Clinical Trials CPD

Adaptive Designs and Multiple Testing Procedures

Two day CPD programme

New dates to be announced soon

Venue: Henry Daysh Building, Newcastle University main campus, Newcastle upon Tyne

About the programme

Adaptive designs are a novel approach to improving the efficiency and participant benefit of clinical trials. With an adaptive design, information gathered during the trial can change in a robust way.

Many types of adaptive designs are possible for different situations in all phases of trials. In both adaptive and non-adaptive trials, there are often numerous hypotheses tested.

Examples include:

• trials with many endpoints
• multiple treatment arms
• when a trial tests a treatment in different patient subgroups

Adaptive trials often mean that a particular hypothesis is tested several times during the trial. This can create issues with multiple testing. Suitable procedures ensure the appropriate error rate is controlled.

In this course we will give an overview of various testing issues and adaptive designs in trials.

You will learn:

• a variety of new adaptive clinical trial designs, including multi-arm multi-stage (MAMS), umbrella studies and adaptive randomisation
• how to design adaptive trials, such as the implications of the design on the analysis and practical aspects of running the trial

Throughout the course, we will use real examples to show the methodology. We will look at how to use available software (in both R and Stata depending on delegate preference) to put in place the procedure in practice.

For further information

 If you have any queries about our CPD programme please email Professor James Wason