Skip to main content

Module

MMB8032 : Toxicology

  • Offered for Year: 2020/21
  • Module Leader(s): Professor Matthew Wright
  • Lecturer: Dr Vanessa Armstrong, Dr Christopher Morris, Dr Ernest Harpur, Dr Simon Wilkinson, Dr Jason Gill, Professor Ann Daly
  • Owning School: FMS Graduate School
  • Teaching Location: Newcastle City Campus
Semesters
Semester 1 Credit Value: 20
ECTS Credits: 10.0

Aims

The aims of the module are to give a broad understanding in Toxicology, from basic concepts and molecular mechanisms to a review of target organ toxicities, pre-clinical and clinical pharmaceutical toxicology testing. The module will provide a broad overview of Toxicology as it is applied in the Pharmaceutical industries.

Outline Of Syllabus

The module will consider:

1. Basic concepts in Toxicology, (type of toxic response/factors affecting toxicity)

2. Toxicokinetics (ADME/toxicokinetic parameters)

3. Xenobiotic metabolism (phase I/II)

4. Molecular mechanisms (oxidative stress, genotoxicity, carcinogenicity, epigentics)

5. Necrosis

6. Apoptosis

7. Non-genotoxic carcinogenesis

8. Target organ toxicity (liver, kidney, skin, immune, neuro, lung)

9. Compound safety – pharmaceuticals – pre-clinical

10. Compound safety – pharmaceuticals – clinical trials

11. Idiosyncratic adverse drug reactions

12. Mechanism-based risk assessment

Teaching Methods

Please note that module leaders are reviewing the module teaching and assessment methods for Semester 2 modules, in light of the Covid-19 restrictions. There may also be a few further changes to Semester 1 modules. Final information will be available by the end of August 2020 in for Semester 1 modules and the end of October 2020 for Semester 2 modules.

Teaching Activities
Category Activity Number Length Student Hours Comment
Guided Independent StudyAssessment preparation and completion150:0050:00Preparation and Submission of 3000 word Essay and end of module 24 hour paper
Guided Independent StudyAssessment preparation and completion127:0027:00Preparation of Oral Presentation based on Paper
Structured Guided LearningLecture materials201:0020:00Non-synchronous
Scheduled Learning And Teaching ActivitiesSmall group teaching61:006:00Present in person: Discussions and formative assessments
Scheduled Learning And Teaching ActivitiesSmall group teaching31:003:00Synchronous online: Tutorials
Scheduled Learning And Teaching ActivitiesSmall group teaching21:002:00Present in person: Seminars - class may be split
Scheduled Learning And Teaching ActivitiesSmall group teaching13:003:00Synchronous online: Assessed oral presentations
Guided Independent StudyReflective learning activity115:0015:00Additional Reading and Reflective Learning
Guided Independent StudyIndependent study174:0074:00Preparation of Notes from Lectures and Reading
Total200:00
Teaching Rationale And Relationship

A grounding in the fundamental tenets of Toxicology will be provided by the lecture materials/small group teaching and through guided private study of course texts, additional suggested materials during the course and through attendance of research seminars. Critical appraisal will be covered in a seminar and essay feedback. Communication of toxicological data will be covered in tutorials and feedback on their presentations.

Assessment Methods

Please note that module leaders are reviewing the module teaching and assessment methods for Semester 2 modules, in light of the Covid-19 restrictions. There may also be a few further changes to Semester 1 modules. Final information will be available by the end of August 2020 in for Semester 1 modules and the end of October 2020 for Semester 2 modules.

The format of resits will be determined by the Board of Examiners

Exams
Description Length Semester When Set Percentage Comment
Written Examination601A6024 hour take home online exam: One question to be answered from a choice of three
Other Assessment
Description Semester When Set Percentage Comment
Report1M20Appraisal of scientific literature (3000 word essay)
Prof skill assessmnt1M20Oral presentation: 10 minutes and 5 minutes for questions
Formative Assessments
Description Semester When Set Comment
Portfolio1MQuizzes on previous weeks lecture material, carried out during small group PIP sessions
Assessment Rationale And Relationship

The written exam will test the students’ knowledge base in toxicology and as a key component forms the majority of the assessment marks. Critical appraisal of toxicological data and presentational skills will be tested by both the 3000 word essay and oral presentation. The significant amount of time required for these tasks warrants the 40% of assessment marks.

Reading Lists

Timetable