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Module

MMB8014 : Genetics of Common Disease

  • Offered for Year: 2020/21
  • Module Leader(s): Professor Heather Cordell
  • Lecturer: Professor John Loughlin, Dr Ian Wilson, Dr Marc Woodbury-Smith, Dr Joanna Elson, Dr Christopher Morris
  • Owning School: FMS Graduate School
  • Teaching Location: Newcastle City Campus
Semesters
Semester 1 Credit Value: 20
ECTS Credits: 10.0

Aims

This module aims to address a major area of current medical research and to provide students with an understanding of the strengths and weakness of both the current subject knowledge in this area and the practical approaches to it. Understanding the genetics of complex disease has been identified as a major post-genome challenge. The module aims to equip Level 7 students with the necessary skills to understand and develop research strategies to investigate the inheritance of complex diseases.
Specific aims are:

•       To inform students in genetic variation and the genetics of non-Mendelian (complex) disease.

•       To introduce students to the different strategies and information input required to identify genes in complex diseases.

•       To compare the various practical approaches used to identify the genetic basis of common disease and to elucidate the role of genes in common disease.

•       To outline the relevance and utility of genetic investigations to understanding the pathogenesis of common diseases.

Outline Of Syllabus

The module will cover:

•       Genetic variation and the definition of complex genetic diseases.

•       How to identify and assess the heritable component of a complex disease.

•       Selecting and applying different research strategies.

•       Linkage versus association analysis.

•       Genome-wide association studies.

•       Data/results interpretation and use of computer packages for performing statistical genetic analysis

•       Knowledge of key examples of complex diseases, including examples such as: Diabetes, Oesteoarthritis, Alzheimer’s Disease, Autism.

Teaching Methods

Please note that module leaders are reviewing the module teaching and assessment methods for Semester 2 modules, in light of the Covid-19 restrictions. There may also be a few further changes to Semester 1 modules. Final information will be available by the end of August 2020 in for Semester 1 modules and the end of October 2020 for Semester 2 modules.

Teaching Activities
Category Activity Number Length Student Hours Comment
Structured Guided LearningLecture materials171:0017:00Non-synchronous online
Guided Independent StudyAssessment preparation and completion151:0015:00Preparation and submission of PC assessment
Guided Independent StudyAssessment preparation and completion151:0015:00Preparation and Submission of Essay 1
Guided Independent StudyAssessment preparation and completion201:0020:00Preparation and submission of Essay 2
Structured Guided LearningStructured research and reading activities151:0015:00Structured directed reading
Scheduled Learning And Teaching ActivitiesSmall group teaching12:002:00Present in person: seminar
Guided Independent StudySkills practice101:0010:00Computer practical work
Scheduled Learning And Teaching ActivitiesSmall group teaching41:004:00Present in person: seminars
Scheduled Learning And Teaching ActivitiesSmall group teaching42:008:00Synchronous online: seminars
Scheduled Learning And Teaching ActivitiesWorkshops41:004:00Present in person: IT Workshop (Computer Practical)
Guided Independent StudyReflective learning activity251:0025:00Additional Reading and Reflective Learning
Guided Independent StudyIndependent study151:0015:00Additional directed reading
Guided Independent StudyIndependent study501:0050:00Additional supplementary reading and revision of course material
Total200:00
Teaching Rationale And Relationship

Lecture materials will provide the students with a specific knowledge as a platform for private study. Together with computer practicals and seminars these lecture materials will encourage the students to reflect both individually and in small groups on the state of knowledge in research in complex diseases. Students will practice critical appraisal, data analysis and interpretation during the computer practicals. Seminars will encourage the students to reflect on their learning. All of these activities relate directly to the learning outcomes above.

Assessment Methods

Please note that module leaders are reviewing the module teaching and assessment methods for Semester 2 modules, in light of the Covid-19 restrictions. There may also be a few further changes to Semester 1 modules. Final information will be available by the end of August 2020 in for Semester 1 modules and the end of October 2020 for Semester 2 modules.

The format of resits will be determined by the Board of Examiners

Other Assessment
Description Semester When Set Percentage Comment
Computer assessment1M30Open book assessment of practical/analytical skills.
Essay1M20Critical evaluation of a published paper from a choice of 8 options. Max 1000 - 1500 words
Essay1M501 essay from a choice of 3 options. Max 2000 words
Assessment Rationale And Relationship

The computer analysis exercise tests application of knowledge, understanding and ability to critically evaluate and interpret a given data set. The first essay tests the student’s comprehension and ability to discuss the subject knowledge critically. The second essay tests the student’s knowledge base, comprehension and ability to discuss the subject knowledge critically.

PC Assessment: Open book assessment of practical/analytical skills involving statistical data analysis. Data set to be provided. The students will be given the data set and a worksheet (suggesting the various analysis approaches to be used) and will have two weeks in which to perform the analysis and to write up their findings. The analysis itself should take around 2-3 hours, with another 2-3 hours required for preparation work and up to 10 hours for writing up. Essay 1: Critical appraisal of a key recent paper in the field, to be chosen from a choice of a minimum of 8 (max 1000 - 1500 words). Preparation work should take around 5 hours, with up to 10 hours for writing up. Essay 2: Description of the current state of knowledge of a topic in the field, to be chosen from 3 options (max 2000 words). Preparation work should take around 10 hours, with up to 10 hours for writing up.

Reading Lists

Timetable