, e003049.
  • Choi H, Han K, Jung JH, De Soyza A, Kim H, Shin DW, Lee H. Impact of rheumatoid arthritis, seropositivity and disease-modifying anti-rheumatic drugs on mortality risk in bronchiectasis. Therapeutic Advances in Respiratory Disease 2025, 19, 1-13.
  • Sobala R, Kibbler J, Yip K, Thompson R, Rafique C, Steward M, Samanta R, Jha A, Rahman N, De Soyza A. Evaluation of real-world use of pulmonary embolism thrombolysis: Erupt. ERJ Open Research 2025, 11(3), 00935-2024.
  • De Soyza A, Nordon C, Coak E, Pennant T, Mullerova H, Fageras M, Alves JA, Janssens W. Clinical Burden of People with Symptomatic and Exacerbating COPD While on Triple Inhaled Therapy †. Journal of Clinical Medicine 2025, 14(18), 6488.
  • Johnson ED, Long MB, Perea L, Shih VH, Fernandez C, Teper A, Cipolla D, McIntosh E, Galloway R, Eke Z, Shuttleworth M, Hull R, Spinou A, De Soyza A, Ringshausen FC, Goeminne P, Lorent N, Haworth C, Loebinger MR, Blasi F, Shteinberg M, Aliberti S, Polverino E, Sibila O, Shoemark A, Mange K, Huang JTJ, Stobo J, Chalmers JD. Broad Immunomodulatory Effects of the Dipeptidyl Peptidase-1 Inhibitor Brensocatib in Bronchiectasis Data from the Phase 2, Double-Blind, Placebo-controlled WILLOW Trial. American Journal of Respiratory and Critical Care Medicine 2025, 211(5), 770-778.
  • Devereux G, Cotton S, Nath M, McMeekin N, Campbell K, Chaudhuri R, Choudhury G, De Soyza A, Fielding S, Gompertz S, Haughney J, Lee A, MacLennan G, Morice A, Norrie J, Price D, Short P, Vestbo J, Walker P, Wedzicha J, Wilson A, Wu O, Lipworth B. Bisoprolol for patients with chronic obstructive pulmonary disease at high risk of exacerbation: the BICS RCT. Health Technology Assessment 2025, 29(17), 1-97.
  • De Soyza A, Saunders T, Wild G, Mawson P, Kelly M, Elborn S, Hill AT, Gatheral T, Sullivan A, Haworth C, Hurst JR, Brown J, Carroll M, Navaratnam V, Loebinger M, Davies G, Upadhyay H, Bradley J, Walker PP, Steer J, Duckers J, Pollock J, Crichton M, Chalmers JD, McNally R. Anxiety, depression, physical disease parameters and health-related quality of life in the BronchUK national bronchiectasis cohort. ERJ Open Research 2025, 11(3), 00348-2024.
  • Armstrong A, Messer B, Cullerton C, Lowes M, Heslop-Marshall K, Sykes A, Wright S, Soyza AD. An Observational, Cross-Sectional Study to Investigate Whether Room Air Ventilators, Used in the Community Setting, Are Colonised by Potential Airborne Pathogens (IPAP Study). Journal of Clinical Medicine 2025, 14(4), 1171.
  • Alfahl Z, Einarsson GG, Elborn JS, Gilpin DF, O'Neill K, Ferguson K, Hill AT, Loebinger MR, Carroll M, Gatheral T, De Soyza A, Chalmers JD, Johnson C, Hurst JR, Brown JS, Bradley JM, Tunney MM. Airway total bacterial density, microbiota community composition and relationship with clinical parameters in bronchiectasis. Respiratory Medicine 2025, 236, 107906.
  • Pollock J, Goeminne PC, Aliberti S, Polverino E, Crichton ML, Ringshausen FC, Dhar R, Vendrell M, Burgel P-R, Haworth CS, De Soyza A, De Gracia J, Bossios A, Rademacher J, Grunewaldt A, McDonnell M, Stolz D, Sibila O, van der Eerden M, Kauppi P, Hill AT, Wilson R, Amorim A, Munteanu O, Menendez R, Torres A, Welte T, Blasi F, Boersma W, Elborn JS, Shteinberg M, Dimakou K, Chalmers JD, Loebinger MR. Aspergillus Serologic Findings and Clinical Outcomes in Patients With Bronchiectasis: Data From the European Bronchiectasis Registry. Chest 2025, 167(4), 975-992.
  • Aliberti S, Ringshausen FC, Dhar R, Haworth CS, Loebinger MR, Dimakou K, Crichton ML, De Soyza A, Vendrell M, Burgel P-R, McDonnell M, Skrgat S, Maiz Carro L, de Roux A, Sibila O, Bossios A, van der Eerden M, Kauppi P, Wilson R, Milenkovic B, Menendez R, Murris M, Borekci S, Munteanu O, Obradovic D, Nowinski A, Amorim A, Torres A, Lorent N, Van Braeckel E, Altenburg J, Shoemark A, Shteinberg M, Boersma W, Goeminne PC, Elborn JS, Hill AT, Welte T, Blasi F, Polverino E, Chalmers JD. Objective sputum colour assessment and clinical outcomes in bronchiectasis: data from the European Bronchiectasis Registry (EMBARC). European Respiratory Journal 2024, 63(4), 2301554.
  • O'Neill K, O'Neill B, McLeese RH, Chalmers JD, Boyd J, De Soyza A, McCallion P, Bradley JM. Digital technologies in bronchiectasis physiotherapy services: a survey of patients and physiotherapists in a UK centre. ERJ Open Research 2024, 10(3), 00013-2024.
  • Elneima O, McAuley HJC, Leavy OC, Chalmers JD, Horsley A, Ho L-P, Marks M, Poinasamy K, Raman B, Shikotra A, Singapuri A, Sereno M, Harris VC, Houchen-Wolloff L, Saunders RM, Greening NJ, Richardson M, Quint JK, Briggs A, Docherty AB, Kerr S, Harrison EM, Lone NI, Thorpe M, Heaney LG, Lewis KE, Aul R, Beirne P, Bolton CE, Brown JS, Choudhury G, Bakerly ND, Easom N, Echevarria C, Fuld J, Hart N, Hurst JR, Jones MG, Parekh D, Pfeffer P, Rahman NM, Rowland-Jones SL, Thompson AR, Jolley C, Shah AM, Wootton DG, Chalder T, Davies MJ, De Soyza A, Geddes JR, Greenhalf W, Heller S, Howard LS, Jacob J, Jenkins RG, Lord JM, Man WD-C, McCann GP, Neubauer S, Openshaw PJ, Porter JC, Rowland MJ, Scott JT, Semple MG, Singh SJ, Thomas DC, Toshner M, Smith N, Sheikh A, Brightling CE, Wain LV, Evans RA. Cohort Profile: Post-Hospitalisation COVID-19 (PHOSP-COVID) study. International Journal of Epidemiology 2024, 53(1), dyad165.
  • Polverino E, Dimakou K, Traversi L, Bossios A, Haworth CS, Loebinger MR, De Soyza A, Vendrell M, Burgel P-R, Mertsch P, McDonnell M, Skrgat S, Maiz Carro L, Sibila O, van der Eerden M, Kauppi P, Hill AT, Wilson R, Milenkovic B, Menendez R, Murris M, Digalaki T, Crichton ML, Borecki S, Obradovic D, Nowinski A, Amorim A, Torres A, Lorent N, Welte T, Blasi F, Van Braeckel E, Altenburg J, Shoemark A, Shteinberg M, Boersma W, Elborn JS, Aliberti S, Ringshausen FC, Chalmers JD, Goeminne PC. Bronchiectasis and asthma: Data from the European Bronchiectasis Registry (EMBARC). Journal of Allergy and Clinical Immunology 2024, 153(6), 1553-1562.
  • Chalmers JD, Burgel P-R, Daley CL, De Soyza A, Haworth CS, Mauger D, Mange K, Teper A, Fernandez C, Conroy D, Metersky M. Brensocatib in non-cystic fibrosis bronchiectasis: ASPEN protocol and baseline characteristics. ERJ Open Research 2024, 10(4).
  • Devereux G, Cotton S, Nath M, McMeekin N, Campbell K, Chaudhuri R, Choudhury G, De Soyza A, Fielding S, Gompertz S, Haughney J, Lee AJ, MacLennan G, Morice A, Norrie J, Price D, Short P, Vestbo J, Walker P, Wedzicha J, Wilson A, Wu O, Lipworth BJ. Bisoprolol in Patients With Chronic Obstructive Pulmonary Disease at High Risk of Exacerbation: The BICS Randomized Clinical Trial. JAMA 2024, 332(6), 462-470.
  • Spinou A, Hererro-Cortina B, Aliberti S, Goeminne PC, Polverino E, Dimakou K, Haworth CS, Loebinger MR, De Soyza A, Vendrell M, Burgel PR, McDonnell M, Sutharsan S, Skrgat S, Maiz-Carro L, Sibila O, Stolz D, Kauppi P, Bossios A, Hill AT, Clifton I, Crichton ML, Walker P, Menendez R, Borecki S, Obradovic D, Nowinski A, Amorim A, Torres A, Lorent N, Welte T, Blasi F, Jankovic Makek M, Shteinberg M, Boersma W, Elborn JS, Chalmers JD, Ringshausen FC. Airway clearance management in people with bronchiectasis: data from the European Bronchiectasis Registry (EMBARC). European Respiratory Journal 2024, 63(6), 2301689.
