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MMB8025 : Transplantation Sciences

  • Offered for Year: 2020/21
  • Module Leader(s): Dr Xiao Wang
  • Lecturer: Dr Gareth Parry, Dr William Howell, Dr Amy Publicover, Professor John Kirby, Dr Christopher Ward, Dr Michael White, Dr Peter Middleton, Professor Francisco Figueiredo, Dr Emily Thompson, Professor Andrew Gennery, Dr Bill Scott, Professor Simi Ali
  • Owning School: FMS Graduate School
  • Teaching Location: Newcastle City Campus
Semester 1 Credit Value: 20
ECTS Credits: 10.0


The module aims:

1. To provide an overview of and introduction to transplantation sciences in the context of solid organ and haematopoietic stem cell transplants

2. To provide sound understanding of the scientific basis underlying the therapeutic benefits and adverse effects of clinical transplants

3. To highlight the research areas in transplantation where applications of immunology, cell biology and novel technology are impacting on clinical outcome and patient wellbeing

Outline Of Syllabus

The module covers following main areas:

1. Transplantation immunology: allo-Ag presentation/recognition, cellular and molecular factors involved in alloreactive immune responses, antibody mediated rejection, immunotolerance induction and immunosuppression.

2. HLA system and tissue typing: the genetic organization and polymorphisms of the HLA system, the protein structure of HLA antigens, non-HLA genetics, HLA in health and disease, and the impact of HLA matching on donor selection and transplant outcome.

3. Transplant therapeutic effect: haematopoietic stem cell transplant for leukaemia, lymphoma, and primary immunodeficiency, islet transplant and beta-cell replacement for type1 diabetes, corneal/limbal stem cell transplant for damaged tissue repair and identification of biomarkers of tolerance and rejection.

4. Transplant complications: The risk factors and pathogenesis, the prevention and development of novel therapies are introduced and discussed in the context of acute and chronic kidney graft rejection, non-immune injury in chronic lung allograft rejection, graft-versus-host disease in haematopoietic stem cell transplant.

5. Techniques and approaches being developed to improve transplant outcome and increase the supply of donor organs, such as manipulation of haematopoietic stem cell grafts for clinical use and reconditioning donor lungs for transplantation.

Teaching Methods

Teaching Activities
Category Activity Number Length Student Hours Comment
Guided Independent StudyAssessment preparation and completion130:0030:00Preparation & Submission of Essay
Guided Independent StudyAssessment preparation and completion130:0030:00Preparation of Presentation & Presentation
Scheduled Learning And Teaching ActivitiesLecture201:0020:00Lectures
Scheduled Learning And Teaching ActivitiesSmall group teaching21:002:00Course subject related seminars and discussions
Guided Independent StudyReflective learning activity118:0018:00Additional Reading & Reflective Learning
Guided Independent StudyIndependent study150:0050:00Revision for Examinations
Guided Independent StudyIndependent study150:0050:00Preparation of Notes from Lectures and Reading
Teaching Rationale And Relationship

Interactive lectures will provide the students with a specific knowledge as a platform for private study. These lectures will promote discussion of key concepts and critical appraisal of current practices and encourage the students to reflect on their learning. Students will practice presentation skills and report writing (for assessment). All of these activities relate directly to the learning outcomes above.

Assessment Methods

The format of resits will be determined by the Board of Examiners

Description Length Semester When Set Percentage Comment
Written Examination601A60Unseen written exam; one essay out of a choice of three
Other Assessment
Description Semester When Set Percentage Comment
Prof skill assessmnt1M20Poster presentation
Essay1M202000 word essay
Assessment Rationale And Relationship

The unseen written paper tests the student's knowledge-base, comprehension, ability to discuss the subject knowledge critically and to synthesise and evaluate scientific literature. The 2000 word in-course essay allows the student to demonstrate and reinforce their understanding of knowledge acquired from taught lectures, which encourages the student to develop intellectual skills and independent learning approaches supported by interactive lectures and additional literature reading. This task also provides the student an opportunity to exercise critical thinking and scientific writing skills.
Poster presentation encourages integration and application of knowledge acquired from the lectures and self-directed studies. It also fosters critical thinking, problem solving and creativity.

The examination will test the student's knowledge and understanding of the subject. In particular the ability to discuss and critically appraise current practices.

Reading Lists