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CHY8825 : Proteins as Drug Targets: structure, function, and molecular modelling

  • Offered for Year: 2022/23
  • Module Leader(s): Dr Agnieszka Bronowska
  • Owning School: Natural and Environmental Sciences
  • Teaching Location: Newcastle City Campus
Semester 1 Credit Value: 10
ECTS Credits: 5.0


The purpose of this course is to equip students with solid foundations in computational structural biology, molecular pharmacology, and proteins as drug targets – from principles governing protein structure and dynamics, drug-protein interactions, through pharmacology, to modern methods in protein structure prediction and protein simulations.

Outline Of Syllabus

Students will learn about relationships between ligand-receptor interactions, protein structure, dynamics and biological activity. The block is intended to make students familiar with the basic terminology, key concepts, data formats and algorithms of modern protein modelling and simulation methods. This will include structure prediction using homology protein modelling and building protein-ligand complexes. During this part of the course, students will learn techniques suitable for generating and visualising macromolecular data using the open-source as well as proprietary software packages.
The second part of the course will focus on concepts of molecular pharmacology, relevant in the context of modern drug chemistry. Students will learn about the methodology of preclinical studies and clinical trials.

Teaching Methods

Teaching Activities
Category Activity Number Length Student Hours Comment
Scheduled Learning And Teaching ActivitiesLecture161:0016:00N/A
Guided Independent StudyAssessment preparation and completion110:0010:00Writing up of dry lab assignment
Structured Guided LearningLecture materials112:0012:00Revision for the final exam
Guided Independent StudyAssessment preparation and completion12:002:00Final examination
Scheduled Learning And Teaching ActivitiesPractical62:0012:00dry labs
Scheduled Learning And Teaching ActivitiesWorkshops21:002:00One orkshop for each thematic block
Scheduled Learning And Teaching ActivitiesDrop-in/surgery61:006:00Drop-in problem-solving sessions
Guided Independent StudyIndependent study140:0040:00Sills practice, background reading and practice exam questions
Teaching Rationale And Relationship


Assessment Methods

The format of resits will be determined by the Board of Examiners

Other Assessment
Description Semester When Set Percentage Comment
Written exercise1M50Assessment of practical work performed in Dry Labs
Written exercise1M50Problem solving exercise
Assessment Rationale And Relationship

The in course assessment will test information literacy and presentation skills.

Reading Lists