CHY3108 : Advanced Organic Chemistry (Inactive)
- Inactive for Year: 2024/25
- Module Leader(s): Dr Michael Hall
- Lecturer: Dr David Fulton, Dr Hanno Kossen, Dr Michael Carroll, Dr Johan Eriksson, Dr Cristina Navarro Reguero
- Practical Supervisor: Dr Zuleykha McMillan
- Owning School: Natural and Environmental Sciences
- Teaching Location: Newcastle City Campus
Semesters
Your programme is made up of credits, the total differs on programme to programme.
| Semester 1 Credit Value: | 20 |
| Semester 2 Credit Value: | 10 |
| ECTS Credits: | 15.0 |
| European Credit Transfer System | |
Aims
To equip students with the necessary knowledge and understanding for them to study organic chemistry at Stage 4; to further enhance the students’ knowledge of the chemistry of aldehydes, ketones, esters, amides and related species; to allow students to design syntheses of compounds containing carbonyl groups; to illustrate the rich and diverse chemistry of the carbonyl group and to show how this can be logically predicted; to introduce the concept of retrosynthetic analysis; to show how the chemistry of the carbonyl unit can be used in total syntheses. To show the importance of carbonyl reactions in enzyme chemistry. To highlight the use of organo-element compounds in the synthesis and reactions of carbonyl compounds.
Outline Of Syllabus
Synthesis of Carbonoyls
Oxidation of alcohols; chromium (Jones, PCC, PDC), ruthenium (TPAP), Swern, hypervalent iodine and MnO2.
Selective Reductions
Oxidative cleavage of C=C; ozonolysis
Addition of hydrides and carbanions; reaction with carboxylic acids, esters, imines and Weinreb amides
Dithianes (unpolung), Benzoin condensation and MPV reaction
P-block and organometallic chemistry
General mechanisms for nucleophilic attack on C=O and C=N
Nucelophilic attack of organometallics; synthesis of organometallics and selectivity
Conjugate additions; hard vs soft nucleophiles and the control of 1,2- versus 1,4-addition to alpha,beta-unsaturated carbonyl compounds
P-Block Chemistry Si, S, P, B
Heteroaromatic Chemistry
Aromatic systems containing heteroatoms; introduction and overview
Membered heteroatromatics containing one heteroatom; pyrroles, furans and thiophenes
Membered heteroaromatics containing one heteroatom; pyridines
Fused heteroaromatics; indoles and quinolines
Heteroaromatics containing more than one heteroatom
Synthesis
Classical synthesis and synthetic strategy
Retrosynthetic analysis
Protecting group chemistry
Syntheses of specific molecules drawn from the classical and recent literature and covering molecules of theoretical interest, natural products and pharmaceuticals
Organic Chemistry Laboratory Course
Each student pair does the experiments from the following list:
An investigation into the Stereoselectivity of Wittig Reactions
Synthesis of a Queen Honeybee Pheromone
Discovering Selectivity in the Diels-Alder Reaction
Teaching Methods
Teaching Activities
| Category | Activity | Number | Length | Student Hours | Comment |
|---|---|---|---|---|---|
| Guided Independent Study | Assessment preparation and completion | 48 | 0:50 | 40:00 | Assessment - Preparation and completion of revision for end of semester alternate assessment |
| Guided Independent Study | Assessment preparation and completion | 1 | 49:00 | 49:00 | Assessment - Preparation and completion of end of semester alternate assessment |
| Structured Guided Learning | Lecture materials | 48 | 1:00 | 48:00 | PiP lectures. Online lectures in case no PiP due to social distancing regulations. |
| Scheduled Learning And Teaching Activities | Practical | 5 | 10:00 | 50:00 | lab sessions with online exercises as backup. |
| Scheduled Learning And Teaching Activities | Workshops | 3 | 1:00 | 3:00 | Online retrosynthesis workshops |
| Scheduled Learning And Teaching Activities | Drop-in/surgery | 16 | 1:00 | 16:00 | PiP drop-ins for student questions or online in case no PiP due to social distancing regulations. |
| Guided Independent Study | Independent study | 1 | 93:00 | 93:00 | Independent study, background reading |
| Scheduled Learning And Teaching Activities | Module talk | 1 | 1:00 | 1:00 | Laboratory induction |
| Total | 300:00 |
Teaching Rationale And Relationship
Lecture materials give students the opportunity to learn advanced concepts in organic chemistry, encompassing synthetic and mechanistic principles. The small group teaching sessions look over these techniques.
In practical classes competencies in practical procedures, observation, record-keeping and report writing, will be taught and learnt.
Assessment Methods
The format of resits will be determined by the Board of Examiners
Exams
| Description | Length | Semester | When Set | Percentage | Comment |
|---|---|---|---|---|---|
| Digital Examination | 180 | 2 | A | 67 | Computer based MCQ and long answers or online assessment as alternative in the case of no PiP examinations |
Other Assessment
| Description | Semester | When Set | Percentage | Comment |
|---|---|---|---|---|
| Practical/lab report | 1 | M | 33 | Laboratory online assessment |
Zero Weighted Pass/Fail Assessments
| Description | When Set | Comment |
|---|---|---|
| Practical/lab report | M | Laboratory Skills assessment |
Assessment Rationale And Relationship
The exam will test the students’ knowledge and understanding of the content of this module in the context of both synthetic and mechanistic chemistry. Formative assessment in the form of coursework will be set in Semester 1.
The laboratory component practical involves the assessment of a complex selection of skills learnt in about 4 experiments per student, spread over the major areas of organic chemistry.
Students are required to obtain at least 35% in the laboratory component in order for the examination mark to be included in the final module mark. Students who score
An alternative assessment will be set for any Semester 1 Study Abroad students taking this module, who will not be in Newcastle during the January assessment period
Reading Lists
Timetable
- Timetable Website: www.ncl.ac.uk/timetable/
- CHY3108's Timetable