Staff Profile

Background

Research Assistant within the Stroke Research Group at Newcastle University. Graduated with a BSc(Hons) in Psychology from Northumbria University in 2016 and an MSc in Cognitive Neuroscience from Durham University in 2018. I should soon graduate with a PhD in Population Health Sciences (pending viva).

Worked on PEARS (Promoting Effective and Rapid Stroke Care) programme from 2018-2019 and SINONIMS (Study In NOvel Neuromuscular Imaging biomarkers for Motor outcome in Stroke) study from 2019-2022. Completed PhD thesis using machine learning for stroke diagnosis and prognosis in 2022-2025. Currently working on SPEEDY (Specialist PrE-hospital rEDirection for ischaemic stroke thrombectomY), as well as PRONTO (PRehospital biomarker and phONe call-based detection for ischaemic stroke thrombecTOmy) and SMART (Standardised stroke risk assessment for patients with MigrAinous symptoms Reviewed as suspected TIA).

Qualifications

BSc (Hons) Psychology

First-Class Honours

Northumbria University

July 2016

MSc Cognitive Neuroscience

Distinction

Durham University

January 2018

PhD Population Sciences

Newcastle University

Hopefully soon!!!

LinkedIn: Click here.

SCOPUS: Click here.

Research Gate: Click here.

ORCID: Click here.

Twitter: Click here.

Scholar: Click here 

GitHub: Click here

Research Projects

Promoting Effective and Rapid Stroke Care (PEARS)

We aimed to increase the efficiency of acute stroke care by implementing and exploring various methods to optimise pre-hospital protocols and access to treatment to improve functional outcomes for patients.

Pre-hospital Diagnostics and Prognostics Literature Reviews

We conducted a scoping review of technologies, with potential for pre-hospital stroke (and sub-type) diagnosis and/or stratification, which could be used by paramedics. 

We also conducted a scoping review of EEG for stroke diagnosis and prognosis.

Study in Novel Neuro-muscular Imaging Biomarkers for Motor Outcome in Stroke (SINONIMS)

The SINONIMS study aimed to utilise neuro-muscular imaging biomarkers to predict lower limb motor outcome following stroke. Advanced Magnetic Resonance Imaging (MRI) was be used to assess white matter integrity in the brain, as well as muscle quality in the lower limb. The study examined the impact of sarcopaenia (age related muscle degeneration), myopaenia (disease related muscle degeneration) and loss of connectivity in the corticospinal tract on motor recovery. The goal was to increase the accuracy of prognosis to allow provision of tailored treatments. Some small correlations were observed.

Specialist PrE-hospital rEDirection for ischaemic stroke thrombectomY (SPEEDY)

SPEEDY is a large multi-centre study involving five regional ambulance services and eight thrombectomy centres. The aim is to evaluate whether direct transfer to a thrombectomy centre can reduce time to treatment compared with the standard pathway.

PRehospital biomarker and phoNe call-based detection for ischaemic stroke thrombectomy (PRONTO)

PRONTO aims to evaluate a biomarker test to identify LVO in the prehospital setting. Glial Fibrillary Acidic Protein (GFAP) usually indicates haemorrhage, whilst D-Dimer indicates clotting. Negative GFAP and positive D-Dimer are postulated to identify LVO stroke.

Standardised stroke risk assessment for patients with MigrAinous symptoms Reviewed as suspected TIA (SMART)

SMART involves a structured patient assessment to identify stroke risk in patients with migrainous symptoms reviewed as suspected TIA.

PhD using machine learning and basic clinical information to improve stroke treatment

My PhD involved retrospective machine learning analysis of stroke patient datasets, with the aim of finding 1. an algorithm to discern stroke from stroke mimic patients, 2. an algorithm to discern LVO from non-LVO patients. The scoping review and subgroup meta-analysis explored clinical factors indicative of prognosis after thrombectomy, a surgery for a subtype of stroke involving occlusion of a large artery. 

Formal Teaching Experience

Tutored undergraduate students..

Taught Biomedical Sciences Seminar on Stroke diagnostic blood biomarkers.

Informal Teaching Experience

Significant time spent personally tutoring friends and course mates during undergraduate and postgraduate study:

-Assistance with statistical methods.

-Providing accessible explanations to assist conceptualisation of complex concepts.

-Writing/editing guidance. 