  • Leavy OC, Russell RJ, Harrison EM, Lone NI, Kerr S, Docherty AB, Sheikh A, Richardson M, Elneima O, Greening NJ, Harris VC, Houchen-Wolloff L, McAuley HJC, Saunders RM, Sereno M, Shikotra A, Singapuri A, Aul R, Beirne P, Bolton CE, Brown JS, Choudhury G, Bakerly ND, Easom N, Echevarria C, Fuld J, Hart N, Hurst JR, Jones M, Parekh D, Pfeffer P, Rahman NM, Rowland-Jones S, Shah AM, Wootton DG, Jolley C, Thompson AA Roger, Chalder T, Davies MJ, De Soyza A, Geddes JR, Greenhalf W, Heller S, Howard L, Jacob J, Jenkins RG, Lord JM, Man WD-C, McCann GP, Neubauer S, Openshaw PJM, Porter J, Rowland MJ, Scott JT, Semple MG, Singh SJ, Thomas D, Toshner M, Lewis K, Heaney LG, Briggs A, Zheng B, Thorpe M, Quint JK, Chalmers JD, Ho L-P, Horsley A, Marks M, Poinasamy K, Raman B, Wain LV, Brightling CE, Evans RA. 1-year health outcomes associated with systemic corticosteroids for COVID-19: a longitudinal cohort study. ERJ Open Research 2024, 10(5), 00474-2024.
  • Davison J, Robinson-Barella A, Davies G, Campos-Hinojosa M, Collins C, Husband A, Okeowo D, Hester KLM, Lee R, Rapley T, De Soyza A. Patient attitudes to nebulised antibiotics in the treatment of bronchiectasis: a mixed-methods study. ERJ Open Research 2023, 9(3), 00735-2022.
  • Morton M, Wilson N, Homer TM, Simms L, Steel A, Maier R, Wason J, Ternent L, Abouhajar A, Allen M, Joyce R, Hildreth V, Lakey R, Cherlin S, Walker A, Devereux G, Chalmers JD, Hill AT, Haworth C, Hurst JR, De Soyza A. Dual bronchodilators in Bronchiectasis study (DIBS): protocol for a pragmatic, multicentre, placebo-controlled, three-arm, double-blinded, randomised controlled trial studying bronchodilators in preventing exacerbations of bronchiectasis. BMJ Open 2023, 13(8), e071906.
  • McLeese RH, O'Neill K, O'Neill B, Chalmers JD, Boyd J, De Soyza A, McChrystal R, Crichton ML, Bradley JM. Airway clearance treatments in bronchiectasis: feasibility of linking survey results to registry data and a survey of patients’ and physiotherapists’ practices. ERJ Open Research 2023, 9(2), 00540.
  • Wilkinson T, De Soyza A, Carroll M, Chalmers JD, Crooks MG, Griffiths G, Shankar-Hari M, Ho L-P, Horsley A, Kell C, Lara B, Mishra B, Moate R, Page C, Pandya H, Raw J, Reid F, Saralaya D, Scott IC, Siddiqui S, Ustianowski A, van Zuydam N, Woodcock A, Singh D, ACCORD Collaborative Group. A randomised phase 2a study to investigate the effects of blocking interleukin-33 with tozorakimab in patients hospitalised with COVID-19: ACCORD-2. ERJ Open Research 2023, 9(5), 00249-2023.
  • Cotton S, Devereux G, Abbas H, Briggs A, Campbell K, Chaudhuri R, Choudhury G, Dawson D, De Soyza A, Fielding S, Gompertz S, Haughney J, Lang CC, Lee AJ, MacLennan G, MacNee W, McCormack K, McMeekin N, Mills NL, Morice A, Norrie J, Petrie MC, Price D, Short P, Vestbo J, Walker P, Wedzicha J, Wilson A, Lipworth BJ. Use of the oral beta blocker bisoprolol to reduce the rate of exacerbation in people with chronic obstructive pulmonary disease (COPD): a randomised controlled trial (BICS). Trials 2022, 23(1), 307.
  • Bakerly ND, Nikitin K, Snowise NG, Cardwell G, Freeman D, Saggu R, De Soyza A. Pragmatic randomised controlled trials in COPD and asthma: how to guide clinical practice. BMJ Open Respiratory Research 2022, 9(1), e001303.
  • O'Neill K, Lakshmipathy GR, Neely C, Cosgrove D, Ferguson K, McLeese R, Hill AT, Loebinger MR, Carroll M, Chalmers JD, Gatheral T, Johnson C, De Soyza A, Hurst JR, Bradbury I, Elborn JS, Bradley JM. Multiple-Breath Washout Outcome Measures in Adults with Bronchiectasis. Annals of the American Thoracic Society 2022, 19(9), 1489-1497.
  • Harbottle J, Carlin H, Payne-Doris T, Tedd HMI, de Soyza A, Messer B. Developing an intrasalivary gland botox service for patients receiving long-term non-invasive ventilation at home: a single-centre experience. BMJ Open Respiratory Research 2022, 9(1), e001188.
  • RECOVERY Collaborative Group, Inc. The Newcastle Upon Tyne Hospitals NHS Foundation Trust, Hunter E, De Soyza A, Agbeko R, Baker K, Barr A, Cameron E, Campbell Hewson Q, Duncan C, Emonts M, Fenn A, Francis S, Glover Bengtsson J, Greenhalgh A, Hanrath A, Houghton K, Jerry D, Jones G, Kelly S, Lane N, Macfarlane J, McAlinden P, McCullagh I, McDonald S, Mohammed O, Obukofe R, Parker J, Patience A, Payne B, Price D, Razvi S, Robson S, Sanchez Gonzalez A, Stephenson E, Welton R, West S, Wong E, Yelnoorkar J. Casirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. The Lancet 2022, 399(10325), 665-676.
  • RECOVERY Collaborative Group. Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis. The Lancet 2022, 400, 359-368.
  • RECOVERY Collaborative Group. Aspirin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. The Lancet 2022, 399(10320), 143-151.
  • Sobala R, Carlin H, Fretwell T, Shakir S, Cattermole K, Royston A, McCallion P, Davison J, Lumb J, Tedd H, Messer B, De Soyza A. An observational study of Pseudomonas aeruginosa in adult long-term ventilation. ERJ Open Research 2022, 8(2), 00687-2021.
  • Evans RA, Harrison EM, Singapuri A, Sereno M, Docherty AB, Lone NI, Leavy OC, Baillie JK, Brown JS, Chalder T, De Soyza A, Geddes JR, Hart N, Heaney LG, Heller S, Howard L, Hurst JR, Jacob J, Jenkins RG, Jolley C, Kerr S, Kon OM, Lewis K, Lord JM, McCann GP, Neubauer S, Openshaw PJM, Parekh D, Pfeffer P, Rahman NM, Raman B, Richardson M, Rowland M, Semple MG, Shah AM, Singh SJ, Sheikh A, Thomas D, Toshner M, Chalmers JD, Ho L-P, Horsley A, Marks M, Wain LV, Brightling CE, Abel K, Adamali H, Adeloye D, Adeyemi O, Adeyemi F, Ahmad S, Ahmed R, Ainsworth M, Alamoudi A, Aljaroof M, Allan L, Allen R, Alli A, Al-Sheklly B, Altmann D, Anderson D, Andrews M, Angyal A, Antoniades C, Arbane G, Armour C, Armstrong N, Armstrong L, Arnold H, Arnold D, Ashworth M, Ashworth A, Assefa-Kebede H, Atkin P, Atkins H, Atkins A, Aul R, Avram C, Baggott R, Baguley D, Baillie JK, Bain S, Bakali M, Bakau M, Baldry E, Baldwin D, Ballard C, Bambrough J, Barker RE, Barratt S, Barrett F, Basu N, Batterham R, Baxendale H, Bayes H, Bayley M, Beadsworth M, Beirne P, Bell R, Bell D, Berry C, Betts S, Bhui K, Bishop L, Blaikely J, Bloomfield C, Bloss A, Bolger A, Bolton CE, Bonnington J, Botkai A, Bourne M, Bourne C, Bradley E, Bramham K, Brear L, Breen G, Breeze J, Briggs A, Bright E, Brightling CE, Brill S, Brindle K, Broad L, Broome M, Brown JS, Brown M, Brown J, Brown R, Brown V, Brown A, Brugha T, Brunskill N, Buch M, Bularga A, Bullmore E, Burn D, Burns G, Busby J, Buttress A, Byrne S, Cairns P, Calder PC, Calvelo E, Card B, Carr L, Carson G, Carter P, Cavanagh J, Chalder T, Chalmers JD, Chambers RC, Channon K, Chapman K, Charalambou A, Chaudhuri N, Checkley A, Chen J, Chetham L, Chilvers ER, Chinoy H, Chong-James K, Choudhury N, Choudhury G, Chowdhury P, Chowienczyk P, Christie C, Clark D, Clark C, Clarke J, Clift P, Clohisey S, Coburn Z, Cole J, Coleman C, Connell D, Connolly B, Connor L, Cook A, Cooper B, Coupland C, Craig T, Crisp P, Cristiano D, Crooks MG, Cross A, Cruz I, Cullinan 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  • O'Neill K, Ferguson K, Cosgrove D, Tunney MM, De Soyza A, Carroll M, Chalmers JD, Gatheral T, Hill AT, Hurst JR, Johnson C, Loebinger MR, Angyalosi G, Haworth CS, Jensen R, Ratjen R, Saunders C, Short C, Davies JC, Elborn JS, Bradley JM. Multiple breath washout in bronchiectasis clinical trials: is it feasible?. ERJ Open Research 2021, 6, 00363-2019.
