Staff Profile
Dr Bill Chaudhry
Senior Lecturer
- Email: bill.chaudhry@ncl.ac.uk
- Telephone: +44 (0) 191 241 8681
- Address: Biosciences Institute
Faculty of Medical Sciences
Newcastle University
International Centre for Life
Central Parkway
Newcastle upon Tyne
NE1 3BZ
Background
Parrs Wood High School, Manchester: 1977 - 1983
Medicine (MBBS) University of Newcastle upon Tyne Medical School: 1983-1988
Adult and Paediatric Medical training, Newcastle, Liverpool and London: 1988-1995
MRCP:1992
FRCPCH: 2006
British Heart Foundation Clinical Research Fellowship and PhD, University College London: 1995-1998
Cardiac and General Paediatric Intensive Care training, Great Ormond Street and Guy's Hospitals: 1998-2002
Consultant Paediatric Intensivist, Newcastle upon Tyne Hospitals NHS Trust: 2002-2009
Senior lecturer in cardiovascular development and disease: 2009-present
Links
ORCID iD: 0000-0003-2833-8882
European Society of Cardiology
Past Chair of the Nucleus (committee) of the Working Group on Development Anatomy and Pathology.
Co-workers
Deborah Henderson, Professor of Cardiac Development
Louise Coats, Consultant in ACHD
Lorraine Eley, BHF Research Associate
Chris Derrick, BHF Research Associate
Ahlam Alqahtani, BHF Research Associate
What are the developmental origins of congenital heart disease?
How does the aortic valve form and what processes lead to bicuspid aortic valve disease
Cardiovascular developmental molecular biology and disease modelling using mice and zebrafish
Hypoplastic left heart syndrome
Hypoplastic Left Heart Syndrome (HLHS) is a rare but serious congenital heart malformation, in which there is severe underdevelopment of the left ventricle and aorta. We are looking for abnormalities in the genes of patients and combining this with our knowledge of how the heart forms, to discover if there is a genetic cause for HLHS.
Left-right signalling and planar cell polarity in cardiac development
Disturbances in the planar cell polarity pathway and in left-right specification cause heart malformations in mice and zebrafish. We are asking if these pathways are linked and if they may point to a genetic cause for malformations such as double outlet right ventricle and atrial/ventricular septal defects in people.
Helping adults with treated congenital heart disease to stay well
Children with congenital heart disease now survive into adulthood and are an expanding patient group. We are interested in understanding their issues, both medical and psychosocial, with the aim of maintaining their holistic wellbeing. We want to find ways to identify problems before they become clinically apparent and nvestigate how we can give this divers patient group the type and degree of support they need.
My teaching responsibilities at Newcastle University are closely linked with my research activity. I provide undergraduate and postgraduate teaching cardiovascular development and congenital heart disease. In the laboratory I provide supervision for PhD, master’s and undergraduate students from our own biomedical sciences course and from other universities across the UK and abroad.
Genetics of Development and its Disorders (BGM3062)
Cardiovascular Science in Health and Disease (MMB8037)
-
Articles
- Chaudhry I, Ghassani A, Wray J, Chaudhry B, Coats L. Outpatient care of adults with congenital heart disease in the UK: a qualitative appraisal of the clinician perspective. Open Heart 2024, 11(1), e002420.
- Derrick CJ, Szenker-Ravi E, Santos-Ledo A, Alqahtani A, Yusof A, Eley L, Coleman AHL, Tohari S, Ng AY-J, Venkatesh B, Alharby E, Mansard L, Bonnet-Dupeyron M-N, Roux A-F, Vache C, Roume J, Bouvagnet P, Almontashiri NAM, Henderson DJ, Reversade B, Chaudhry B. Functional analysis of germline VANGL2 variants using rescue assays of vangl2 knockout zebrafish. Human Molecular Genetics 2024, 33(2), 150-169.
- Eley L, Richardson RV, Alqahtani A, Chaudhry B, Henderson DJ. eNOS plays essential roles in the developing heart and aorta linked to disruption of Notch signalling. Disease Models & Mechanisms 2024, 17(1), dmm050265.
- Anderson RH, Lamers WH, Hikspoors JPJM, Mohun TJ, Bamforth SD, Chaudhry B, Eley L, Kerwin J, Crosier M, Henderson DJ. Development of the arterial roots and ventricular outflow tracts. Journal of Anatomy 2024, 244(3), 497-513.
- Derrick CJ, Santos-Ledo A, Eley L, Paramita IA, Henderson DJ, Chaudhry B. Sequential action of JNK genes establishes the embryonic left-right axis. Development (Cambridge) 2022, 149(9).
- Coats L, Chaudhry B. Ambulatory Care in Adult Congenital Heart Disease—Time for Change?. Journal of Clinical Medicine 2022, 11(7), 2058.
