Skip to main content

Module

BGM3061 : Genetic variation in common disease

  • Offered for Year: 2020/21
  • Module Leader(s): Professor Julie Irving
  • Lecturer: Dr Catherine Meplan, Professor Mark Walker, Professor Quentin Anstee, Professor Heather Cordell, Dr Daryl Shanley, Professor John Loughlin
  • Owning School: Biomedical, Nutritional and Sports Scien
  • Teaching Location: Newcastle City Campus
Semesters
Semester 1 Credit Value: 10
ECTS Credits: 5.0

Aims

The module aims to use expertise in common human disease (eg., type II diabetes, osteoarthritis, non-alcoholic fatty liver disease and diseases associated with ageing) to;
•       explore the principle that nearly all human disease has a genetic component and that several common diseases do not fit into simple Mendelian patterns of inheritance but fall into the category of disease genetics termed “complex disease”.
•       consider how the genetic (heritable) component of a complex disease (CD) can be assessed and how genes responsible for CD can be identified and this knowledge used in diagnosis and patient management.
•       consider the role of inherited variation in genes and drug responses (pharmacogenetics.
•       consider how knowledge of disease genetics informs the debate about disease pathogenesis and the social and ethical issues that can arise from the genome project and from the use and misuse of genetics and genetic information.

Outline Of Syllabus

The module covers the following broad issues:

• Definition of complex diseases
• How to identify and assess the heritable component of a complex disease
• Selecting and applying different research strategies
• Linkage versus association analysis
• Pharmacogenetics
• Data Interpretation
• Knowledge of key examples of complex diseases.
• Social and Ethical issues arising from the study of complex diseases

Teaching Methods

Please note that module leaders are reviewing the module teaching and assessment methods for Semester 2 modules, in light of the Covid-19 restrictions. There may also be a few further changes to Semester 1 modules. Final information will be available by the end of August 2020 in for Semester 1 modules and the end of October 2020 for Semester 2 modules.

Teaching Activities
Category Activity Number Length Student Hours Comment
Structured Guided LearningLecture materials91:009:00Non-synchronous online
Scheduled Learning And Teaching ActivitiesSmall group teaching21:002:00Seminars - PIP
Guided Independent StudyIndependent study188:0088:00Writing up lecture notes, revision and general reading.
Scheduled Learning And Teaching ActivitiesModule talk11:001:00Synchronous online
Total100:00
Jointly Taught With
Code Title
BGM3056Evolution and Genomics
BGM3058Integrated Genetics
BMS3010Genetics and Human Disease
BGM3062Genetics of Development and its Disorders
Teaching Rationale And Relationship

This is an undergraduate module based on an area of research excellence within the University. The module is mostly based on lecture materials with discussion of key concepts. The learning outcomes are predominantly knowledge based with key skills in critical evaluation and written communication of that knowledge being assessed. In addition, there is assessment of data interpretation which will test the student’s understanding of key principles on which the taught material is based and basic numeracy. The seminar provides the students with an opportunity to have a broad based discussion of some of the major issues in medical science in the presence of their peers.

Assessment Methods

Please note that module leaders are reviewing the module teaching and assessment methods for Semester 2 modules, in light of the Covid-19 restrictions. There may also be a few further changes to Semester 1 modules. Final information will be available by the end of August 2020 in for Semester 1 modules and the end of October 2020 for Semester 2 modules.

The format of resits will be determined by the Board of Examiners

Exam Pairings
Module Code Module Title Semester Comment
BMS3010Genetics and Human Disease1N/A
Other Assessment
Description Semester When Set Percentage Comment
Essay1M30Paper Interpretation Exercise. Online (remote) with word count of 500-1000.
Essay2A70Open Book Essay (1 from a choice of 3). Students will be required to complete the essay over a 5-7 day period.
Assessment Rationale And Relationship

The open book essay provides evidence of key writing skills that allow knowledge and understanding of the topics to be demonstrated along with the ability to integrate this within the context of published material.

The paper interpretation exercise tests the understanding of research literature,
discipline knowledge, data analyses, methodologies and critical appraisal abilities.

Reading Lists

Timetable