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Module

MMB8006 : Drug discovery and development

  • Offered for Year: 2020/21
  • Module Leader(s): Dr Simon Hill
  • Lecturer: Dr Ian Hardcastle, Professor Ruth Plummer, Dr Simon Wilkinson, Dr Adam Potts, Professor Simon Thomas, Dr Ruben Thanacoody, Dr Matthew Leach, Professor Ann Daly
  • Visiting Lecturer: Prof. Frank Bonner
  • Owning School: FMS Graduate School
  • Teaching Location: Newcastle City Campus
Semesters
Semester 1 Credit Value: 20
ECTS Credits: 10.0

Aims

To develop a cohort of learners who have a detailed and practical understanding of the drug discovery and development process and the necessary actions needed to take a basic science concept and translate it into a first in man study of a potential drug. To situate the learning within UK regulatory and the research governance framework.

Outline Of Syllabus

The module covers the following topics, delivered through a series of lectures and formative assessments delivered through e-learning, supported by weekly interactive face-to-face seminars.

Pharmacokinetics (Drug absorption, distribution, metabolism and elimination)
Pharmacodynamics (Mechanisms of drug action)
Pharmacogenomics and Inter-individual variability in pharmacokinetics and drug effects
Targets and target validation
Screening and hits
Molecular biology underpinning drug discovery
Optimising molecules
Pre-clinical studies
Toxicology
Clinical Trial Authorisation / First-in-man

Teaching Methods

Please note that module leaders are reviewing the module teaching and assessment methods for Semester 2 modules, in light of the Covid-19 restrictions. There may also be a few further changes to Semester 1 modules. Final information will be available by the end of August 2020 in for Semester 1 modules and the end of October 2020 for Semester 2 modules.

Teaching Activities
Category Activity Number Length Student Hours Comment
Structured Guided LearningLecture materials21:002:00Pharmacogenomics
Guided Independent StudyAssessment preparation and completion182:3082:30Preparation of in-course assessment
Guided Independent StudyDirected research and reading128:0096:00E-learning sessions, to be completed in specified weeks preceding scheduled seminars
Scheduled Learning And Teaching ActivitiesSmall group teaching22:004:00Present in person: Seminars
Scheduled Learning And Teaching ActivitiesSmall group teaching52:0010:00Synchronous online: Seminars
Scheduled Learning And Teaching ActivitiesSmall group teaching11:001:00Present in person: First in man
Scheduled Learning And Teaching ActivitiesDrop-in/surgery10:300:30Present in person: in-course assessment
Scheduled Learning And Teaching ActivitiesModule talk21:002:00Present in person
Scheduled Learning And Teaching ActivitiesModule talk21:002:00Present in person
Total200:00
Teaching Rationale And Relationship

This module is taught by a flipped classroom approach in conjunction with the Pharmaceutical Industry.
Core theoretical content will be provided by e-learning via Canvas and will provide a framework on which to construct further self- directed learning. Weekly interactive seminars will involve collaborative, problem based activities and tasks that will encourage students to activate and build on the previous week’s learning and facilitate deeper learning through social interaction - this key module feature is to allow learners to develop practical knowledge, skills and attitudes that can be applied in practice and future careers. Seminars also provide an opportunity to develop other skills including interpersonal and oral communication, collaboration and information literacy.
Private study is used for self-directed learning including further reading, preparation for the seminars, undertaking a piece of written coursework and preparing for examinations. This will allow the learners to develop skills in locating and appraising appropriate literature.

Assessment Methods

Please note that module leaders are reviewing the module teaching and assessment methods for Semester 2 modules, in light of the Covid-19 restrictions. There may also be a few further changes to Semester 1 modules. Final information will be available by the end of August 2020 in for Semester 1 modules and the end of October 2020 for Semester 2 modules.

The format of resits will be determined by the Board of Examiners

Other Assessment
Description Semester When Set Percentage Comment
Design/Creative proj1M100Written report, 3500 words, based on study design and problem solving
Assessment Rationale And Relationship

The written report will test achievement of the stated intended knowledge and skills outcomes and ability to apply these skills to a specific case study.

Reading Lists

Timetable