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Module

CHY3305 : Advanced Inorganic Chemistry (Distance Learning)

  • Offered for Year: 2020/21
  • Module Leader(s): Professor Andrew Houlton
  • Lecturer: Dr Keith Izod, Dr Simon Doherty
  • Owning School: Natural and Environmental Sciences
  • Teaching Location: Newcastle City Campus
Semesters
Semester 1 Credit Value: 10
Semester 2 Credit Value: 10
ECTS Credits: 10.0

Aims

To introduce the fundamental principles and reactions of organometallic chemistry; to introduce concepts of homogeneous catalysis; to demonstrate the diverse chemistry of the s- and p-elements; to introduce inorganic aspects of biological systems and metals in biomedicine

Outline Of Syllabus

Organometallic Chemistry
Dr S Doherty

Background and introduction
The 18-Electron rule
Important ligand types; carbonyl (bonding and binary carbonyls)
Pi-ligands, hydrides, phosphines
The synthesis of organometallic compounds
Organometallic reaction mechanisms 1. Reaction at the metal: ligand substitution, oxidative addition and reductive elimination
Organometallic reaction mechanisms 2: Reactions involving the ligand: migratory insertion, reductive elimination and nucleophilic additions and abstractions
Transition metal carbene complexes: synthesis, structure and reactivity
Homogeneous catalysis: an introduction

Comparative Main Group Chemistry
Dr KJ Izod

General principles. Complexes of the s-elements: macrocycles and the macrocyclic effect, alkalides and electrides
Organometallics of the electropositive metals: an introduction to electron-deficient compounds
More electron-deficient compounds: boranes and carboranes, Zintl ions
Low oxidation states of the p-block elements (groups 13 and 14)
E=E bonds (groups 14 and 15); synthesis and reactions. Phosphorus (V) ylides and related compounds
E=E’ bonds – stability, synthesis and reactions

Bioinorganic Chemistry
Professor A Houlton

An introduction to bioinorganic chemistry; the essential metals, metal ion overload-deficiency and treatments.
An introduction to metalloproteins. Protein structure, metal ion binding groups, protein function and role of metal ions.
Myoglobin– protein structure and function, haem group, oxidation and spin states of the metal centre before and after oxygen coordination
Haemoglobin – protein structure and function, comparison with Mb, the cooperative nature of oxygen binding in haemoglobin
Metallo-enzymes – details of the structure and function of Zn and Fe-containing systems
Metal ion binding in DNA. Discovery of metal-containing anti-tumour drugs. mode of action, side effects. Metal-based drugs

Teaching Methods

Module leaders are revising this content in light of the Covid 19 restrictions.
Revised and approved detail information will be available by 17 August.

Assessment Methods

Module leaders are revising this content in light of the Covid 19 restrictions.
Revised and approved detail information will be available by 17 August.

Reading Lists

Timetable