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MMB8015 : Applied Immunobiology of Human Disease

  • Offered for Year: 2020/21
  • Module Leader(s): Dr Catharien Hilkens
  • Lecturer: Professor Sophie Hambleton, Dr Amy Anderson, Professor John Isaacs, Dr Kevin Marchbank, Professor John Kirby, Professor Simi Ali, Professor Claire Harris, Professor David Jones, Dr Lei Huang, Dr Andrew Filby, Professor Andrew Gennery
  • Owning School: FMS Graduate School
  • Teaching Location: Newcastle City Campus
Semester 1 Credit Value: 20
ECTS Credits: 10.0


The purpose of this module is to provide an up-to-date overview and introduction to selected aspects of Immunobiology. The module will comprise a series of lectures on recent developments, with an emphasis on understanding the supportive biological concepts. This module aims to address a major area of current medical research and to provide students with an understanding of the strengths and weakness of both the current subject knowledge in this area and the practical approaches to it. This module is designed to be multi-disciplinary, drawing upon the specialized expertise and research strengths of academic staff drawn from the Faculty of Medical Sciences. It will provide a strong platform for those students aiming to pursue research projects in cellular or molecular immunology.

Outline Of Syllabus

The syllabus contains the following topics:

• Basic concepts in immunology
• T cell responses in health and disease
• Generation of B cell immunity
• General features and mechanisms of immunologic tolerance
• Regulation of immunity and tolerance by dendritic cells
• Cell migration in the immune system
• Transplantation and graft rejection
• Immunodeficiency disorders
• Autoimmunity: mechanisms and treatment
• Tumour Immunobiology
• Complement: role in immune regulation and therapeutic application
• Immunological defence mechanisms in infection
• New developments in cytometry-based technologies – applications in immunology
• Immunological Biomarkers: role in diagnostics, prognostics and theragnostics

Teaching Methods

Teaching Activities
Category Activity Number Length Student Hours Comment
Guided Independent StudyAssessment preparation and completion137:0037:00Preparation for and completion of MCQ test
Guided Independent StudyAssessment preparation and completion150:0050:00Revision for Examination
Scheduled Learning And Teaching ActivitiesLecture231:0023:00Lectures
Guided Independent StudyIndependent study150:0050:00Preparation of Notes from Lectures and Reading
Guided Independent StudyIndependent study140:0040:00Preparation of 2000 word Essay
Teaching Rationale And Relationship

Interactive lectures will provide the students with a specific knowledge as a platform for private study. These lectures will encourage the students to reflect both individually and in small groups on the state of knowledge in research in applied immunobiology. All of these activities relate directly to the learning outcomes above.

Assessment Methods

The format of resits will be determined by the Board of Examiners

Description Length Semester When Set Percentage Comment
Written Examination601A60Unseen examination
Other Assessment
Description Semester When Set Percentage Comment
Essay1M201500 words
Computer assessment1M20Test in MCQ format
Assessment Rationale And Relationship

The unseen written examination will test the knowledge and understanding that students have gained for the taught sessions and from private study. The in-course essay will test students' detailed knowledge and critical understanding of a selected area of applied immunology. The in-course MCQ test will test students' knowledge across the breadth of the course and aid preparation for the examination.

Reading Lists