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Module

BGM2060 : Proteins and Enzymes

  • Offered for Year: 2021/22
  • Module Leader(s): Dr David Bolam
  • Lecturer: Professor Jeremy Lakey, Dr Kevin Waldron, Dr Elizabeth Veal, Dr Nick Watkins
  • Practical Supervisor: Professor Jane Endicott
  • Owning School: Biomedical, Nutritional and Sports Scien
  • Teaching Location: Newcastle City Campus
Semesters
Semester 2 Credit Value: 20
ECTS Credits: 10.0

Aims

The aim of the module is to provide students with a detailed understanding of protein structure, function and application, with particular focus on enzymes.

Outline Of Syllabus

•Properties of proteins and enzymes, macromolecules essential to all life.

•Protein secondary structure, super secondary structure and tertiary folds and introduce key concepts in protein folding.

•Specific interactions between enzymes and substrates are determined by protein structure and how preferential binding of the transition state by enzymes leads to catalysis

•Kinetic parameters that describe enzyme catalysis, inhibition and allosteric regulation

•Mechanisms of action of several major enzyme classes to illustrate key catalytic strategies.

•Catalysis by RNA and comparison to protein enzymes.

Teaching Methods

Please note that module leaders are reviewing the module teaching and assessment methods for Semester 2 modules, in light of the Covid-19 restrictions. There may also be a few further changes to Semester 1 modules. Final information will be available by the end of August 2020 in for Semester 1 modules and the end of October 2020 for Semester 2 modules.

Teaching Activities
Category Activity Number Length Student Hours Comment
Scheduled Learning And Teaching ActivitiesLecture201:0020:00PIP on campus
Guided Independent StudyAssessment preparation and completion180:0080:00Preparation and completion of lab reports and revision for online exam
Scheduled Learning And Teaching ActivitiesPractical27:0014:00PIP on campus
Scheduled Learning And Teaching ActivitiesSmall group teaching51:005:00Sync online seminars to facilitate discussion of module content and check for understanding
Scheduled Learning And Teaching ActivitiesSmall group teaching31:003:00PIP seminars - Practical write up guidance and feedback sessions
Guided Independent StudyIndependent study178:0078:00Writing up lecture notes, revision and general reading
Total200:00
Teaching Rationale And Relationship

The lectures will cover the key points of the module and will be reinforced by the practicals. Seminars offer students an opportunity to discuss their understanding and check their learning against the module outcomes.

The practicals form the core of this module as they will give the students ‘hands-on’ experience of the key methods discussed in the lectures, and provide training in data acquisition, interpretation and critical analysis.



Public health contingency:
All lectures, practicals and seminars can/will move to online either as synchronous or non-synchronous delivery.

Assessment Methods

Please note that module leaders are reviewing the module teaching and assessment methods for Semester 2 modules, in light of the Covid-19 restrictions. There may also be a few further changes to Semester 1 modules. Final information will be available by the end of August 2020 in for Semester 1 modules and the end of October 2020 for Semester 2 modules.

The format of resits will be determined by the Board of Examiners

Exams
Description Length Semester When Set Percentage Comment
Written Examination1202A70Online 24 hour take home paper. Open book 4 short answer questions (350 word limit each). All questions to be answered
Other Assessment
Description Semester When Set Percentage Comment
Practical/lab report2M151,200 words
Practical/lab report2M151,200 words
Assessment Rationale And Relationship

Exams test all knowledge across the module.

Practicals assess students understanding of key points in the lectures, ability to report and analyse results, and tests their teamwork skills (students will work in groups of 2) and general laboratory skills.

The practical write up tests data analysis, critical thinking and report-writing skills.

Reading Lists

Timetable