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Module

MMB8032 : Toxicology

  • Offered for Year: 2021/22
  • Module Leader(s): Professor Matthew Wright
  • Lecturer: Dr Ernest Harpur, Dr Simon Wilkinson, Dr Jason Gill, Professor Ann Daly, Dr Vanessa Armstrong, Dr Christopher Morris
  • Owning School: FMS Graduate School
  • Teaching Location: Newcastle City Campus
Semesters
Semester 1 Credit Value: 20
ECTS Credits: 10.0

Aims

The aims of the module are to give a broad understanding in Toxicology, from basic concepts and molecular mechanisms to a review of target organ toxicities, pre-clinical and clinical pharmaceutical toxicology testing. The module will provide a broad overview of Toxicology as it is applied in the Pharmaceutical industries.

Outline Of Syllabus

The module will consider:

1. Basic concepts in Toxicology, (type of toxic response/factors affecting toxicity)

2. Toxicokinetics (ADME/toxicokinetic parameters)

3. Xenobiotic metabolism (phase I/II)

4. Molecular mechanisms (oxidative stress, genotoxicity, carcinogenicity, epigenetics)

5. Necrosis

6. Apoptosis

7. Non-genotoxic carcinogenesis

8. Target organ toxicity (liver, kidney, skin, immune, neuro, lung)

9. Compound safety – pharmaceuticals – pre-clinical

10. Compound safety – pharmaceuticals – clinical trials

11. Idiosyncratic adverse drug reactions

12. Mechanism-based risk assessment

Teaching Methods

Teaching Activities
Category Activity Number Length Student Hours Comment
Scheduled Learning And Teaching ActivitiesLecture201:0020:00Present in person (PIP) Lectures
Guided Independent StudyAssessment preparation and completion127:0027:00Preparation of Oral Presentation based on Paper
Guided Independent StudyAssessment preparation and completion150:0050:00Preparation and Submission of 2500 word Essay
Scheduled Learning And Teaching ActivitiesSmall group teaching21:002:00Present in person (PIP): Seminars - class may be split
Scheduled Learning And Teaching ActivitiesSmall group teaching31:003:00Synchronous online: Tutorials
Scheduled Learning And Teaching ActivitiesSmall group teaching41:306:00Present in person (PIP): Discussions and formative assessments
Scheduled Learning And Teaching ActivitiesSmall group teaching13:003:00Synchronous online: Assessed oral presentations
Guided Independent StudyReflective learning activity115:0015:00Additional Reading and Reflective Learning
Guided Independent StudyIndependent study174:0074:00Preparation of Notes from Lectures and Reading
Total200:00
Teaching Rationale And Relationship

A grounding in the fundamental tenets of Toxicology will be provided by the lectures/small group teaching and through guided private study of course texts, additional suggested materials during the course and through attendance of research seminars. Critical appraisal will be covered in a seminar and essay feedback. Communication of toxicological data will be covered in tutorials and feedback on their presentations.

Should public health circumstances dictate that it is necessary, in person sessions will be moved to online alternatives.

Assessment Methods

The format of resits will be determined by the Board of Examiners

Other Assessment
Description Semester When Set Percentage Comment
Report1M50Appraisal of scientific literature (2500 word essay)
Prof skill assessmnt1M50Synchronous online Oral presentation: 10 minutes and 5 minutes for questions
Formative Assessments
Description Semester When Set Comment
Portfolio1MQuizzes on previous weeks lecture material carried out in small group PIP sessions (split into 4 sessions = 1 formative assessment)
Assessment Rationale And Relationship

Critical appraisal of toxicological data and presentational skills will be tested by both the 2500 word essay and oral presentation. The significant amount of time required for these tasks warrants the 100% of assessment marks.

The formative assessment will test knowledge and understanding of the lecture material.

Reading Lists

Timetable