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Module

MMB8014 : Genetics of Common Disease

  • Offered for Year: 2020/21
  • Module Leader(s): Professor Heather Cordell
  • Lecturer: Dr Ian Wilson, Dr Christopher Miles Morris, Dr Marc Woodbury-Smith, Dr Joanna Elson, Professor John Loughlin
  • Owning School: FMS Graduate School
  • Teaching Location: Newcastle City Campus
Semesters
Semester 1 Credit Value: 20
ECTS Credits: 10.0

Aims

This module aims to address a major area of current medical research and to provide students with an understanding of the strengths and weakness of both the current subject knowledge in this area and the practical approaches to it. Understanding the genetics of complex disease has been identified as a major post-genome challenge. The module aims to equip Level 7 students with the necessary skills to understand and develop research strategies to investigate the inheritance of complex diseases.
Specific aims are:

•       To inform students in genetic variation and the genetics of non-Mendelian (complex) disease.

•       To introduce students to the different strategies and information input required to identify genes in complex diseases.

•       To compare the various practical approaches used to identify the genetic basis of common disease and to elucidate the role of genes in common disease.

•       To outline the relevance and utility of genetic investigations to understanding the pathogenesis of common diseases.

Outline Of Syllabus

The module will cover:

•       Genetic variation and the definition of complex genetic diseases.

•       How to identify and assess the heritable component of a complex disease.

•       Selecting and applying different research strategies.

•       Linkage versus association analysis.

•       Genome-wide association studies.

•       Data/results interpretation and use of computer packages for performing statistical genetic analysis

•       Knowledge of key examples of complex diseases, including examples such as: Diabetes, Oesteoarthritis, Alzheimer’s Disease, Autism.

Teaching Methods

Module leaders are revising this content in light of the Covid 19 restrictions.
Revised and approved detail information will be available by 17 August.

Assessment Methods

Module leaders are revising this content in light of the Covid 19 restrictions.
Revised and approved detail information will be available by 17 August.

Reading Lists

Timetable