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Module

PED2001 : Drug Disposition and Pharmacokinetics

  • Offered for Year: 2021/22
  • Module Leader(s): Dr Simon Wilkinson
  • Other Staff: Professor Gareth Veal, Dr Lindi Chen, Professor Farhad Kamali, Professor Ann Daly, Professor Matthew Wright
  • Owning School: Biomedical, Nutritional and Sports Scien
  • Teaching Location: Newcastle City Campus
Semesters
Semester 2 Credit Value: 20
ECTS Credits: 10.0

Aims

The aims of the course are to:

(i) Provide an understanding how drugs are handled by the body, the factors that may influence this process and how drug metabolism is studied experimentally.

(ii) Provide students with a detailed knowledge and understanding of the role of drug absorption, distribution, metabolism, excretion, pharmacokinetics and the enzymes of drug metabolism.

(iii)Introduce students to modern experimental methods commonly used in drug metabolism studies and to develop practical, critical and written communication skills. This will equip students with an appreciation of the role of studies on drug disposition in the drug development process.

Outline Of Syllabus

The syllabus will be divided into four themes which cover drug disposition following administration, the role of individual enzymes systems in drug metabolism, factors affecting drug metabolism, and transport of drug metabolites out of tissues and excretion from the body. The syllabus will cover the principles of administration and distribution of drugs (including the influence of delivery systems and routes), the different enzyme systems involved in metabolism of drugs and how this process is modulated, the influence of genetic polymorphisms on drug efficacy and toxicity, experimental methods for reaction phenotyping employed in drug development, and how metabolites are effluxed from cells and tissues and excreted from the body. The syllabus also covers exemplar techniques for measuring key metabolic activities, the induction of enzyme activities and the detection of genetic polymorphisms in enzymes and the functional consequences of polymorphisms for drug metabolism.

Teaching Methods

Teaching Activities
Category Activity Number Length Student Hours Comment
Scheduled Learning And Teaching ActivitiesLecture211:0021:00PIP - Lectures
Guided Independent StudyAssessment preparation and completion16:006:00Timed essay
Scheduled Learning And Teaching ActivitiesPractical43:0012:00PIP - laboratory practicals
Scheduled Learning And Teaching ActivitiesPractical23:006:00Non-synchronous laboratory practicals
Scheduled Learning And Teaching ActivitiesSmall group teaching41:004:00PIP x 1 seminar Synchronous online x 3 seminars
Scheduled Learning And Teaching ActivitiesDrop-in/surgery11:001:00PIP - End of module summary, feedback, Q&A session
Guided Independent StudyIndependent study1149:00149:00Writing up lecture notes, revision and general reading
Scheduled Learning And Teaching ActivitiesModule talk11:001:00PIP - Intro talk
Total200:00
Teaching Rationale And Relationship

Lectures will impart new information regarding fundamental principles and will act as an indication of the scope of material required for guided independent study.

Seminar sessions will reinforce taught material and will provide an opportunity for students to clarify concepts or challenge their learning through peer and staff discussions, as well as developing scientific writing skills and laboratory record keeping.

The drop-in surgery will provide critical feedback on assessed material and encourage an increased understanding of the material through discussion.

The practical class will provide experience in performing fundamental techniques, recording and analysing data to support the core module knowledge as well as the opportunity to carry out scientific calculations.

Guided independent study will be used for self-directed learning, including further reading and preparation for assessments.



Public Health Contingency:
All lectures, practicals, drop-in/surgeries and seminars can/will move online either as synchronous online or non-synchronous delivery.

Assessment Methods

The format of resits will be determined by the Board of Examiners

Exams
Description Length Semester When Set Percentage Comment
Written Examination1202A70Invigilated Exam: 50% SAQ / 50% essay)
Other Assessment
Description Semester When Set Percentage Comment
Essay2M10Timed essay (undertaken on campus)
Practical/lab report2M20Structured report (1250 words)
Assessment Rationale And Relationship

The examination questions will be used to assess knowledge, independent learning and understanding of the material relevant to this module, the ability to integrate this material, the ability to communicate clearly in writing and ability for critical thought and problem solving.

The timed essay is used to assess knowledge and understanding of material and ability to integrate across sources.

The practical report ensures an understanding of practical work undertaken and provide practice in numerical calculations. The first two practicals provide formative practice in completing an effective laboratory record book.



Public Health Contingency:
The timed essay can/will move to online timed delivery.
Invigilated exam will/can move to online, 24-hour take home exam: 50% SAQ – 4 each with a 400 word limit; 50% essay 1250 words

Reading Lists

Timetable