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BGM2060 : Proteins and Enzymes

  • Offered for Year: 2019/20
  • Module Leader(s): Dr David Bolam
  • Lecturer: Dr Nick Watkins, Professor Jeremy Lakey, Dr Elizabeth Veal
  • Practical Supervisor: Professor Martin Noble, Dr Kevin Waldron, Professor Jane Endicott
  • Owning School: Biomedical, Nutritional and Sports Scien
  • Teaching Location: Newcastle City Campus
Semester 2 Credit Value: 20
ECTS Credits: 10.0


The aim of the module is to provide students with a detailed understanding of protein structure, synthesis, function and use, with particular focus on enzymes.

Outline Of Syllabus

•properties of proteins and enzymes, macromolecules essential to all life.
•protein secondary structure, super secondary structure and tertiary folds and introduce key concepts in protein folding.
•catalysis by RNA and comparison to protein enzymes.
•specific interactions between enzymes and substrates are determined by protein structure and how preferential binding of the transition state by enzymes leads to catalysis
•kinetic parameters that describe enzyme catalysis, inhibition and allosteric regulation
•mechanisms of action of several major enzyme classes to illustrate key catalytic strategies.

Teaching Methods

Teaching Activities
Category Activity Number Length Student Hours Comment
Scheduled Learning And Teaching ActivitiesLecture21:002:00Practical Feedback Sessions
Scheduled Learning And Teaching ActivitiesLecture201:0020:00Lectures
Scheduled Learning And Teaching ActivitiesPractical26:0012:00N/A
Guided Independent StudyIndependent study1166:00166:00N/A
Teaching Rationale And Relationship

The lectures will cover the key points of the module and will be reinforced by the practicals. The practicals form the core of this module as they will give the students ‘hands-on’ experience of the key methods discussed in the lectures, and provide training in data acquisition, interpretation and critical analysis.

Assessment Methods

The format of resits will be determined by the Board of Examiners

Description Length Semester When Set Percentage Comment
Written Examination902A80Two essays to be answered from a choice of 4. Each essay contributes 50% of the mark
Other Assessment
Description Semester When Set Percentage Comment
Practical/lab report2M101,200 words
Practical/lab report2M101,200 words
Assessment Rationale And Relationship

Exams test all knowledge across the module.
Practicals assess students understanding of key points in the lectures, ability to report and analyse results, and tests their team work skills (students will work in groups of 2 or more) and general laboratory skills.
The practical write up tests data analysis, critical thinking and report-writing skills.

Reading Lists