CSC8316 : Modelling Cellular Systems (Inactive)
- Inactive for Year: 2021/22
- Module Leader(s): Dr Paolo Zuliani
- Owning School: Computing
- Teaching Location: Newcastle City Campus
Semesters
| Semester 1 Credit Value: | 10 |
| ECTS Credits: | 5.0 |
Aims
To understand how biological systems can be represented at different levels of abstraction.
To introduce a range of computational modelling approaches and to select an appropriate modelling strategy for a given biological domain and problem.
To understand how models may be used to represent cellular machinery at a systems level and how models can be used to generate biological hypotheses.
Outline Of Syllabus
Introduction to modelling biochemical systems.
Abstraction and levels of abstraction in modelling.
Structural models: ER modelling and network models.
Metabolic modelling using flux balance analysis.
Dynamic modelling using continuous differential equations.
Simulation.
Modelling discrete stochastic systems.
Parameter estimation and inference.
Biological hypothesis generation.
Model optimisation.
Teaching Methods
Teaching Activities
| Category | Activity | Number | Length | Student Hours | Comment |
|---|---|---|---|---|---|
| Scheduled Learning And Teaching Activities | Lecture | 24 | 1:00 | 24:00 | Lectures |
| Guided Independent Study | Assessment preparation and completion | 24 | 1:00 | 24:00 | Lecture follow-up |
| Scheduled Learning And Teaching Activities | Practical | 12 | 2:00 | 24:00 | Practicals |
| Guided Independent Study | Project work | 12 | 1:00 | 12:00 | Coursework |
| Guided Independent Study | Independent study | 16 | 1:00 | 16:00 | Background reading |
| Total | 100:00 |
Teaching Rationale And Relationship
Lectures will be used to introduce the learning material and for demonstrating the key concepts by example. Students are expected to follow-up lectures within a few days by re-reading and annotating lecture notes to aid deep learning.
This is a very practical subject, and it is important that the learning materials are supported by hands-on opportunities provided by practical classes. Students are expected to spend time on coursework outside timetabled practical classes.
Students aiming for 1st class marks are expected to widen their knowledge beyond the content of lecture notes through background reading.
Assessment Methods
The format of resits will be determined by the Board of Examiners
Other Assessment
| Description | Semester | When Set | Percentage | Comment |
|---|---|---|---|---|
| Practical/lab report | 1 | M | 50 | 4 practicals. Report - 1500 words max excluding figures and tables. |
| Practical/lab report | 1 | M | 50 | 4 practicals. Report - 1500 words max excluding figures and tables |
Assessment Rationale And Relationship
The coursework will assess the students’ ability to understand and apply the concepts of a range of a biological modelling theories and techniques to a given biological system.
Reading Lists
Timetable
- Timetable Website: www.ncl.ac.uk/timetable/
- CSC8316's Timetable