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Module

CHY3111 : Advanced Organic Chemistry (Inactive)

  • Inactive for Year: 2020/21
  • Module Leader(s): Dr Michael Hall
  • Owning School: Natural and Environmental Sciences
  • Teaching Location: Newcastle City Campus
Semesters
Semester 1 Credit Value: 10
Semester 2 Credit Value: 10
ECTS Credits: 10.0

Aims

Organic compounds are central to a wide range of industries (pharmaceuticals, polymers, dyes, coatings and more) and of fundamental importance for biochemistry, biotechnology and life sciences. This module equips students with the necessary knowledge and understanding for them to study organic chemistry at Stage 4 and/or in the chemical industries; to further enhance the students’ knowledge of synthetic organic chemistry; to introduce modern synthetic chemistry functional group transformations; to highlight the use of organo-element compounds in synthesis; to further develop knowledge of aromatic chemistry to more complex heteroaromatic systems; to introduce transition metal catalysed C-C bond forming reactions; to further develop the concept of retrosynthetic analysis; to equip students with the tools to design and synthesize complex molecules.

Outline Of Syllabus

Oxidations and Reductions in Organic Chemistry and the Formation of Carbonyl Compounds

Transition metal-mediated oxidation of alcohols.
Oxidation of alcohols with organic oxidising agents.
Selective Reductions.
Oxidative cleavage of C=C; ozonolysis.
Synthesis with Dithianes (unpolung).
Nucleophilic additions to carbonyls; Benzoin condensation and MPV reaction.
Hydrogenation/Hydrogenolysis.

P-Block and Organometallic Chemistry

Nucelophilic attack of organometallics; synthesis of organometallics and selectivity
Conjugate additions; hard vs soft nucleophiles and the control of 1,2- versus 1,4-addition
to alpha,beta-unsaturated carbonyl compounds
P-Block Chemistry, including the organo-element chemistry of Si, S, P and B

Heteroaromatic and Coupling Reaction Chemistry

Aromatic systems containing heteroatoms; introduction and overview
Membered heteroatromatics containing one heteroatom; pyrroles, furans and thiophenes
Membered heteroaromatics containing one heteroatom; pyridines
Fused heteroaromatics; indoles and quinolines
Heteroaromatics containing more than one heteroatom
Transition metal catalysed C-C bond forming reactions

Synthesis

Classical synthesis and synthetic strategy
Protecting group chemistry
Retrosynthetic analysis
Syntheses of complex molecules

Teaching Methods

Please note that module leaders are reviewing the module teaching and assessment methods for Semester 2 modules, in light of the Covid-19 restrictions. There may also be a few further changes to Semester 1 modules. Final information will be available by the end of August 2020 in for Semester 1 modules and the end of October 2020 for Semester 2 modules.

Teaching Activities
Category Activity Number Length Student Hours Comment
Guided Independent StudyAssessment preparation and completion13:003:00End of semester 2 examination
Guided Independent StudyAssessment preparation and completion240:5020:00Revision for end of semester 2 examination
Guided Independent StudyAssessment preparation and completion11:001:00End of semester 1 formative examination
Guided Independent StudyAssessment preparation and completion240:5020:00Revision of end of semester 1 formative examination
Scheduled Learning And Teaching ActivitiesLecture481:0048:00Lectures
Guided Independent StudyIndependent study1108:00108:00Independent study, background reading and practice examination papers
Total200:00
Teaching Rationale And Relationship

A variety of methods will be used for delivery of the material and to ensure that students actively engage with the subject matter. Lectures will provide the basis for enhancing the subject and allow students to take the learning element into future practical sessions.

Assessment Methods

Please note that module leaders are reviewing the module teaching and assessment methods for Semester 2 modules, in light of the Covid-19 restrictions. There may also be a few further changes to Semester 1 modules. Final information will be available by the end of August 2020 in for Semester 1 modules and the end of October 2020 for Semester 2 modules.

The format of resits will be determined by the Board of Examiners

Exams
Description Length Semester When Set Percentage Comment
Written Examination1802A100End of module examination
Formative Assessments
Description Semester When Set Comment
PC Examination1AAssessment of part module examination
Assessment Rationale And Relationship

The formative exam will assess the level of knowledge and understanding from topics studied in semester 1. This will allow the module team to review and feedback on any topic which may have been problematic.

The summative written examination will assess the level of knowledge and understanding of all aspects of the module. The examination will present students with questions from a selection of topics learnt throughout semester 1 and 2 module content.

Reading Lists

Timetable