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Module

BGM3065 : Biochemistry of Cancer and Chronic Diseases

  • Offered for Year: 2020/21
  • Module Leader(s): Professor Craig Robson
  • Lecturer: Dr Ian Cowell, Professor Steven Clifford, Professor Julie Irving, Dr Julian Rutherford, Dr Jill Hunter, Professor Neil Perkins, Dr Caroline Wilson
  • Owning School: Biomedical, Nutritional and Sports Scien
  • Teaching Location: Newcastle City Campus
Semesters
Semester 1 Credit Value: 20
ECTS Credits: 10.0

Aims

Through lectures and seminars this module aims to;

• provide an understanding of the biochemistry and clinical aspects of a number of chronic human diseases.
• explain how knowledge of the biochemistry of a disorder can be used to develop rational drug design for its treatment.
• provide an opportunity for students to further develop their written skills and critical analytical skills.
• inform students about the genetic and molecular basis of cancer and its treatment.
• introduce current technologies used in cancer detection, diagnostics and molecular pathology and allow students to explore how these techniques are being applied to advance our understanding of cancer.
• facilitate an understanding of the problems associated with cancer treatments.

Outline Of Syllabus

The biochemistry and clinical aspects of a number of chronic human diseases will be explored to explain how knowledge of the biochemistry of a disorder can be used to develop rational drug design for treatment. Topics include:
• biochemistry of trace metal sensing and its relevance to disease.
• core mechanisms of metal-homeostasis (metallochaperones, metal-sensing transcriptional and translational regulators, metal-specific transporters and storage proteins) and provide some examples of the ways in which these processes fail in disease.
• NF-kB signalling in health and disease.
• G-protein-coupled receptor (GPCR) signalling and disease.
• background to the biochemistry and molecular biology of cancer.
• cancer as a multi-process genetic disease.
• role of oncogenes and tumour suppressor genes.
• roles of failures in the DNA repair mechanisms in causing cancer
• factors that lead to metastasis.
• experimental genetic models of tumour development.
• methods of anticancer treatment and the problems of drug resistance.

Teaching Methods

Please note that module leaders are reviewing the module teaching and assessment methods for Semester 2 modules, in light of the Covid-19 restrictions. There may also be a few further changes to Semester 1 modules. Final information will be available by the end of August 2020 in for Semester 1 modules and the end of October 2020 for Semester 2 modules.

Teaching Activities
Category Activity Number Length Student Hours Comment
Structured Guided LearningLecture materials271:0027:00Non-synchronous online
Scheduled Learning And Teaching ActivitiesSmall group teaching40:302:00Seminars - PIP
Scheduled Learning And Teaching ActivitiesSmall group teaching21:002:00Essay Information Sessions - PIP
Scheduled Learning And Teaching ActivitiesSmall group teaching11:001:00Seminar - synchronous online
Guided Independent StudyIndependent study1168:00168:00Writing up lecture notes, revision and general reading.
Total200:00
Teaching Rationale And Relationship

Lecture materials will provide the students with essential information to achieve learning outcomes. Seminars will provide additional information and develop the student’s critical skills.

The seminars focus on major topics covered in the lectures, providing in-depth knowledge of the
topics and opportunities for students to discuss topic areas where they require additional information or clarification is
required.

Assessment Methods

Please note that module leaders are reviewing the module teaching and assessment methods for Semester 2 modules, in light of the Covid-19 restrictions. There may also be a few further changes to Semester 1 modules. Final information will be available by the end of August 2020 in for Semester 1 modules and the end of October 2020 for Semester 2 modules.

The format of resits will be determined by the Board of Examiners

Exam Pairings
Module Code Module Title Semester Comment
BGM3024The Molecular Basis of Cancer2Exams to be scheduled at the same time. Shared lectures/topics will allow the same questions to be used by these 2 modules
BMS3012Cancer Biology and Therapy2Exams to be scheduled at the same time. Shared lectures/topics will allow the same questions to be used by these 2 modules
Other Assessment
Description Semester When Set Percentage Comment
Essay1M15Essay 1 (max 2000 words)
Essay1M15Essay 2 (max 2000 words)
Essay2A70Open Book Essay (1 essay from a choice of 3). Students will be required to complete the essay over a 5-7 day period.
Assessment Rationale And Relationship

The open book essay primarily assesses students' knowledge and understanding.

The essays, written after tutorial discussions, will develop the students' ability to assimilate and analyse complex scientific information and to develop their written skills.

Reading Lists

Timetable