Staff Profile
Dr Paul Donaghy
NIHR Intermediate Clinical Fellow
- Email: paul.donaghy@ncl.ac.uk
- Telephone: 0191 208 1318
- Address: Campus for Ageing and Vitality
Level 3 Biomedical Research Buidling
Newcastle upon Tyne
NE4 5PL
Background
I am an NIHR Intermediate Clinical Fellow in Old Age Psychiatry. My research interests are dementia with Lewy bodies, imaging biomarkers in dementia and early diagnosis.
Publications
- Donaghy PC, Firbank M, Petrides G, Lloyd J, Barnett N, Olsen K, Thomas AJ, O'Brien JT. Diffusion imaging in dementia with Lewy bodies: associations with amyloid burden, atrophy, vascular factors and clinical features. Parkinsonism and Related Disorders 2020. In Press.
- Schumacher J, Thomas AJ, Peraza LR, Firbank M, Cromarty R, Hamilton CA, Donaghy PC, O'Brien JT, Taylor JP. EEG alpha reactivity and cholinergic system integrity in Lewy body dementia and Alzheimer's disease. Alzheimers' Research & Therapy 2020, 12, 46.
- Donaghy PC, Firbank M, Mitra D, Petrides G, Lloyd J, Barnett N, Olsen K, Thomas AJ, O'Brien JT. Microbleeds in dementia with Lewy bodies. Journal of Neurology 2020, 267, 1491-1498.
- Durcan R, Donaghy PC, Barnett NA, Olsen K, Yarnall AJ, Taylor J-P, McKeith I, O'Brien JT, Thomas AJ. Prevalence and severity of symptoms suggestive of gastroparesis in prodromal dementia with Lewy bodies. International Journal of Geriatric Psychiatry 2020, 34(7), 990-998.
- Thomas AJ, Hamilton CA, Donaghy PC, Martin-Ruiz C, Morris CM, Barnett N, Olsen K, Taylor JP, O'Brien JT. Prospective Longitudinal Evaluation of Cytokines in mild cognitive impairment due to AD and Lewy Body Disease. International Journal of Geriatric Psychiatry 2020, 35(10), 1250-1259.
- Hamilton CA, Matthews FE, Donaghy PC, Taylor JP, O'Brien JT, Barnett N, Olsen K, McKeith IG, Thomas AJ. Prospective predictors of decline versus stability in mild cognitive impairment with Lewy bodies or Alzheimer’s disease. Psychological Medicine 2020, 51(15), 2590-2598.
- Schumacher J, Taylor J-P, Hamilton CA, Firbank M, Cromarty RA, Donaghy PC, Roberts G, Allan L, Lloyd J, Durcan R, Barnett N, O'Brien JT, Thomas AJ. Quantitative EEG as a biomarker in mild cognitive impairment with Lewy bodies. Alzheimer's research & therapy 2020, 12(1), 82.
- McKeith IG, Ferman TJ, Thomas AJ, Blanc F, Boeve BF, Fujishiro H, Kantarci K, Muscio C, O'Brien JT, Postuma RB, Aarsland D, Ballard C, Bonanni L, Donaghy P, Emre M, Galvin JE, Galasko D, Goldman JG, Gomperts SN, Honig LS, Ikeda M, Leverenz J, Lewis SJG, Marder KS, Masellis M, Salmon DP, Taylor JP, Tsuang DW, Walker Z, Tiraboschi P. Research criteria for the diagnosis of prodromal dementia with Lewy bodies. Neurology 2020, 94(17), 743-755.
- Roberts G, Lloyd JJ, Petrides GS, Donaghy PC, Kane JPM, Durcan R, Lawley S, Howe K, Sims AJ, Taylor JP, O'Brien JT, Thomas AJ. 123I-FP-CIT striatal binding ratios do not decrease significantly with age in older adults. Annals of Nuclear Medicine 2019, 33(6), 434-443.
- Donaghy PC, Firbank MJ, Thomas AJ, Lloyd J, Petrides G, Barnett N, Olsen K, O'Brien JT. Amyloid imaging and longitudinal clinical progression in dementia with Lewy bodies. American Journal of Geriatric Psychiatry 2020, 28(5), 573-577.
- Mak E, Donaghy P, McKiernan E, Firbank M, Lloyd J, Petrides G, Thomas A, O'Brien J. Beta-amyloid deposition maps onto hippocampal and subiculum atrophy in dementia with Lewy bodies. Neurobiology of Aging 2019, 73, 74-81.
- Outeiro TF, Koss DJ, Erskine D, Walker L, Kurzawa-Akanbi M, Burn DJ, Donaghy P, Morris CM, Taylor JP, Thomas AJ, Attems J, McKeith IG. Dementia with Lewy bodies: an update and outlook. Molecular Neurodegeneration 2019, 14, 5.
- Thomas A, Donaghy P, Roberts G, Colloby SJ, Barnett NA, Petrides G, Lloyd J, Olsen K, Taylor J-P, McKeith I, O'Brien JT. Diagnostic Accuracy of Dopaminergic Imaging in Prodromal Dementia with Lewy Bodies. Psychological Medicine 2019, 49(3), 396-402.
- Mc Ardle R, Galna B, Donaghy P, Thomas A, Rochester L. Do Alzheimer’s and Lewy body disease have discrete pathological signatures of gait?. Alzheimer's and Dementia 2019, 15(10), 1367-1377.