• Articles

  • Lumley H, Shaw L, Morris J, Alton A, White P, Ford G, James M, Price C. Associations between basic physiological observations recorded pre-thrombectomy and functional outcome: a systematic review and meta-analysis. Frontiers in Stroke 2023, 2, 1283312.
  • Elameer M, Lumley H, Moore SA, Marshall K, Alton A, Smith FE, Gani A, Blamire A, Rodgers H, Price CIM, Mitra D. A prospective study of MRI biomarkers in the brain and lower limb muscles for prediction of lower limb motor recovery following stroke. Frontiers in Neurology 2023, 14, 1229681.
  • Sutcliffe L, Lumley H, Shaw L, Francis R, Price CI. Surface Electroencephalography (EEG) During the Acute Phase of Stroke to Assist With Diagnosis and Prediction of Prognosis: a Scoping Review. BMC Emergency Medicine 2022, 22, 29.
  • Coughlan D, McMeekin P, Flynn D, Ford GA, Lumley H, Burgess D, Balami J, Mawson A, Craig D, Rice S, White P. Secondary transfer of emergency stroke patients eligible for mechanical thrombectomy by air in rural England: economic evaluation and considerations. Emergency Medicine Journal 2021, 38(1), 33-39.
  • Balami JS, Coughlan D, White PM, McMeekin P, Flynn D, Roffe C, Natarajan I, Chembala J, Nayak S, Wiggam I, Flynn P, Simister R, Sammaraiee Y, Sims D, Nader K, Dixit A, Craig D, Lumley H, Rice S, Burgess D, Foddy L, Hopkins E, Hudson B, Jones R, James MA, Buchan AM, Ford GA, Gray AM. The cost of providing mechanical thrombectomy in the UK NHS: a micro-costing study. Clinical Medicine Journal 2020, 20(3), e40-e45.
  • Lumley HA, Flynn D, Shaw L, McClelland G, Ford GA, White P, Price C. A Scoping Review of Pre-hospital Technology to Assist Ambulance Personnel with Patient Diagnosis or Stratification during the Emergency Assessment of Suspected Stroke. BMC Emergency Medicine 2020, 20, 30.
  • McMeekin P, Flynn D, Allen M, Coughlan D, Ford GA, Lumley H, Balami JS, James MA, Stein K, Burgess D, White P. Estimating the Effectiveness and Cost-Effectiveness of Establishing Additional Endovascular Thrombectomy Stroke Centres in England: A Discrete Event Simulation. BMC Health Services Research 2019, 19, 821.

• Conference Proceedings (inc. Abstracts)

  • Shaw L, Lendrem C, Lumley H, Morris J, White P, Price C. Stroke Biomarker Evaluation for Large Vessel Occlusion (StroBE-LVO): Work in Progress. In: UK Stroke Forum. 2024, Birmingham: International Journal of Stroke. In Preparation.
  • Lumley H, Shaw L, Lendrem C, McClelland G, McMeekin P, Price C. Development and Accuracy of a Machine Learning Algorithm to Predict Stroke Mimic Conditions during Prehospital Assessment. In: 19th UK Stroke Forum Conference. 2024, Liverpool: Sage Publications Ltd.
  • Lumley HA, Shaw L, Morris J, Alton A, White P, Ford GA, James M, Price C. Associations between basic physiological observations recorded pre-thrombectomy and functional outcome: a systematic review and meta-analysis. In: UK Stroke Forum. 2024, Birmingham: International Journal of Stroke. In Preparation.
  • Shaw L, Lumley H, Lendrem C, White P, Price C. Whole Blood Purine And D-Dimer Measurement For Identification Of Large Vessel Occlusion Stroke: A Prospective Observational Study. In: UK Stroke Forum 2024. 2024, Liverpool: International Journal of Stroke. In Preparation.
  • Lumley H, Elameer M, Price CI, Moore SA, Gani A, Smith F, English P, Rodgers H, Blamire A, Mitra D. Study in Novel Neuro-muscular Imaging Biomarkers for Motor Outcome in Stroke (SINONIMS). In: Communications to the International Sarcopenia Translational Research Conference 2021. Journal of Frailty, Sarcopenia and Falls. 2021, Virtual: Hylonome Publications.
  • Lumley H, Flynn D, Coughlan D, McMeekin P, Ford GA, Craig D, Rice S, Burgess D, Balami J, Mawson A, White P. Secondary transfers by helicopter emergency services for thrombectomy in rural England: a feasibility study (updated). In: UK Stroke Forum. 2019, Telford: Sage Publications Ltd.
  • Lumley H, Flynn D, Coughlan D, McMeekin P, Ford GA, Craig D, Rice S, Burgess D, Balami JS, Mawson A, White PM. Secondary Transfers by Helicopter Emergency Services for Thrombectomy in Rural England: a Feasibility Study. In: UK Stroke Forum 2018. 2018, Telford, UK: Sage Publications Ltd.
  • Flynn D, Coughlan D, McMeekin P, Ford GA, Craig D, Rice S, Burgess D, Balami J, Mawson A, Lumley H, White P. Secondary Transfer of Stroke Patients for Thrombectomy by Air Ambulance in England: A Cost-Effectiveness Analysis. In: European Stroke Organisation Conference. 2018, Gothenburg, Sweden: Sage Publications Ltd.
  • Balami JS, Coughlan D, McMeekin P, White PM, Flynn D, Roffe C, Wiggam I, Flynn P, Chembala J, Natarajan I, Dixit A, Hunter A, Foddy L, Hopkins E, Lumley H, Rice S, Burgess D, Craig D, Buchan AM, Ford GA, Gray A. Case Costing of Mechanical Thrombectomy for Acute Ischaemic Stroke in Routine Clinical Setting: Cost Differences Between Mothership vs Drip and Ship. In: UK Stroke Forum 2018. 2018, Telford, United Kingdom: International Journal of Stroke.

• Review

  • Lumley H, Flynn D, Ford GA, Inskip A, McClelland G, Shaw L, White PM, Price CIM. A Review of Technology to Assist with Patient Stratification during the Emergency Assessment of Suspected Stroke. PROSPERO 2018 2018, CRD42018087611.