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Module

CHY3305 : Advanced Inorganic Chemistry (Distance Learning)

  • Offered for Year: 2021/22
  • Module Leader(s): Professor Andrew Houlton
  • Lecturer: Dr Keith Izod, Dr Simon Doherty
  • Owning School: Natural and Environmental Sciences
  • Teaching Location: Newcastle City Campus
Semesters
Semester 1 Credit Value: 10
Semester 2 Credit Value: 10
ECTS Credits: 10.0

Aims

To introduce the fundamental principles and reactions of organometallic chemistry; to introduce concepts of homogeneous catalysis; to demonstrate the diverse chemistry of the s- and p-elements; to introduce inorganic aspects of biological systems and metals in biomedicine

Outline Of Syllabus

Organometallic Chemistry

Background and introduction
The 18-Electron rule
Important ligand types; carbonyl (bonding and binary carbonyls)
Pi-ligands, hydrides, phosphines
The synthesis of organometallic compounds
Organometallic reaction mechanisms 1. Reaction at the metal: ligand substitution, oxidative addition and reductive elimination
Organometallic reaction mechanisms 2: Reactions involving the ligand: migratory insertion, reductive elimination and nucleophilic additions and abstractions
Transition metal carbene complexes: synthesis, structure and reactivity
Homogeneous catalysis: an introduction

Comparative Main Group Chemistry

General principles. Complexes of the s-elements: macrocycles and the macrocyclic effect, alkalides and electrides
Organometallics of the electropositive metals: an introduction to electron-deficient compounds
More electron-deficient compounds: boranes and carboranes, Zintl ions
Low oxidation states of the p-block elements (groups 13 and 14)
E=E bonds (groups 14 and 15); synthesis and reactions. Phosphorus (V) ylides and related compounds
E=E’ bonds – stability, synthesis and reactions

Bioinorganic Chemistry

An introduction to bioinorganic chemistry; the essential metals, metal ion overload-deficiency and treatments.
An introduction to metalloproteins. Protein structure, metal ion binding groups, protein function and role of metal ions.
Myoglobin– protein structure and function, haem group, oxidation and spin states of the metal centre before and after oxygen coordination
Haemoglobin – protein structure and function, comparison with Mb, the cooperative nature of oxygen binding in haemoglobin
Metallo-enzymes – details of the structure and function of Zn and Fe-containing systems
Metal ion binding in DNA. Discovery of metal-containing anti-tumour drugs. mode of action, side effects. Metal-based drugs

Teaching Methods

Please note that module leaders are reviewing the module teaching and assessment methods for Semester 2 modules, in light of the Covid-19 restrictions. There may also be a few further changes to Semester 1 modules. Final information will be available by the end of August 2020 in for Semester 1 modules and the end of October 2020 for Semester 2 modules.

Teaching Activities
Category Activity Number Length Student Hours Comment
Structured Guided LearningLecture materials61:006:00Course material will be released online throughout semester 1 and 2
Structured Guided LearningLecture materials10:300:30Formative worksheets provided throughout semester 1 and 2 to support learning
Guided Independent StudyAssessment preparation and completion130:0030:00Assessment to cover topics taught throughout the module
Placement/Study AbroadEmployer-based learning480:3024:00Preparation and completion for take home exam
Structured Guided LearningLecture materials61:006:00Synchronous online - 2 x 1hr online session (per lecturer - KJI, SD, AHo)
Structured Guided LearningLecture materials31:003:00Online revision sessions at the end of module
Guided Independent StudyDirected research and reading81:008:00Reading of online materials
Guided Independent StudyIndependent study1122:30122:30Independent study - review topics and materials taught within the module
Total200:00
Jointly Taught With
Code Title
CHY3306Advanced Inorganic Chemistry
CHY8841Contemporary Inorganic and Physical Chemistry
Teaching Rationale And Relationship

Lecture materials are delivered electronically and are used to impart knowledge. Student learning is supported by the provision of worksheets.

Assessment Methods

Please note that module leaders are reviewing the module teaching and assessment methods for Semester 2 modules, in light of the Covid-19 restrictions. There may also be a few further changes to Semester 1 modules. Final information will be available by the end of August 2020 in for Semester 1 modules and the end of October 2020 for Semester 2 modules.

The format of resits will be determined by the Board of Examiners

Exams
Description Length Semester When Set Percentage Comment
Written Examination1802A100Examination or Alternate written online assessment
Exam Pairings
Module Code Module Title Semester Comment
CHY3306Advanced Inorganic Chemistry2N/A
CHY8841Contemporary Inorganic and Physical Chemistry2N/A
Assessment Rationale And Relationship

The online alternate assessment will test the student's knowledge and understanding from all topics covered in the inorganic chemistry module.

Students sit the examination on their return to Newcastle for one week during the Semester 2 examination period.

Reading Lists

Timetable