  • De Soyza A, Mawson P, Hill AT, Elborn S, Bradley JM, Haworth CS, Floto RA, Wilson R, Loebinger MR, Carroll M, Crichton M, Chalmers JD, Sullivan A, Brown J, Hurst JR, Duckers J, Kelly M, Steer J, Gatheral T, Walker PP, Winstanley C, McGuire A, Denning D, McNally R. BronchUK: protocol for an observational cohort study and biobank in bronchiectasis. ERJ Open Research 2021, 7(2), 00775-2020.
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Whole-genome sequencing of patients with rare diseases in a national health system. Nature 2020, 583, 96-102.
  • Gao Y-H, Abo Leyah H, Finch S, Lonergan M, Aliberti S, De Soyza A, Fardon TC, Tino G, Chalmers JD. Relationship between Symptoms, Exacerbations, and Treatment Response in Bronchiectasis. American journal of respiratory and critical care medicine 2020, 201(12), 1499-1507.
  • Cuthbertson L, Walker AW, Oliver AE, Rogers GB, Rivett DW, Hampton TH, Ashare A, Elborn JS, De Soyza A, Carroll MP, Hoffman LR, Lanyon C, Moskowitz SM, O'Toole GA, Parkhill J, Planet PJ, Teneback CC, Tunney MM, Zuckerman JB, Bruce KD, Van Der Gast CJ. Lung function and microbiota diversity in cystic fibrosis. Microbiome 2020, 8, 45.
  • Cunniffe NG, Gunter SJ, Brown M, Burge SW, Coyle C, De Soyza A, Dymond T, Esmail H, Francis DP, Galloway J, Galloway JB, Gkrania-Klotsas E, Greenaway J, Katritsis G, Kanagaratnam P, Knolle MD, Leonard K, McIntyre ZC, Prudon B, Rampling T, Torok ME, Warne B, Yates M, Matheson NJ, Su L, Villar S, Stewart GD, Toshner M. How achievable are COVID-19 clinical trial recruitment targets? A UK observational cohort study and trials registry analysis. BMJ Open 2020, 10(10), e044566.
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  • Hester KLM, Ryan V, Newton J, Rapley T, De Soyza A. Bronchiectasis Information and Education: a randomised, controlled feasibility trial. Trials 2020, 21, 331.
  • Tariq MA, Everest FLC, Cowley LA, Wright R, Holt GS, Ingram H, Duignan LAM, Nelson A, Lanyon CV, Perry A, Perry JD, Bourke S, Brockhurst MA, Bridge SH, De Soyza A, Smith DL. Temperate Bacteriophages from Chronic Pseudomonas aeruginosa Lung Infections Show Disease-Specific Changes in Host Range and Modulate Antimicrobial Susceptibility. mSystems 2019, 4(4), e00191-18.
  • Devereux G, Cotton S, Fielding S, McMeekin N, Barnes PJ, Briggs A, Burns G, Chaudhuri R, Chrystyn H, Davies L, De Soyza A, Gompertz S, Haughney J, Innes K, Kaniewska J, Lee A, Morice A, Norrie J, Sullivan A, Wilson A, Price D. Low-dose oral theophylline combined with inhaled corticosteroids for people with chronic obstructive pulmonary disease and high risk of exacerbations: a RCT. Health Technology Assessment 2019, 23(37), 1-146.
  • Dhar R, Singh S, Talwar D, Mohan M, Tripathi SK, Swarnakar R, Trivedi S, Rajagopala S, D'Souza G, Padmanabhan A, Baburao A, Mahesh PA, Ghewade B, Nair G, Jindal A, Jayadevappa GDH, Sawhney H, Sarmah KR, Saha K, Anantharaj S, Khanna A, Gami S, Shah A, Shah A, Dutt N, Garg H, Vyas S, Venugopal K, Prasad R, Aleemuddin NM, Karmakar S, Singh V, Jindal SK, Sharma S, Prajapat D, Chandrashekaria S, McDonnell MJ, Mishra A, Rutherford R, Ramanathan RP, Goeminne PC, Vasudev P, Dimakou K, Crichton ML, Jayaraj BS, Kungwani R, Das A, Sawhney M, Polverino E, Torres A, Gulecha NS, Shteinberg M, De Soyza A, Mangala A, Shah P, Chauhan NK, Jajodia N, Singhal A, Batra S, Hasan A, Limaye S, Salvi S, Aliberti S, Chalmers JD. Bronchiectasis in India: results from the European Multicentre Bronchiectasis Audit and Research Collaboration (EMBARC) and Respiratory Research Network of India Registry. The Lancet Global Health 2019, 7(9), e1269-e1279.
  • Hill AT, Sullivan AL, Chalmers JD, De Soyza A, Elborn JS, Floto RA, Grillo L, Gruffydd-Jones K, Harvey A, Haworth CS, Hiscocks E, Hurst JR, Johnson C, Kelleher WP, Bedi P, Payne K, Saleh H, Screaton NJ, Smith M, Tunney M, Whitters D, Wilson R, Loebinger MR. British Thoracic Society Guideline for bronchiectasis in adults. Thorax 2019, 74(suppl. 1), 1-69.
  • Kunadian V, Wilson N, Stocken D, Hani A, McColl E, Burns G, Howe N, Fisher A, De Soyza A. Antiplatelet therapy in the primary prevention of cardiovascular diseasein patients with chronic obstructive pulmonary disease: a randomised controlled proof-of-concept trial. ERJ Open Research 2019, 5(3).
  • Stephenson D, Perry A, Appleby MR, Lee D, Davison J, Johnston A, Jones AL, Nelson A, Bourke SJ, Thomas MF, De Soyza A, Lordan JL, Lumb J, Robb AE, Samuel JR, Walton KE, Perry JD. An evaluation of methods for the isolation of nontuberculous mycobacteria from patients with cystic fibrosis, bronchiectasis and patients assessed for lung transplantation. BMC Pulmonary Medicine 2019, 19(1), 19.
  • Bradley JM, Anand R, O'Neill B, Ferguson K, Clarke M, Carroll M, Chalmers J, De Soyza A, Duckers J, Hill AT, Loebinger MR, Copeland F, Gardner E, Campbell C, Agus A, McGuire A, Boyle R, McKinney F, Dickson N, McAuley DF, Elborn S, on behalf of the CLEAR study group. A 2 × 2 factorial, randomised, open-label trial to determine the clinical and cost-effectiveness of hypertonic saline (HTS 6%) and carbocisteine for airway clearance versus usual care over 52 weeks in adults with bronchiectasis: A protocol for the CLEAR clinical trial. Trials 2019, 20(1), 747.
  • Araujo D, Shteinberg M, Aliberti S, Goeminne PC, Hill AT, Fardon TC, Obradovic D, Stone G, Trautmann M, Davis A, Dimakou K, Polverino E, De Soyza A, McDonnell MJ, Chalmers JD. The independent contribution of Pseudomonas aeruginosa infection to long-term clinical outcomes in bronchiectasis. European Respiratory Journal 2018, 51(2), 1701953.
  • Carnell SC, Perry JD, Borthwick L, Vollmer D, Biboy J, Facchini M, Bragonzi A, Silipo A, Vergunst AC, Vollmer W, Khan ACM, De Soyza A. Targeting the bacterial cytoskeleton of the Burkholderia cepacia complex for antimicrobial development: A cautionary tale. International Journal of Molecular Sciences 2018, 19(6), 1604.
  • Heslop-Marshall K, Baker C, Carrick-Sen D, Newton J, Echvarria C, Stenton C, Jambon M, Gray J, Pearce K, Burns G, De Soyza A. Randomised controlled trial of cognitive behavioural therapy in COPD. ERJ Open Research 2018, 4(4), 00094-2018.
  • Evans R, Brutsche M, Busca R, Deslee G, de Soyza A, Fellrath J-M, Franzen D, Hartman J, Mealing S, Morton T, Munavvar M, Sculpher M, Shah P, Slebos D-J, Durand-Zaleski I. Quantifying patient centered outcomes associated with the use of bilateral endobronchial coil treatment in patients with severe emphysema. Current Medical Research and Opinion 2018, 34(11), 1927-1932.
  • O'Neill K, Lakshmipathy GR, Ferguson K, Cosgrove D, Hill AT, Loebinger MR, Carroll M, Chalmers JD, Gatheral T, Johnson C, DeSoyza A, Hurst JR, Bradbury I, Elborn JS, Bradley JM. Quality control for multiple breath washout tests in multicentre bronchiectasis studies: Experiences from the BRONCH-UK clinimetrics study. Respiratory Medicine 2018, 145, 206-211.
  • Birch J, Sunny SS, Hester KLM, Parry G, Kate Gould F, Dark JH, Clark SC, Meachery G, Lordan J, Fisher AJ, Corris PA, De Soyza A. Outcomes of lung transplantation in adults with bronchiectasis. BMC Pulmonary Medicine 2018, 18, 82.
