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Module

CMB2001 : Control of Eukaryotic Gene Expression

  • Offered for Year: 2020/21
  • Module Leader(s): Dr Simon Whitehall
  • Lecturer: Professor Neil Perkins, Dr Nick Watkins
  • Owning School: Biomedical, Nutritional and Sports Scien
  • Teaching Location: Newcastle City Campus
Semesters
Semester 1 Credit Value: 10
ECTS Credits: 5.0

Aims

To develop knowledge and understanding of the mechanisms by which eukaryotes regulate gene expression through control of transcription, chromatin, mRNA stability and translation.

Outline Of Syllabus

This module introduces the basics of gene structure and transcription in eukaryotes; the role of, promoters, polymerases, and transcription factors and the regulation of their interaction with DNA. The structure of chromatin will be covered and the key role played by chromatin modifying enzymes in the regulation of transcription will be discussed. The mechanisms by which the activity of key human transcription factors is controlled in response to stress and infection will also be covered. The lectures provide an introduction to mRNA splicing and will also describe how regulation of mRNA stability can contribute to control of gene expression in eukaryotes. Because ultimately proteins are usually the final gene product, it is not surprising that translation, the last step in protein synthesis, is under precise cellular control. The lectures will therefore describe eukaryotic translation and the mechanisms by which it is regulated

Teaching Methods

Module leaders are revising this content in light of the Covid 19 restrictions.
Revised and approved detail information will be available by 17 August.

Assessment Methods

Module leaders are revising this content in light of the Covid 19 restrictions.
Revised and approved detail information will be available by 17 August.

Reading Lists

Timetable