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Module

MMB8034 : Mitochondrial Biology & Medicine

  • Offered for Year: 2020/21
  • Module Leader(s): Professor Zofia Chrzanowska-Lightowlers
  • Lecturer: Dr Amy Reeve, Professor Robert Lightowlers, Dr Sarah Pickett, Dr Laura Greaves, Professor Robert Taylor, Dr Joanna Elson, Professor Mary Herbert, Dr Monika Olahova, Dr Gavin Hudson, Professor Bobby McFarland, Dr Grainne Gorman, Professor Robert Hirt
  • Owning School: FMS Graduate School
  • Teaching Location: Newcastle City Campus
Semesters
Semester 1 Credit Value: 20
ECTS Credits: 10.0

Aims

The module will provide detailed information on aspects of basic mitochondrial biology including the origins and essential functions of mitochondria, the maintenance and expression of the mitochondrial genome, and the metabolic processes in which mitochondria play a role. The module will also provide information on disease that results from mitochondrial dysfunction. This information will be informed by current research and the current state of knowledge in the field of mitochondrial biology.

Outline Of Syllabus

This module is designed to provide both a thorough understanding of human mitochondrial genetics; the maintenance, replication and segregation of the mitochondrial genome (mtDNA); mtDNA transcription and intra-organellar translation; and appreciation of the metabolic processes that mitochondria are involved in; a detailed understanding of oxidative phosphorylation (OXPHOS) and the underlying biochemistry; an understanding of the interplay and coordination of nuclear and mitochondrially encoded proteins that maintains a healthy organelle; and an appreciation of the disease states and contribution to ageing that can arise as a consequence of dysfunction in any of the above.

Teaching Methods

Please note that module leaders are reviewing the module teaching and assessment methods for Semester 2 modules, in light of the Covid-19 restrictions. There may also be a few further changes to Semester 1 modules. Final information will be available by the end of August 2020 in for Semester 1 modules and the end of October 2020 for Semester 2 modules.

Teaching Activities
Category Activity Number Length Student Hours Comment
Guided Independent StudyAssessment preparation and completion140:0040:00Student Preparation Time for Graphical abstract for Assessment
Structured Guided LearningLecture materials71:007:00Non-synchronous online
Guided Independent StudyAssessment preparation and completion170:0070:00Preparation for the essay (2000 word max)
Guided Independent StudyDirected research and reading160:0060:00Making Notes and Reading from Lectures and other Sources
Scheduled Learning And Teaching ActivitiesSmall group teaching101:0010:00Present in person: Seminars/Debates in small groups
Guided Independent StudyReflective learning activity111:0011:00Reading and Reflective Learning
Scheduled Learning And Teaching ActivitiesModule talk21:002:00Synchronous online
Total200:00
Teaching Rationale And Relationship

Knowledge and understanding are gained from the lectures and workshop/group sessions.

Intellectual skills are developed in the completion of the coursework assessments.

Key (transferable skills – communication, literacy, critical appraisal) are developed by the coursework and practised in the assessments.

Comprehension and ability to discuss the subject knowledge critically will be developed in the essay and graphical abstract.

There is adequate time for reading and reflection built into the module and students will be guided (in lecture materials and seminars) to find appropriate and up-to-date sources as well as being encouraged to find their own sources for relevant information.

Assessment Methods

Please note that module leaders are reviewing the module teaching and assessment methods for Semester 2 modules, in light of the Covid-19 restrictions. There may also be a few further changes to Semester 1 modules. Final information will be available by the end of August 2020 in for Semester 1 modules and the end of October 2020 for Semester 2 modules.

The format of resits will be determined by the Board of Examiners

Other Assessment
Description Semester When Set Percentage Comment
Prof skill assessmnt1M30Set in Week 4, submit week 7. Graphical abstract of pre-selected paper
Prof skill assessmnt1M70Set in Week 6, submit week 9. 2000 word max essay to practice skills in succinctly summarising argument.
Assessment Rationale And Relationship

The essay tests the student’s knowledge base, comprehension, ability to discuss the subject knowledge critically, evaluation of scientific literature.

The graphical abstract tests application of knowledge, understanding and ability to critically evaluate and interpret research data. This is coupled with the ability to cogent visual explanations.

Reading Lists

Timetable