  • Price D, Devereux G, Cotton S, Fielding S, McMeekin N, Barnes PJ, Briggs A, Burns G, Chaudhuri R, Chrystyn H, Davies L, De Soyza A, Gompertz S, Haughney J, Innes K, Kaniewska J, Lee A, Morice A, Norrie J, Sullivan A, Wilson A. Effect of Theophylline as Adjunct to Inhaled Corticosteroids on Exacerbations in Patients with COPD: A Randomized Clinical Trial. JAMA - Journal of the American Medical Association 2018, 320(15), 1548-1559.
  • Chalmers JD, Aliberti S, Filonenko A, Shteinberg M, Goeminne PC, Hill AT, Fardon TC, Obradovic D, Gerlinger C, Sotgiu G, Operschall E, Rutherford RM, Dimakou K, Polverino E, De Soyza A, McDonnell MJ. Characterisation of the "Frequent Exacerbator Phenotype" in Bronchiectasis. American Journal of Respiratory and Critical Care Medicine 2018, 197(11), 1410-1420.
  • Hill AT, Sullivan AL, Chalmers JD, De Soyza A, Elborn JS, Floto RA, Grillo L, Gruffydd-Jones K, Harvey A, Haworth CS, Hiscocks E, Hurst JR, Johnson C, Kelleher WP, Bedi P, Payne K, Saleh H, Screaton NJ, Smith M, Tunney M, Whitters D, Wilson R, Loebinger MR. British Thoracic Society guideline for bronchiectasis in adults. BMJ Open Respiratory Research 2018, 5(1), e000348.
  • Kunadian V, Chan D, Ali H, Wilkinson N, Howe N, McColl E, Thornton J, von Wilamowitz-Moellendorff A, Holstein EM, Burns G, Fisher A, Stocken D, De Soyza A. Antiplatelet therapy in the primary prevention of cardiovascular disease in patients with chronicobstructive pulmonary disease: protocol of a randomised controlled proof-of-concept trial (APPLE COPD-ICON 2). BMJ Open 2018, 8, e020713.
  • Jaat FG, Hasan SF, Perry A, Cookson S, Murali S, Perry JD, Lanyon CV, De Soyza A, Todryk SM. Anti-bacterial antibody and T cell responses in bronchiectasis are differentially associated with lung colonization and disease. Respiratory Research 2018, 19, 106.
  • Aksamit T, Bandel T-J, Criollo M, De Soyza A, Elborn JS, Operschall E, Polverino E, Roth K, Winthrop KL, Wilson R. The RESPIRE trials: Two phase III, randomized, multicentre, placebo-controlled trials of Ciprofloxacin Dry Powder for Inhalation (Ciprofloxacin DPI) in non-cystic fibrosis bronchiectasis. Contemporary Clinical Trials 2017, 58, 78-85.
  • Saleh AD, Chalmers JD, De Soyza A, Fardon TC, Koustas SO, Scott J, Simpson AJ, Brown JS, Hurst JR. The heterogeneity of systemic inflammation in bronchiectasis. Respiratory Medicine 2017, 127, 33-39.
  • Chalmers JD, Crichton M, Goeminne PC, Loebinger MR, Haworth C, Almagro M, Vendrell M, De Soyza A, Dhar R, Morgan L, Blasi F, Aliberti S, Boyd J, Polverino E. The European multicentre bronchiectasis audit and research collaboration (EMBARC): Experiences from a successful ERS clinical research collaboration. Breathe 2017, 13(3), 180-192.
  • Perry E, Eggleton P, De Soyza A, Hutchinson D, Kelly C. Increased disease activity, severity and autoantibody positivity in rheumatoid arthritis patients with co-existent bronchiectasis. International Journal of Rheumatic Diseases 2017, 20(12), 2003-2011.
  • Clarke A, Perry E, Kelly C, De Soyza A, Heesom K, Gold LI, Ollier W, Hutchinson D, Eggleton P. Heightened autoantibody immune response to citrullinated calreticulin in bronchiectasis: Implications for rheumatoid arthritis. International Journal of Biochemistry and Cell Biology 2017, 89, 199-206.
  • McCallion P, De Soyza A. Cough and bronchiectasis. Pulmonary Pharmacology and Therapeutics 2017, 47, 77-83.
  • De Soyza A, McDonnell MJ, Goeminne PC, Aliberti S, Lonni S, Davison J, Dupont LJ, Fardon TC, Rutherford RM, Hill AT, Chalmers JD. Bronchiectasis Rheumatoid overlap syndrome is an independent risk factor for mortality in patients with bronchiectasis: A multicenter cohort study. Chest 2017, 151(6), 1247-1254.
  • De Soyza A, Aliberti S. Bronchiectasis and Aspergillus: How are they linked?. Medical Mycology 2017, 55(1), 69-81.
  • Chalmers JD, McDonnell MJ, Rutherford R, Davidson J, Finch S, Crichton M, Dupont L, Hill AT, Fardon TC, De Soyza A, Aliberti S, Goeminne P. The generalizability of bronchiectasis randomized controlled trials: A multicentre cohort study. Respiratory Medicine 2016, 112, 51-58.
  • Chalmers JD, Aliberti S, Polverino E, Vendrell M, Crichton M, Loebinger M, Dimakou K, Clifton I, van der Eerden M, Rohde G, Murris-Espin M, Masefield S, Gerada E, Shteinberg M, Ringshausen F, Haworth C, Boersma W, Rademacher J, Hill AT, Aksamit T, O'Donnell A, Morgan L, Milenkovic B, Tramma L, Neves J, Menendez R, Paggiaro P, Botnaru V, Skrgat S, Wilson R, Goeminne P, De Soyza A, Welte T, Torres A, Elborn JS, Blasi F. The EMBARC European bronchiectasis registry: Protocol for an international observational study. ERS Monograph 2016, 2(1), 1-9.
  • Aliberti S, Masefield S, Polverino E, De Soyza A, Loebinger MR, Menendez R, Ringshausen FC, Vendrell M, Powell P, Chalmers JD, EMBARC Study Group. Research priorities in bronchiectasis: a consensus statement from the EMBARC Clinical Research Collaboration. European Respiratory Journal 2016, 48(3), 632-647.
  • Hamilton DW, Bins JE, McMeekin P, Pedersen A, Steen N, De Soyza A, Thomson R, Paleri V, Wilson JA. Quality compared to quantity of life in laryngeal cancer: A time trade off study. Head & Neck 2016, 38(S1), E631 - E637.
  • McDonnell MJ, Aliberti S, Goeminne PC, Dimakou K, Zucchetti SC, Davidson J, Ward C, Laffey JG, Finch S, Pesci A, Dupont LJ, Fardon TC, Skrbic D, Obradovic D, Cowman S, Loebinger MR, Rutherford RM, De Soyza A, Chalmers JD. Multidimensional severity assessment in bronchiectasis: an analysis of seven European cohorts. Thorax 2016, 71(12), 1110-1118.
  • Hester KLM, Newton J, Rapley T, De Soyza A. Evaluation of a novel information resource for patients with bronchiectasis: study protocol for a randomised controlled trial. Trials 2016, 17, 210.
  • Navaratnam V, Muirhead CR, Hubbard RB, De Soyza A. Critical care admission trends and outcomes in individuals with bronchiectasis in the UK. QJM: an international journal of medicine 2016, 109(8), 523-526.
  • McDonnell MJ, Alibert S, Goeminne PC, Restrepo MI, Finch S, Pesci A, Dupont LJ, Fardon TC, Wilson R, Loebinger MR, Skrbic D, Obradovic D, De Soyza A, Ward C, Laffey JG, Rutherford RM, Chalmers JD. Comorbidities and the risk of mortality in patients with bronchiectasis: an international multicentre cohort study. The Lancet Respiratory Medicine 2016, 4(12), 969-979.
  • De Soyza A, Aksamit T. Ciprofloxacin dry powder for inhalation in non-cystic fibrosis bronchiectasis. Expert Opinion on Orphan Drugs 2016, 4(8), 875-884.
  • Hester KLM, McDonnell M, De Soyza A. Bronchiectasis: What We Don't Know Yet But Should. BRN Reviews 2016, 2(1), 14-26.
  • Devereux G, Cotton S, Barnes P, Briggs A, Burns G, Chaudhuri R, Chrystyn H, Davies L, De Soyza A, Fielding S, Gompertz S, Haughney J, Lee AJ, McCormack K, McPherson G, Morice A, Norrie J, Sullivan A, Wilson A, Price D. Use of low-dose oral theophylline as an adjunct to inhaled corticosteroids in preventing exacerbations of chronic obstructive pulmonary disease: study protocol for a randomised controlled trial. Trials 2015, 16, 267.
  • Pascual S, Feimer J, De Soyza A, Roig JS, Haughney J, Padulles L, Seoane B, Rekeda L, Ribera A, Chrystyn H. Preference, satisfaction and critical errors with Genuair and Breezhaler inhalers in patients with COPD: a randomised, cross-over, multicentre study. NPJ Primary Care Respiratory Medicine 2015, 25, 15018.