- Murphy LB, Santos-Ledo A, Dhanaseelan T, Eley L, Burns D, Henderson DJ, Chaudhry B. Exercise, programmed cell death and exhaustion of cardiomyocyte proliferation in aging zebrafish. Disease Models and Mechanisms 2021, dmm.049013.
- Alqahtani A, Skelton A, Eley L, Annavarapu S, Henderson DJ, Chaudhry B. Isolation and next generation sequencing of archival formalin-fixed DNA. Journal of Anatomy 2020, 237(3), 587-600.
- Santos-Ledo A, Washer S, Dhanaseelan T, Eley L, Alqatani A, Chrystal PW, Papoutsi T, Henderson DJ, Chaudhry B. Alternative splicing of jnk1a in zebrafish determines first heart field ventricular cardiomyocyte numbers through modulation of hand2 expression. PLoS Genetics 2020, 16(5), e1008782.
- Verykiou S, Alexander M, Edwards N, Plummer R, Chaudhry B, Lovat PE, Hill DS. Harnessing autophagy to overcome MEK-inhibitor induced resistance in metastatic melanoma. British Journal of Dermatology 2019, 180(2), 346-356.
- Hill D, Chen L, Snaar-Jagalska E, Chaudhry B. Embryonic zebrafish xenograft assay of human cancer metastasis. F1000Research 2018, 7, 1682.
- Richardson R, Eley L, Donald-Wilson C, Davis J, Curley N, Alqahtani A, Murphy L, Anderson RH, Henderson DJ, Chaudhry B. Development and maturation of the fibrous components of the arterial roots in the mouse heart. Journal of Anatomy 2018, 232(4), 554-567.
- Eley L, Alqahtani A, MacGrogan D, Richardson R, Murphy L, Salguero-Jimenez A, Rodriguez San Pedro M, Tiurma S, McCutcheon L, Gilmore A, de La Pompa JL, Chaudhry B, Henderson D. A novel source of arterial valve cells linked to bicuspid aortic valve without raphe in mice. eLife 2018, 7, e34110.
- Crucean A, Alqahtani A, Barron DJ, Brawn WJ, Richardson RV, O'Sullivan J, Anderson RH, Henderson DJ, Chaudhry B. Re-evaluation of hypoplastic left heart syndrome from a developmental and morphological perspective. Orphanet Journal of Rare Diseases 2017, 12, 138.
- Piatek MJ, Henderson V, Fearn A, Chaudhry B, Werner A. Ectopically expressed Slc34a2a sense-antisense transcripts cause a cerebellar phenotype in zebrafish embryos depending on RNA complementarity and Dicer. PLoS ONE 2017, 12(5), e0178219.
- Ramsbottom SA, Sharma V, Rhee HJ, Eley L, Phillips HM, Rigby HF, Dean C, Chaudhry B, Henderson DJ. Vangl2-Regulated Polarisation of Second Heart Field-Derived Cells Is Required for Outflow Tract Lengthening during Cardiac Development. PLoS Genetics 2014, 10(12), e1004871.
- Boczonadi V, Gillespie R, Keenan ID, Ramsbottom SA, Donald-Wilson C, Al Nazer M, Humbert P, Schwarz RJ, Chaudhry B, Henderson DJ. Scrib:Rac1 interactions are required for the morphogenesis of the ventricular myocardium. Cardiovascular Research 2014, 104(1), 103-115.
- Anderson RH, Mohun TJ, Spicer DE, Bamforth SD, Brown NA, Chaudhry B, Henderson DJ. Myths and Realities Relating to Development of the Arterial Valves. Journal of Cardiovascular Development and Disease 2014, 1(3), 177-200.
- Phillips HM, Mahendran P, Singh E, Anderson RH, Chaudhry B, Henderson DJ. Neural crest cells are required for correct positioning of the developing outflow cushions and pattern the arterial valve leaflets. Cardiovascular Research 2013, 99(3), 452-460.
- Bamforth SD, Chaudhry B, Bennett M, Wilson R, Mohun TJ, van Mierop LHS, Henderson DJ, Anderson RH. Clarification of the identity of the mammalian fifth pharyngeal arch artery. Clinical Anatomy 2013, 26(2), 173-182.
- Keenan ID, Rhee HJ, Chaudhry B, Henderson DJ. Origin of non-cardiac endothelial cells from an Isl1+ lineage. FEBS Letters 2012, 586(13), 1790-1794.
- Anderson RH, Chaudhry B, Mohun TJ, Bamforth SD, Hoyland D, Phillips HM, Webb S, Moorman AF, Brown NA, Henderson DJ. Normal and abnormal development of the intrapericardial arterial trunks in humans and mice. Cardiovascular Research 2012, 95(1), 108-115.
