MMB8032 : Toxicology (Inactive)
- Inactive for Year: 2023/24
- Module Leader(s): Professor Matthew Wright
- Lecturer: Professor Ann Daly, Dr Vanessa Armstrong, Dr Christopher Morris, Dr Tarek Mamdouh Abdelghany, Dr Ernest Harpur, Dr Simon Wilkinson, Dr Jason Gill
- Owning School: FMS Graduate School
- Teaching Location: Newcastle City Campus
Semesters
| Semester 1 Credit Value: | 20 |
| ECTS Credits: | 10.0 |
Aims
The aims of the module are to give a broad understanding in Toxicology, from basic concepts and molecular mechanisms to a review of target organ toxicities, pre-clinical and clinical pharmaceutical toxicology testing. The module will provide a broad overview of Toxicology as it is applied in the Pharmaceutical industries.
Outline Of Syllabus
The module will consider:
1. Basic concepts in Toxicology, (type of toxic response/factors affecting toxicity)
2. Toxicokinetics (ADME/toxicokinetic parameters)
3. Xenobiotic metabolism (phase I/II)
4. Molecular mechanisms (oxidative stress, genotoxicity, carcinogenicity, epigenetics)
5. Necrosis
6. Apoptosis
7. Non-genotoxic carcinogenesis
8. Target organ toxicity (liver, kidney, skin, immune, neuro, lung)
9. Compound safety – pharmaceuticals – pre-clinical
10. Compound safety – pharmaceuticals – clinical trials
11. Idiosyncratic adverse drug reactions
12. Mechanism-based risk assessment
Teaching Methods
Teaching Activities
| Category | Activity | Number | Length | Student Hours | Comment |
|---|---|---|---|---|---|
| Scheduled Learning And Teaching Activities | Lecture | 20 | 1:00 | 20:00 | Present in person (PIP) Lectures |
| Guided Independent Study | Assessment preparation and completion | 1 | 50:00 | 50:00 | Preparation and Submission of 2500 word Essay |
| Guided Independent Study | Assessment preparation and completion | 1 | 27:00 | 27:00 | Preparation of Oral Presentation based on Paper |
| Scheduled Learning And Teaching Activities | Small group teaching | 1 | 3:00 | 3:00 | Synchronous online: Assessed oral presentations |
| Scheduled Learning And Teaching Activities | Small group teaching | 3 | 1:00 | 3:00 | Synchronous online: Tutorials |
| Scheduled Learning And Teaching Activities | Small group teaching | 4 | 1:30 | 6:00 | Present in person (PIP): Discussions and formative assessments |
| Scheduled Learning And Teaching Activities | Small group teaching | 2 | 1:00 | 2:00 | Present in person (PIP): Seminars - class may be split |
| Guided Independent Study | Reflective learning activity | 1 | 15:00 | 15:00 | Additional Reading and Reflective Learning |
| Guided Independent Study | Independent study | 1 | 74:00 | 74:00 | Preparation of Notes from Lectures and Reading |
| Total | 200:00 |
Teaching Rationale And Relationship
A grounding in the fundamental tenets of Toxicology will be provided by the lectures/small group teaching and through guided private study of course texts, additional suggested materials during the course and through attendance of research seminars. Critical appraisal will be covered in a seminar and essay feedback. Communication of toxicological data will be covered in tutorials and feedback on their presentations.
Assessment Methods
The format of resits will be determined by the Board of Examiners
Other Assessment
| Description | Semester | When Set | Percentage | Comment |
|---|---|---|---|---|
| Report | 1 | M | 50 | Appraisal of scientific literature (2500 word essay) |
| Prof skill assessmnt | 1 | M | 50 | Synchronous online Oral presentation: 10 minutes and 5 minutes for questions |
Formative Assessments
| Description | Semester | When Set | Comment |
|---|---|---|---|
| Portfolio | 1 | M | Quizzes on previous weeks lecture material carried out in small group PIP sessions (split into 4 sessions = 1 formative assessment) |
Assessment Rationale And Relationship
Critical appraisal of toxicological data and presentational skills will be tested by both the 2500 word essay and oral presentation. The significant amount of time required for these tasks warrants the 100% of assessment marks.
The formative assessment will test knowledge and understanding of the lecture material.
Reading Lists
Timetable
- Timetable Website: www.ncl.ac.uk/timetable/
- MMB8032's Timetable