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Module

MMB8025 : Transplantation Sciences

  • Offered for Year: 2020/21
  • Module Leader(s): Dr Xiao Wang
  • Lecturer: Dr Emily Thompson, Professor John Kirby, Professor Francisco Figueiredo, Dr Gareth Parry, Professor Andrew Gennery, Dr Bill Scott, Dr Laura Jardine, Dr William Howell, Dr Amy Publicover, Professor Simi Ali, Professor Christopher Ward
  • Owning School: FMS Graduate School
  • Teaching Location: Newcastle City Campus
Semesters
Semester 1 Credit Value: 20
ECTS Credits: 10.0

Aims

The module aims:

1. To provide an overview of and introduction to transplantation sciences in the context of solid organ and haematopoietic stem cell transplants

2. To provide sound understanding of the scientific basis underlying the therapeutic benefits and adverse effects of clinical transplants

3. To highlight the research areas in transplantation where applications of immunology, cell biology and novel technology are impacting on clinical outcome and patient wellbeing

Outline Of Syllabus

The module covers following main areas:

1. Transplantation immunology: allo-Ag presentation/recognition, cellular and molecular factors involved in alloreactive immune responses, antibody mediated rejection, immunotolerance induction and immunosuppression.

2. HLA system and tissue typing: the genetic organization and polymorphisms of the HLA system, the protein structure of HLA antigens, non-HLA genetics, HLA in health and disease, and the impact of HLA matching on donor selection and transplant outcome.

3. Transplant therapeutic effect: haematopoietic stem cell transplant for leukaemia, lymphoma, and primary immunodeficiency, islet transplant and beta-cell replacement for type1 diabetes, corneal/limbal stem cell transplant for damaged tissue repair and identification of biomarkers of tolerance and rejection.

4. Transplant complications: The risk factors and pathogenesis, the prevention and development of novel therapies are introduced and discussed in the context of acute and chronic kidney graft rejection, non-immune injury in chronic lung allograft rejection, graft-versus-host disease in haematopoietic stem cell transplant.

5. Techniques and approaches being developed to improve transplant outcome and increase the supply of donor organs, such as manipulation of haematopoietic stem cell grafts for clinical use and reconditioning donor lungs for transplantation.

Teaching Methods

Please note that module leaders are reviewing the module teaching and assessment methods for Semester 2 modules, in light of the Covid-19 restrictions. There may also be a few further changes to Semester 1 modules. Final information will be available by the end of August 2020 in for Semester 1 modules and the end of October 2020 for Semester 2 modules.

Teaching Activities
Category Activity Number Length Student Hours Comment
Structured Guided LearningLecture materials91:009:00Non-synchronous online
Guided Independent StudyAssessment preparation and completion127:0027:00Preparation of Presentation
Guided Independent StudyAssessment preparation and completion130:0030:00Preparation & Submission of Essay
Scheduled Learning And Teaching ActivitiesSmall group teaching81:008:00Synchronous online
Scheduled Learning And Teaching ActivitiesSmall group teaching41:004:00Present in person: Seminars
Scheduled Learning And Teaching ActivitiesWorkshops13:003:00Present in person: Oral presentation
Guided Independent StudyReflective learning activity119:0019:00Additional Reading & Reflective Learning
Guided Independent StudyIndependent study1100:00100:00Preparation of Notes from Lectures and Reading
Total200:00
Teaching Rationale And Relationship

Interactive sessions, pre-recorded lectures and seminars will provide the students with a specific knowledge as a platform for private study. This material will promote discussion of key concepts and critical appraisal of current practices and encourage the students to reflect on their learning. Students will practice presentation skills and report writing (for assessment). All of these activities relate directly to the learning outcomes above.

Assessment Methods

Please note that module leaders are reviewing the module teaching and assessment methods for Semester 2 modules, in light of the Covid-19 restrictions. There may also be a few further changes to Semester 1 modules. Final information will be available by the end of August 2020 in for Semester 1 modules and the end of October 2020 for Semester 2 modules.

The format of resits will be determined by the Board of Examiners

Other Assessment
Description Semester When Set Percentage Comment
Prof skill assessmnt1M40Poster and presentation of poster: 5 minutes and 2-3 minutes question and answer
Essay1M603000 word essay
Assessment Rationale And Relationship

The 3000 word in-course essay allows the student to demonstrate and reinforce their understanding of knowledge acquired from taught lectures, which encourages the student to develop intellectual skills and independent learning approaches supported by interactive lectures and additional literature reading. This task also provides the student an opportunity to exercise critical thinking and scientific writing skills.
Poster presentation encourages integration and application of knowledge acquired from the lectures and self-directed studies. It also fosters critical thinking, problem solving and creativity.

Reading Lists

Timetable