- Phillips HM, Papoutsi T, Soenen H, Ybot-Gonzalez P, Henderson DJ, Chaudhry B. Neural Crest Cell Survival is Dependent on Rho Kinase and is Required for Development of the Mid Face in Mouse Embryos. PLoS One 2012, 7(5), e37685.
- Taylor JM, Saunter CD, Love GD, Girkin JM, Henderson DJ, Chaudhry B. Real-time optical gating for three-dimensional beating heart imaging. Journal of Biomedical Optics 2011, 16(11), 116021.
- Simms RJ, Hynes AM, Eley L, Inglis D, Chaudhry B, Dawe HR, Sayer JA. Modelling a ciliopathy: ahi1 knockdown in model systems reveals an essential role in brain, retinal and renal development. Cellular and Molecular Life Sciences 2011, 69(6), 993-1009.
- van't Padje S, Chaudhry B, Severijnen L, van der Linde H, Mientjes E, Oostra B, Willemsen R. Reduction in fragile X related 1 protein causes cardiomyopathy and muscular dystrophy in zebrafish. Journal of Experimental Biology 2009, 212(16), 2564-2570.
- Chaudhry B, Ashton H, Muhamed A, Yost M, Bull S, Frankel D. Nanoscale viscoelastic properties of an aligned collagen scaffold. Journal of Materials Science: Materials in Medicine 2009, 20(1), 257-263.
- Hildreth V, Webb S, Chaudhry B, Peat JD, Phillips HM, Brown N, Anderson RH, Henderson DJ. Left cardiac isomerism in the Sonic hedgehog null mouse. Journal of Anatomy 2009, 214(6), 894-904.
- Bradshaw L, Chaudhry B, Hildreth V, Webb S, Henderson DJ. Dual role for neural crest cells during outflow tract septation in the neural crest-deficient mutant Splotch(2H). Journal of Anatomy 2009, 214(2), 245-257.
- Hammond KL, Loynes HE, Mowbray C, Runke G, Hammerschmidt M, Mullins MC, Hildreth V, Chaudhry B, Whitfield TT. A Late Role for bmp2b in the Morphogenesis of Semicircular Canal Ducts in the Zebrafish Inner Ear. PLoS One 2009, 4(2), e4368.
- Phillips HM, Hildreth V, Peat JD, Murdoch JN, Kobayashi K, Chaudhry B, Henderson DJ. Non-cell-autonomous roles for the planar cell polarity gene vangl2 in development of the coronary circulation. Circulation Research 2008, 102(5), 615-623.
- Phillips HM, Rhee HJ, Murdoch JN, Hildreth V, Peat JD, Anderson RH, Copp AJ, Chaudhry B, Henderson DJ. Disruption of planar cell polarity signaling results in congenital heart defects and cardiomyopathy attributable to early cardiomyocyte disorganization. Circulation Research 2007, 101(2), 137-145.
- Phillips HM, Murdoch JN, Chaudhry B, Copp AJ, Henderson DJ. Vangl2 acts via RhoA signaling to regulate polarized cell movements during development of the proximal outflow tract. Circulation Research 2005, 96(3), 292-299.
- McKinney PA, Jones S, Parslow R, Davey N, Darowski M, Chaudhry B, Stack C, Parry G, Draper ES, PICANet Consent Study Grp. A feasibility study of signed consent for the collection of patient identifiable information for a national paediatric clinical audit database. British Medical Journal 2005, 330(7496), 877-879.
- Ioannides AS, Chaudhry B, Henderson DJ, Spitz L, Copp AJ. Dorsoventral patterning in oesophageal atresia with tracheo-oesophageal fistula: Evidence from a new mouse model. Journal of Pediatric Surgery 2002, 37(2), 185-191.
-
Book Chapters
- Anderson RH, Bamforth SD, Spicer DE, Henderson DJ, Chaudhry B, Brown NA, Mohun TJ. Development and maldevelopment of the ventricular outflow tracts. In: Lacour-Gayet F; Bove EL; Hraška V; Morell V; Spray T, ed. Surgery of Conotruncal Anomalies. Cham, Switzerland: Springer International Publishing, 2016, pp.27-59.
- Anderson RH, Moorman AFM, Brown NA, Bamforth SD, Chaudhry B, Henderson DJ, Mohun TJ. Normal and abnormal development of the heart. In: Pediatric and Congenital Cardiology, Cardiac Surgery and Intensive Care. London: Springer-Verlag, 2014, pp.151-177.
-
Conference Proceedings (inc. Abstracts)
- Hill D, Verykiou S, Robinson N, Chaudhry B, Przyborski S, Lovat P. Modelling melanoma metastasis using organotypic skin equivalent and zebrafish models. In: British Society for Investigative Dermatology Annual Meeting. 2014, Newcastle, UK: Nature Publishing Group.
