Introduction 

Funding

Alzheimers Brain Bank UK, Brains for dementia research post-mortem brain cell bank (2018 to present), Co-I

Foundation for research on Alzheimers Disease (2019 to present), Co-I

NIHR, Health Protection Research Unit Bid (2015 to 2020), Co-I

NC3Rs CRACK-IT Challenge 20 - Metaboderm phase 2 (2016 to 2018), Co-I

NC3Rs CRACK-IT Challenge 20 - Metaboderm phase 1 (2016), Co-I

Alzheimer's Society UK, (2013 to 2015) Co-I

I am interested in proteomic changes that occur within the human brain due to degenerative disorders and have worked in the areas of Dementia, Parkinson’s Disease and Depression.

• Reynolds WJ, Bowman A, Hanson PS, Critchley A, Griffiths B, Chavan B, Birch-Machin MA. Adaptive responses to air pollution in human dermal fibroblasts and their potential roles in ageing. FASEB BioAdvances 2021, 3(10), 855-865.
• Reynolds WJ, Hanson PS, Critchley A, Griffiths B, Chavan B, Birch-Machin MA. Exposing human primary dermal fibroblasts to particulate matter induces changes associated with skin aging. FASEB Journal 2020, 34(11), 14725-14735.
• Keane PC, Hanson PS, Patterson L, Blain PG, Hepplewhite P, Khundakar AA, Judge SJ, Kahle PJ, LeBeau FEN, Morris CM. Trichloroethylene and its metabolite TaClo lead to degeneration of substantia nigra dopaminergic neurones: Effects in wild type and human A30P mutant α-synuclein mice . Neuroscience Letters 2019, 711, 134437.
• Nisar R, Hanson PS, Keane PC, He L, Taylor R, Blain PG, Morris CM. Manganese-Containing Thiocarbamates Cause Free Radical Production and Caspase-Independent Cell Death following Mitochondrial Dysfunction in Neural Cells. Reactive Oxygen Species 2018, 6(18), 428-444.
• Erskine D, Ding J, Thomas AJ, Kaganovich A, Khundakar AA, Hanson PS, Taylor JP, McKeith IG, Attems J, Cookson MR, Morris CM. Molecular changes in the absence of severe pathology in the pulvinar in dementia with Lewy bodies. Movement Disorders 2018, 33(6), 982-991.
• Erskine D, Patterson L, Alexandris A, Hanson PS, McKeith IG, Attems J, Morris CM. Regional levels of physiological α-synuclein are directly associated with Lewy body pathology. Acta Neuropathologica 2018, 135(1), 153-154.
• Singh P, Hanson PS, Morris CM. SIRT1 ameliorates oxidative stress induced neural cell death and is down-regulated in Parkinson’s disease. BMC Neuroscience 2017, 18(1), 46.
• Singh P, Hanson PS, Morris CM. Sirtuin-2 Protects Neural Cells from Oxidative Stress and Is Elevated in Neurodegeneration. Parkinson's Disease 2017, 2017, 1-17.
• Khundakar AA, Hanson PS, Erskine D, Lax NZ, Roscamp J, Karyka E, Tsefou E, Singh P, Cockell SJ, Gribben A, Ramsay L, Blain PJ, Mosimann UP, Lett DJ, Elstner M, Turnbull DM, Xiang CC, Brownstein MJ, O'Brien JT, Taylor JP, Attems J, Thomas AJ, McKeith IG, Morris CM. Analysis of primary visual cortex in dementia with Lewy bodies indicates GABAergic involvement associated with recurrent complex visual hallucinations. Acta Neuropathologica Communications 2016, 4, 66.
• Hanson PS, Matthias K, Tsefou E, Thomas SLH, Blain PG, Morris CM. Neurotoxicity of novel psychoactive substances. In: British Toxicology Annual Congress 2016. 2016, Manchester, UK.
• Ishaq A, Hanson PS, Morris CM, Saretzki G. Telomerase Activity is Downregulated Early During Human Brain Development. Genes 2016, 7(6), 27.
• Nisar R, Hanson PS, He L, Taylor RW, Blain PG, Morris CM. Diquat causes caspase-independent cell death in SH-SY₅Y cells by production of ROS independently of mitochondria. Archives of Toxicology 2015, 89(10), 1811-1825.
• Madgwick A, Fort P, Hanson PS, Thibault P, Gaudreau MC, Lutfalla G, Möröy T, Abou-Elela S, Chaudhry B, Elliott DJ, Morris CM, Venables JP. Neural Differentiation Modulates the Vertebrate Brain Specific Splicing Program. PLoS One 2015, 10(5), e0125998.
• Mandler M, Walker L, Santic R, Hanson P, Upadhaya AR, Colloby SJ, Morris CM, Thal DR, Thomas AJ, Schneeberger A, Attems J. Pyroglutamylated amyloid-β is associated with hyperphosphorylated tau and severity of Alzheimer’s disease. Acta Neuropathologica 2014, 128(1), 67-79.
• Hanson PS, Blain PG, Mulligan J, Morris CM. Brominated flame retardants - Neurotoxic to humans?. In: Health Protection. 2012, University of Warwick.
• Kurzawa-Akanbi M, Hanson PS, Blain PG, Lett DJ, McKeith IG, Chinnery PF, Morris CM. Glucocerebrosidase Mutations alter the endoplasmic reticulum and lysosomes in Lewy body disease. Journal of Neurochemistry 2012, 123(2), 298-309.
• Hanson PS, Hiscock DRR, Morris CM, Thomas AJ. Biomarkers For Depression. GB: GE Healthcare Limited, PCT/EP2009/055943, 15/05/2009.
• Hanson PS, Hiscock DRR, Morris CM, Thomas AJ. GABA Biomarkers of Depression. GB: GE Healthcare Limited, WO/2009/138500, 2009, 15/05/2008.
• Hanson PS, Hiscock DRR, Morris CM, Thomas AJ. Glutamine Biomarkers of Depression. GB: GE Healthcare Limited, PCT/EP2009/055945, 15/05/2009.
• Mahad DJ, Ziabreva I, Campbell G, Lax N, White K, Hanson PS, Lassmann H, Turnbull DM. Mitochondrial changes within axons in multiple sclerosis. Brain 2009, 132(5), 1161-1174.
• Morris CM, Nisar R, Hanson PS, Judge SJ, Blain PG. HUMAN EMBRYONIC NEURAL PRECURSOR STEM CELLS: A SUITABLE CELL POPULATION FOR IN VITRO NEUROTOXICOLOGY?. In: Environmental Etiologies of Neurological Disorders: Scientific, Translational and Policy Implications. 2008, Rochester, NY.
• Mahad DJ, Ziabreva I, Campbell G, Hanson P, Lassman H, Turnbull DM. Mitochondrial dysfunction within chronically demyelinated axons in multiple sclerosis. In: World Congress on Treatment and Research in Multiple Sclerosis. 2008, Montreal, Canada: Multiple Sclerosis: Sage Publications.