Skip to main content

Module

BGM3062 : Genetics of Development and its Disorders

  • Offered for Year: 2021/22
  • Module Leader(s): Dr Katarzyna Pirog
  • Lecturer: Professor Lyle Armstrong, Dr Chris Blau, Dr Helen Phillips, Dr Steven Lisgo, Dr Colin Miles, Dr Bill Chaudhry, Professor John Sayer, Dr Gavin Clowry, Dr Michael Jackson
  • Owning School: Biomedical, Nutritional and Sports Scien
  • Teaching Location: Newcastle City Campus
Semesters
Semester 1 Credit Value: 10
ECTS Credits: 5.0

Aims

The module aims are:

•       to provide an overview of vertebrate development
•       to describe in more detail the development of several organ systems.
•       to identify key developmental processes and the genes and genetic pathways that are involved.
•       to consider how the same gene families are important in the development of multiple organs and that there are processes that are common to the development of many organs.
•       to consider the role of developmental genes in genetic disorders.

Outline Of Syllabus

Many human disorders have a developmental origin and knowledge of the processes underpinning development is an important step towards understanding gene function and disease mechanisms. As the normal and abnormal development of a range of model organisms is analysed as part of studies of gene function, this module will include information from several species, although it is focused on vertebrate development.

The module will provide an overview of key concepts in vertebrate development and a framework for understanding developmental research and its role in underpinning research on human genetic disorders.

The module syllabus will include:

•       establishment of the basic body plan
•       establishment and breaking of symmetry
•       development of organs derived from endoderm, mesoderm and ectoderm covering their patterning and organization from stem cells to genetic disorders. Examples might be gut, kidney, limb, the hematopoietic system and brain.

Teaching Methods

Teaching Activities
Category Activity Number Length Student Hours Comment
Structured Guided LearningLecture materials101:0010:00Non-synchronous online
Guided Independent StudyAssessment preparation and completion121:0012:00Generation of research paper.
Scheduled Learning And Teaching ActivitiesLecture51:005:00PIP
Scheduled Learning And Teaching ActivitiesWorkshops11:001:00workshop/seminar on ethics - PIP
Scheduled Learning And Teaching ActivitiesWorkshops14:004:00Working through online expression/development database - PIP
Guided Independent StudyIndependent study168:0068:00Writing up lecture notes, revision and general reading.
Total100:00
Jointly Taught With
Code Title
BGM3056Evolution and Genomics
BGM3058Integrated Genetics
BGM3061Genetic variation in common disease
Teaching Rationale And Relationship

Lecture materials will provide the majority of the knowledge base and should stimulate the students to reflect and do further reading (independent study).

Workshops 1) will expose the students to ethical concerns surrounding use of animals and human tissues in research 2) provide the key foundation for generation of the in course assessed research paper which they will complete as guided independent study.



Public health contingency:
All workshops and lectures can/will move to online either as synchronous or non-synchronous delivery.

Assessment Methods

The format of resits will be determined by the Board of Examiners

Exams
Description Length Semester When Set Percentage Comment
Written Examination902A7024 hour open book exam 70% essay (1 essay from choice of 2) (60 mins) 30% SAQs (30 mins) (online remote)
Other Assessment
Description Semester When Set Percentage Comment
Research paper1M30Arising from use of developmental databases. Written exercise, 1,500 words maximum'. Submission via Turnitin/Canvas
Assessment Rationale And Relationship

The open book essay assesses the depth of understanding of one aspect of the module while the short answer questions enable knowledge and understanding over the breadth of the module to be demonstrated.

The research paper tests the ability to synthesize data from online resources, allows students to show further in-depth understanding of the topic, and critical evaluation skills.

Reading Lists

Timetable