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BGM2056 : DNA Replication, recombination and Repair

  • Offered for Year: 2021/22
  • Module Leader(s): Dr Simon Whitehall
  • Lecturer: Professor Heath Murray
  • Owning School: Biomedical, Nutritional and Sports Scien
  • Teaching Location: Newcastle City Campus
Semester 2 Credit Value: 10
ECTS Credits: 5.0


1. To provide a sound understanding of the molecular mechanisms underlying the replication, repair and recombination of DNA and to demonstrate the unique importance of the accuracy of these processes.

2. To provide a framework for understanding the different types of DNA damage, the mechanisms by which they are repaired and the diseases that result from defects in these repair processes.

Outline Of Syllabus

This module provides an understanding of the following key DNA-dependent processes:

- accurate replication of the genome

- recombination, mechanisms of genetic variation

- repair of DNA damage

- results of failure to correct DNA damage (e.g. mutation, genetic instability, cancer).
development of genetic diseases (e.g. developmental disorders, cancer predisposition and premature ageing)

Teaching Methods

Teaching Activities
Category Activity Number Length Student Hours Comment
Scheduled Learning And Teaching ActivitiesLecture121:0012:00PIP - Theory/themes/methodologies/techniques re DNA replication recombination & repair
Scheduled Learning And Teaching ActivitiesPractical15:005:00PIP - Laboratory practical sessions. UV survival curves
Guided Independent StudyIndependent study182:0082:00Writing up lecture notes, revision and general reading
Scheduled Learning And Teaching ActivitiesModule talk11:001:00PIP - Feedback and opportunity for queries
Teaching Rationale And Relationship

The lectures will be used to deliver theory, themes, methodologies and techniques relating to DNA replication, recombination and repair.

These sessions will be reinforced by the material covered in the practical/data analysis sessions.

The module talk will reinforce the lecture material and allow feedback on the practical/data handling exercise.

Public health contingency:
All lectures and practicals can/will move to online either as synchronous or non-synchronous delivery.

Assessment Methods

The format of resits will be determined by the Board of Examiners

Description Length Semester When Set Percentage Comment
Written Examination752A80Invigilated exam: (30%) MCQ questions and (70%) Essay, 1 from a choice of 2.
Other Assessment
Description Semester When Set Percentage Comment
Practical/lab report2M20Experience gained in accurate recording & with determination of UV survival curves. All pre-set questions must be answered.
Assessment Rationale And Relationship

The practical report will test understanding of the material delivered, as well as providing training in key laboratory and numeracy skills.

Public health contingency:
Invigilated exam can/will move to online (24-hour take home); 30% MCQ or may replace MCQ with SAQs and 70% essay (1 from 2; 1250 words)

Reading Lists