- Mc Ardle R, Del Din S, Donaghy P, Galna B, Thomas A, Rochester L. Factors that influence habitual activity in mild cognitive impairment and dementia. Gerontology 2020, 66, 197-208.
- Durcan R, Donaghy P, Osborne C, Taylor J-P, Thomas AJ. Imaging in prodromal dementia with Lewy bodies: Where do we stand?. International Journal of Geriatric Psychiatry 2019, 34(5), 635-646.
- King E, O'Brien JT, Donaghy P, Morris C, Barnett N, Olsen K, Martin-Ruiz C, Taylor JP, Thomas AJ. Peripheral inflammation in mild cognitive impairment with possible and probable Lewy body disease and Alzheimer’s disease. International Psychogeriatrics 2019, 31(4), 551-560.
- Lloyd JJ, Petrides G, Donaghy PC, Colloby SJ, Attems J, O'Brien JT, Roberts G, Thomas AJ. A new visual rating scale for Ioflupane imaging in Lewy body disease. NeuroImage: Clinical 2018, 20, 823-829.
- Rapoport MJ, Chee JN, Carr DB, Molnar F, Naglie G, Dow J, Marottoli R, Mitchell S, Tant M, Herrmann N, Lanctot KL, Taylor J-P, Donaghy PC, Classen S, O'Neill D. An International Approach to Enhancing a National Guideline on Driving and Dementia. Current Psychiatry Reports 2018, 20, 16.
- Donaghy PC, Firbank MJ, Thomas AJ, Lloyd J, Petrides G, Barnett N, Olsen K, O'Brien JT. Clinical and imaging correlates of amyloid deposition in dementia with Lewy bodies. Movement Disorders 2018, 33(7), 1130-1138.
- Donaghy PC, Taylor JP, O'Brien JT, Barnett N, Olsen K, Colloby SJ, Lloyd J, Petrides G, McKeith IG, Thomas AJ. Neuropsychiatric symptoms and cognitive profile in mild cognitive impairment with Lewy bodies. Psychological Medicine 2018, 48(14), 2384-2390.
- King E, O'Brien JT, Donaghy P, Morris C, Barnett N, Olsen K, Martin-Ruiz C, Taylor J-P, Thomas AJ. Peripheral inflammation in prodromal Alzheimer’s and Lewy body dementias. Journal of Neurology, Neurosurgery and Psychiatry 2018, 89(4), 339-345.
- Donaghy PC, Barnett N, Olsen K, Taylor J-P, McKeith IG, O'Brien JT, Thomas AJ. Symptoms associated with Lewy body disease in mild cognitive impairment. International Journal of Geriatric Psychiatry 2017, 32(11), 1163-1171.
- Chee JN, Rapoport MJ, Molnar F, Herrmann N, O'Neill D, Marottoli R, Mitchell S, Tant M, Dow J, Ayotte D, Lanctôt KL, McFadden R, Taylor JP, Donaghy PC, Olsen K, Classen S, Elzohairy Y, Carr DB. Update on the Risk of Motor Vehicle Collision or Driving Impairment with Dementia: A Collaborative International Systematic Review and Meta-Analysis. American Journal of Geriatric Psychiatry 2017, 25(12), 1376-1390.
- McKeith I, Taylor JP, Thomas A, Donaghy P, Kane J. Revisiting DLB Diagnosis: A Consideration of Prodromal DLB and of the Diagnostic Overlap With Alzheimer Disease. Journal of Geriatric Psychiatry and Neurology 2016, 29(5), 249-253.
- Donaghy P, Thomas AJ, O'Brien JT. Amyloid PET Imaging in Lewy Body Disorders. American Journal of Geriatric Psychiatry 2015, 23(1), 23-37.
- Thomas A, Blanc F, Donaghy P, Bousiges O. Clinical profile of prodromal DLB: The Newcastle LewyPro study. In: 17th IPA International Congress. 2015, Berlin, Germany: Cambridge University Press.
- Bousiges O, Donaghy P, Blanc F, Thomas A. Conventional Alzheimer's biomarkers in cerebrospinal fluid are not pathological in patients with prodromal dementia with Lewy bodies. In: Balancing Cure with Care: Advances in Late Life Mental Health. 17th IPA International Congress. 2015, Berlin, Germany: Cambridge University Press.
- Blanc F, Thomas A, Donaghy P, Bousiges O. Cortical thickness in dementia with Lewy bodies and Alzheimer's disease: A comparison of prodromal and dementia stages. In: 17th IPA International Conference: Balancing Cure with Care - Advances in Late Life Mental Health. 2015, Berlin, Germany: Cambridge University Press.
- Donaghy P, Blanc F, Thomas A, Bousiges O. FP CIT imaging in prodromal DLB. In: Balancing Cure with Care: Advances in Late Life Mental Health. 17th IPA International Congress. 2015, Berlin, Germany: Cambridge University Press.
- Donaghy PC, O'Brien JT, Thomas AJ. Prodromal dementia with Lewy bodies. Psychological Medicine 2015, 45(2), 259-268.
- Donaghy PC, McKeith IG. The clinical characteristics of dementia with Lewy bodies and a consideration of prodromal diagnosis. Alzheimer's Research & Therapy 2014, 6(4), 46.