- Chaudhry B, Burns D, Murphy L, Henderson D. Exercise and cardiomyocyte turnover in the aging zebrafish heart. In: Third Congress of the ESC Council on Basic Cardiovascular Science: Frontiers in Cardiovascular Biology. 2014, Barcelona, Spain: Oxford University Press.
- Chaudhry B, Chrystal P, Henderson DJ. Fast Digital Laser Sheet Microscopy: swimaging in 6 dimensions. In: 2nd Congress of the European Society of Cardiology Council on Basic Cardiovascular Science: Frontiers in Cardiovascular Biology. 2012, London, UK: Oxford University Press.
- Hunt NC, Batsivari A, Chaudhry B, Henderson DJ. ECM control of neural crest cell (NCC) behaviour and implications for heart development. In: Autumn Meeting of the British Society for Matrix Biology (BSMB). 2012, Newcastle upon Tyne, UK: Wiley-Blackwell Publishing Ltd.
- Henderson DJ, Boczonadi V, Humbert P, Chaudhry B. Conditional deletion of Scrib gene in the developing myocardium leads to congenital heart defects. In: 2nd Congress of the European Society of Cardiology Council on Basic Cardiovascular Science: Frontiers in Cardiovascular Biology. 2012, London, UK: Oxford University Press.
- Chaudhry B, Burns D, Henderson DJ. Cardiomyocyte aging: swimming against the clock. In: 2nd Congress of the European Society of Cardiology Council on Basic Cardiovascular Science: Frontiers in Cardiovascular Biology. 2012, London, UK: Oxford University Press.
- Boczonadi V, Chen V, Henderson D, Chaudhry B. Cell traction force microscopy in cardiac morphogenesis. In: Mechanisms of Development: 16th International Society of Developmental Biologists Congress. 2009, Edinburgh, UK: Elsevier Ireland Ltd.
- Phillips H, Boczonadi V, Chaudhry B, Henderson D. 03-P015: Rho kinase is required for cohesive behaviour of neural crest cells during outflow tract morphogenesis. In: Mechanisms of Development: 16th Annual Conference of the International Society of Development Biologists. 2009, Edinburgh, UK: Elsevier Ireland Ltd.
-
Editorial
- Anderson RH, Henderson DJ, Chaudhry B. Development and maintenance of the arterial valves. European Heart Journal 2017, 38(9), 687-689.
-
Reviews
- Anderson RH, Kerwin J, Lamers WH, Hikspoors JPJM, Mohun TJ, Chaudhry B, Lisgo S, Henderson DJ. Cardiac development demystified by use of the HDBR atlas. Journal of Anatomy 2024, epub ahead of print.
- Chaudhry B, Alqahtani A, Eley L, Coats L, Moldovan C, Annavarapu SR, Henderson DJ. The Left Ventricular Myocardium in Hypoplastic Left Heart Syndrome. Journal of Cardiovascular Development and Disease 2022, 9(8), 279.
- Evans PC, Davidson SM, Wojta J, Back M, Bollini S, Brittan M, Catapano AL, Chaudhry B, Cluitmans M, Gnecchi M, Guzik TJ, Hoefer I, Madonna R, Monteiro JP, Morawietz H, Osto E, Padro T, Sluimer JC, Tocchetti CG, Van der Heiden K, Vilahur G, Waltenberger J, Weber C. From novel discovery tools and biomarkers to precision medicine—basic cardiovascular science highlights of 2021/22. Cardiovascular Research 2022, 118(13), 2754-2767.
- Henderson DJ, Eley L, Turner JE, Chaudhry B. Development of the Human Arterial Valves: Understanding Bicuspid Aortic Valve. Frontiers in Cardiovascular Medicine 2022, 8, 802930.
- Henderson DJ, Eley L, Chaudhry B. New concepts in the development and malformation of the arterial valves. Journal of Cardiovascular Development and Disease 2020, 7(4), 1-27.
- Henderson DJ, Chaudhry B. Getting to the Heart of Planar Cell Polarity Signaling. Birth Defects Research Part A: Clinical and Molecular Teratology 2011, 91(6), 460-467.
- Anderson RH, Cook A, Brown NA, Henderson DJ, Chaudhry B, Mohun T. Development of the outflow tracts with reference to aortopulmonary windows and aortoventricular tunnels. Cardiology in the Young 2010, 20(s3), 92-99.
- Henderson DJ, Phillips HM, Chaudhry B. Vang-like 2 and noncanonical Wnt signaling in outflow tract development. Trends in Cardiovascular Medicine 2006, 16(2), 38-45.