Skip to main content

Module

CHY2410 : Medicinal Chemistry (Inactive)

  • Inactive for Year: 2020/21
  • Module Leader(s): Dr Celine Cano
  • Owning School: Natural and Environmental Sciences
  • Teaching Location: Newcastle City Campus
Semesters
Semester 2 Credit Value: 10
ECTS Credits: 5.0

Aims

To equip students with knowledge and understanding of drug-receptor interactions, enzyme chemistry and the principles of drug design and drug action. To provide students with an understanding of the molecular mechanisms underpinning the action of chosen case study drugs.

Outline Of Syllabus

Principles of Medicinal Chemistry and Enzyme Action

Principles of Medicinal Chemistry - Pharmacokinetics; Lipinski’s rule of five;
Pharmacodynamics; Drug-receptor Interactions
Enzymes - What are enzymes?; How do they work?; Mechanisms of Enzyme Catalysis;
Enzyme inhibition and co-enzyme catalysis
Physicochemical properties of drugs - Ionisation constants; Aqueous solubility;
Fick’s Law of diffusion; Lipophilicity; Partition and Distribution Coefficients
Isosterism and Bioisosterism in Drug Discovery
Case studies – Design of Small Molecule Enzyme Inhibitors

Drug Design

Drug Discovery and SARs
Lead optimisation
Mechanisms of Enzyme Inhibition
Case studies in Drug Discovery
Introduction to Structure-Based Drug Design using CCP4 Molecular Graphics (including
a computing workshop with hands on ligand-bound protein crystal structures)

Teaching Methods

Please note that module leaders are reviewing the module teaching and assessment methods for Semester 2 modules, in light of the Covid-19 restrictions. There may also be a few further changes to Semester 1 modules. Final information will be available by the end of August 2020 in for Semester 1 modules and the end of October 2020 for Semester 2 modules.

Teaching Activities
Category Activity Number Length Student Hours Comment
Guided Independent StudyAssessment preparation and completion12:002:00End of semester examination
Guided Independent StudyAssessment preparation and completion220:5018:20Revision for end of semester examination
Scheduled Learning And Teaching ActivitiesLecture221:0022:00Lectures
Guided Independent StudyIndependent study157:4057:40Reading of textbooks and practice past papers and questions
Total100:00
Teaching Rationale And Relationship

Traditional lecture delivery will be used for the material and to ensure that students actively engage with the subject matter.

Assessment Methods

Please note that module leaders are reviewing the module teaching and assessment methods for Semester 2 modules, in light of the Covid-19 restrictions. There may also be a few further changes to Semester 1 modules. Final information will be available by the end of August 2020 in for Semester 1 modules and the end of October 2020 for Semester 2 modules.

The format of resits will be determined by the Board of Examiners

Exams
Description Length Semester When Set Percentage Comment
Written Examination1202A100N/A
Assessment Rationale And Relationship

The summative written examination will assess the level of knowledge and understanding of all aspects of the module. The examination will present students with questions from a selection of topics learnt throughout semester 1 and 2 module content.

Reading Lists

Timetable