  • Cullen L, Weiser R, Olszak T, Maldonado RF, Moreira AS, Slachmuylders L, Brackman G, Paunova-Krasteva TS, Zarnowiec P, Czerwonka G, Reilly J, Drevinek P, Kaca W, Melter O, De Soyza A, Perry A, Winstanley C, Stoitsova SR, Lavigne R, Mahenthiralingam E, Sa-Correia I, Coenye T, Drulis-Kawa Z, Augustyniak D, Valvano MA, McClean S. Phenotypic characterization of an international Pseudomonas aeruginosa reference panel: strains of cystic fibrosis (CF) origin show less in vivo virulence than non-CF strains. Microbiology 2015, 161, 1961-1977.
  • McDonnell MJ, Jary HR, Perry A, MacFarlane JG, Hester KL, Small T, Molyneux C, Perry JD, Walton KE, De Soyza A. Non cystic fibrosis bronchiectasis: A longitudinal retrospective observational cohort study of Pseudomonas persistence and resistance. Respiratory Medicine 2015, 109(6), 716-726.
  • Olszak T, Zarnowiec P, Kaca W, Danis-Wlodarczyk K, Augustyniak D, Drevinek P, de Soyza A, McClean S, Drulis-Kawa Z. In vitro and in vivo antibacterial activity of environmental bacteriophages against Pseudomonas aeruginosa strains from cystic fibrosis patients. Applied Microbiology and Biotechnology 2015, 99(14), 6021-6033.
  • Lonni S, Chalmers JD, Goeminne PC, McDonnell MJ, Dimakou K, De Soyza A, Polverino E, Van De Kerkhove C, Rutherford R, Davison J, Rosales E, Pesci A, Restrepo MI, Torres A, Aliberti S. Etiology of non-cystic fibrosis bronchiectasis in adults and its correlation to disease severity. Annals of the American Thoracic Society 2015, 12(12), 1764-1770.
  • Birch J, Anderson RK, Correia-Melo C, Jurk D, Hewitt G, Marques FM, Green NJ, Moisey E, Birrell MA, Belvisi MG, Black F, Taylor JJ, Fisher AJ, De Soyza A, Passos JF. DNA damage response at telomeres contributes to lung aging and chronic obstructive pulmonary disease. American Journal of Physiology: Lung Cellular and Molecular Physiology 2015, 309(10), L1124-L1137.
  • Quirke AM, Perry E, Cartwright A, Kelly C, De Soyza A, Eggleton P, Hutchinson D, Venables PJ. Bronchiectasis Is a Model for Chronic Bacterial Infection Inducing Autoimmunity in Rheumatoid Arthritis. Arthritis & Rheumatology 2015, 67(9), 2335-2342.
  • Di Lorenzo F, Kubik L, Oblak A, Lore NI, Cigana C, Lanzetta R, Parrilli M, Hamad MA, De Soyza A, Silipo A, Jerala R, Bragonzi A, Valvano MA, Martin-Santamaria S, Molinaro A. Activation of Human Toll-like Receptor 4 (TLR4)center dot Myeloid Differentiation Factor 2 (MD-2) by Hypoacylated Lipopolysaccharide from a Clinical Isolate of Burkholderia cenocepacia. Journal of Biological Chemistry 2015, 290(35), 21305-21319.
  • De Soyza A, Pavord I, Elborn JS, Smith D, Wray H, Puu M, Larsson B, Stockley R. A randomised, placebo-controlled study of the CXCR2 antagonist AZD5069 in bronchiectasis. European Respiratory Journal 2015, 46(4), 1021-1032.
  • Tariq MA, Everest FL, Cowley LA, De Soyza A, Holt GS, Bridge SH, Perry A, Perry JD, Bourke SJ, Cummings SP, Lanyon CV, Barr JJ, Smith DL. A metagenomic approach to characterize temperate bacteriophage populations from Cystic Fibrosis and non-Cystic Fibrosis bronchiectasis patients. Frontiers in Microbiology 2015, 6, 97.
  • Chalmers JD, Goeminne P, Aliberti S, McDonnell MJ, Lonni S, Davidson J, Poppelwell L, Salih W, Pesci A, Dupont LJ, Fardon TC, De Soyza A, Hill AT. The Bronchiectasis Severity Index An International Derivation and Validation Study. American Journal of Respiratory and Critical Care Medicine 2014, 189(5), 576-585.
  • Purcell P, Jary H, Perry A, Perry JD, Stewart CJ, Nelson A, Lanyon C, Smith DL, Cummings SP, De Soyza A. Polymicrobial airway bacterial communities in adult bronchiectasis patients. BMC Microbiology 2014, 14, 130.
  • McDonnell MJ, Anwar GA, Rutherford RM, De Soyza A, Worthy S, Corris PA, Lordan JL, Bourke S, Afolabi G, Ward C, Middleton P, Middleton D. Lack of association between KIR and HLA-C type and susceptibility to idiopathic bronchiectasis. Respiratory Medicine 2014, 108(8), 1127-1133.
  • Bilton D, Tino G, Barker AF, Chambers DC, De Soyza A, Dupont LJ, O'Dochartaigh C, van Haren EH, Vidal LO, Welte T, Fox HG, Wu J, Charlton B, B-305 Study Investigators. Inhaled mannitol for non-cystic fibrosis bronchiectasis: a randomised, controlled trial. Thorax 2014, 69(12), 1073-1079.
  • Wells TJ, Whitters D, Sevastsyanovich YR, Heath JN, Pravin J, Goodall M, Browning DF, O'Shea MK, Cranston A, De Soyza A, Cunningham AF, MacLennan CA, Henderson IR, Stockley RA. Increased severity of respiratory infections associated with elevated anti-LPS IgG2 which inhibits serum bactericidal killing. Journal of Experimental Medicine 2014, 211(9), 1893-1904.
  • Musson JA, Reynolds CJ, Rinchai D, Nithichanon A, Khaenam P, Favry E, Spink N, Chu KKY, De Soyza A, Bancroft GJ, Lertmemongkolchai G, Maillere B, Boyton RJ, Altmann DM, Robinson JH. CD4⁺ T Cell Epitopes of FliC Conserved between Strains of Burkholderia: Implications for Vaccines against Melioidosis and Cepacia Complex in Cystic Fibrosis. Journal of Immunology 2014, 193(12), 6041-6049.
  • Barker AF, O'Donnell AE, Flume P, Thompson PJ, Ruzi JD, de Gracia J, Boersma WG, De Soyza A, Shao LX, Zhang J, Haas L, Lewis SA, Leitzinger S, Montgomery AB, McKevitt MT, Gossage D, Quittner AL, O'Riordan TG. Aztreonam for inhalation solution in patients with non-cystic fibrosis bronchiectasis (AIR-BX1 and AIR-BX2): two randomised double-blind, placebo-controlled phase 3 trials. Lancet Respiratory Medicine 2014, 2(9), 738-749.
  • Borthwick LA, Corris PA, Mahida R, Walker A, Gardner A, Suwara M, Johnson GE, Moisey EJ, Brodlie M, Ward C, Perry JD, de Soyza A, Mann DA, Fisher AJ. TNFα From Classically Activated Macrophages Accentuates Epithelial to Mesenchymal Transition in Obliterative Bronchiolitis. American Journal of Transplantation 2013, 13(3), 621-633.
  • De Soyza A, Brown JS, Loebinger MR. Research priorities in bronchiectasis. Thorax 2013, 68(7), 695-696.
  • Anwar GA, McDonnell MJ, Worthy SA, Bourke SC, Afolabi G, Lordan J, Corris PA, De Soyza A, Middleton P, Ward C, Rutherford RM. Phenotyping adults with non-cystic fibrosis bronchiectasis: A prospective observational cohort study. Respiratory Medicine 2013, 107(7), 1001-1007.
  • Stockley R, De Soyza A, Gunawardena K, Perrett J, Forsman-Semb K, Entwistle N, Snell N. Phase II study of a neutrophil elastase inhibitor (AZD9668) in patients with bronchiectasis. Respiratory Medicine 2013, 107(4), 524-33.
  • Serisier DJ, Bilton D, De Soyza A, Thompson PJ, Kolbe J, Greville HW, Cipolla D, Bruinenberg P, Gonda I, the ORBIT-2 Investigators. Inhaled, dual release liposomal ciprofloxacin in non-cystic fibrosis bronchiectasis (ORBIT-2): a randomised, double-blind, placebo-controlled trial. Thorax 2013, 68(9), 812-817.
  • Heslop K, Newton J, Baker C, Burns G, Carrick-Sen D, De Soyza A. Effectiveness of cognitive behavioural therapy (CBT) interventions for anxiety in patients with chronic obstructive pulmonary disease (COPD) undertaken by respiratory nurses: the COPD CBT CARE study: (ISRCTN55206395). BMC Pulmonary Medicine 2013, 13, 62.
  • Ruchaud-Sparagano MH, Gertig H, Hester KL, Macfarlane JG, Corris P, Simpson AJ, De Soyza A. Effect of granulocyte-macrophage colony-stimulating factor on neutrophil function in idiopathic bronchiectasis. Respirology 2013, 18(8), 1230-1235.
  • De Soyza A, Hall AJ, Mahenthiralingam E, Drevinek P, Kaca W, Drulis-Kawa Z, Stoitsova SR, Toth V, Coenye T, Zlosnik JEA, Burns JL, Sa-Correia I, De Vos D, Pirnay JP, Kidd TJ, Reid D, Manos J, Klockgether J, Wiehlmann L, Tummler B, McClean S, Winstanley C. Developing an international Pseudomonas aeruginosa reference panel. MicrobiologyOpen 2013, 2(6), 1010-1023.
