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BGM2056 : DNA Replication, recombination and Repair

  • Offered for Year: 2019/20
  • Module Leader(s): Dr Simon Whitehall
  • Lecturer: Professor Heath Murray
  • Owning School: Biomedical, Nutritional and Sports Scien
  • Teaching Location: Newcastle City Campus
Semester 2 Credit Value: 10
ECTS Credits: 5.0


1. To provide a sound understanding of the molecular mechanisms underlying the replication, repair and recombination of DNA and to demonstrate the unique importance of the accuracy of these processes.

2. To provide a framework for understanding the different types of DNA damage, the mechanisms by which they are repaired and the diseases that result from defects in these repair processes.

Outline Of Syllabus

This module provides an understanding of the following key DNA-dependent processes:

accurate replication of the genome and recombination;
mechanisms of genetic variation;
repair of DNA damage;
results of failure to correct DNA damage (e.g. mutation, genetic instability, cancer).
development of genetics diseases (e.g. developmental disorders, cancer predisposition and premature ageing)

Teaching Methods

Teaching Activities
Category Activity Number Length Student Hours Comment
Scheduled Learning And Teaching ActivitiesLecture121:0012:00
Scheduled Learning And Teaching ActivitiesPractical16:006:00The practical runs over 2 days
Scheduled Learning And Teaching ActivitiesSmall group teaching11:001:00Seminar - Discussion on practical results
Guided Independent StudyIndependent study181:0081:00
Teaching Rationale And Relationship

The lectures will be used to introduce the intended knowledge outcomes for the module. These will be reinforced by the material covered in the data analysis and practical sessions. The seminar will reinforce the lecture material and acts as a feedback session for the practical and data-handing exercise.

Assessment Methods

The format of resits will be determined by the Board of Examiners

Description Length Semester When Set Percentage Comment
Written Examination752A80MCQ (30%): 25 minutes Essay x 1 (70%): 50 minutes.
Other Assessment
Description Semester When Set Percentage Comment
Practical/lab report2M20Students will gain experience in the accurate recording and also with determination of UV survival curves
Assessment Rationale And Relationship

The assessments will test understanding of the material delivered, as well as providing training in key laboratory and
numeracy skills.

Reading Lists