Staff Profile
Rhianna Rowland
Research Associate
- Email: rhianna.rowland@ncl.ac.uk
- Address: Translational & Clinical Research Institute
CRUK Newcastle Drug Discovery Centre
Paul O'Gorman Building
Faculty of Medical Sciences
Newcastle University
NE2 4HH
I am currently a post-doctoral research associate in the structural biology group of Professors Jane Endicott and Martin Noble in the CRUK Newcastle Drug Discovery Centre. My research predominantly involves the application of Cryo-EM to the structural solution and evaluation of protein complexes involved in cell cycle regulation and transcription to guide downstream drug discovery.
I obtained my PhD in 2021 at the York Structural Biology Laboratory (YSBL) at the University of York under the supervision of Professor Gideon Davies. My project was funded by the BBSRC and focussed on the structural and biochemical characterisation of human lysosomal glycoside hydrolyses and their aberrant function in lysosomal storage disorders.
Google scholar: R. J. Rowland
- Rowland RJ, Chen J, Breen I, Wu L, Offen WA, Beenakker TJM, Su Q, van den Nieuwendijk AMCH, Aerts JMFG, Perez de Azanza ME, Overkleeft HS, Davies GJ. Design, Synthesis and Structural Analysis of Glucocerebrosidase Imaging Agents. Chemistry - A European Journal 2021, 27(66), 16377-16388.
- Rowland RJ, Wu L, Liu F, Davies GJ. A baculoviral system for the production of human β-glucocerebrosidase enables atomic resolution analysis. Acta Crystallographica Section D: Structural Biology 2020, 76(6), 565-580.
- Artola M, Hedberg C, Rowland RJ, Raich L, Kytidou K, Wu L, Schaaf A, Ferraz MJ, van der Marel GA, Codee JDC, Rovira C, Aerts JMFG, Davies GJ, Overkleeft HS. α-D-Gal-cyclophellitol cyclosulfamidate is a Michaelis complex analog that stabilizes therapeutic lysosomal α-galactosidase A in Fabry disease. Chemical Science 2019, 10, 9233-9243.
- Artola M, Kuo CL, Lelieveld LT, Rowland RJ, van der Marel GA, Codee JDC, Boot RG, Davies GJ, Aerts JMFG, Overkleeft HS. Functionalized Cyclophellitols Are Selective Glucocerebrosidase Inhibitors and Induce a Bona Fide Neuropathic Gaucher Model in Zebrafish. Journal of the American Chemical Society 2019, 141(10), 4214-4218.
- Schroder SP, de Boer C, McGregor NGS, Rowland RJ, Moroz O, Blagova E, Reijngoud J, Arentshorst M, Osborn D, Morant MD, Abbate E, Stringer MA, Krogh KBRM, Raich L, Rovira C, Berrin J, van Wezel GP, Ram AFJ, Florea BI, van der Marel GA, Codée JDC, Wilson KS, Wu L, Davies GD, Overkleeft HS. Dynamic and Functional Profiling of Xylan-Degrading Enzymes in Aspergillus Secretomes Using Activity-Based Probes. ACS Central Science 2019, 5(6), 1067-1078.