  • Nelson A, Perry A, Perry JD, Bourke SJ, Cummings SP, De Soyza A. Determining the influence of environmental and patient specific factors on the polymicrobial communities of the cystic fibrosis airway. Antonie Van Leeuwenhoek 2013, 103(4), 755-762.
  • Nelson A, Perry A, Perry JD, Bourke SJ, Cummings SP, De Soyza A. Determining the influence of environmental and patient specific factors on the polymicrobial communities of the cystic fibrosis airway. Antonie van Leeuwenhoek 2013, 103(4), 755-762.
  • Borthwick LA, Gardner A, De Soyza A, Mann DA, Fisher AJ. Transforming Growth Factor-β1 (TGF-β1) Driven Epithelial to Mesenchymal Transition (EMT) is Accentuated by Tumour Necrosis Factor α (TNFα) via Crosstalk Between the SMAD and NF-κB Pathways. Cancer Microenvironment 2012, 5(1), 45-57.
  • Borthwick LA, Gardner A, De-Soyza A, Mann DA, Fisher AJ. Transforming Growth Factor-β1 (TGF-β1) Driven Epithelial to Mesenchymal Transition (EMT) is Accentuated by Tumour Necrosis Factor α (TNFα) via Crosstalk Between the SMAD and NF-κB Pathways. Cancer Microenvironment 2012, 5(1), 45-57.
  • Macfarlane JG, Jary H, Hester KL, McAlinden P, Wake J, Small T, Walton KE, Spickett G, De Soyza A. Low serum mannose-binding lectin level is not associated with disease severity in non-cystic fibrosis bronchiectasis. Innate Immunity 2012, 18(6), 787-792.
  • Nicholson A, Perry JD, James AL, Stanforth SP, Carnell S, Wilkinson K, Anjam Khan CM, De Soyza A, Gould FK. In vitro activity of S-(3,4-dichlorobenzyl)isothiourea hydrochloride and novel structurally related compounds against multidrug-resistant bacteria, including Pseudomonas aeruginosa and Burkholderia cepacia complex. International Journal of Antimicrobial Agents 2012, 39(1), 27-32.
  • Hester KL, Macfarlane JG, Tedd H, Jary H, McAlinden P, Rostron L, Small T, Newton JL, De Soyza A. Fatigue in bronchiectasis. Quarterly Journal of Medicine 2012, 105(3), 235-240.
  • Wilson R, Welte T, Polverino E, De Soyza A, Greville H, O'Donnell A, Alder J, Reimnitz P, Hampel B. Ciprofloxacin dry powder for inhalation in non-cystic fibrosis bronchiectasis: a phase II randomised study. European Respiratory Journal 2012, 41(5), 1107-1115.
  • Savelev S, Perry J, Bourke S, Taylor R, Fisher A, Corris P, Jary H, Petrie M, De Soyza A. Volatile biomarkers of Pseudomonas aeruginosa in cystic fibrosis and non cystic fibrosis bronchiectasis. Letters in Applied Microbiology 2011, 52(6), 610-613.
  • Borthwick LA, Sunny SS, Oliphant V, Perry J, Brodlie M, Johnson GE, Ward C, Gould K, Corris PA, De Soyza A, Fisher AJ. Pseudomonas aeruginosa accentuates epithelial-to-mesenchymal transition in the airway. European Respiratory Journal 2011, 37(5), 1237-1247.
  • Ierano T, Silipo A, Sturiale L, Garozzo D, Corris P, Perry J, Lanzetta R, Parrilli M, De Soyza A, Molinaro A. Structural Elucidation of a Novel B. cenocepacia ET-12 Lipooligosaccharide Isolated from a Cystic Fibrosis Patient after Lung Transplantation. European Journal of Organic Chemistry 2010, 2010(7), 1299-1306.
  • De Soyza A, Meachery G, Hester KLM, Nicholson A, Parry G, Tocewicz K, Pillay T, Clark S, Lordan JL, Schueler S, Fisher AJ, Dark JH, Gould FK, Corris PA. Lung transplantation for patients with cystic fibrosis and Burkholderia cepacia complex infection: A single-center experience. Journal of Heart and Lung Transplantation 2010, 29(12), 1395-1404.
  • Nelson A, De Soyza A, Bourke SJ, Perry JD, Cummings SP. Assessment of sample handling practices on microbial activity in sputum samples from patients with cystic fibrosis. Letters in Applied Microbiology 2010, 51(3), 272-277.
  • Heslop K, De Soyza A, Baker CR, Stenton C, Burns GP. Using individualised cognitive behavioural therapy as a treatment for people with COPD. Nursing Times 2009, 105(14), 14-17.
  • Ierano T, Silipo A, Sturiale L, Garozzo D, Bryant C, Lanzetta R, Parrilli M, Aldridge C, Gould FK, Corris PA, Khan CMA, De Soyza A, Molinaro A. First structural characterization of Burkholderia vietnamiensis lipooligosaccharide from cystic fibrosis-associated lung transplantation strains. Glycobiology 2009, 19(11), 1214-1223.
  • Ieranò T, Silipo A, Sturiale L, Garozzo D, Brookes H, Khan CM, Bryant C, Gould FK, Corris PA, Lanzetta R, Parrilli M, De Soyza A, Molinaro A. The structure and proinflammatory activity of the lipopolysaccharide from Burkholderia multivorans and the differences between clonal strains colonizing pre and posttransplanted lungs. Glycobiology 2008, 18(11), 871-881.
  • Meachery G, De Soyza A, Nicholson A, Parry G, Hasan A, Tocewicz K, Pillay T, Clark S, Lordan JL, Schueler S, Fisher AJ, Dark JH, Gould FK, Corris PA. Outcomes of lung transplantation for cystic fibrosis in a large UK cohort. Thorax 2008, 63(8), 725-731.
  • Silipo A, Molinaro A, Ierano T, De Soyza A, Sturiale L, Garozzo D, Aldridge C, Corris PA, Khan CMA, Lanzetta R, Parrilli M. The complete structure and pro-inflammatory activity of the lipooligosaccharide of the highly epidemic and virulent gram-negative bacterium Burkholderia cenocepacia ET-12 (strain J2315). Chemistry - A European Journal 2007, 13(12), 3501-3511.
  • Ward C, De Soyza A, Fisher AJ, Pritchard G, Forrest I, Corris P. A descriptive study of small airway reticular basement membrane thickening in clinically stable lung transplant recipients. Journal of Heart and Lung Transplantation 2005, 24(5), 533-537.
  • Ward C, De Soyza A, Fisher AJ, Pritchard G, Forrest IA, Corris PA. Reticular basement membrane thickening in airways of lung transplant recipients is not affected by inhaled corticosteroids. Clinical and Experimental Allergy 2004, 34(12), 1905-1909.
  • De Soyza A, Morris K, McDowell A, Doherty C, Archer L, Perry J, Govan JRW, Corris PA, Gould K. Prevalence and clonality of Burkholderia cepacia complex genomovars in UK patients with cystic fibrosis referred for lung transplantation. Thorax 2004, 59(6), 526-528.
  • De Soyza A, Ellis CD, Khan CMA, Corris P, Demarco de Hormaeche R. Burkholderia Cenocepacia Lipopolysaccharide, Lipid A and Proinflammatory Activity. American Journal of Respiratory and Critical Care Medicine 2004, 170(1), 70-77.
  • Ward C, Camara M, Forrest I, Rutherford R, Pritchard G, Daykin M, Hardman A, De Soyza A, Fisher AJ, Williams P, Corris PA. Preliminary findings of quorum signal molecules in clinically stable lung allograft recipients. Thorax 2003, 58(5), 444-446.
  • De Soyza A, Fisher AJ, Small T, Corris PA. Inhaled corticosteroids and the treatment of lymphocytic bronchiolitis following lung transplantation. American Journal of Respiratory and Critical Care Medicine 2001, 164(7), 1209-1212.
  • De Soyza AG, Dark JH, Parums DV, Curtis A, Corris PA. Donor acquired small cell lung cancer following pulmonary transplantation. Chest 2001, 120(3), 1030-1031.
  • De Soyza A, McDowell A, Archer L, Dark JH, Elborn SJ, Mahenthiralingam E, Gould K, Corris PA. Burkholderia cepacia complex genomovars and pulmonary transplantation outcomes in patients with cystic fibrosis. Lancet 2001, 358(9295), 1780-1781.
  • Milne DS, Moy JV, Corris PA, Robertson H, De Soyza A, Kirby JA, Cunningham AC. Intragraft Proliferating T Lymphocytes are associated with Moderate Acute Pulmonary Rejection 1. Transplantation 2000, 69(9), 1981-1984.

• Conference Proceedings (inc. Abstracts)

  • DeSoyza A, Wells TJ, Davison J, Sheehan E, Kanagasundaram S, Spickett G, Davies G, MacLennan CA, Stockley R, Henderson I. Plasmapheresis as rescue therapy in severe bronchiectasis with blocking anti pseudomonas antibodies. In: 1st World Bronchiectasis Conference. 2016, Hannover, Germany: Georg Thieme Verlag KG.
