NES3402 : Advanced Organic Chemistry
- Offered for Year: 2024/25
- Module Leader(s): Dr Michael Hall
- Lecturer: Dr Roly Armstrong, Dr Johan Eriksson, Dr David Fulton
- Owning School: Natural and Environmental Sciences
- Teaching Location: Newcastle City Campus
Semesters
Your programme is made up of credits, the total differs on programme to programme.
| Semester 1 Credit Value: | 10 |
| Semester 2 Credit Value: | 10 |
| ECTS Credits: | 10.0 |
| European Credit Transfer System | |
Aims
Organic compounds are central to a wide range of industries (pharmaceuticals, polymers, dyes, coatings and more) and of fundamental importance for biochemistry, biotechnology and life sciences. This module equips students with the necessary knowledge and understanding for them to study organic chemistry at Stage 4 and/or in the chemical industries; to further enhance the students’ knowledge of synthetic organic chemistry; to introduce modern synthetic chemistry functional group transformations; to highlight the use of organo-element compounds in synthesis; to further develop knowledge of aromatic chemistry to more complex heteroaromatic systems; to introduce transition metal catalysed C-C bond forming reactions; to further develop the concept of retrosynthetic analysis; to equip students with the tools to design and synthesize complex molecules.
Outline Of Syllabus
Oxidations and Reductions in Organic Chemistry and the Formation of Carbonyl Compounds
Transition metal-mediated oxidation of alcohols.
Oxidation of alcohols with organic oxidising agents.
Selective Reductions.
Oxidative cleavage of C=C; ozonolysis.
Synthesis with Dithianes (unpolung).
Nucleophilic additions to carbonyls; Benzoin condensation and MPV reaction.
Hydrogenation/Hydrogenolysis.
P-Block and Organometallic Chemistry
Nucelophilic attack of organometallics; synthesis of organometallics and selectivity
Conjugate additions; hard vs soft nucleophiles and the control of 1,2- versus 1,4-addition
to alpha,beta-unsaturated carbonyl compounds
P-Block Chemistry, including the organo-element chemistry of Si, S, P and B
Heteroaromatic and Coupling Reaction Chemistry
Aromatic systems containing heteroatoms; introduction and overview
Membered heteroatromatics containing one heteroatom; pyrroles, furans and thiophenes
Membered heteroaromatics containing one heteroatom; pyridines
Fused heteroaromatics; indoles and quinolines
Heteroaromatics containing more than one heteroatom
Transition metal catalysed C-C bond forming reactions
Synthesis
Classical synthesis and synthetic strategy
Protecting group chemistry
Retrosynthetic analysis
Syntheses of complex molecules
Teaching Methods
Teaching Activities
| Category | Activity | Number | Length | Student Hours | Comment |
|---|---|---|---|---|---|
| Guided Independent Study | Assessment preparation and completion | 1 | 3:00 | 3:00 | End of semester 2 examination |
| Guided Independent Study | Assessment preparation and completion | 41 | 1:00 | 41:00 | Revision for end of semester 2 examination |
| Scheduled Learning And Teaching Activities | Lecture | 64 | 1:00 | 64:00 | Lecture |
| Guided Independent Study | Assessment preparation and completion | 1 | 4:00 | 4:00 | Formative assessment completion - online MCQs and questions |
| Scheduled Learning And Teaching Activities | Workshops | 3 | 1:00 | 3:00 | Retrosynthesis workshops |
| Guided Independent Study | Independent study | 1 | 85:00 | 85:00 | Independent study, background reading and practice examination papers |
| Total | 200:00 |
Jointly Taught With
| Code | Title |
|---|---|
| NES3406 | Advanced Organic Chemistry (Distance Learning) |
Teaching Rationale And Relationship
A variety of methods will be used for delivery of the material and to ensure that students actively engage with the subject matter. Lectures will provide the basis for enhancing the subject and allow students to take the learning element into future practical sessions.
Assessment Methods
The format of resits will be determined by the Board of Examiners
Exams
| Description | Length | Semester | When Set | Percentage | Comment |
|---|---|---|---|---|---|
| Digital Examination | 180 | 2 | A | 100 | Computer based MCQs and written long answers. Online assessment as alternative in the case of no PiP examinations. |
Exam Pairings
| Module Code | Module Title | Semester | Comment |
|---|---|---|---|
| Advanced Organic Chemistry (Distance Learning) | 2 | N/A |
Formative Assessments
Formative Assessment is an assessment which develops your skills in being assessed, allows for you to receive feedback, and prepares you for being assessed. However, it does not count to your final mark.
| Description | Semester | When Set | Comment |
|---|---|---|---|
| Prob solv exercises | 2 | M | Formative assessments will take place throughout the course via online MCQs and questions |
Assessment Rationale And Relationship
The summative written examination will assess the level of knowledge and understanding of all aspects of the module. The examination will present students with questions from a selection of topics learnt throughout semester 1 and 2 module content.
Formative assessments will take place throughout the course via online MCQs and questions.
Reading Lists
Timetable
- Timetable Website: www.ncl.ac.uk/timetable/
- NES3402's Timetable