CHY8825 : Proteins as Drug Targets: structure, function, and molecular modelling
- Offered for Year: 2022/23
- Module Leader(s): Dr Agnieszka Bronowska
- Owning School: Natural and Environmental Sciences
- Teaching Location: Newcastle City Campus
Semesters
| Semester 1 Credit Value: | 10 |
| ECTS Credits: | 5.0 |
Aims
The purpose of this course is to equip students with solid foundations in computational structural biology, molecular pharmacology, and proteins as drug targets – from principles governing protein structure and dynamics, drug-protein interactions, through pharmacology, to modern methods in protein structure prediction and protein simulations.
Outline Of Syllabus
Students will learn about relationships between ligand-receptor interactions, protein structure, dynamics and biological activity. The block is intended to make students familiar with the basic terminology, key concepts, data formats and algorithms of modern protein modelling and simulation methods. This will include structure prediction using homology protein modelling and building protein-ligand complexes. During this part of the course, students will learn techniques suitable for generating and visualising macromolecular data using the open-source as well as proprietary software packages.
The second part of the course will focus on concepts of molecular pharmacology, relevant in the context of modern drug chemistry. Students will learn about the methodology of preclinical studies and clinical trials.
Teaching Methods
Teaching Activities
| Category | Activity | Number | Length | Student Hours | Comment |
|---|---|---|---|---|---|
| Scheduled Learning And Teaching Activities | Lecture | 16 | 1:00 | 16:00 | N/A |
| Guided Independent Study | Assessment preparation and completion | 1 | 10:00 | 10:00 | Writing up of dry lab assignment |
| Structured Guided Learning | Lecture materials | 1 | 12:00 | 12:00 | Revision for the final exam |
| Guided Independent Study | Assessment preparation and completion | 1 | 2:00 | 2:00 | Final examination |
| Scheduled Learning And Teaching Activities | Practical | 6 | 2:00 | 12:00 | dry labs |
| Scheduled Learning And Teaching Activities | Workshops | 2 | 1:00 | 2:00 | One orkshop for each thematic block |
| Scheduled Learning And Teaching Activities | Drop-in/surgery | 6 | 1:00 | 6:00 | Drop-in problem-solving sessions |
| Guided Independent Study | Independent study | 1 | 40:00 | 40:00 | Sills practice, background reading and practice exam questions |
| Total | 100:00 |
Teaching Rationale And Relationship
N/A
Assessment Methods
The format of resits will be determined by the Board of Examiners
Other Assessment
| Description | Semester | When Set | Percentage | Comment |
|---|---|---|---|---|
| Written exercise | 1 | M | 50 | Assessment of practical work performed in Dry Labs |
| Written exercise | 1 | M | 50 | Problem solving exercise |
Assessment Rationale And Relationship
The in course assessment will test information literacy and presentation skills.
Reading Lists
Timetable
- Timetable Website: www.ncl.ac.uk/timetable/
- CHY8825's Timetable