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Dispersal of Clinical Biofilms from Titanium & Cobalt Chrome Surfaces

Dispersal of Clinical Biofilms from Titanium & Cobalt Chrome Surfaces

This project investigated the effect of a novel marine deoxyribonuclease (Nuc B) on biofilms from infected joint replacement prostheses.

Project leader

Professor Grant Burgess

Dates

December 2014 to November 2016

Project staff

Dr Nick Jakubovics

Mr Mike Reed

Sponsors

Orthopaedic Research UK

Description

The project had the following aims:

  • Demonstrate the effectiveness of Nuc B on Staphylococcus aureus / Staphylococcus epidermidis biofilm formation and biofilm dispersal
  • Demonstrate the synergistic effect of Nuc B and antibiotics used to treat prosthetic joint infections on established Staphylococcus aureus / Staphylococcus epidermidis biofilms
  • Demonstrate increased antibiotic activity against bacteria within biofilms. Also the planktonic phase in the presence of Nuc B