  • Cole CC, Carnell SC, Jiwa KJ, Birch JB, Hester KH, Ward CW, Simpson JS, De Soyza ADS. Neutrophil vascular endothelial growth factor (VEGF) as a driving force for angiogenesis in bronchiectasis?. In: British Thoracic Society Winter Meeting 2016. 2016, London: BMJ Group.
  • McDonnell MJ, Aliberti S, Goeminne PC, Dimakou K, Zucchetti SC, Davidson J, Ward C, Laffey JG, Finch S, Pesci A, Dupont LJ, Fardon TC, Skrbic D, Obradovic D, Cowman S, Loebinger MR, Rutherford RM, De Soyza A, Chalmers JD. Multidimensional Severity Assessment in Bronchiectasis-An Analysis of 7 European Cohorts. In: ITS Annual Scientific Meeting 2016. 2016, Dublin: Springer UK.
  • Hester KLM, Newton J, Rapley T, Ryan V, De Soyza A. Evaluation of a novel intervention for patients with bronchiectasis: the bronchiectasis information and education feasibility (brief) study. In: British Thoracic Society Winter Meeting 2016. 2016, London: BMJ Group.
  • McDonnell MJ, De Soyza A, Goeminne PC, Aliberti S, Lonni S, Davidson J, Dupont LJ, Fardon TC, Rutherford RM, Hill AT, Chalmers JD. Bronchiectasis Rheumatoid Overlap Syndrome(BROS) is an Independent Risk Factor for Mortalityin Patients with Bronchiectasis: A Multicentre CohortStudy. In: ITS Annual Scientific Meeting. 2016, Killiney, Co.Dublin: Springer London.
  • Koustas S, Peel A, Scott J, Davison J, Jiwa K, Carnell S, Simpson AJ, De Soyza A. Sputum Neutrophils but not Interleukin-8 (IL-8) or Interleukin 17 (IL-17) Correlate with the Bronchiectasis Severity Index (BSI). In: British Thoracic Society. 2015, London, UK: BMJ Publishing Group.
  • Usmani Z, Carson K, Heslop K, Esterman A, De Soyza A, Jayasinghe H, Smith B. Psychological Therapies for the Treatment of Anxiety Disorders in COPD: A Cochrane Systematic Review and Meta-analysis. In: Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science, Anuual Scientific Meeting. 2015, Queensland, Australia: Wiley-Blackwell.
  • Jayasinghe H, Usmani Z, Carson K, Heslop K, Esterman A, De Soyza A, Smith B. Psychological therapies for the treatment of anxiety disorders in COPD: a Cochrane systematic review and meta-analysis. In: 20th Congress of the Asia Pacific Society of Respirology. 2015, Kuala Lumpur, Malaysia: Wiley-Blackwell.
  • Heslop-Marshall K, Baker C, Carrick-Sen D, Stenton SC, Newton J, Burns GP, De Soyza A. Prevalence of anxiety and paitent characteristics from a randomised controlled trial (RCT) to identify if cognitive behavioural therapy (CBT) by respiratory nurses reduces anxiety in COPD. In: British Thoracic Society. 2015, London, UK: BMJ Publishing Group.
  • Hester KLM, Newton J, DeSoyza A, Rapley T. Living your life with bronchiectasis: an exploration of patients and carers information needs informing development of a novel information resource. In: British Thoracic Winter Meeting 2015. 2015, London, UK: BMJ Group.
  • Thirugnanasothy L, Davison J, Whitters D, Stockley RA, MacLennan CA, Cunningham AF, Kanagasundaram S, Spickett G, Stroud C, Wells TJ, Henderson IR, DeSoyza A. Immune dysfunction in bronchiectasis: blocking antibodies and a role for IVIG therapy?. In: British Society for Allergy and Clinical Immunology 2014 Annual Meeting. 2015.
  • McDonnell MJ, O'Toole D, Rutherford R, De Soyza A, Lordan J, Pearson J, Ward C, Laffey JG. Bile Acids Cause Direct Inflammation And Injury And Worsen Acid Induced Injury In The Pulmonary Epithelium. In: American Thoracic Society 2015 International Conference. 2015, Denver, Colorado, USA: American Thoracic Society.
  • McDonnell MJ, O'Toole D, Rutherford R, De Soyza A, Lordan J, Pearson J, Ward C, Laffey JG. Bile Acids Cause Direct Inflammation and Injury and Worsen Acid Induced Injury in the Pulmonary Epithelium. In: Irish Thoracic Society Annual Scientific Meeting 2015. 2015, Cork, Ireland: Springer.
  • McDonnell MJ, O'Toole D, Rutherford R, De Soyza A, Lordan J, Pearson J, Ward C, Laffey JG. Azithromycin Attenuates Release of Bile Acid-Mediated Neutrophilic and Remodelling Factors from Human Bronchial Epithelial Cells. In: Irish Thoracic Society Annual Scientific Meeting 2015. 2015, Cork, Ireland: Springer London.
  • McDonnell MJ, O'Toole D, Rutherford R, De Soyza A, Lordan J, Pearson J, Ward C, Laffey JG. Azithromycin Attenuates Release Of Bile Acid-Mediated Neutrophilic And Remodeling Factors From Human Bronchial Epithelial Cells. In: American Thoracic Society International Conference. 2015, Denver, Colorado, USA: American Thoracic Society.
  • Jaat F, Hasan S, Lanyon C, De Soyza A, Todryk S. Anti-microbial immune responses in obstructive lung diseases. In: British Thoracic Society Winter Meeting 2015. 2015, London, UK: BMJ Group.
  • Navaratnam V, Muirhead C, Hubbard RB, De Soyza A. Admission trends and outcomes of individuals with bronchiectasis admitted to adult general critical care units in England, Wales and Northern Ireland. In: British Thoracic Society Winter Meeting 2015. 2015, London, UK: BMJ Group.
  • McDonnell M, Chalmers J, Goemmine P, Aliberti S, Lonni S, Davison J, Poppelwell L, Salih W, Pesci A, Dupont L, Fardon T, Hill A, De Soyza A. Validation of a Disease Specific Severity Index for Non-Cystic Fibrosis Bronchiectasis: The BSI Index. In: CHEST World Congress 2014. 2014, Madrid, Spain: American College of Chest Physicians.
  • Quirke AM, Perry E, Kelly C, de-Soyza A, Eggleton P, Hutchinson D, Venables P. Patients with bronchiectasis, with or without rheumatoid arthritis, have an elevated anti-citrullinated peptide antibodies (ACPA) response. In: European Workshop for Rheumatology Research. 2014, Lisbon, PORTUGAL: BMJ Group.
  • Perry E, Quirke AM, Kelly C, Eggleton P, De Soyza A, Hutchinson D, Venables P. Diverse Pulmonary Insults Lead to Common Anti-Citrullinated Peptide Fine Specificity Profiles and May Promote Autoimmunity in RA. In: Rheumatology 2014. 2014, Liverpool, UK: Oxford University Press.
  • Saleh AD, Hurst JR, Davison J, Stroud C, Lowe D, De Soyza A. Bronchiectasis Seversity in Primary Immunodeficiency - A Two Centre Study. In: British Thoracic Society Winter Meeting. 2014, London, UK: BMJ Publishing Group.
  • Birch J, Johnson G, Jiwa K, Anderson R, Ward C, Taylor JJ, Corris PA, Passos JF, Fisher AJ, De Soyza A. Small Airway Epithelial Cell Senescence Present in COPD and Bronchiectasis?. In: British Thoracic Society Winter Meeting. 2013, London, UK: BMJ Publishing Group.
  • Perry E, Kelly C, de-Soyza A, Moullaali T, Eggleton P, Hutchinson D. Natural History, Disease Characteristics and Autoantibody Positivity in Patients with Bronchiectasis and RA: Is the Lung an Initiating Site of Autoimmunity in Rheumatoid Arthritis?. In: Rheumatology 2013. 2013, Birmingham, UK: Oxford University Press.
  • Davison J, Johnson G, Jiwa K, Cranson A, Wake R, Hood B, Small T, Birch J, Fisher A, De Soyza A. DEEPER PHENOTYPING OF NON CF BRONCHIECTASIS THROUGH SPUTUM DIFFERENTIAL COUNTS. In: British Thoracic Society Winter Meeting. 2013, London, UK: BMJ Publishing Group.
  • Sunny SS, Burns A, Jary H, Aspray T, De Soyza A. Osteoporosis in Non-Cystic Fibrosis Bronchiectasis (NCFBr) Adults. In: British Thoracic Society Winter Meeting. 2012, London, UK: BMJ Publishing Group.

• Editorials

  • Goeminne PC, De Soyza A. Bronchiectasis: how to be an orphan with many parents?. European Respiratory Journal 2016, 47(1), 10-13.
  • Hurst JR, Elborn JS, De Soyza A, BRONCH-UK Consortium. COPD-bronchiectasis overlap syndrome. European Respiratory Journal 2015, 45(2), 310-313.

