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CHY8822 : Drug Metabolism and Toxicology

  • Offered for Year: 2022/23
  • Module Leader(s): Professor Mike Waring
  • Owning School: Natural and Environmental Sciences
  • Teaching Location: Newcastle City Campus
Semester 1 Credit Value: 10
ECTS Credits: 5.0


To introduce the principles of pharmacokinetics, drug metabolism and toxicology; to understand the importance of optimising these parameters in drug discovery; to understand the chemical basis of drug metabolism and its importance in drug discovery; to equip students with a knowledge and understanding of the mechanism of toxicity of drug molecules and other the environmental toxins

Outline Of Syllabus

Pharmacokinetics and drug metabolism (Professor M Waring)
Principles of pharmacokinetics
Processes and mechanisms of drug metabolism
Selected case studies in drug metabolism

Toxicology (Professor M Waring)
Principles of Toxicology and toxicokinetics
Critical toxicological issues for drug discovery
Allergens and reactive metabolites
Ion channels – hERG and acetyl choline signalling

Teaching Methods

Teaching Activities
Category Activity Number Length Student Hours Comment
Scheduled Learning And Teaching ActivitiesLecture121:0012:00PiP lectures
Guided Independent StudyAssessment preparation and completion121:0012:00Online materials via Canvas
Guided Independent StudyAssessment preparation and completion210:0020:00Online assessments - Structured literature exercise: case study and literature reading
Guided Independent StudyAssessment preparation and completion120:0020:00Revision for end of Semester 1 examination
Guided Independent StudyAssessment preparation and completion12:002:00End of Semester examination
Guided Independent StudyIndependent study134:0034:00Independent study
Jointly Taught With
Code Title
CHY3410Advanced Medicinal Chemistry
Teaching Rationale And Relationship

Students acquire knowledge and understanding through online lecture content and live module talks. Problem-solving skills are practiced in module talks and in private study.

Assessment Methods

The format of resits will be determined by the Board of Examiners

Description Length Semester When Set Percentage Comment
Written Examination1201A50If PiP exams do not take place this will be an alternative assessment
Exam Pairings
Module Code Module Title Semester Comment
CHY3410Advanced Medicinal Chemistry1N/A
Other Assessment
Description Semester When Set Percentage Comment
Computer assessment1M50Online assessment
Assessment Rationale And Relationship

The exam will test the student’s knowledge and understanding of the coursework as well as information literacy and presentation skills.

Study Abroad students may request to take their exam before the semester 1 exam period, in which case the format of the paper may differ from that shown in the MOF. Study Abroad students should contact the school to discuss this.

Reading Lists