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Module

BGM2056 : DNA Replication, recombination and Repair

  • Offered for Year: 2020/21
  • Module Leader(s): Dr Simon Whitehall
  • Lecturer: Professor Heath Murray
  • Owning School: Biomedical, Nutritional and Sports Scien
  • Teaching Location: Newcastle City Campus
Semesters
Semester 2 Credit Value: 10
ECTS Credits: 5.0

Aims

1. To provide a sound understanding of the molecular mechanisms underlying the replication, repair and recombination of DNA and to demonstrate the unique importance of the accuracy of these processes.

2. To provide a framework for understanding the different types of DNA damage, the mechanisms by which they are repaired and the diseases that result from defects in these repair processes.

Outline Of Syllabus

This module provides an understanding of the following key DNA-dependent processes:

- accurate replication of the genome

- recombination, mechanisms of genetic variation

- repair of DNA damage

- results of failure to correct DNA damage (e.g. mutation, genetic instability, cancer).
development of genetic diseases (e.g. developmental disorders, cancer predisposition and premature ageing)

Teaching Methods

Please note that module leaders are reviewing the module teaching and assessment methods for Semester 2 modules, in light of the Covid-19 restrictions. There may also be a few further changes to Semester 1 modules. Final information will be available by the end of August 2020 in for Semester 1 modules and the end of October 2020 for Semester 2 modules.

Teaching Activities
Category Activity Number Length Student Hours Comment
Structured Guided LearningLecture materials121:0012:00Non-sync online. Theory/themes/methodologies/techniques re DNA replication recombination & repair
Scheduled Learning And Teaching ActivitiesPractical13:003:00PIP - Laboratory practical sessions. UV survival curves
Guided Independent StudyIndependent study184:0084:00Writing up lecture notes, revision and general reading
Scheduled Learning And Teaching ActivitiesModule talk11:001:00Synchronous online. Feedback and opportunity for queries
Total100:00
Teaching Rationale And Relationship

The lecture materials will be used to deliver theory, themes, methodologies and techniques relating to DNA replication, recombination and repair. These sessions will be reinforced by the material covered in the practical/data analysis (PIP) sessions. The module talk (synchronous online session) will reinforce the lecture material, allow feedback on the practical/data handling exercise.

Assessment Methods

Please note that module leaders are reviewing the module teaching and assessment methods for Semester 2 modules, in light of the Covid-19 restrictions. There may also be a few further changes to Semester 1 modules. Final information will be available by the end of August 2020 in for Semester 1 modules and the end of October 2020 for Semester 2 modules.

The format of resits will be determined by the Board of Examiners

Exams
Description Length Semester When Set Percentage Comment
Written Examination752A80Online 24 hour take home paper. Two short answer questions - students must answer both questions (350 word limit for each question)
Other Assessment
Description Semester When Set Percentage Comment
Practical/lab report2M20Experience gained in accurate recording & with determination of UV survival curves. All pre-set questions must be answered.
Assessment Rationale And Relationship

The assessments will test understanding of the material delivered, as well as providing training in key laboratory and numeracy skills.

Reading Lists

Timetable