• Letters

  • Rose L, Camporota L, Contreras A, Couper K, Hadfield D, Alleyne S, Barabas J, Boex SM, Connolly BA, Dark P, Davies C, Dawson A, De Soyza A, Felton TW, Guck J, Hale D, Hill MC, Hopkins PA, Hossain A, Ji C, Jin H, Kandiyali R, Khan KA, Kitchen GB, Krovi DN, Lall R, Law E, Lea K, Madan JJ, McGrath BA, Michael A, Mills GH, Mildner R, Noufaily A, Parekh D, Parvin C, Patel V, Perkins G, Rafferty GF, Shankar-Hari M, Shyamsunder M, Steiner M, Tassie E, Thirlwall J, Thompson M, Watkins B, Williams RL, Yeung J, Zanganeh M, Starr K, McAuley D. The COnfederation of REspiratory Critical Care Trials (CoReCCT): a UK research confederation. British Journal of Anaesthesia 2025, 134(2), 566-568.
  • Wilson N, Morton M, Homer T, Konkoth AB, Joyce R, Kershaw A, Wilde H, Liddle A, Wason J, Ternent L, Allen M, Lord R, Steer J, Devereux G, Chalmers JD, Hill AT, Haworth CS, Hurst JR, De Soyza A. Dual Bronchodilators in Bronchiectasis Study: a randomised controlled trial. ERJ Open Research 2025, 11(3), 01079-2024.
  • Chalmers JD, De Soyza A, Aliberti S, Polverino E. Reply to Chen et al.: Reexamining Chronic Obstructive Pulmonary Disease in Bronchiectasis: Elucidating Overdiagnosis and Outcomes from EMBARC's ROSE Criteria. American Journal of Respiratory and Critical Care Medicine 2024, 210(2), 248-249.
  • Perkins GD, Couper K, Connolly B, Baillie JK, Bradley JM, Dark P, De Soyza A, Gorman E, Gray A, Hamilton L, Hart N, Ji C, Lall R, McGowan N, Regan S, Simonds AK, Skilton E, Stallard N, Stimpson E, Yeung J, McAuley DF. RECOVERY- Respiratory Support: Respiratory Strategies for patients with suspected or proven COVID-19 respiratory failure; Continuous Positive Airway Pressure, High-flow Nasal Oxygen, and standard care: A structured summary of a study protocol for a randomised controlled trial. Trials 2020, 21(1), 687.
  • Wilkinson T, Dixon R, Page C, Carroll M, Griffiths G, Ho L-P, De Soyza A, Felton T, Lewis KE, Phekoo K, Chalmers JD, Gordon A, McGarvey L, Doherty J, Read RC, Shankar-Hari M, Martinez-Alier N, O'Kelly M, Duncan G, Walles R, Sykes J, Summers C, Singh D. ACCORD: A Multicentre, Seamless, Phase 2 Adaptive Randomisation Platform Study to Assess the Efficacy and Safety of Multiple Candidate Agents for the Treatment of COVID-19 in Hospitalised Patients: A structured summary of a study protocol for a randomised controlled trial. Trials 2020, 21(1), 691.
  • Wells TJ, Davison J, Sheehan E, Kanagasundaram S, Spickett G, MacLennan CA, Stockley RA, Cunningham AF, Henderson IR, De Soyza A. The Use of Plasmapheresis in Patients with Bronchiectasis with Pseudomonas aeruginosa Infection and Inhibitory Antibodies. American Journal of Respiratory and Critical Care Medicine 2017, 195(7), 955-958.
  • Birch J, Victorelli S, Rahmatika D, Anderson RK, Jiwa K, Moisey E, Ward C, Fisher AJ, De Soyza AJ, Passos JF. Telomere Dysfunction and Senescence-associated Pathways in Bronchiectasis. American Journal of Respiratory and Critical Care Medicine 2016, 193(8), 929-932.
  • Perry E, Stenton C, Kelly C, Eggleton P, Hutchinson D, De Soyza A. RA autoantibodies as predictors of rheumatoid arthritis in non-cystic fibrosis bronchiectasis patients. European Respiratory Journal 2014, 44(4), 1082-1085.
  • De Soyza A, Perry A, Hall AJ, Sunny SS, Walton KE, Mustafa N, Turton J, Kenna DT, Winstanley C. Molecular epidemiological analysis suggests cross-infection with Pseudomonas aeruginosa is rare in non-cystic fibrosis bronchiectasis. European Respiratory Journal 2014, 43(3), 900-903.

• Note

  • Sobala R, Brooks K, Davison J, Lumb J, De Soyza A. Family case studies: absence of Pseudomonas aeruginosa transmission in bronchiectasis. ERJ Open Research 2022, 8(4).

• Reviews

  • Upadhyay H, Aliberti S, Husband A, Chalmers JD, Hester K, De Soyza A. Safety profile of drugs used in non-cystic fibrosis bronchiectasis: a narrative review. Therapeutic Advances in Drug Safety 2024, 15, 1-18.
  • Marsland I, Sobala R, de Soyza A, Witham M. Multimorbidity in bronchiectasis: a systematic scoping review. ERJ Open Research 2023, 9(1), 00296.
  • Sobala R, De Soyza A. Bronchiectasis and Chronic Obstructive Pulmonary Disease Overlap Syndrome. Clinics in Chest Medicine 2022, 43(1), 61-70.
  • Adeloye D, Elneima O, Daines L, Poinasamy K, Quint JK, Walker S, Brightling CE, Siddiqui S, Hurst JR, Chalmers JD, Pfeffer PE, Novotny P, Drake TM, Heaney LG, Rudan I, Sheikh A, De Soyza A. The long-term sequelae of COVID-19: an international consensus on research priorities for patients with pre-existing and new-onset airways disease. The Lancet Respiratory Medicine 2021, 9(12), 1467-1478.
  • McLeese RH, Spinou A, Alfahl Z, Tsagris M, Elborn JS, Chalmers JD, De Soyza A, Loebinger MR, Birring SS, Fragkos KC, Wilson R, O'Neill K, Bradley JM. Psychometrics of health-related quality of life questionnaires in bronchiectasis: A systematic review and meta-analysis. European Respiratory Journal 2021, 58(5), 2100025.
  • Oriano M, Amati F, Gramegna A, De Soyza A, Mantero M, Sibila O, Chotirmall SH, Voza A, Marchisio P, Blasi F, Aliberti S. Protease–Antiprotease Imbalance in Bronchiectasis. International Journal of Molecular Sciences 2021, 22(11), 5996.
  • David B, Bafadhel M, Koenderman L, De Soyza A. Eosinophilic inflammation in COPD: From an inflammatory marker to a treatable trait. Thorax 2021, 76(2), 188-195.
  • Hester KLM, Newton J, Rapley T, De Soyza A. Patient information, education and self-management in bronchiectasis: Facilitating improvements to optimise health outcomes. BMC Pulmonary Medicine 2018, 18, 80.
  • McDonnell MJ, O'Toole D, Ward C, Pearson JP, Lordan JL, De Soyza A, Loebinger M, Chalmers JD, Laffey JG, Rutherford RM. A qualitative synthesis of gastro-oesophageal reflux in bronchiectasis: Current understanding and future risk. Respiratory Medicine 2018, 141, 132-143.
  • Usmani ZA, Carson KV, Heslop K, Esterman AJ, De Soyza A, Smith BJ. Psychological therapies for the treatment of anxiety disorders in chronic obstructive pulmonary disease. Cochrane Database of Systematic Reviews 2017, 2017(3).
  • Polverino E, Goeminne PC, McDonnell MJ, Aliberti S, Marshall SE, Loebinger MR, Murris M, Canton R, Torres A, Dimakou K, De Soyza A, Hill AT, Haworth CS, Vendrell M, Ringshausen FC, Subotic D, Wilson R, Vilaro J, Stallberg B, Welte T, Rohde G, Blasi F, Elborn S, Almagro M, Timothy A, Ruddy T, Tonia T, Rigau D, Chalmers JD. European Respiratory Society guidelines for the management of adult bronchiectasis. European Respiratory Journal 2017, 50(3), 1700629.
  • Wilson R, Aksamit T, Aliberti S, De Soyza A, Elborn JS, Goeminne P, Hill AT, Menendez R, Polverino E. Challenges in managing Pseudomonas aeruginosa in non-cystic fibrosis bronchiectasis. Respiratory Medicine 2016, 117, 179-189.
  • De Soyza A, Calverley PMA. Large trials, new knowledge: the changing face of COPD management. European Respiratory Journal 2015, 45(6), 1692-1703.
  • Perry E, Kelly C, Eggleton P, De Soyza A, Hutchinson D. The lung in ACPA-positive rheumatoid arthritis: an initiating site of injury?. Rheumatology 2014, 53(11), 1940-1950.
  • Ghoorah K, De Soyza A, Kunadian V. Increased Cardiovascular Risk in Patients with Chronic Obstructive Pulmonary Disease and the Potential Mechanisms Linking the Two Conditions: A Review. Cardiology in Review 2013, 21(4), 196-202.
  • Nelson A, De Soyza A, Perry JD, Sutcliffe IC, Cummings SP. Polymicrobial challenges to Koch's postulates: Ecological lessons from the bacterial vaginosis and cystic fibrosis microbiomes. Innate Immunity 2012, 18(5), 774-783.
  • De Soyza A, Silipo A, Lanzetta R, Govan JR, Molinaro A. Review: Chemical and biological features of Burkholderia cepacia complex lipopolysaccharides. Innate Immunity 2008, 14(3), 127-144.
  • De Soyza A, Corris PA. Lung transplantation and the Burkholderia cepacia complex. Journal of Heart and Lung Transplantation 2003, 22(9), 954-958.