Dispersal of Clinical Biofilms from Titanium & Cobalt Chrome Surfaces
This project investigated the effect of a novel marine deoxyribonuclease (Nuc B) on biofilms from infected joint replacement prostheses.
Project leader
Professor Grant Burgess
Dates
December 2014 to November 2016
Project staff
Dr Nick Jakubovics
Mr Mike Reed
Sponsors
Orthopaedic Research UK
Description
The project had the following aims:
- Demonstrate the effectiveness of Nuc B on Staphylococcus aureus / Staphylococcus epidermidis biofilm formation and biofilm dispersal
- Demonstrate the synergistic effect of Nuc B and antibiotics used to treat prosthetic joint infections on established Staphylococcus aureus / Staphylococcus epidermidis biofilms
- Demonstrate increased antibiotic activity against bacteria within biofilms. Also the planktonic phase in the presence of Nuc B